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The prevalence and related factors of depressive episodes in patients with chronic insomnia disorder

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The prevalence and related factors of depressive episodes in...

中国睡眠研究会第十五届全国学术年会

作者： Qi Zhou Dongsheng Zhou haihang yu Ningbo Kangning Hospital

Backgrounds: Insomnia with depressive episodes differs significantly from insomnia alone in terms of clinical presentation, treatment, and prognosis and has a worse prognosis and more severe risks, requiring high priority and active *** investigated the incidence and risk factors of depressive episodes in patients with chronic ***: A total of 819 patients with first chronic insomnia were recruited.A detailed self-designed questionnaire collected general information and socio-demographic characteristics, including age, gender, weight, height, education level, marital status, somatic symptoms, suicide attempts, smoking, and alcohol *** included the Hamilton Depression Scale(HAMD), the Clinical Global ImpressionSeverity Scale(CGI-S), the Hamilton Anxiety Scale(HAMA), and the Pittsburgh Sleep Quality Index(PSQI).Results: The prevalence of depressive episodes in patients with chronic insomnia(68.6%) was much higher than that of non-depressive episodes(31.4%).PSQI scores, HAMD scores, HAMA scores, and CGIS scores were significantly higher in the group with depressive episodes than in the group without depressive episodes, and age was significantly lower in the group with depressive episodes than in the group without depressive *** were significant differences in marital status, occupation, and somatic symptoms between the two groups but no significant differences in gender, suicidal intent, smoking, and alcohol *** addition, correlation analyses revealed that age was negatively associated with depression severity in patients with chronic *** scores, HAMA scores, and CGI-S scores were positively associated with depression severity in patients with chronic *** further regression analyses, marital status, occupation, age, PSQI score, and HAMA score were independent risk factors for depressive episodes associated with chronic insomnia ***: Our findings suggest that people with chro

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Effect of Repetitive Transcranial Magnetic Stimulation Combined with Transcranial Direct Current Stimulation for the Treatment of Chronic Insomnia: A Randomized, Double-Blind, Parallel-Group, Controlled Clinical Trial

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Effect of Repetitive Transcranial Magnetic Stimulation Combi...

中国睡眠研究会第十五届全国学术年会

作者： Qi Zhou Dongsheng Zhou haihang yu Ningbo Kangning Hospital

Background: Chronic insomnia affects an individual's normal life and work, increases the risk of various health problems, and increases the probability of mental ***, there is an urgent need for an efficient and safe treatment method to improve ***: This study aimed to verify the efficacy and safety of repetitive transcranial magnetic stimulation(rTMS) combined with transcranial direct current stimulation(tDCS) in the treatment of adult patients with chronic ***: 157 participants with chronic primary insomnia were randomly assigned three physical therapy *** combined group was first treated with tDCS at a stimulation intensity of 2mA for 20 *** anode and cathode electrodes were placed on the left and right DLPFC, *** TMS treatment was carried out, and the right DLPFC was selected to receive 1Hz low-frequency transcranial magnetic stimulation with a stimulation intensity of 100% motor threshold, a simulation time of 6 seconds, an interval time of 4 seconds, and a total number of pulses of 1,*** rTMS+sham tDCS group was first treated with tDCS for pseudo-stimulation, and the location of stimulating electrodes, the stimulation area, and the stimulation time were the same as that of the combined *** TMS treatment was performed, and the stimulation position and stimulation time were consistent with that of the combined *** tDCS+sham rTMS group was first treated with tDCS, and the stimulation electrode position, stimulation area and stimulation time were consistent with that of the combined *** TMS pseudo-stimulation treatment was performed, and the stimulation position and stimulation time were consistent with that of the combined *** treatments were separated by 30 minutes in all groups, and subjects received 20 treatments over 4 consecutive weeks on *** primary outcomes were response rate, remission rate, and different dimensions of insomnia as measured by the

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Prevalence,risk factors and clinical correlates of insomnia among front-line medical staff in Ningbo and Wuhan(assisted by Ningbo) during the COVID-19 outbreak

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Prevalence,risk factors and clinical correlates of insomnia ...

2020年浙江省医学会精神病学学术大会浙江省医师协会精神科医师分会第十三届年会

作者： Xingxing Li haihang yu Guolin Bian Zhenyu Hu Xiaoli Liu Qi Zhou Chang yu Xiang Wu Ti-Fei yuan Dongsheng Zhou Ningbo Key Laboratory of Sleep Medicine Ningbo Kangning Hospital The Affiliated Hospital of Medical School Ningbo University Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of Medicine

Objective:2019 novel coronavirus disease(COVID-19) caused huge public health ***,the psychological impact on medical staff has been *** purpose of this study was to investigate the sleep status and related factors of insomnia among medical staff in Ningbo and Wuhan(assisted by Ningbo) during the outbreak of ***:A cross-sectional study of 948 medical staffs in Ningbo and Wuhan was conducted online from February 15 to February 22,*** data were collected with questionnaire stars,and mental health variables were evaluated by Athens Insomnia Scale(AIS) and Self Reporting Questionnaire-20(SRQ-20).Results:There was no significant difference in sex,age,educational background and marital status between the medical staff in Ningbo and Wuhan(all p>0.05).According to the insomnia severity index(total score≥6),the medical staff in Wuhan had higher insomnia than in Ningbo(58.90 vs.24.97%;p=0.001),and had more severe physical and psycho-emotional symptoms(13.24 vs. 8.64%;p=0.044). Multivariate Logistic regression analysis showed that among the medical staff in Wuhan,the symptoms of insomnia were related to gender(OR=1.379,P=0.042,95% CI=0.65-2.17),education(OR=1.54,P=0.0076,95%CI=0.69-2.52),and physical and psychoemotional symptoms(OR=2.124,P<0.01,95%CI=1.69-2.67).Among the medical staff in Ningbo,they are not only related to physical and psycho-emotional symptoms(OR=1.60,P<0.01, 95%CI=1.48-1.74),but also related to marital status(OR=0.57,P=0.046,95%CI=0.33-0.99).Conclusion:Our study found that front-line workers in Ningbo who went to support Wuhan had a higher rate of *** we are talking about patients,we should also give medical staffs more rest time and intervene in time for insomnia among medical staff.

关键词： insomnia medical staff COVID-19 Athens Insomnia Scale

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后处理对高速激光熔覆表面性能的影响

中国表面工程 2023年第5期36卷 88-99页

作者：王海楠程延海马昆杨金勇于海航中国矿业大学机电工程学院徐州221116 国家能源集团宁夏煤业有限责任公司银川751410

液压立柱表面镀铬涂层易出现微小裂纹并导致涂层剥落,对煤矿生产造成安全隐患。为强化液压立柱表面性能、提高液压立柱使用寿命,利用高速激光熔覆技术在27SiMn钢表面制备铁基耐腐蚀熔覆层,并对熔覆层进行车-滚后处理提升强化熔覆层表面... 详细信息

液压立柱表面镀铬涂层易出现微小裂纹并导致涂层剥落,对煤矿生产造成安全隐患。为强化液压立柱表面性能、提高液压立柱使用寿命,利用高速激光熔覆技术在27SiMn钢表面制备铁基耐腐蚀熔覆层,并对熔覆层进行车-滚后处理提升强化熔覆层表面性能。使用扫描电子显微镜、形状测量激光显微镜、显微硬度计、电化学工作站等对高速激光熔覆层、车削及不同滚压力作用后的熔覆层微观组织、表面粗糙度、残余应力、显微硬度、耐腐蚀性能进行研究分析。结果表明:初始熔覆层显微组织致密,无明显孔隙、裂纹等缺陷,从结合处到表面依次为平面晶、树枝晶、等轴晶;滚压加工的“削峰填谷”效应使熔覆层表面发生塑性变形,滚压力为2.8 MPa时,表面轮廓平整,表面粗糙度降低至0.768μm;熔覆层硬度随滚压力的增大而增加,熔覆层顶部出现明显的塑性变形区和硬化层;车-滚复合加工使熔覆层表面残余应力由拉应力状态转变为压应力,滚压力增大,残余压应力先增大后减小;车-滚复合加工使熔覆层表层晶粒细化,增强Cr元素扩散,提高耐蚀能力,但过大的滚压力使熔覆层表面损伤,耐蚀能力下降。车-滚后处理工艺有效提升了熔覆层表面性能,可为高速激光熔覆高效低成本的后处理工艺研发提供参考。

关键词：高速激光熔覆后处理表面粗糙度滚压显微硬度

Mental Health and Psychosocial function of General Population during the COVID-19 Epidemic in China

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Mental Health and Psychosocial function of General Populatio...

2020年浙江省医学会精神病学学术大会浙江省医师协会精神科医师分会第十三届年会

作者： Qi Zhou Zhenyu Hu Guolin Bian haihang yu Xingxing Li Yin Lu Chang yu Xianglan Li Qin Yao Wenhua Zhou Ti-Fei yuan Dongsheng Zhou Ningbo Kangning Hospital Laboratory of Behavioral Neuroscience Ningbo Addiction Research and Treatment CenterSchool of MedicineNingbo UniversityNingboChina3 Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of Medicine Co-innovation Center of Neuroregeneration Nantong University

Objective:To investigate the mental health states of the general public during the COVID-19 epidemic in ***:This cross-sectional,survey-based study collected responses from 2435 subjects from February 23,2020 to March 1,2020,in *** degree of symptoms of insomnia,stress and social function was assessed by the Self-Report Questionnaire-20(SRQ-20),the Athens Insomnia Scale(AIS),the Chinese version of the Perceived Stress Scale(CPSS),*** Mann-Whitney U test and Kruskal-Wallis test,Spearman’s correlation analysis and multivariate logistic regression analysis were employed to assess factors associated with mental ***:Of all participants,784 were males(32.2%) and 1651 were females(67.8%).The perceived stress(CPSS score) is higher in the male(mean(SD)=27.26(10.09)) than the female(mean(SD)=27.03(8.03)).People under 20 years had the lowest AIS scores(mean(SD)=2.85(3.31)) and CPSS scores(mean(SD)=26.47(9.48)).Those above60 years old presented the highest score on AIS scores(mean(SD)=4.02(4.80)) and CPSS scores(mean(SD)=30.09(10.8)).The divorced group presented the highest score on AIS scores(mean(SD)=3.57(4.51)) and CPSS scores(mean(SD)=27.62(8.93)).The farmer reported the highest score on AIS scores(mean(SD)=6.56(7.99)) and the civil servants had the highest score on CPSS scores(mean(SD)=30.59(8.54)).Illiterate people had the highest AIS scores(mean(SD)=10.67(12.22)) and CPSS scores(mean(SD)=31.00(28.48)).Hubei province presented the highest AIS scores(mean(SD)=4.63(8.05)) and CPSS scores(mean(SD)=32.63(12.27)).Spearman’ s correlation analysis showed that there were significant correlations between SRQ-20,AIS and CPSS scales with age,marital status and geographical location.A binary logistic regression analysis showed the risk of insomnia in the general population were independently associated with four variables:age,occupation,marital status and geographical location(p<0.01 or 0.05).The risk of stress in the general popula

关键词： Stress COVID-19 perceived stress insomnia age

紫外线灯消毒对冬季学校乙型流感疫情防控效果分析

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中国学校卫生 2019年第6期40卷 893-895,899页

作者：李雪梅孙宇珊徐震东于海航广东省深圳市盐田区疾病预防控制中心传染病防治科

目的评估紫外线灯消毒在冬季学校乙型流感疫情防控中的实际效果,为开展学校乙型流感防控提供参考。方法采用多阶段分层整群抽样方法,现场检测深圳盐田区11所学校98个班级紫外线灯下不同距离的辐照值,通过统计建模,与学生健康监测信息系... 详细信息

目的评估紫外线灯消毒在冬季学校乙型流感疫情防控中的实际效果,为开展学校乙型流感防控提供参考。方法采用多阶段分层整群抽样方法,现场检测深圳盐田区11所学校98个班级紫外线灯下不同距离的辐照值,通过统计建模,与学生健康监测信息系统报告的班级流感病例数进行相关分析。结果共检测473盏紫外线灯,合格率为53.91%,达到合格辐照值对应灯下有效距离为(1.43±0.54)m,每个班级单位时间总有效辐照体积为(13.65±32.66)m^3。共74个班报告流感599例,罹患率为13.76%,其中58个班报告流感聚集性疫情,占59.18%,疫情持续时间(14.5±25.25)d。Spearman相关分析显示,单位时间紫外线灯有效辐照体积占教室体积比与班级流感罹患率呈负相关(r=-0.32,P=0.00),与流感疫情持续时间的关联无统计学意义(P=0.78)。纳入"不同学校"进行协方差分析显示,班级流感罹患率、流感疫情持续时间与紫外线灯有效辐射照体积占教室体积比的关联均无统计学意义(P值均>0.05)。结论紫外线灯消毒措施未能有效降低2017-2018年冬季深圳盐田区学校各班级乙型流感罹患率及流感疫情持续时间。

关键词：消毒流感,人学生

蓝花耧斗菜Expansin基因家族的全基因组鉴定及其在盐胁迫下的表达分析

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华北农学报 2024年第5期39卷 42-51页

作者：马艳梅于海航沈轩羽肖芳丽白云吉林农业大学吉林长春130118

扩展蛋白(EXP)可以调节细胞壁组分间松弛度和增强细胞壁的柔韧性,在植物适应环境胁迫过程中起着关键作用。为探究蓝花耧斗菜EXP家族成员特征及其在盐胁迫下表达模式,挖掘蓝花耧斗菜耐盐基因,利用生物信息学方法对蓝花耧斗菜AcEXP家族进... 详细信息

扩展蛋白(EXP)可以调节细胞壁组分间松弛度和增强细胞壁的柔韧性,在植物适应环境胁迫过程中起着关键作用。为探究蓝花耧斗菜EXP家族成员特征及其在盐胁迫下表达模式,挖掘蓝花耧斗菜耐盐基因,利用生物信息学方法对蓝花耧斗菜AcEXP家族进行全基因组鉴定及分析,并通过RNA-seq表达数据和qRT-PCR分析其在盐胁迫下的表达模式。结果表明,蓝花耧斗菜全基因组包含27个EXP基因,分布于6条染色体及1个scaffold上;蛋白质二级结构以β-折叠和无规则卷曲为主;27个EXP均定位于细胞壁。系统发育树显示,AcEXP家族成员被划分为4个亚家族(EXPA、EXPB、EXLA、EXLB),同一亚族成员具有相似的基因结构和蛋白保守基序。AcEXP的启动子区域富含多个植物激素响应元件和胁迫响应元件。利用转录组数据,对盐胁迫下AcEXP的表达模式分析表明,21个EXP响应盐胁迫,在根系和叶片中的表达模式存在差异。AcEXPA8/9/12,AcEXPB1、AcEXLB1、AcEXLB2在叶片和根系中均差异表达,且qRT-PCR结果进一步验证了AcEXP基因在盐胁迫下的表达模式。该研究全面分析了蓝花耧斗菜EXP基因家族成员的基本特征及在盐胁迫下的表达变化,初步证明AcEXPA8/9/12、AcEXPB1、AcEXLB1、AcEXLB2参与了盐胁迫应答过程并作出积极响应。

关键词：蓝花耧斗菜扩展蛋白全基因组鉴定盐胁迫表达分析

欧耧斗菜AP2/ERF基因家族鉴定及盐胁迫下表达分析

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广西植物 2023年第10期43卷 1861-1875页

作者：王玉凤孟缘于海航崔丁元白云吉林农业大学林学与草学学院长春130118

AP2/ERF转录因子在植物生长发育和响应非生物胁迫中发挥着重要作用。为探究欧耧斗菜(Aquilegia vulgaris)中AP2/ERF对盐胁迫的响应,该研究基于前期试验获得的盐胁迫下转录组数据,通过生物信息学方法筛选欧耧斗菜AP2/ERF家族基因,分析其... 详细信息

AP2/ERF转录因子在植物生长发育和响应非生物胁迫中发挥着重要作用。为探究欧耧斗菜(Aquilegia vulgaris)中AP2/ERF对盐胁迫的响应,该研究基于前期试验获得的盐胁迫下转录组数据,通过生物信息学方法筛选欧耧斗菜AP2/ERF家族基因,分析其生化特征、保守基序、系统进化等,并对其在盐胁迫处理下不同时间的根与叶中的表达量变化进行分析,利用qRT-PCR技术对候选基因表达量进行验证。结果表明:(1)筛选出86个AvAP2/ERF基因,其编码的氨基数目为132~722个,分子量为14 763.30~79 069.47 Da,等电点介于4.49~9.68之间,偏酸性蛋白较多,均为亲水性蛋白;对AvAP2/ERF蛋白进行亚细胞定位预测,大多数定位于细胞核。(2)二级结构以无规则卷曲和α-螺旋为主,均具有AP2保守结构域,有两个高度保守的基序Motif 1和Motif 2。(3)在盐胁迫下,71个AvAP2/ERF基因表达量发生变化,其中叶片中差异表达基因18个、根中19个;欧耧斗菜与拟南芥AP2/ERF基因聚类为5个亚家族、15个亚组,通过表达分析及同源关系,确定3个响应盐胁迫的基因AvAP2/ERF-56、AvAP2/ERF-61与AvAP2/ERF-80,其qRT-PCR结果与转录组数据一致。该研究结果为深入探究欧耧斗菜AP2/ERF基因的功能及逆境响应机制奠定了基础。

关键词：欧耧斗菜 AP2/ERF 生物信息学盐胁迫转录组表达分析

Linux下基于I2C的电源管理芯片驱动设计

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兵工自动化 2011年第6期30卷 78-80,90页

作者：于海航杜刚石仁协中国地质大学信息工程学院北京100083

为了提高驱动运行效率,对Linux下内部集成电路(inter-integrated circuit,I2C)设备的电源管理芯片驱动进行设计。介绍I2C总线时序以及Linux内核中I2C总线所特有的体系结构,在分析Linux内核I2C总线驱动框架的基础上,结合具体的电源管理芯... 详细信息

为了提高驱动运行效率,对Linux下内部集成电路(inter-integrated circuit,I2C)设备的电源管理芯片驱动进行设计。介绍I2C总线时序以及Linux内核中I2C总线所特有的体系结构,在分析Linux内核I2C总线驱动框架的基础上,结合具体的电源管理芯片AXP192,介绍了I2C设备驱动的实现方法。结果证明,该设计能有效地提高效率。

关键词： I2C总线 Linux 电源管理芯片驱动