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Carvacrol combined with NIR light-responsive nano-drug delivery system with specific anti-bacteria,anti-inflammation,and immunomodulation for periodontitis

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Nano Research 2023年第5期16卷 7199-7215页

作者： Daorun Hu Congkai Zhang Chao Sun haijing bai Jialiang Xie Yawen Gu Mengyuan Li Junkai Jiang Aiping Le Jiaxuan Qiu Xiaolei Wang Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330006China The National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational MedicineNanchang UniversityNanchang 330088China Department of Transfusion Medicine The First Affiliated Hospital of Nanchang UniversityKey Laboratory of Jiangxi Province for Transfusion MedicineThe First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330088China

Bacterial infection,biofilm formation,immune dysfunction are common triggers and aggravators in periodontitis,which render periodontal restoration challenging.Thus,a strategy with antibacterial,anti-inflammatory,immunoregulatory capacities has great promise in the clinical practice of periodontitis.Herein,carvacrol(CA)-based near-infrared(NIR)lightresponsive nano-drug delivery system is developed for the first time.The system consists of upconversion nanoparticles(UCNPs,which upconvert 808 nm NIR to blue light),mesoporous silica(mSiO_(2),the carrier channel),hydrophobic CA(blue light response properties).Under the irradiation of 808 nm NIR,owing to the synergy of CA and upconverted blue light,the UCNPs@mSiO_(2)-CA(UCMCs)exhibit the properties of specific anti-bacteria(including anaerobic bacteria),anti-inflammation,and immunomodulation.Notably,high-throughput sequencing results exhibit that many classic inflammatory immune-related signaling pathways,including the MAPK signaling pathway,tumor necrosis factor(TNF)signaling pathway,IL-17 signaling pathway,are enriched to remodel the immune microenvironment.Additionally,UCMCs with NIR irradiation accelerate periodontal restoration and serve as promising non-invasive management of periodontitis.Altogether,this study verifies the feasibility of herbal monomer combined with light-responsive in situ nano-drug delivery system and provides a more effective and reliable strategy for various potential applications of deep tissue diseases.

关键词： anti-bacteria near-infrared light upconversion nanoparticle periodontitis drug delivery

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山羊绒形成发育特性及细度相关分子标记的研究进展

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中国畜牧杂志 2024年第2期60卷 99-107页

作者：白晶晶屈雷朱海鲸李思琪刑宇佳榆林学院陕西省陕北白绒山羊工程技术研究中心陕西榆林719000

山羊绒纤维柔软纤细且产量稀少,是高档面料的纺织原料,在国际上素有“软黄金”的称号。近年来,绒山羊产业中存在为了追求高产肉量和产绒量而忽视对山羊绒细度选育的问题,选择和保持绒山羊的绒细度优势性状,寻找和利用绒细度相关分子标... 详细信息

山羊绒纤维柔软纤细且产量稀少,是高档面料的纺织原料,在国际上素有“软黄金”的称号。近年来,绒山羊产业中存在为了追求高产肉量和产绒量而忽视对山羊绒细度选育的问题,选择和保持绒山羊的绒细度优势性状,寻找和利用绒细度相关分子标记是非常重要的方法之一。根据山羊绒的生长发育特性,本文从山羊毛囊结构、绒毛纤维结构和组成成分、毛囊的形态发生发育及周期性发育机制,以及KAPs基因家族、Wnt和Notch信号通路等山羊绒细度相关基因的研究现状进行综述,旨在为山羊绒品质控制提供有利的理论参考。

关键词：绒细度分子标记发育机制山羊绒

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Highly efficient photocatalytic dehydrogenative coupling of amines with supported platinum catalyst under the oxidant-free conditions

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Green Chemical Engineering 2022年第4期3卷 313-320页

作者： Peng bai Guobao Yang haijing Sun Xinli Tong School of Chemistry and Chemical Engineering Tianjin University of TechnologyTianjin300384China

A highly efficient photocatalytic dehydrogenative coupling(PDC)of amines to prepare value-added imines has been developed under the mild conditions.A complete conversion of benzylamine with a 99%selectivity of Nbenzylidenebenzylamine could be obtained using the 2%Pt@g-C_(3)N_(4)as photocatalyst in the absence of hydrogen acceptor at room temperature.Moreover,the relationship between the physical properties of different photocatalysts and their activities has been discussed according to the characterization results of the XRD,BET,SEM,TEM,and XPS techniques.Next,the PDC of different amines have been further investigated,where ca.70.2%-99.0%yields of corresponding imines were attained.Finally,based on the experimental results and heterogeneous catalytic principle,a possible reaction mechanism for the PDC of benzylamine is proposed.

关键词： Photocatalysis Green synthesis Benzylamine Acceptorless dehydrogenation Platinum

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内蒙古绒山羊KAP6.2基因多态性与生长性状和绒细度性状的关联分析

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家畜生态学报 2024年第3期45卷 16-21页

作者：王聪亮张政轩白晶晶付琪蓝贤勇陈生会屈雷朱海鲸榆林学院陕西省绒山羊工程技术研究中心陕西榆林719000 榆林市榆阳区牛家梁区域畜牧兽医站陕西榆林719000 西北农林科技大学动物科技学院陕西杨凌712000 陕西神奥农业生物技术开发股份有限公司陕西神木719318 陕西省“四主体一联合”肉羊工程技术校企联合研究中心陕西神木719318 陕西浩丽绒山羊科技发展有限公司陕西子洲718499

为探讨角蛋白关联蛋白6.2(keratin-associated protein 6.2,KAP6.2)基因遗传多态性与内蒙古绒山羊生长性状和绒细度性状的相关性,以期为内蒙古绒山羊遗传育种改良提供理论依据,本研究采集598只雌性内蒙古绒山羊耳组织,提取基因组DNA并进... 详细信息

为探讨角蛋白关联蛋白6.2(keratin-associated protein 6.2,KAP6.2)基因遗传多态性与内蒙古绒山羊生长性状和绒细度性状的相关性,以期为内蒙古绒山羊遗传育种改良提供理论依据,本研究采集598只雌性内蒙古绒山羊耳组织,提取基因组DNA并进行PCR扩增,检测KAP6.2基因的插入/缺失(Insertion/Deletion,InDel)突变,分析突变位点与生长性状和绒细度性状的相关性。结果显示,在育成羊中,该突变位点与胸围和十字部显著相关(P<0.05),与体长、胸宽和胸深极显著相关(P<0.01);在成年羊中,该突变位点与胸宽显著相关(P<0.05),与胸围、十字部高和胸深极显著相关(P<0.01);在育成羊和成年羊全部群体中,该突变位点与体长、胸围、十字部高、胸深和胸宽极显著相关(P<0.01),与绒细度显著相关(P<0.05)。上述结果提示,KAP6.2基因外显子区24 bp InDel突变位点与内蒙古绒山羊部分生长性状显著或极显著相关,与绒细度显著相关,可作为内蒙古绒山羊部分生长性状和绒细度性状选育的遗传标记,为内蒙古绒山羊的选育提供科学依据。

关键词： KAP6.2基因绒山羊 InDel 关联分析

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面向“双碳”目标的虚拟电厂能源需求响应策略

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能源与环保 2024年第4期46卷 218-221,227页

作者：张海静刘霄慧孙小斌李秋爽厉艳白颖国网山东省电力公司营销服务中心山东济南250001 国网山东省电力公司经济技术研究院山东济南250001

在我国“双碳”目标引领下,新型电力系统产业结构持续优化升级,虚拟电厂技术作为破解清洁能源消纳和绿色能源转型的解决方案,对我国能源战略转型和“双碳”目标的实现具有重大意义。基于构成分析法对考虑碳排放的虚拟电厂基本架构以及... 详细信息

在我国“双碳”目标引领下,新型电力系统产业结构持续优化升级,虚拟电厂技术作为破解清洁能源消纳和绿色能源转型的解决方案,对我国能源战略转型和“双碳”目标的实现具有重大意义。基于构成分析法对考虑碳排放的虚拟电厂基本架构以及功率交互模式进行探究,提出了一种虚拟电厂需求响应调度策略;采用三级聚合的方式对用户负荷进行调控,并对各级聚合商的分工提出明确要求,以保障能源供应的供需平衡;最后,对虚拟电厂的发展进行规划,旨在充分发挥虚拟发电厂在负荷调控及系统控制等方面的价值作用,参与电力市场绿色交易持续完善市场交易准则,更好地服务到市场中去,这对促进“双碳”目标实现具有重要指导意义。

关键词：虚拟电厂 “双碳” 需求响应碳排放

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An effective poly（p-phenylenevinylene） polymer adhesion route toward three-dimensional nitrogen-doped carbon nanotube/reduced graphene oxide composite for direct electrocatalytic oxygen reduction

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Nano Research 2016年第11期9卷 3364-3376页

作者： Yu Fu Chungui Tian Fangyuan Liu Lei Wang haijing Yan bai Yang State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jifin University Changchun 130012 China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China Heilongjiang University Harbin 150080 China

Heteroatom-doped nanocarbons have excellent potential for use in the oxygen reduction reaction （ORR）. However, construction of three-dimensional （3D） N-doped carbon materials with good electrocatalytic performance remains a challenge. Herein, a poly（p-phenylenevinylene）（PPV）-precursor adhesion route was developed for construction of 3D N-doped reduced graphene oxide-PPV calcined-carbon nanotubes （N-RGO-PPV（c）-CNTs）. In the synthesis, the PPV- precursor plays the role of a ＂glue＂ for strong adhesion of the RGO and CNTs. At high temperature, PPV can undergo transformation from the glassy state to a viscous state. Thus, the N-RGO-PPV（c）-CNT composite with multi-porous structure and ridge-like folded graphene flakes could be formed during nitridation at high temperature, which was favorable for production of more active sites for the ORR. As an ORR catalyst, the N-RGO-PPV（c）-CNT composites exhibited superior catalytic activity in alkaline electrolyte. The obtained onset potential （Eonset） of 0.92 V and catalytic current density of 5.7 mA·cm^-2 at 0.6 V （vs. RHE） are comparable to those of the 20% Pt/C composite （0.98 V and 5.2 mA·cm^-2）. The electron transfer number for the N-RGO-PPV（c）-CNT catalyst was about 3.99, which is close to that of the 20% Pt/C （4.01） catalyst. Notably, the optimal N-RGO-PPV（c）-CNT catalyst shows better durability and methanol tolerance than commercial 20% Pt/C. The good performance of the N-RGO-PPV（c）-CNT catalyst for the ORR may be attributed to the synergistic effects of the unique 3D structure for effective mass-transfer, the effective N-doping for production of more active sites, and the good contact between the RGO and CNTs for easy charge-transfer.

关键词： three dimensionalgraphene/carbonnanotube,nitrogen-doped,electrocatalysis,oxygen reduction

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Study of themovable collimator for CEPC

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Radiation Detection Technology and Methods 2021年第3期5卷 339-346页

作者： Peng Zhang haijing Wang Sha bai Yudong Liu Huamin Qu Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Background Movable collimators for the circular electron positron collider(CEPC)are required to cut off spent electrons/positrons just near the beam orbit and reduce the background of the detector.Due to the extremely high energy and luminosity of CEPC,a lot of challenges are brought to the collimators,including the huge synchrotron radiation power,the high-energy beam impact,and low impedance requirement.Purpose The purpose of this paper is to design a movable collimator suitable for CEPC and calculate its performance.Method Based on geant4 simulations and finite element method(FEM)analyses,a lot of studies were done:synchrotron radiation power,thermal and mechanical calculation,beam impact,and impedance,respectively.Result The maximum temperature of the design during normal operation is 143℃,and the loss factor is only 0.021 V/pC ignoring the shielding of clearance.Conclusions The conceptual design of collimator was completed,and the calculations show the design can work well under normal operating condition.

关键词： Movable collimator Synchrotron radiation Beam impact Impedance

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Insertion/deletion variants within the IGF2BP2 gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第9期22卷 757-766页

作者： Dongyun XIN Yangyang bai Yi BI Libang HE Yuxin KANG Chuanying PAN haijing ZHU Hong CHEN Lei QU Xianyong LAN Lab of Animal Genome and Gene Function College of Animal Science and TechnologyShaanxi Key Laboratory of Molecular Biology for AgricultureNorthwest A&F UniversityYangling 712100China Life Science Research Center Shaanxi Provincial Engineering and Technology Research Center of Cashmere GoatsYulin UniversityYulin 719000China

Insulin-like growth factor 2 m RNA-binding protein 2(IGF2 BP2,also called IMP2)plays an essential role in the development and maturation of germ cells and embryos and is a candidate gene for goat litter size,based on a previous genomewide selective sweep analysis.In this study,the m RNA expression level of IGF2 BP2 was found to be significantly higher in a single-lamb group than in a multi-lamb group.Insertions/deletions(indels)within the goat IGF2 BP2 gene,including P4-Ins-13 bp and P5-Del-12 bp,were verified in 918 Shaanbei White Cashmere(SBWC)female goats.The minor allelic frequencies(MAFs)of P4-Ins-13 bp and P5-Del-12 bp loci were 0.349 and 0.295,respectively.Analysis using the Chi-square(χ^(2))test showed that the genotype(χ^(2)=14.479,P=0.006)distribution of P4-Ins-13 bp was significantly different between the single-lamb and multi-lamb groups.Correlation analysis demonstrated that P4-Ins-13 bp was significantly associated with goat litter size(P=0.022),and individual goats with the homozygous deletion/deletion(DD)genotype produced more litters than other goats.Therefore,considered as a potential molecular marker significantly related to lambing traits,the P4-Ins-13 bp mutation of the goat IGF2 BP2 gene can be used in goat breeding with practical molecular marker-assisted selection(MAS)to optimize female reproduction and improve economic efficiency in the goat industry.

关键词： Goat Insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2) Litter size Indel Marker-assisted selection(MAS)

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考虑数据传输可靠性的自由空间光网络路由研究

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激光杂志 2023年第8期44卷 182-187页

作者：远海静王政白向伟河北工程技术学院石家庄050091

为提升自由空间光网络通信传输时的数据可靠性,提出了考虑数据传输可靠性的自由空间光网络路由方法。分析在大气环境的通信损耗,构建可靠性模型,通过可靠性模型对比直传链路与中继链路的可靠性,并按照距离阈值选取最佳通信链路,采用绿... 详细信息

为提升自由空间光网络通信传输时的数据可靠性,提出了考虑数据传输可靠性的自由空间光网络路由方法。分析在大气环境的通信损耗,构建可靠性模型,通过可靠性模型对比直传链路与中继链路的可靠性,并按照距离阈值选取最佳通信链路,采用绿色路由算法,以能耗作为权重,降低路由的链路选择能耗,实现光网络通信传输节能优化。经实验验证,该方法的光网络能耗小于0.16 J,最大传输数据时延小于12 s下,数据传播范围250 m,链路传输数据的可靠性高,工作节点与死亡节点分布均匀。

关键词：数据传输可靠性自由空间光网络路由直传链路中继链路

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紫外告警技术现状及发展分析

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红外技术 2017年第9期39卷 773-779页

作者：郑海晶白廷柱北京理工大学光电学院光电成像技术与系统教育部重点实验室北京100081

讨论了紫外告警技术原理,研究了导弹紫外辐射特性和导弹紫外辐射相关的发动机尾焰高温物质以及尾焰中可燃性物质二次燃烧,介绍了国内外紫外告警装备的发展及现状,论述了从第一代概略型紫外告警装备到第二代成像型紫外告警装备的发展过... 详细信息

讨论了紫外告警技术原理,研究了导弹紫外辐射特性和导弹紫外辐射相关的发动机尾焰高温物质以及尾焰中可燃性物质二次燃烧,介绍了国内外紫外告警装备的发展及现状,论述了从第一代概略型紫外告警装备到第二代成像型紫外告警装备的发展过程。最后,分析总结了紫外告警技术的发展动向。

关键词：紫外告警日盲紫外发动机尾焰

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