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Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo

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Science China(Life Sciences) 2022年第6期65卷 1181-1197页

作者： Haoran Peng Cuiling Ding Liangliang Jiang Wanda Tang Yan Liu Lanjuan zhao Zhigang Yi Hao Ren Chong Li Yanhua He Xu Zheng hailin Tang Zhihui Chen Zhongtian Qi Ping zhao Department of Microbiology Second Military Medical UniversityShanghai Key Laboratory of Medical BiodefenseShanghai 200433China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China Cancer Institute Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Infectious Disease Changhai HospitalShanghai 200433China

The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a global *** candidates with high efficacy,ready availability,and that do not develop resistance are in urgent *** that screening to repurpose clinically approved drugs has provided a variety of hits shown to be effective against SARS-CoV-2 infection in cell culture,there are few confirmed antiviral candidates in *** this study,94 compounds showing high antiviral activity against SARS-CoV-2 in Vero E6 cells were identified from 2,580 FDA-approved small-molecule *** them,24 compounds with low cytotoxicity were selected,and of these,17 compounds also effectively suppressed SARS-CoV-2 infection in He La cells transduced with human *** compounds disturb multiple processes of the SARSCoV-2 life *** prophylactic efficacies were determined in vivo using Syrian hamsters challenged with *** compounds reduced weight loss and promoted weight regain of hamsters infected not only with the original strain but also the D614G *** for cisatracurium,six compounds reduced hamster pulmonary viral load,and IL-6 and TNF-αm RNAwhen assayed at 4 d *** particular,sertraline,salinomycin,and gilteritinib showed similar protective effects as remdesivir in vivo and did not induce antiviral drug resistance after 10 serial passages of SARS-CoV-2 in vitro,suggesting promising application for COVID-19 treatment.

关键词： SARS-CoV-2 drug repurposing drug screening hamster model D614G variant drug resistance

两种不同灌溉方式对华北低平原区油葵生长发育的影响

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分子植物育种 2018年第2期16卷 678-682页

作者：李积铭李和平赵海林刘桂华李爱国宋聪敏河北省农林科学院旱作农业研究所河北省农作物抗旱研究重点实验室衡水053000

为了探索适宜的华北低平原区油葵种植模式,通过田间试验,比较研究了干播湿出膜下滴灌和传统的冬春灌覆膜播种方式在华北低平原区对油葵生长发育的影响。结果表明:干播湿出膜下滴灌较传统的冬春灌覆膜播种可以有效降低油葵株高,增大茎粗... 详细信息

为了探索适宜的华北低平原区油葵种植模式,通过田间试验,比较研究了干播湿出膜下滴灌和传统的冬春灌覆膜播种方式在华北低平原区对油葵生长发育的影响。结果表明:干播湿出膜下滴灌较传统的冬春灌覆膜播种可以有效降低油葵株高,增大茎粗,提高油葵的抗倒伏能力;同时可以有效地提高土壤表层温度,并为油葵苗期生长发育和地下部生长提供有利的土壤环境,能促进油葵根系生长,增加地下部生物量,提高产量。

关键词：冬春灌覆膜播种干播湿出膜下滴灌油葵影响

基于Winpcap的网络流量测量系统的应用研究

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电脑编程技巧与维护 2009年第8期 57-59,98页

作者：赵海琳黄生叶刘平波中南林业科技大学职业技术学院长沙410004 湖南大学计算机与通信学院长沙410082

本文设计和实现一个基于WinpCap的网络流量监测系统,详细阐述了数据包捕获和Web显示界面的设计与实现,给出了相关的函数体,并描述了系统的实现。

关键词：流量监测 WinPcap 数据采集

浅谈乌海电业局10kV配电变压器的选择与安装

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内蒙古电力技术 2006年第2期24卷 38-40页

作者：孙伟红张志强赵海林乌海电业局内蒙古海勃湾016000

介绍了乌海电业局配网建设与改造中,配电变压器位置、型号及容量的选择方法,以及安装配电变压器台架时,各种电气设备、引下线和接地装置的安装要求与方法。

关键词：配电变压器台架安装接地装置

Fractal Uniform Circular Arrays Based Multi-Orbital-Angular-Momentum-Mode Multiplexing Vortex Radio MIMO

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China Communications 2018年第9期15卷 118-135页

作者： Linjun zhao hailin Zhang Wenchi Cheng State Key Laboratory of Integrated Services Networks (ISN) and School of Telecommunications EngineeringXidian University Xi'an 710071 China School of Electrical Engineering Shaanxi University of Technology Hanzhong 723000 China

A radio wave driven by Orbital angular momentum(OAM) is called a vortex radio and has a helical wavefront. The differential helical wavefronts of several vortex radios are closely related to their topological charges or mode numbers. In physics, two or more radio waves with different mode numbers are orthogonal to their azimuth angles. With the development of radio communication technologies, some researchers have been exploring the OAM-based multi-mode multiplexing(multi-OAM-mode multiplexing) technologies in order to enhance the channel spectrum efficiency(SE) of a radio communication system by using the orthogonal properties of vortex radios. After reviewing the reported researches of OAM-based radio communication, we find that some breakthroughs have been made in the combination of OAM and traditional Multi-Input-Multi-Output(MIMO). However, the existing technology is not sufficient to support OAM-based MIMO system to achieve maximum the channel SE. To maximize the spectrum efficiency of OAM-based MIMO system, we present a reused multi-OAM-mode multiplexing vortex radio(RMMVR) MIMO system, which is based on fractal uniform cir-cular arrays(UCAs). The scheme described in this study can effectively combine multiOAM-mode multiplexing with MIMO spatial multiplexing. First, we present the generation of RMMVR MIMO signals. Second, under line-of-sight(LOS) propagation conditions, we derive the channels of the RMMVR MIMO system. Third, we separate the RMMVR MIMO signals using an orthogonal separation method based on full azimuth sampling. Finally, we introduce the method for calculating the channel capacity of the RMMVR MIMO system. Theoretical analysis shows that the scheme proposed in this study is feasible. Moreover, the simulation results show that spatial and mode diversity are obtained by exploiting fractal UCAs. However, to enhance the channel SE of RMMVR MIMO system, an interference cancellation method needs to be introduced for zero-mode vortex radios, and some

关键词： MIMO 收音机分数维旋涡数组圆形通讯系统维护管理

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三峡库区龙门寨危岩体崩塌产生涌浪研究

地质力学学报 2020年第4期26卷 533-543页

作者：郑嘉豪黄波林张全赵海林冯万里王健陈小婷防灾减灾湖北省重点实验室(三峡大学) 湖北宜昌443002

长江两岸高耸的危岩体对航道、沿岸居民带来巨大安全隐患。大宁河属于长江一级支流,龙门寨危岩体位于大宁河上,距离巫山县城仅1 km。利用FLOW-3D软件,模拟了145 m、175 m两种水位工况下龙门寨危岩体崩塌产生涌浪过程和涌浪传播过程。模... 详细信息

长江两岸高耸的危岩体对航道、沿岸居民带来巨大安全隐患。大宁河属于长江一级支流,龙门寨危岩体位于大宁河上,距离巫山县城仅1 km。利用FLOW-3D软件,模拟了145 m、175 m两种水位工况下龙门寨危岩体崩塌产生涌浪过程和涌浪传播过程。模拟结果表明,涌浪在145 m水位工况下最大浪高约为17.9 m,175 m水位工况下最大浪高约为11.6 m;在巫山县的五个码头处,两种水位工况最大涌浪爬高分别约为10.9 m、3.8 m;根据涌浪高度,对大宁河进行危险分区,145 m水位工况下极高危险区长度约4.4 km,很高危险区长度约1.9 km;175 m水位工况下极高危险区长度约3.0 km,很高危险区长度约1.0 km。研究结果有助于防控龙门寨危岩体潜在涌浪灾害危害,保障大宁河航道和巫山县码头安全,同时也为三峡库区滑坡涌浪灾害提供了预警依据。

关键词：龙门寨危岩体滑坡-涌浪 FLOW-3D软件传播过程危险区划分

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棉花病虫害遥感监测研究进展

山东农业科学 2024年第4期56卷 164-171页

作者：胡连槟兰玉彬于海琳张帅领田秉权王小丽王泽生赵静李永军山东理工大学农业工程与食品科学学院山东淄博255000 滨州市滨城区农喜棉花专业合作社山东滨州256600

病虫害严重威胁棉花的产量与质量,阻碍棉花产业的发展,传统人工田间调查病虫害发生状况的方法难以满足大范围病虫害监测预报的需求。遥感监测技术可以无损获取棉花表型信息,能快速、大面积解译病虫害发生程度及空间分布信息,已发展成为... 详细信息

病虫害严重威胁棉花的产量与质量,阻碍棉花产业的发展,传统人工田间调查病虫害发生状况的方法难以满足大范围病虫害监测预报的需求。遥感监测技术可以无损获取棉花表型信息,能快速、大面积解译病虫害发生程度及空间分布信息,已发展成为棉花病虫害监测的重要途径。本文阐述了棉花病虫害近地、低空、卫星遥感监测的研究进展,总结了现有发展面临的问题,并对未来的研究方向和应用前景进行了展望,以期为棉花病虫害遥感监测研究提供指导和建议。

关键词：遥感监测棉花病虫害光谱响应识别预测研究进展

同方期刊数据库博看期刊评论

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响应面法优化浓香型白酒扣盖蒸料工艺

中国酿造 2024年第6期43卷 233-238页

作者：商海林邢宪卿吕志远刘玉涛张梦梦赵巧珍任广花缪坤辰苏静齐鲁工业大学(山东省科学院)生物工程学院山东济南250353 济南趵突泉酿酒有限责任公司山东济南250115

该研究以淀粉糊化率和酸度为考察指标,采用单因素试验探究蒸料时间、蒸汽通量以及稻壳用量对入池酒醅蒸料效果的影响。在单因素试验的基础上,以淀粉糊化率为响应值,通过Plackett-Burman试验及响应面试验优化浓香型白酒扣盖蒸料的工艺条... 详细信息

该研究以淀粉糊化率和酸度为考察指标,采用单因素试验探究蒸料时间、蒸汽通量以及稻壳用量对入池酒醅蒸料效果的影响。在单因素试验的基础上,以淀粉糊化率为响应值,通过Plackett-Burman试验及响应面试验优化浓香型白酒扣盖蒸料的工艺条件,并将其与开盖蒸料工艺进行比较。结果表明,蒸料时间、蒸汽通量以及稻壳用量对入池酒醅的淀粉糊化程度影响显著(P0.05),其中酸度为(2.22±0.13)mmol/10 g、原酒出酒率为(38.11±0.11)%、己酸乙酯含量为(2.89±0.06)g/L,酒醅入池发酵过程中的温度变化趋势一致,说明扣盖蒸料工艺能够保证浓香型白酒的正常发酵。

关键词：浓香型白酒入池酒醅扣盖蒸料工艺淀粉糊化率响应面法

Experimental study of density gradient-driven micro-instabilities and the confinement degradation during H-mode in EAST

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Plasma Science and Technology 2023年第8期25卷 28-37页

作者：陈斐李亚东王晓洁吴国将李磐耿靖森汪宇豪孙鹏军李二众周天富赵海林臧庆王守信刘海庆金仡飞吕波裴千镐李建刚 Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People's Republic of China University of Science and Technology of China Hefei 230026People's Republic of China

A broadband(BB)mode is observed by collective Thomson scattering diagnostics in repeatable shots of EAST and analyzed for the first *** BB mode usually grows during L–H transitions,featuring a BB quasi-coherent mode with increasing *** H-mode operations,it is characterized by steady-state BB in the high-frequency range(f~200–2000 k Hz),at the electron scale(k_(θ)ρ_(s)=1–2),mainly driven by the density gradient,and is sensitive to the value ofηein the region of interest(ρ=0.4–0.8),wherehe=(R/L_(Te))/(R/L_(ne))is the ratio of the normalized electron temperature gradient and density gradient,and the regionρ=0.4–0.8 usually has a relatively low collisionality(v_(eff)<5).The frequency of BB is found to be dependent on the electron temperature and density gradient,which is a typical feature of electron-driven turbulence.A negative correlation between the energy confinement and the intensity of the BB turbulence during H-mode has been found,which indicates a strong electron thermal transport induced by the BB *** BB significantly decreases the electron temperature and causes flatter electron temperature profiles in the region of interest(ρ=0.4–0.8),thus makingηedecrease and the BB destabilize *** characteristics of BB are related to the theoretical density gradient-driven trapped electron *** should be noted that this mode is not observed by other diagnostics in EAST,and shows very different features to the coherent modes in the edge.

关键词： micro-instabilities H-mode confinement degradation