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Cerebrospinal fluid liver pseudocyst:A bizarre long-term complication of ventriculoperitoneal shunt:A case report

World Journal of Hepatology 2023年第5期15卷 715-724页

作者： Muhammad Nadeem Yousaf haider a naqvi Shriya Kane Fizah S Chaudhary Jason Hawksworth Vikram V Nayar Thomas W Faust Division of Gastroenterology and Hepatology Department of MedicineUniversity of MissouriColumbiaMO 65212United States Department of Medicine MedStar Union Memorial HospitalBaltimoreMD 21218United States Department of Surgery University Iowa School of MedicineIowa CityIA 52242United States Department of Medicine University of MissouriColumbiaMO 65212United States Department of Surgery Transplant HepatologyMedStar Georgetown University HospitalWashingtonDC 20007United States Department of Neurosurgery MedStar Georgetown University HospitalWashingtonDC 20007United States Department of Medicine Transplant HepatologyJames D.Eason Transplant InstituteMethodist Le Bonheur HealthcareMemphisTN 38104United States

BACKGROUND Ventriculoperitoneal(VP)shunt placement has become a standard of care procedure in managing hydrocephalus for drainage and absorption of cerebrospinal fluid(CSF)into the *** pseudocysts containing CSF are the common long-term complication of this frequently performed procedure,mainly because VP shunts have significantly prolonged *** these,liver CSF pseudocysts are rare entities that may cause shunt dysfunction,affect normal organ function,and therefore pose therapeutic *** SUMMARY A 49-year-old man with history of congenital hydrocephalus status post bilateral VP shunt placement presented with progressively worsening dyspnea on exertion,abdominal discomfort/*** computed tomography(CT)scan revealed a large CSF pseudocyst in the right hepatic lobe with the tip of VP shunt catheter into the hepatic cyst *** underwent robotic laparoscopic cyst fenestration with a partial hepatectomy,and repositioning of VP shunt catheter to the right lower quadrant of the ***-up CT demonstrated a significant reduction in hepatic CSF *** A high index of clinical suspicion is required for early detection of liver CSF pseudocysts since their presentation is often asymptomatic and cunning early in the ***-stage liver CSF pseudocysts could have adverse outcomes on the treatment course of hydrocephalus as well as on hepatobiliary *** is paucity of data to define the management of liver CSF pseudocyst in current guidelines due to rare nature of this *** reported occurrences have been managed by laparotomy with debridement,paracentesis,radiological imaging guided fluid aspiration and laparoscopic-associated cyst *** surgery is an additional minimally invasive option in the management of hepatic CSF pseudocyst;however,its use is limited by lack of widespread availability and cost of surgery.

关键词： shunt fluid peritoneal

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Doping Induced Tailoring in the Morphology,Band-Gap and Ferromagnetic Properties of Biocompatible ZnO Nanowires, Nanorods and Nanoparticles

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Nano-Micro Letters 2014年第3期6卷 242-251页

作者： Javed Iqbal Tariq Jan Yu Ronghai Sa jjad haider naqvi Ishaq Ahmad Laboratory of Advanced Materials Department of Material Science and Engineering Tsinghua University Laboratory of Nanoscience and Technology Department of Physics International Islamic University Islamabad School of Materials Science and Engineering Beihang University Karachi University Nanational Center for Physics (NCP) Quaid-i-Azam University

The modification of nanostructured materials is of great interest due to controllable and unusual inherent properties in such materials. Single phase Fe doped Zn O nanostructures have been fabricated through simple, versatile and quick low temperature solution route with reproducible results. The amount of Fe dopant is found to play a significant role for the growth of crystal dimension. The effect of changes in the morphology can be obviously observed in the structural and micro-structural investigations, which may be due to a driving force induced by dipole-dipole interaction. The band gap of Zn O nanostructures is highly shifted towards the visible range with increase of Fe contents, while ferromagnetic properties have been significantly *** prepared nanostructures have been found to be nontoxic to SH-SY5 Y Cells. The present study clearly indicates that the Fe doping provides an effective way of tailoring the crystal dimension, optical band-gap and ferromagnetic properties of Zn O nanostructure-materials with nontoxic nature, which make them potential for visible light activated photocatalyst to overcome environmental pollution, fabricate spintronics devices and biosafe drug delivery agent.

关键词： ZnO Fe doping Dipole-dipole interaction Band-gap tailoring Ferromagnetism Cytotoxicity

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Priming mesenchymal stem cells to develop “super stem cells”

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World Journal of Stem Cells 2024年第6期16卷 623-640页

作者： Khawaja Husnain haider Department of Basic Sciences Sulaiman AlRajhi UniversityAlQaseem 52736Saudi Arabia

The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of stem cells to growth factor treatment,genetic manipulation,and chemical and pharmacological treatment,each strategy having advantages and *** of these pre-treatment protocols are *** editorial is a continuum of Li et al’s published article and Wan et al’s editorial focusing on the significance of pre-treatment strategies to enhance their stemness,immunoregulatory,and immunosuppressive *** have elaborated on the intricacies of the combinative pre-treatment protocol using pro-inflammatory cytokines and *** a well-defined multi-pronged combinatorial strategy of mesenchymal stem cells(MSCs),pre-treatment based on the mechanistic understanding is expected to develop“Super MSCs”,which will create a transformative shift in MSC-based therapies in clinical settings,potentially revolutionizing the *** optimized,the standardized protocols may be used with slight modifications to pre-treat different stem cells to develop“super stem cells”with augmented stemness,functionality,and reparability for diverse clinical applications with better outcomes.

关键词： Cell survival Cell therapy Preconditioning Pre-treatment Stem cells Super stem cells

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Enhancing Healthcare Data Security and Disease Detection Using Crossover-Based Multilayer Perceptron in Smart Healthcare Systems

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 977-997页

作者： Mustufa haider Abidi Hisham Alkhalefah Mohamed K.Aboudaif Department of Industrial Engineering College of EngineeringKing Saud UniversityP.O.Box-800Riyadh11421Saudi Arabia

The healthcare data requires accurate disease detection analysis,real-timemonitoring,and advancements to ensure proper treatment for ***,Machine Learning methods are widely utilized in Smart Healthcare Systems(SHS)to extract valuable features fromheterogeneous and high-dimensional healthcare data for predicting various diseases and monitoring patient *** methods are employed across different domains that are susceptible to adversarial attacks,necessitating careful ***,this paper proposes a crossover-based Multilayer Perceptron(CMLP)*** collected samples are pre-processed and fed into the crossover-based multilayer perceptron neural network to detect adversarial attacks on themedical records of *** an attack is detected,healthcare professionals are promptly alerted to prevent data *** paper utilizes two datasets,namely the synthetic dataset and the University of Queensland Vital Signs(UQVS)dataset,from which numerous samples are *** results are conducted to evaluate the performance of the proposed CMLP model,utilizing various performancemeasures such as Recall,Precision,Accuracy,and F1-score to predict patient *** the proposed method with existing approaches,it achieves the highest accuracy,precision,recall,and ***,the proposedmethod achieves a precision of 93%,an accuracy of 97%,an F1-score of 92%,and a recall of 92%.

关键词： Smart healthcare systems multilayer perceptron cybersecurity adversarial attack detection Healthcare 4.0

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Refined Anam-Net:Lightweight Deep Learning Model for Improved Segmentation Performance of Optic Cup and Disc for Glaucoma Diagnosis

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Computers, Materials & Continua 2024年第7期80卷 1381-1405页

作者： Khursheed Aurangzeb Syed Irtaza haider Musaed Alhussein Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia

In this work,we aim to introduce some modifications to the Anam-Net deep neural network(DNN)model for segmenting optic cup(OC)and optic disc(OD)in retinal fundus images to estimate the cup-to-disc ratio(CDR).The CDR is a reliable measure for the early diagnosis of *** this study,we developed a lightweight DNN model for OC and OD segmentation in retinal fundus *** DNN model is based on modifications to Anam-Net,incorporating an anamorphic depth embedding *** reduce computational complexity,we employ a fixed filter size for all convolution layers in the encoder and decoder stages as the network *** modification significantly reduces the number of trainable parameters,making the model lightweight and suitable for resource-constrained *** evaluate the performance of the developed model using two publicly available retinal image databases,namely RIM-ONE and *** results demonstrate promising OC segmentation performance across most standard evaluation metrics while achieving analogous results for OD *** used two retinal fundus image databases named RIM-ONE and Drishti-GS that contained 159 images and 101 retinal images,*** OD segmentation using the RIM-ONE we obtain an f1-score(F1),Jaccard coefficient(JC),and overlapping error(OE)of 0.950,0.9219,and 0.0781,***,for OC segmentation using the same databases,we achieve scores of 0.8481(F1),0.7428(JC),and 0.2572(OE).Based on these experimental results and the significantly lower number of trainable parameters,we conclude that the developed model is highly suitable for the early diagnosis of glaucoma by accurately estimating the CDR.

关键词： Refined Anam-Net parameter tuning deep learning optic cup optic disc cup-to-disc ratio glaucoma diagnosis

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Cellular preconditioning and mesenchymal stem cell ferroptosis

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World Journal of Stem Cells 2024年第2期16卷 64-69页

作者： Doaa Hussein Zineldeen Mazhar Mushtaq Khawaja Husnain haider Basic Sciences Sulaiman AlRajhi UniversityAlbukairiyah 52736AlQaseemSaudi Arabia Department of Medical Biochemistry and Molecular Biology Faculty of MedicineTanta UniversityTanta 6632110Egypt

In this editorial,we comment on the article published in the recent issue of the World Journal of Stem *** focus on stem cell preconditioning to prevent ferroptosis by modulating the cystathionineγ-lyase/hydrogen sulfide(H_(2)S)pathway as a novel approach to treat vascular disorders,particularly pulmonary *** stem cells are gaining popularity in regenerative medicine due to their unique ability to survive by resisting the harsh,unfavorable microenvironment of the injured *** also secrete various paracrine factors against apoptosis,necrosis,and ferroptosis to enhance cell ***,a regulated form of cell death characterized by iron accumulation and oxidative stress,has been implicated in various pathologies encompassing dege-nerative disorders to *** lipid peroxidation cascade initiates and sustains ferroptosis,generating many reactive oxygen species that attack and damage multiple cellular *** these intertwined mechanisms provi-des significant insights into developing therapeutic modalities for ferroptosis-related *** editorial primarily discusses stem cell preconditioning in modulating ferroptosis,focusing on the cystathionase gamma/H_(2)S ferroptosis *** presents a significant challenge in mesenchymal stem cell(MSC)-based therapies;hence,the emerging role of H_(2)S/cystathionase gamma/H_(2) S signaling in abrogating ferroptosis provides a novel option for therapeutic *** research into understanding the precise mechanisms of H_(2)S-mediated cytoprotection against ferroptosis is warranted to enhance the thera-peutic potential of MSCs in clinical settings,particularly vascular disorders.

关键词： Cell survival Cell therapy Hydrogen sulfide Ferroptosis Preconditioning Stem cells Umbilical cord

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Coping Styles and Depression among Patients with Solid Organ Cancers Attending Two Tertiary Care Hospitals of Karachi: A Cross Sectional Study

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Open Journal of Epidemiology 2017年第1期7卷 69-83页

作者： Khadija Vadsaria Adnan Jabbar Iqbal Azam Sameera Rizvi Ghulam haider haider naqvi Department of Community Health Sciences Aga Khan University Karachi Pakistan Department of Oncology Aga Khan University Karachi Pakistan Department of Clinical Oncology Jinnah Post Graduate Medical Centre Karachi Pakistan Psychiatry Department Ziauddin University Karachi Pakistan

Cancer undoubtedly affects patients in all aspects. Cancer diagnosis is a stressful event and coping is the primary mechanism used to adjust and counteract the stress. This study aims to assess the coping styles and prevalence of depression among solid organ cancer patients during treatment phase, attending two tertiary care hospitals of Karachi. A cross-sectional survey was conducted among solid organ cancer patients at Aga Khan University Hospital and Jinnah Post Graduate Medical Center. Coping and depression were assessed by Brief COPE and Self Reporting Questionnaire (SRQ) 20 respectively. Purposive sampling technique was used to recruit 488 patients. Coping styles are reported as mean ± SD. Prevalence has been computed for depression and Chi-square test is used to assess the relationship of depression with different variables. Correlation was assessed for coping styles and depression. The frequently used coping styles were active coping, acceptance, religion and self-distraction. 48.4% depression was estimated among patients. The significantly positive correlation of depression was found with active coping, planning, self-blame, venting, use of emotional support and substance use. While depression correlated negatively with acceptance, religion, self-distraction and humor. Depression was significantly associated with study sites, age, socioeconomic quintiles, past history of hospitalization and substance use. Our research addressed the missing element of mental health in oncology. Depression is a common mental ailment and often the initial manifestation towards deterioration of mental health. Each cancer patient copes differently which either promotes or hinders their fighting spirit. Hence, mental health screening and counseling are recommended in the treatment protocol of cancer patients. Also, support group interventions can help cancer patients to cope effectively.

关键词： Coping Depression Cancer Patients Mental Health

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The Effectiveness or Efficacy of Modified Nursing Interventions Classification (NIC) in Reducing the Severity of Depression among Patients with Myocardial Infarction

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Open Journal of Psychiatry 2017年第2期7卷 103-114页

作者： Suriya Nisar Abu Talib Iftikhar haider naqvi Jawahar Lal Shaheed Mohtarma Benazir Bhutto Medical University Larkana Pakistan Dow University of Health Sciences Karachi Pakistan Medical Unit-III Civil Hospital Karachi Pakistan

Background: Post myocardial infarction depression is common and puts a negative effect on recovery. Modified Nursing interventions effectively reduce the frequency and severity of depression in such patients. Objective: The study aimed to determine the effectiveness of Modified Nursing Interventions Classification (NIC) in reducing the severity of depression among patients with Myocardial Infarction. Methods: Sixty-eight stable patients with myocardial infarction (>1 month history) having mild to moderate depression in accordance to Patient Health Questionnaire-9 (PHQ-9) [with a score of 5 to 14] were enrolled. Patients were assorted into interventional and control group. Modified Nursing Intervention was offered in Interventional Group. The frequency and effectiveness of Modified Nursing Intervention among the groups were determined and compared. Results: Both moderate and mild level depression was decreased in Intervention Group as compare to Control Group. Baseline mean depression PHQ-9 score was 2.35 point statistically significantly higher in the Control Group than Interventional Group (Conclusion: Modified Nursing intervention is effective in reducing the frequency and severity of depression compared to routine care in patients with Myocardial infarction.

关键词： Modified Nursing Intervention Classification Depression Myocardial Infarction

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Antituberculosis Drug-Induced Liver Injury: An Ignored Fact, Assessment of Frequency, Patterns, Severity and Risk Factors

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Open Journal of Gastroenterology 2015年第12期5卷 173-184页

作者： Iftikhar haider naqvi Khalid Mahmood Abu Talib Aamer Mahmood Department of Medicine Dow University of Health Sciences Karachi Pakistan Agha Khan University Hospital Karachi Pakistan

Background/Aims: Antituberculosis drug-induced liver injury (TB DILI) is a frequent medical problem in Pakistan. Critical understanding of various aspects of TB DILI is not only important to manage liver injury but may also prevent unnecessary discontinuation of antituberculosis treatment. The study is aimed to determine the frequency, types, severity and patterns of TB DILI. Study further evaluates various risk factors of TB DILI. Materials and Methods: This is a prospective cohort study of two seventy-eight patients with the diagnosis of tuberculosis, where patients were followed during tuberculosis treatment. TB DILI was defined in accordance to international DILI expert working group. Results: Out of two seventy eight-patients, ninety-five (34.14%) had TB DILI. The most common pattern of TB DILI was hepatocellular (63.15%) followed by mixed (23.15%) and Cholestatic (13.68%). Most of the patients had mild DILI (43.15%) followed by moderate (30.52%), severe (20.01%) and very severe (5.26%). Age > 35 years, concomitant hepatotoxic drugs, extrapulmonary TB and malnutrition are important risk factors for TB DILI. Conclusion: All patterns of TB DILI with varying severity were present. Age > 35 years, malnutrition, extrapulmonary TB and concomitant use of hepatotoxic drugs were risk factors for TB DILI.

关键词： Antituberculosis Drug-Induced Liver Injury Antituberculosis Treatment Subjective Global Assessment Liver Function Test

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High glucose microenvironment and human mesenchymal stem cell behavior

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World Journal of Stem Cells 2024年第3期16卷 237-244页

作者： Muhammad Abdul Mateen Nouralsalhin Alaagib Khawaja Husnain haider Basic Sciences Sulaiman AlRajhi UniversityAlQaseem 52736Saudi Arabia Cellular and Molecular Pharmacology Sulaiman AlRajhi Medical SchoolAl Bukairiyah 51941Saudi Arabia

High glucose(HG)culture conditions in vitro and persistent exposure to hyperglycemia in diabetes patients are detrimental to stem cells,analogous to any other cell type in our *** interferes with diverse signaling pathways,*** target of rapamycin(mTOR)-phosphoinositide 3-kinase(PI3K)-Akt signaling,to impact physiological cellular functions,leading to low cell survival and higher cell apoptosis *** elucidating the underlying mechanism responsible for the apoptosis of adipose tissue-derived mesenchymal stem cells(MSCs),a recent study has shown that HG culture conditions dysregulate mTORPI3K-Akt signaling in addition to mitochondrial malfunctioning due to defective mitochondrial membrane potential(MtMP)that lowers ATP *** organelle-level dysfunction energy-starves the cells and increases oxidative stress and ultrastructural *** of the mitochondrial electron transport chain produces an altered mitochondrial NAD+/NADH redox state as evidenced by a low NAD+/NADH ratio that primarily contributes to the reduced cell survival in *** previous studies have also reported altered mitochondrial membrane polarity(causing hyperpolarization)and reduced mitochondrial cell mass,leading to perturbed mitochondrial *** hostile microenvironment created by HG exposure creates structural and functional changes in the mitochondria,altering their bioenergetics and reducing their capacity to produce *** are significant data,as MSCs are extensively studied for tissue regeneration and restoring their normal functioning in cell-based ***,MSCs from hyperglycemic donors should be cautiously used in clinical settings for cell-based therapy due to concerns of their poor sur-vival rates and increased rates of post engraftment *** hypergly-cemia alters the bioenergetics of donor MSCs,rectifying the loss of MtMP may be an excellent target for future research to restore the normal functioning of MSCs i

关键词： Adipose tissue Apoptosis Bioenergetics Cell survival Cell therapy Hyperglycemia Mitochondria Mesenchymal stem cells Stem cells

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