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Science China Chemistry 2024年第6期67卷 1881-1903页

作者： Dayang Wang Xiaohua Li Huanchen Yao Xin Liu Yan Gao hailin cong Bing Yu Youqing Shen College of Chemistry and Chemical Engineering College of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific *** have the characteristics of wide sources,excellent biocompatibility,and *** addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar *** polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for ***,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of *** is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

关键词： polysaccharide hydrophobic modification micelle drug delivery biomedicine

Bimetallic selenide heterostructure with directional built-in electricfield confined in N-doped carbon nanofibers for superior sodium storage with ultralong lifespan

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Journal of Energy Chemistry 2024年第4期91卷 407-416页

作者： Junying Weng Degui Zou Wenyong Yuan Pengfei Zhou Minghui Ding Jin Zhou hailin cong Fangyi Cheng School of Materials Science and Engineering Shandong University of TechnologyZibo 255000ShandongChina School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000ShandongChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

Constructing heterostructure is considered as an effective strategy to address the sluggish electronic and ionic kinetics of anode materials for sodium ion batteries(SIBs).However,realizing the orientated growth and uniform distribution of the heterostructure is still a great ***,the regulated novel CoSe_(2)/NiSe_(2)heterostructure confined in N-doped carbon nanofibers(CoSe_(2)/NiSe_(2)@N-C)are prepared by using Co/Ni-ZIF template,in which,the CoSe_(2)/NiSe_(2)heterostructures realize uniform distribution on a micro *** from the unique heterostructure and N-doped carbon nanofibers,the CoSe_(2)/NiSe_(2)@N-C deliveries superior rate capability and durable cycle lifespan with a reversible capacity of 400.5 mA h g^(-1)after 5000 cycles at 2 A g^(-1).The Na-ion full battery with CoSe_(2)/NiSe_(2)@N-C anode and layered oxide cathode displays a remarkable energy density of 563 W h kg^(-1)with 241.1 W kg^(-1)at 0.1 A g^(-1).The theoretical calculations disclose that the periodic and directional built-in electric-field along with the heterointerfaces of CoSe_(2)/NiSe_(2)@N-C can accelerate electrochemical reaction *** in(ex)situ experimental measurements reveal the reversible conversion reaction and stable structure of CoSe_(2)/NiSe_(2)@N-C during Na+insertion/*** study highlights the potential ability of precisely controlled heterostructure to stimulate the electrochemical performances of advanced anode for SIBs.

关键词： CoSe_(2)/NiSe_(2) heterostructure Built-in electric-field Rate capability Ultralong lifespan Sodium ion batteries

Hybrid brominated sulfonated poly(2,6-diphenyl-1,4-phenylene oxide) and SiO2 nanocomposite membranes for CO2/N2 separation

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Progress in Natural Science:Materials International 2012年第6期22卷 661-667页

作者： Bing Yu hailin cong Xiusong Zhao College of Chemical and Environmental Engineering Qingdao University Laboratory for New Fiber Materials and Modern Textile Growing Base for State Key Laboratory The University of Queensland School of Chemical EngineeringBrisbaneQLD 4072Australia

Brominated sulfonated poly(2,6-diphenyl-1,4-phenylene oxide)(BSPPOdp) was synthesized as a new membrane material for CO2/*** 90%brominated-10%sulfonated PPOdp(BSPPOdp9010) was selected as representative material for membrane *** formed flexible membranes with higher CO2permeability(PCO2= 58 Barrer) and selectivity (αCO2/N2=36) than poly(2,6-dimethyl-1,4-phenylene oxide)(PPOdm) ***9010 membranes containing silica nanoparticles enhanced CO2permeability while maintaining the CO2/ N2selectivity as compared with the pure BSPPOdp9010 *** CO2permeability increased as a function of the silica content in the *** separation mechanism for CO2/N2in the membranes was attributed to the gas solubility effect rather than the gas diffusivity.

关键词： Poly(2,6-diphenyl-1,4-phenylene oxide) Silica Nanocomposites Gas separation

Research on GGT-responsive drug carrier with active transport effect

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Nano Research 2023年第5期16卷 7075-7084页

作者： Han Yan He Ma Bin He Bing Yu Youqing Shen hailin cong Institute of Biomedical Materials and Engineering College of Materials Science and EngineeringCollege of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao 266071China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for BionanoengineeringDepartment of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Shandong University of TechnologyZibo 255000China

Although a great quantity research has been done on cancer nano-drug carriers,how to deliver more cancer nano-drugs to tumor sites accurately and then endocytosis by cells is still a key problem in the process of cancer *** the concentration ofγ-glutamyl transpeptidase(GGT)in the microenvironment will be greatly increased when the liver,kidney,other organs become cancerous,we have designed a polymer nanomicelle as drug carrier that can respond to the GGT in the tumor *** the drug delivery system participates in blood circulation through the vascular wall cells to the tumor tissue,the overexpressed GGT on the surface of the cancer cells will recognize and cut theγ-glutamyl group on the carrier,the primary amines will be released to make the system with weak positive charge,which not only improves the carrier’s active transport ability for nanodrugs,but also improves the cell’s endocytosis ability for nano-drugs,so as to realize the release of nano-drugs in cancer ***’s more,the positive charge on the surface of the carrier also improves the permeability of the carrier in the tumor tissue,so that the cancer cells in the hypoxic area can also endocytosis drugs.

关键词： micelles enzyme response active transport endocytosis

The drug loading behavior of PAMAM dendrimer:Insights from experimental and simulation study

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Science China(Technological Sciences) 2023年第4期66卷 1129-1140页

作者： ZHOU LiPing LI JiaWei YU Bing ZHANG Jun HU Hao cong hailin SHEN YouQing Institute of Biomedical Materials and Engineering College of Materials Science and EngineeringQingdao UniversityQingdao 266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao 266071China Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering China University of PetroleumQingdao 266580China Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China

Poly(amidoamine)(PAMAM)dendrimers are widely studied as drug vectors due to their particular structure and excellent *** molecules can be loaded in the internal cavity of dendrimers or adsorbed on the *** this paper,the interaction force and spatial configuration between PAMAM and several typical chemotherapy drugs(doxorubicin(DOX),paclitaxel(TAX),hydroxycamptothecin(HCPT))is studied by molecular dynamics(MD)*** essential parameters of dendrimers as drug carriers are analyzed by combining experiments and MD simulations,including particle size,drug loading,drug release,and *** simulation of dendrimer@drug complexes demonstrates that many cavities are semi-open,and most drug molecules are not completely *** internal structure of PAMAM dendrimers became looser with more extended nuclei,which increased the non-covalent interactions between PAMAM dendrimers and drug *** umbrella sampling simulations reveal that the change of binding energies between dendrimers and drug molecules is responsible for the variation in drug release *** study provides valuable enlightenment information for the drug loading/release of PAMAM dendrimers.

关键词： PAMAM dendrimer chemotherapy molecular dynamics simulation binding energies

Preparation and anti-tumor application of hyaluronic acid-based material for disulfide and copper ions co-delivery

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Science China(Technological Sciences) 2021年第9期64卷 2023-2032页

作者： PANG Long ZHONG Wei WANG QiuBo FENG HaoHui DONG HaoNan WANG Song cong hailin SHEN YouQing YU Bing Institute of Biomedical Materials and Engineering College of Chemistry and Chemical EngineeringCollege of Materials Science and EngineeringAffiliated Hospital of Qingdao UniversityQingdao UniversityQingdao 266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao 266071China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for BionanoengineeringDepartment of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

Disulfide(DSF) has been proved good anti-tumor effect and even better with coadministration of Cu^(2+). In this work, we report the use of hyaluronic acid(HA) based materials to construct vectors for the delivery of both DSF and Cu^(2+). HA was firstly modified with polyethylene glycol monomethyl ether(mPEG) and polycaprolactone(PCL) to synthesize an amphiphilic polymer(HA-PEG-PCL). DSF could be loaded in the hydrophobic core and Cu^(2+) could be cooperated to the negative hydrophilic segment. The Cu^(2+) also played a role as crosslinking agent, which prevented DSF leakage prematurely, avoiding the bad side effects to normal tissues. The interaction between HA and CD44 improved the distribution of nanodrugs in tumor cells. When the nanodrugs were delivered to the cancer cell, the acidic micro-environment would separate the Cu^(2+) from the surface, leading to the disintegration of the micelles, promoting the release of DSF from the micelle core. The results of in vitro and in vivo experiments showed that the DSF and Cu^(2+) co-delivery vector constructed in this work could enhance the antitumor effect and have low biological toxicity.

关键词： hyaluronic acid disulfide Cu^(2+) cancer co-delivery

Bioinspired nanochannels based on polymeric membranes

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Science China Materials 2021年第6期64卷 1320-1342页

作者： He Ma Song Wang Bing Yu Xin Sui Youqing Shen hailin cong Institute of Biomedical Materials and Engineering College of Materials Science and EngineeringCollege of Chemistry and Chemical EngineeringAffiliated Hospital of Qingdao UniversityQingdao UniversityQingdao 266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao 266071China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for BionanoengineeringDepartment of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China

Bio-nanochannels in living organisms participate in the physiological activities by selectively transporting ions through cell *** structure and function of biological ion channels inspire the development of artificial ion nanochannels with practical *** bioinspired nanochannels based on polymer materials present good mechanical stability,high-performance ion transport and designability,which have attracted much *** this review,we mainly focus on the fabrication and application of polymer-based biomimetic nanochannels especially in environmentally responsive biosensor and energy *** firstly introduce the basic understanding of nanochannels in ion regulation and osmotic energy ***,we discuss the fabrication methods of polymer-based nanochannels and highlight their advantages compared with other *** practical applications of polymer-based biomimetic nanochannels,especially in energy conversion and environmentally responsive biosensor,are detailedly ***,we summarize the unsolved problems in bioinspired nanochannels and overview the further developing direction in this field.

关键词： bioinspired nanochannel polymeric membrane environmentally responsive biosensor energy conversion

A site-oriented nanosystem for active transcellular chemo-immunotherapy to prevent tumor growth and metastasis

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Science China Materials 2022年第5期65卷 1391-1402页

作者： Min Zhang Wenli Wang He Ma Bing Yu hailin cong Youqing Shen Institute of Biomedical Materials and Engineering College of Materials Science and EngineeringQingdao UniversityQingdao 266071China State Key Laboratory of Bio-Fibers and Eco-Textiles College of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071China Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China

Immunotherapy has shown promising potential in cancer therapy;however, poor delivery by nanocarriers and insufficient immune response in tumors have severely impeded its clinical application. To overcome these disadvantages, a site-specific and active transcellular drug delivery system was developed herein for chemotherapyenhanced immunotherapy. When arriving at the tumor site,the matrix metallopeptidase 2(MMP2)-responsive shell detached from the nanosystem, releasing positively charged cores. The cationic surface of the inner cores induced adsorption-meditated transcytosis, which facilitated transendothelial transportation and transcellular drug delivery into distal tumor cells. PD-L1 antibody and chemotherapeutic drugs were loaded in the outer layer and inner cores of the nanosystem, respectively, to be precisely delivered to target sites, thereby achieving synchronized delivery and siteoriented release of different anticancer agents. PD-L1 antibody released in the tumor microenvironment effectively blocked the binding of PD-L1 to its receptors on the T cell surface. Oxaliplatin and indoximod co-delivered in the cationic cores can induce immunogenic cell death and attenuate the immunosuppressive effect throughout the tumor tissues,recruiting a large amount of T cells and further enhancing the immunotherapy. The resulting synergistic antitumor response could not only efficiently inhibit the growth of primary tumors, but also help prevent metastasis of primary tumor to distant sites. This study offers a novel nano-enabled strategy for chemo-immunotherapy in immunosuppressive tumors.

关键词： active transcellular drug delivery site-oriented drug release chemo-immunotherapy immunosuppressive effect reversion tumor metastasis inhibition

Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

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Science China(Life Sciences) 2024年第9期67卷 1849-1866页

作者： Kumar Ganesan cong Xu Jianming Wu Bing Du Qingqing Liu Yue Sui Cailu Song Jinhui Zhang hailin Tang Jianping Chen School of Chinese Medicine LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Pharmacy Southwest Medical UniversityEducation Ministry Key Laboratory of Medical ElectrophysiologySichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSouthwest Medical UniversityLuzhou 646000China College of Food Science South China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510080China

The spreading of cancer cells from the primary tumor site to other parts of the body,known as metastasis,is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC).Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70%of TNBC *** is crucial for promoting tumor metastasis and associated with poor ***,it is vital to identify effective therapeutic strategies targeting EGFR ***,an isoflavonoid found in various plants,such as clover and soybeans,has been shown to have anticancer properties in several *** the present study,we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular *** used various assays,including cell viability,colony formation,Transwell,wound healing,ELISA,Western blotting,and staining techniques,to achieve this *** results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis,as evidenced by the cell viability assay,colony formation assay,and expression of apoptosis markers,and reduced the metastatic capabilities of TNBC *** effects were achieved through the direct suppression of cell adhesion,invasiveness and ***,in TNBC xenograft lung metastatic models,ononin treatment significantly reduced tumor growth and lung ***,ononin reversed the epithelial-mesenchymal transition(EMT)by downregulating the expression of EMT markers and matrix metalloproteinases,as confirmed by Western blot ***,ononin treatment reduced EGFR phosphorylation and suppressed the PI3K,Akt,and m TOR signaling pathways,which was further confirmed using EGFR agonists or ***,ononin treatment did not exert any toxic effects on liver or kidney *** conclusion,our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRm

关键词： ononin TNBC breast cancer lung metastasis EGFR PI3k/Akt EMT therapeutic effect

Co-delivery of chemotherapeutic drugs and cell cycle regulatory agents using nanocarriers for cancer therapy

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Science China Materials 2021年第8期64卷 1827-1848页

作者： Ying Sun Hao Hu Xiaodong Jing Qingye Meng Bing Yu hailin cong Youqing Shen Institute of Biomedical Materials and Engineering College of Materials Science and EngineeringQingdao UniversityQingdao 266071China Laboratory for New Fiber Materials and Modern Textile Growing Base for State Key LaboratoryCollege of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071China Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China

Combination chemotherapy is widely exploited to overcome multidrug resistance(MDR) and enhance the therapeutic effect of anti-tumor agents clinically. The traditional combination regimens applied in clinical practice still suffer from various obstacles, such as inevitable side ***, the application of nanotechnology and the proposal of co-delivery systems make the combination therapy more effective. The occurrence, development, and metastasis of tumors are closely related to the cell cycle. The sensitivity of tumor cells to chemotherapeutic drugs can be improved with the cooperation of cell cycle regulators. In this review, the influence of the cell cycle on tumorigenesis and development is introduced briefly. The current strategies of combining chemotherapeutic drugs and cell cycle regulators through codelivery systems are discussed in detail. We also sketch the possibility of treating tumors mildly via artificially controlling the cell cycle and outline the challenges and perspectives about the improvement of co-delivery systems for cancer therapy.

关键词： chemotherapy cell cycle regulation co-delivery system combination therapy cancer therapy