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The pathogenic role of innate lymphoid cells in autoimmune-related and inflammatory skin diseases

Cellular & Molecular Immunology 2020年第4期17卷 335-346页

作者： Suqing Zhou Qianwen Li Haijing Wu Qianjin Lu Department of Dermatology The Second Xiangya Hospital of Central South UniversityHunan Key Laboratory of Medical Epigenomics139 Middle Renmin RoadChangshaHunan 410011China

Innate lymphoid cells(ILCs),as an important component of the innate immune system,arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues,including the intestine,skin,lung,and adipose tissue.ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orchestrating immune response and contribute to maintain metabolic homeostasis and regulate tissue inflammation.Currently,more details about the pathways for the development and differentiation of ILCs have largely been elucidated,and cytokine secretion and downstream immune cell responses in disease pathogenesis have been reported.Recent research has identified that several distinct subsets of ILCs at skin barriers are involved in the complex regulatory network in local immunity,potentiating adaptive immunity and the inflammatory response.Of note,additional studies that assess the effects of ILCs are required to better define how ILCs regulate their development and functions and how they interact with other immune cells in autoimmune-related and inflammatory skin disorders.In this review,we will distill recent research progress in ILC biology,abnormal functions and potential pathogenic mechanisms in autoimmune-related skin diseases,including systemic lupus erythematosus(SLE),scleroderma and inflammatory diseases,as well as psoriasis and atopic dermatitis(AD),thereby giving a comprehensive review of the diversity and plasticity of ILCs and their unique functions in disease conditions with the aim to provide new insights into molecular diagnosis and suggest potential value in immunotherapy.

关键词： ILC SLE scleroderma psoriasis atopic dermatitis autoimmunity

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Recent progress in synergistic electrocatalysis for generation of valuable products based on water cycle

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Nano Research 2023年第5期16卷 6444-6476页

作者： Yue Li Yanqing Jiao haijing Yan Chungui Tian Aiping wu Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of China Heilongjiang UniversityHarbin 150080China

Given the grim situation of global warming and energy crisis,replacing traditional energy conversions based on carbon cycle with water cycle is a sustainable development trend.The synergistic electrocatalysis for value-added chemical production through oxygen species(O_(ads):OH^(*),O^(*),and OOH^(*))and the active hydrogen species(H_(ads))derived from water splitting powered by“green”electricity from renewable energy resource(wind,solar,etc.)is a promising manner,because of its reduced energy consumption and emission and high Faradaic efficiency.The study and summarization of catalytic mechanism of synergistic electrocatalysis are particularly significant,but are rarely involved.In this review,recent progress of various synergistic electrocatalysis systems for generating valuable products based on water cycle is systematically summarized.Importantly,the catalytic mechanism of synergistic electrocatalysis and the positive effect of O_(ads) and H_(ads) species produced by water splitting during the synergistic electrocatalytsis are detailedly elucidated.Furthermore,the regulation of water-derived O_(ads) and H_(ads) species for achieving efficient matchability of synergistic electrocatalysis is emphatically discussed.Finally,we propose the limitations and future goals of this synergistic system based on water cycle.This review is guidance for design of synergistic electrocatalysis architectures for producing valuable substances based on water cycle.

关键词： synergistic electrocatalysis water cycle active oxygen and hydrogen species valuable products

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Tuning electronic structure of Ni_(3)S_(2) with tungsten doping for high-performance electrooxidation of 5-hydroxymethylfurfural

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Science China Chemistry 2023年第12期66卷 3636-3644页

作者： Shuangyue Wang Ganceng Yang Yanqing Jiao Yue Liu Chungui Tian Aiping wu haijing Yan Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

Electrooxidation of the biomass derivative 5-hydroxymethylfurfural (HMF) is a highly promising approach for attaining versatile value-added chemicals (e.g.,2,5-furandicarboxylic acid,FDCA).Ni-based sulfides are promising electrocatalysts for HMF electrooxidation reaction (HMFOR).However,the HMFOR activity of Ni-based catalysts is far from satisfactory due to the unfavorable adsorption of HMF and OH^(*).Herein,we propose controlled W doping to effectively modify the electronic configuration of nanostructured Ni_(3)S_(2) to manipulate adsorption of HMF and OH^(*),for efficiently converting HMF into FDCA.Experimental and theoretical calculations indicate the incorporation of high-valence W results in the upshift of d-band center of Ni_(3)S_(2),which facilitates the adsorption and dissociation of water to produce more OH^(*).Meanwhile,the high-valence W has strong electron-withdrawing ability and attracts electrons from Ni,leading to the elevated Ni valence,which is beneficial to optimizing the adsorption energy of HMF.Both concurrently contribute to the superb HMFOR performance.As a result,W_(20)-Ni_(3)S_(2)@NF with optimal W dopant exhibits a low driving potential (1.34 V vs.RHE at 10 mA cm^(-2)),accompanying with the 100% HMF conversion,99.2%FDCA selectivity,and 97.3%Faraday efficiency.This work provides a design principle for HMFOR electrocatalysts by modulating the adsorption behaviors of HMF and OH^(*)via rational electronic structure engineering.

关键词： 5-hydroxymethylfurfural electrooxidation W doping Ni-based sulfides electronic structure adsorption energy

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Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer

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Bioactive Materials 2023年第9期27卷 72-81页

作者： Qiongyu Qin Ming Yang Yu Shi haijing Cui Chunshu Pan Wenzhi Ren Aiguo wu Jianqing Hu School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510640GuangdongPR China Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCAS1219 ZhongGuan West RoadNingbo315201PR China Advanced Energy Science and Technology Guangdong Laboratory Huizhou516000PR China Department of Radiology Ningbo No.2 HospitalNingbo315010PR China

Currently,precise ablation of tumors without damaging the surrounding normal tissue is still an urgent problem for clinical microwave therapy of liver cancer.Herein,we synthesized Mn-doped Ti MOFs(Mn-Ti MOFs)nanosheets by in-situ doping method and applied them for microwave therapy.Infrared thermal imaging results indicate Mn-Ti MOFs can rapidly increase the temperature of normal saline,attributing to the porous structure improving microwave-induced ion collision frequency.Moreover,Mn-Ti MOFs show higher 1O2 output than Ti MOFs under 2 W of low-power microwave irradiation due to the narrower band-gap after Mn doping.At the same time,Mn endows the MOFs with a desirable T1 contrast of magnetic resonance imaging(r2/r1=2.315).Further,results on HepG2 tumor-bearing mice prove that microwave-triggered Mn-Ti MOFs nearly eradicate the tumors after 14 days of treatment.Our study offers a promising sensitizer for synergistic microwave thermal and microwave dynamic therapy of liver cancer.

关键词： Metal-organic framework Titanium-based nanomaterials Microwave dynamic therapy Microwave thermal therapy MR image

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Synchronous regulation of morphology and electronic structure of FeNi-P nanosheet arrays by Zn implantation for robust overall water splitting

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Nano Research 2023年第4期16卷 5733-5742页

作者： Li Sun Ying Dang Aiping wu Chungui Tian Dongxu Wang haijing Yan Yachen Gao Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China Key Laboratory of Electronics Engineering College of Heilongjiang ProvinceHeilongjiang UniversityHarbin 150080China Chemistry and Chemical Engineering Institute Qiqihar UniversityQiqihar 161006China

FeNi-based phosphides are one of the most hopeful electrocatalysts,whereas the significant challenge is to achieve prominent bifunctional catalytic activity with low voltage for water splitting.The morphology and electronic structure of FeNi-based phosphides can intensively dominate effective catalysis,therefore their simultaneous regulating is extremely meaningful.Herein,a robust bifunctional catalyst of Zn-implanted FeNi-P nanosheet arrays(Zn-FeNi-P)vertically well-aligned on Ni foam is successfully fabricated by Zn implanting strategy.The Zn fulfills the role of electronic donor due to its low electronegativity to enhance the electronic density of FeNi-P for optimized water dissociation kinetics.Meanwhile,the implantation of Zn into FeNi-P can effectively regulate morphology of the catalyst from thick and irregular nanosheets to ultrathin lamellar structure,which generates enriched catalytic active sites,leading to accelerating electron/mass transport ability.Accordingly,the designed Zn-FeNi-P catalyst manifests remarkable hydrogen evolution reaction(HER)activity with low overpotentials of 55 and 225 mV at 10 and 200 mA·cm^(−2),which is superior to the FeNi-P(82 mV@10 mA·cm^(−2)and 301 mV@200 mA·cm^(−2)),and even out-performing the Pt/C catalyst at a high current density>200 mA·cm^(−2).Moreover,the oxygen evolution reaction(OER)activity of Zn-FeNi-P also has dramatically improved(207 mV@10 mA·cm^(−2))comparable to FeNi-P(221 mV@10 mA·cm^(−2))and RuO_(2)(239 mV@10 mA·cm^(−2)).Noticeably,an electrolyzer based on Zn-FeNi-P electrodes requires a low cell voltage of 1.47 V to achieve 10 mA·cm^(−2),far beyond the catalytic activities of FeNi-P||FeNi-P(1.51 V@10 mA·cm^(−2))and the benchmark RuO_(2)||Pt/C couples(1.56 V@10 mA·cm^(−2)).This Zn-implanting strategy paves a new perspective for the development of admirable bifunctional catalysts.

关键词： Zn-implanted FeNi-P nanosheet arrays regulating morphology and electron density bifunctional catalyst overall water splitting

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Epigenetic regulation of B cells and its role in autoimmune pathogenesis

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Cellular & Molecular Immunology 2022年第11期19卷 1215-1234页

作者： Fan Xiao Ke Rui Xiaofei Shi Haijing Wu Xiaoyan Cai Kathy O.Lui Qianjin Lu Esteban Ballestar Jie Tian Hejian Zou Liwei Lu Department of Pathology Shenzhen Institute of Research and Innovation and Shenzhen HospitalThe University of Hong KongHong KongChongqing International Institute for ImmunologyChongqingChina Institute of Medical Immunology Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Rheumatology and Immunology The First Affiliated Hospital and School of MedicineHenan University of Science and TechnologyLuoyangChina Department of Dermatology Second Xiangya HospitalCentral South UniversityHunan Key Laboratory of Medical EpigenomicsChangshaHunanChina Department of Rheumatology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouChina Department of Chemical Pathology Faculty of MedicinePrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Epigenetics and Immune Disease Group Josep Carreras Research InstituteBadalona08916 BarcelonaSpain Epigenetics in Inflammatory and Metabolic Diseases Laboratory Health Science CenterEast China Normal UniversityShanghaiChina Department of Rheumatology Huashan HospitalFudan UniversityShanghaiChina Centre for Oncology and Immunology Hong Kong Science ParkHong KongChina

B cells play a pivotal role in the pathogenesis of autoimmune diseases.Although previous studies have shown many genetic polymorphisms associated with B-cell activation in patients with various autoimmune disorders,progress in epigenetic research has revealed new mechanisms leading to B-cell hyperactivation.Epigenetic mechanisms,including those involving histone modifications,DNA methylation,and noncoding RNAs,regulate B-cell responses,and their dysregulation can contribute to the pathogenesis of autoimmune diseases.Patients with autoimmune diseases show epigenetic alterations that lead to the initiation and perpetuation of autoimmune inflammation.Moreover,many clinical and animal model studies have shown the promising potential of epigenetic therapies for patients.In this review,we present an up-to-date overview of epigenetic mechanisms with a focus on their roles in regulating functional B-cell subsets.Furthermore,we discuss epigenetic dysregulation in B cells and highlight its contribution to the development of autoimmune diseases.Based on clinical and preclinical evidence,we discuss novel epigenetic biomarkers and therapies for patients with autoimmune disorders.

关键词： B cells Epigenetic regulation Autoimmune disease Biomarker Therapy

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Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity

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Cellular & Molecular Immunology 2018年第7期15卷 676-684页

作者： Haijing Wu Yaxiong Deng Yu Feng Di Long Kongyang Ma Xiaohui Wang Ming Zhao Liwei Lu Qianjin Lu Department of Dermatology Second Xiangya HospitalCentral South UniversityHunan Key Laboratory of Medical EpigenomicsChangshaHunan 410011China Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina

B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated byautoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreign antigens andsignals from helper T cells for differentiating into either memory B cells or antibody-producing plasma cells.Accumulating evidence has shown that epigenetic regulations modulate somatic hypermutation and class switchDNA recombination during B-cell activation and differentiation. Any abnormalities in these complex regulatoryprocesses may contribute to aberrant antibody production, resulting in autoimmune pathogenesis such as systemiclupus erythematosus. Newly generated knowledge from advanced modern technologies such as next-generationsequencing, single-cell sequencing and DNA methylation sequencing has enabled us to better understand B-cellbiology and its role in autoimmune development. Thus this review aims to summarize current research progress inepigenetic modifications contributing to B-cell activation and differentiation, especially under autoimmuneconditions such as lupus, rheumatoid arthritis and type 1 diabetes.

关键词： autoimmunity B cell DNA methylation histone modification microRNA

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The confined growth of few-layered and ultrashort-slab Ni-promoted MoS_(2)on reduced graphene oxide for deep-degree hydrodesulfurization

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Nano Research 2022年第8期15卷 7052-7062页

作者： Dongxu Wang Lei Wang Yanqing Jiao Aiping wu haijing Yan Xin Kang Chungui Tian Jiancong Liu Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

Hydrodesulfurization(HDS)is an essential process in clean fuel oil production,however,the huge challenge is the synthesis of the catalyst with plentiful active sites.Here,we have shown the design of few-layered,ultrashort Ni-Mo-S slabs dispersed on reduced graphene oxide(Ni-Mo-S/rGO-A)based on anchoring[PMo_(12)O_(40)]3−clusters and Ni^(2+)on polyethyleneimine(PEI)-modified graphite oxide.Structural characterizations(transmission electron microscopy(TEM),X-ray absorption fine structure(XAFS),etc.)show that Ni-Mo-S slabs with predominant monolayer and partial substitution of edge Mo atoms by isolated Ni atoms have rich accessible edge Ni-Mo-S sites and high sulfurization degree.All virtues endow it with plentiful edge-active sites,and consequently,the enhanced performance for hydrodesulfurization of dibenzothiophene(DBT).The hydrodesulfurization proceeds via a more-favorable direct desulfurization(DDS)route with a reaction rate constant(kHDS)of 48.6×10^(−7)mol·g^(−1)·s^(−1)over Ni-Mo-S/rGO-A catalyst,which is 4.3 times greater than that over traditional Ni-Mo-S/Al_(2)O_(3)catalyst and at the forefront of reported catalysts.

关键词： few-layered Ni-promoted MoS_(2) confined growth reduced graphene oxide high sulfurization degree hydrodesulfurization

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Ethylene Emission as a Potential Indicator of Fuji Apple Flavor Quality Evaluation Under Low Temperature

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Horticultural Plant Journal 2020年第4期6卷 231-239页

作者： Weiyan Qi haijing Wang Zhen Zhou Peng Yang Wenbin wu Zhemin Li Xian Li Agricultural Information Institute Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081China Graduate School of Chinese Academy of Agricultural Sciences Beijing 100081China

Fuji apple(Malus×domestica Borkh.)is a popular fruit cultivar and occupies an important position in the fruit market due to its excellent flavor and storage quality.Ethylene emission can induce respiration,which would reduce postharvest quality and increase storage losses.In order to maintain fruit quality and extend shelf life,apples are usually stored in a low-temperature environment after harvest to reduce the formation of ethylene.Volatile aroma components are regarded as one of the most important aspects of flavor quality and a key factor for apple quality grading and customer satisfaction.Ethylene emission and its relationship with volatile aromas during low temperature,however,have not been determined.In this study,the dynamic changes of volatile aroma compounds of Fuji apples stored at 4°C were detected and analyzed for 42 days.The variation of ethylene released from Fuji apple was studied correspondingly.The results showed that ethyl butyrate,ethyl caproate,ethyl 2-methylbutyrate and 2-methylbutyl acetate were the main aroma components of Fuji apple.The change in ethylene emission and the normalized peak area of volatile aroma compounds exhibited a similar tendency that increased significantly from the 3rd day to the peak on the 14th day and then decreased;there was a positive linear correlation between them with a correlation coefficient of 0.79(P<0.05).Therefore,ethylene release can be used as a potential indicator for evaluation of volatile aroma compounds in apples.Using ethylene emission as an indicator could reduce the difficulty and complexity of volatile aroma evaluation,which could be a new non-destructive inspection choice for apple flavor quality assessment.

关键词： apple aroma flavor quality ethylene correlation analysis

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随机梯度下降的交互式VR影像拼接均匀性校正

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黑龙江工业学院学报（综合版） 2023年第11期23卷 105-111页

作者：吴海静六安职业技术学院幼儿教育与旅游管理学院安徽六安237158

研究基于随机梯度下降的交互式VR影像拼接均匀性校正方法,通过将重叠率转换成用于拼接图像的关联参数获取影像重叠区域;将上述区域进行投影,利用亮度像素调整镜头畸变和影像像素点幅值,完成影像拼接均匀性调整;通过随机梯度下降算法不... 详细信息

研究基于随机梯度下降的交互式VR影像拼接均匀性校正方法,通过将重叠率转换成用于拼接图像的关联参数获取影像重叠区域;将上述区域进行投影,利用亮度像素调整镜头畸变和影像像素点幅值,完成影像拼接均匀性调整;通过随机梯度下降算法不断进行优化校正,获取拼接均匀性最佳的交互式VR影像。实验表明:该方法校正后的交互式VR影像质量较好,拼缝处更加平滑、均匀,拼接后图像均匀性总误差较小;结构相似度评分和边缘差分谱评分较高。

关键词：随机梯度下降交互式VR影像影像拼接均匀性校正

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