检索结果-南通市图书馆

Automatic recognition of tweek atmospherics and plasma diagnostics in the lower ionosphere with the machine learning method

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2023年第3期7卷 407-413页

作者： Mao Zhang GaoPeng Lu hailiang huang ZhengWei Cheng YaZhou Chen Steven A.Cummer JiaYi Zheng JiuHou Lei School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Atmospheric Optics Anhui Institute of Optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China National Key Laboratory on Electromagnetic Environment Effects Army Engineering UniversityShijiazhuang CampusShijiazhuang 050003China Electrical and Computer Engineering Department Duke UniversityDurhamNC 27708USA

Tweek atmospherics are extremely low frequency and very low frequency pulse signals with frequency dispersion characteristics that originate from lightning discharges and that propagate in the Earth–ionosphere waveguide over long distances.In this study,we developed an automatic method to recognize tweek atmospherics and diagnose the lower ionosphere based on the machine learning method.The differences(automatic−manual)in each ionosphere parameter between the automatic method and the manual method were−0.07±2.73 km,0.03±0.92 cm^(−3),and 91±1,068 km for the ionospheric reflection height(h),equivalent electron densities at reflection heights(Ne),and propagation distance(d),respectively.Moreover,the automatic method is capable of recognizing higher harmonic tweek sferics.The evaluation results of the model suggest that the automatic method is a powerful tool for investigating the long-term variations in the lower ionosphere.

关键词： machine learning method tweek atmospherics reflection height D-region ionosphere

Availability modeling for periodically inspection system with different lifetime and repair-time distribution

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2019年第7期32卷 1667-1672页

作者： Junliang LI Yueliang CHEN Yong ZHANG hailiang huang Qingdao Campus Naval Aviation UniversityQingdao266041China The92635th Unit of Navy Qingdao266041China

Availability is a main feature of design and operation of all engineering system. Recently,availability evaluation of periodical inspection systems with different structures is at the center of attention due to the wide application in engineering. In this paper, an analytical and probabilistic availability model for periodical inspection system is proposed by a new recursively algorithm,which can achieve limiting average availability and instantaneous availability of periodical inspection system under arbitrary lifetime and repair-time distributions. Then three application examples are presented, the systems lifetime and repair-time are respectively fellow exponential/exponential,Weibull/normal and Weibull/lognormal distribution. Finally, a Weibull/lognormal system is studied to analyze the dynamic relationship between inspection period and availability. The results indicate that the proposed approach can provide the technology support for improving system availability and determining reasonable inspection period.

关键词： Availability Inspection period Lifetime distribution Reliability Repair-time distribution

Ag Nanowire-Ag Nanoparticle Hybrids for the Highly Enhanced Fluorescene Detection of Protoporphyrin IX Based on Surface Plasmon-Enhanced Fluorescence

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2016年第12期34卷 1321-1328页

作者： Yunjia Wang Xihong Zu Guobin Yi Hongsheng Luo hailiang huang Xuliang Song School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou Guangdong 510006 China

In this study, we developed an approach to fabricate novel 1D Ag NWs-Ag NPs hybrid substrate for enhanced fluorescene detection of protoporphyrin 1X （PplX） based on surface plasmon-enhanced fluorescence. The Ag NWs-Ag NPs hybrid was synthesized by combining the hydrothermal method and self-assembly method with the asisstance of polyvinylpyrrolidone （PVP）. When the Ag NWs-Ag NPs hybrid was deposited on the glass substrate and employed as active substrate to detect PplX, the fluorescence intensity of PplX was enhanced greatly due to the coupling effect of localized surface plasmon-localized surface plasmon （LSP-LSP） and localized surface plasmon- surface plasmon propagation （LSP-SPP） which induced great enhancement of the electromagnetic field. Furthermore, the enhancement effect was approximately linear when the concentration of PpIX was ranged from 1×10^-7 mol/L to 2×10^-5 mol/L, and the photobleaching phenomenon of PplX was reduced greatly, indicating that the fab- ricated Ag NWs-Ag NPs hybrid substrate had well performance for PplX imaging. This work provides an effective approach to prepare highly sensitive and stable fluorescence enhancement substrate, and has great potential application in fluorescence imaging.

关键词： hybrid localized surface plasmon coupling surface plasmon resonance fluorescence enhancement

生物医学领域碳纳米材料10年研究前沿与热点

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第4期29卷 752-760页

作者：党小雯黄海量黄雷王亚洁山东中医药大学康复医学院山东省济南市250355

背景:生物医学领域碳纳米材料的研究蓬勃发展,相关科研成果逐年增加,但此领域的年发文量、国家、机构、作者的研究情况及研究热点与趋势等内容的可视化分析相对匮乏。目的:展现生物医学领域碳纳米材料研究现状,揭示主要的研究主体,探索... 详细信息

背景:生物医学领域碳纳米材料的研究蓬勃发展,相关科研成果逐年增加,但此领域的年发文量、国家、机构、作者的研究情况及研究热点与趋势等内容的可视化分析相对匮乏。目的:展现生物医学领域碳纳米材料研究现状,揭示主要的研究主体,探索研究热点及发展趋势,为此领域未来发展提供参考。方法:以Web of Science核心集数据库为文献来源,检索2012-2023年生物医学领域碳纳米材料的相关文献,运用Citespace软件以国家、机构、作者、关键词、共被引为节点生成知识图谱并进行可视化分析。结果与结论:①共纳入2932篇文献,碳纳米材料在医学领域年发文量多且增长速度较快;美国发文量较多;中国是该领域的新兴力量,发文量虽然最多,但研究水平和影响力还有待提高;中国科学院是最大的合作网络机构,主要以国内机构为合作对象,缺少与国外知名单位的合作。②关键词分析显示,碳点的绿色合成方式及应用是近年来的研究热点;其次碳纳米材料与癌症光疗、免疫疗法相结合的新方法是未来研究中的重点方向。③共被引动态发展趋势提示,组织工程是生物医学领域碳纳米材料的热点研究主题,主要包括碳纳米材料对于心脏和神经组织修复和再生的研究以及作为3D和4D生物打印的生物墨水添加剂。④未来随着生物医学领域朝着以治疗为中心的精准方向发展,科研人员应加快创建科学有效的碳纳米材料与科技、新型聚合物或有机分子及新治疗方法等结合形成的碳基体系,发挥碳纳米材料的最大效应。

关键词：碳纳米材料生物医学可视化共被引文献计量学生物安全性研究热点癌症组织工程 Citespace

激光增材制造Al_(x)CoCrFeNi高熵合金的组织与性能

在线全文

学校读者我要写书评

暂无评论

材料工程 2024年第1期52卷 220-230页

作者：于丽莹王晨朱礼龙张华黄海亮阮晶晶张尚洲江亮周鑫烟台大学精准材料高等研究院山东烟台264005 中南大学粉末冶金国家重点实验室长沙410083

为了研究Al含量对FeCoCrNi合金组织性能的影响,采用多路送粉激光熔覆设备高通量制备Al_(x)CoCrFeNi高熵合金(0≤x≤0.9),通过X射线衍射仪、金相显微镜、扫描电子显微镜、电子探针和显微硬度计测试合金的相组成、显微组织结构、成分和硬... 详细信息

为了研究Al含量对FeCoCrNi合金组织性能的影响,采用多路送粉激光熔覆设备高通量制备Al_(x)CoCrFeNi高熵合金(0≤x≤0.9),通过X射线衍射仪、金相显微镜、扫描电子显微镜、电子探针和显微硬度计测试合金的相组成、显微组织结构、成分和硬度。结果表明:随着Al含量的增加,Al_(x)CoCrFeNi高熵合金由单一FCC相(x≤0.35)转变为FCC+BCC双相结构(0.35

关键词：激光熔覆高熵合金 Al_(x)CoCrFeNi 相组成微观组织

基于Nrf2/GPX4信号通路探讨半夏泻心汤诱导胃癌细胞铁死亡的机制

在线全文

学校读者我要写书评

暂无评论

中国实验方剂学杂志 2024年第6期30卷 10-19页

作者：李灵李亚星王雪邱啸郭炜黄海量刘西建韩涛山东中医药大学中医学院济南250355 山东中医药大学实验中心济南250355 山东中医药大学康复学院济南250355

目的:观察半夏泻心汤(BXT)对人胃癌HGC-27、MKN-45、AGS细胞增殖的影响及其作用机制。方法:采用细胞增殖与活性检测法(CCK-8)检测不同浓度的BXT含药血清(5%、10%、20%)对HGC-27、MKN-45、AGS细胞增殖的影响;线粒体膜电位探针(TMRE)检测... 详细信息

目的:观察半夏泻心汤(BXT)对人胃癌HGC-27、MKN-45、AGS细胞增殖的影响及其作用机制。方法:采用细胞增殖与活性检测法(CCK-8)检测不同浓度的BXT含药血清(5%、10%、20%)对HGC-27、MKN-45、AGS细胞增殖的影响;线粒体膜电位探针(TMRE)检测细胞内线粒体膜电位表达,采用试剂盒对铁离子(Fe^(2+))含量、脂质过氧化物(LPO)与超氧化物歧化酶(SOD)活性进行检测,采用蛋白免疫印迹法(Western blot)检测糖原合成激酶3β(GSK3β)、磷酸化GSK3β(p-GSK3β)、核转录因子E2相关因子2(Nrf2)和谷胱甘肽过氧化物酶4(GPX4)的蛋白表达水平,实时荧光定量聚合酶链式反应(Real-time PCR)检测胱氨酸/谷氨酸逆向转运蛋白溶质载体家族7成员11(SLC7A11)、重链溶质载体家族3成员2(SLC3A2)、转铁蛋白受体3(TFRC)和肿瘤蛋白P53(TP53)mRNA表达。结果:CCK-8结果显示含药血清干预3种胃癌细胞24 h,与空白组比较,BXT组与卡培他滨组均可显著降低胃癌细胞存活率(P<0.01);含药血清干预胃癌细胞48 h,与空白组比较,卡培他滨组与BXT组均可明显降低3种胃癌细胞存活率,BXT组呈现剂量依赖,以20%效果最明显(P<0.01)。在铁死亡生化指标方面,与空白组比较,BXT组与卡培他滨组可以显著降低胃癌细胞中线粒体膜电位表达、SOD活性(P<0.01),显著提高LPO、Fe^(2+)的含量(P<0.01),从而提高胃癌细胞对铁死亡的敏感。在Nrf2/GPX4通路方面,与空白组比较,BXT组可以通过降低胃癌细胞中p-GSK3β、Nrf2、GPX4蛋白表达(P<0.01),提高SLC7A11、SLC3A2 mRNA表达(P<0.05),提高胃癌细胞中GSK3β的蛋白表达(P<0.01),提高TP53、TFRC mRNA表达(P<0.05,P<0.01),抑制Nrf2/GPX4通路诱导胃癌细胞发生铁死亡。与卡培他滨组比较,20%BXT组效果更为明显。结论:半夏泻心汤可以通过抑制Nrf2/GPX4通路的诱导胃癌细胞HGC-27、MKN-45、AGS发生铁死亡。

关键词：半夏泻心汤胃癌铁死亡核因子E2相关因子2(Nrf2) 谷胱甘肽过氧化物酶4(GPX4)

GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive Patients with Schizophrenia

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第2期36卷 97-109页

作者： Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei Bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang hailiang huang Nanyin Zhang Tao Li Mental Health Center and Psychiatric Laboratory State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China West China Brain Research Center West China Hospital of Sichuan UniversityChengdu 610041China Department of Biomedical Engineering Pennsylvania State UniversityUniversity ParkPA 16802USA Analytic and Translational Genetics Unit Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Broad Institute of MIT and Harvard CambridgeMA 02141USA

The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients with schizophrenia.We used prepulse inhibition(PPI)and brain structural and diffusion MRI scans in 23 mice with conditional ErbB4 knockout in parvalbumin interneurons and 27 matched controls.Quantitative real-time PCR was used to assess the differential levels of GABA-related transcripts in brain regions.Concurrently,we measured structural and diffusion MRI and the cumulative contribution of risk alleles in the GABA pathway genes in firstepisode treatment-naı¨ve schizophrenic patients(n=117)and in age-and sex-matched healthy controls(n=86).We present the first evidence of gray and white matter impairment of right sensorimotor cortico-striatal networks and reproduced the sensorimotor gating deficit in a mouse model of schizophrenia.Significant correlations between gray matter volumes(GMVs)in the somatosensory cortex and PPI as well as glutamate decarboxylase 1 mRNA expression were found in controls but not in knockout mice.Furthermore,these findings were confirmed in a human sample in which we found significantly decreased gray and white matter in sensorimotor cortico-striatal networks in schizophrenic patients.The psychiatric risk alleles of the GABA pathway also displayed a significant negative correlation with the GMVs of the somatosensory cortex in patients.Our study identified that ErbB4 ablation in parvalbumin interneurons induced GABAergic dysregulation,providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia.

关键词： ErbB4 Schizophrenia MRI Gene pathway Mouse

在线全文

学校读者我要写书评

暂无评论

一体化双总线电源屏辅助电源板电路改造方案

模具制造 2024年第2期24卷 202-204页

作者：林焕文伦敏杰黄海亮广州地铁集团有限公司广东广州510000

一体化双总线电源屏采用配电、储能、变电、供电集成一体化设计,是信号专业设备供电的重要发展方向,而电源屏稳定的供电输出则是影响信号系统功能的关键因素。针对复杂故障条件下一体化双总线电源屏无法实现冗余供电的缺陷开展研究,分... 详细信息

一体化双总线电源屏采用配电、储能、变电、供电集成一体化设计,是信号专业设备供电的重要发展方向,而电源屏稳定的供电输出则是影响信号系统功能的关键因素。针对复杂故障条件下一体化双总线电源屏无法实现冗余供电的缺陷开展研究,分析具体故障原因,提出相应电路改造方案,并在实际运用中验证并推广了改造,完善了一体化电源屏的供电冗余功能,提升了电源屏供电稳定性。

关键词：一体化电源屏辅助电源板冗余供电

碳点复合聚多巴胺载药体系用于肿瘤协同治疗的评价

在线全文

学校读者我要写书评

暂无评论

沈阳药科大学学报 2024年第3期41卷 281-289,379页

作者：罗心怡王熙辰于千耘黄海亮郝雪贻赵勤富沈阳药科大学药学院辽宁沈阳110016

目的为了提高药物的治疗效果,降低毒性和不良反应,研究制备了一种基于碳点(CDs)修饰的聚多巴胺(polydopamine,PDA)的特异性药物递送系统。方法采用水热法制备直径约为4 nm的CDs,然后制备碳点复合聚多巴胺(PDA@CDs)载体。以盐酸阿霉素(D... 详细信息

目的为了提高药物的治疗效果,降低毒性和不良反应,研究制备了一种基于碳点(CDs)修饰的聚多巴胺(polydopamine,PDA)的特异性药物递送系统。方法采用水热法制备直径约为4 nm的CDs,然后制备碳点复合聚多巴胺(PDA@CDs)载体。以盐酸阿霉素(DOX)作为模型药物,制备DOX/PDA@CDs载药体系。采用透射电子显微镜、Zeta电位、动态光散射和荧光光谱等对载药体系进行表征。模拟肿瘤微环境以及NIR光照射对载药体系进行体外释放的考察,采用细胞水平实验评价该体系的热疗和化疗协同治疗效果。结果PDA@CDs载体具有优良的光热性能和光热稳定性。体外释放曲线表明,在pH 7.4 PBS和无近红外光照射的情况下,DOX释放量较少,在高过氧化氢浓度、pH 5.0 PBS和近红外光照射下,DOX的释放显著增加。细胞摄取实验证明PDA@CDs能被细胞摄取,且可以发射绿色荧光。细胞毒实验表明,DOX/PDA@CDs在NIR光照后显示出优异的化疗/热疗协同杀伤肿瘤细胞的作用。结论DOX/PDA@CDs具有pH/H2O2/NIR多重响应性释药的特点,能够实现热疗与化疗的协同治疗效果,在癌症治疗领域具有光明的前景。

关键词：聚多巴胺碳点抗癌药物光热疗法