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Association of chromosome 7 aneuploidy measured by fluorescence in situ hybridization assay with muscular invasion in bladder cancer

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Cancer Communications 2020年第4期40卷 167-180页

作者： Xiayao Diao Jinhua Cai Junjiong Zheng Jianqiu Kong Shaoxu Wu Hao Yu Hao Huang Weibin Xie Xiong Chen Chengran Huang Lifang Huang haide qin Jian Huang Tianxin Lin Department of Urology Sun Yat-sen Memorial HospitalSun Yat-senUniversityGuangzhouGuangdong510120P.R.China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouGuangdong510120P.R.China Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong510120P.R.China State Key Laboratory of Oncology in South China GuangzhouGuangdong510120P.R.China

Background:The preoperative prediction of muscular invasion status is important for adequately treating bladder cancer(BC)but nevertheless,there are some existing dilemmas in the current preoperative diagnostic accuracy of BC with muscular invasion.Here,we investigated the potential association between the fluorescence in situ hybridization(FISH)assay and muscular invasion among patients with BC.A cytogenetic-clinical nomogram for the individualized preoperative differentiation of muscle-invasive BC(MIBC)from non-muscle-invasive BC(NMIBC)is also proposed.Methods:All eligible BC patients were preoperatively tested using a FISH assay,which included 4 sites(chromosome-specific centromeric probe[CSP]3,7,and 17,and gene locus-specific probe[GLP]-p16 locus).The correlation between the FISH assay and BC muscular invasion was evaluated using the Chi-square tests.In the training set,univariate and multivariate logistic regression analyses were used to develop a cytogenetic-clinical nomogram for preoperative muscular invasion prediction.Then,we assessed the performance of the nomogram in the training set with respect to its discriminatory accuracy and calibration for predicting muscular invasion,and clinica usefulness,which were then validated in the validation set.Moreover,model comparison was set to evaluate the discrimination and clinical usefulness between the nomogram and the individual variables incorporated in the nomogram.Results:Muscular invasion was more prevalent in BC patients with positive CSP3,CSP7 and CSP17 status(OR[95%CI],2.724[1.555 to 4.774],P<0.001;3.406[1.912 to 6.068],P<0.001 and 2.483[1.436 to 4.292],P=0.001,respectively).Radiologydetermined tumor size,radiology-determined clinical tumor stage and CSP7 status were identified as independent risk factors of BC muscular invasion by the multivariate regression analysis in the training set.Then,a cytogenetic-clinical nomogram incorporating these three independent risk factors was constructed and was observed to have satisfactory discrimination in the trai

关键词： chromosome aneuploidy fluorescence in situ hybridization muscular invasion nomogram preoperative prediction urinary bladder neoplasms

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A nomogram for individualized estimation of survival among adult patients with adrenocortical carcinoma after surgery:a retrospective analysis and multicenter validation study

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Cancer Communications 2019年第1期39卷 683-695页

作者： Jianqiu Kong Junjiong Zheng Jinhua Cai Shaoxu Wu Xiayao Diao Weibin Xie Xiong Chen Chenyi Liao Hao Yu Xinxiang Fan Chaowen Huang Zhuowei Liu Wei Chen Qiang Lv haide qin Jian Huang Tianxin Lin Department of Urology Sun Yat-Sen Memorial HospitalSun Yat-Sen University107 Yan Jiang West RoadGuangzhou 510120GuangdongP.R.China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120GuangdongP.R.China Department of Neurology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120GuangdongP.R.China Department of Obstetrics and Gynecology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630GuangdongP.R.China Department of Urology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Urology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongP.R.China Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029JiangsuP.R.China State Key Laboratory of Oncology in South China Guangzhou 510120GuangdongP.R.China

Background:Clinical outcome of adrenocortical carcinoma(ACC)varies because of its heterogeneous nature and reliable prognostic prediction model for adult ACC patients is limited.The objective of this study was to develop and externally validate a nomogram for overall survival(OS)prediction in adult patients with ACC after surgery.Methods:Based on the data from the Surveillance Epidemiology,and End Results(SEER)database,adults patients diagnosed with ACC between January 1988 and December 2015 were identified and classified into a training set,comprised of 404 patients diagnosed between January 2007 and December 2015,and an internal validation set,com-prised of 318 patients diagnosed between January 1988 and December 2006.The endpoint of this study was OS.The nomogram was developed using a multivariate Cox proportional hazards regression algorithm in the training set and its performance was evaluated in terms of its discriminative ability,calibration,and clinical usefulness.The nomogram was then validated using the internal SEER validation,also externally validated using the Cancer Genome Atlas set(TCGA,82 patients diagnosed between 1998 and 2012)and a Chinese multicenter cohort dataset(82 patients diag-nosed between December 2002 and May 2018),respectively.Results:Age at diagnosis,T stage,N stage,and M stage were identified as independent predictors for OS.A nomo-gram incorporating these four predictors was constructed using the training set and demonstrated good calibration and discrimination(C-index 95%confidence interval[CI],0.715[0.679-0.751]),which was validated in the internal validation set(C-index[95%CI],0.672[0.637-0.707]),the TCGA set(C-index[95%CI],0.810[0.732-0.888])and the Chi-nese multicenter set(C-index[95%CI],0.726[0.633-0.819]),respectively.Encouragingly,the nomogram was able to successfully distinguished patients with a high-risk of mortality in all enrolled patients and in the subgroup analyses.Decision curve analysis indicated that the nomogram was clinically useful and applicable.Conclusions:T

关键词： Adrenocortical carcinoma Adult patients Overall survival Nomogram Validation Decision curve analysis Surveillance Epidemiology and End Results(SEER) The Cancer Genome Atlas(TCGA) Multicenter

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构建基于临床病理特征的复合模型预测甲状腺乳头状癌颈部淋巴结转移风险

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温州医科大学学报 2023年第4期53卷 276-284页

作者：林琼琼赵志光庄晓苹黄龙覃海德阮红莲温州医科大学附属第二医院病理科浙江温州325000 温州市中西医结合医院病理科浙江温州325000 中山大学孙逸仙纪念医院、广东省恶性肿瘤表观遗传学与基因调控重点实验室广东广州510120 广州医科大学公共卫生学院广东广州511436

目的:探讨甲状腺乳头状癌颈部淋巴结转移的风险因素,构建临床风险预测模型对颈部淋巴结转移的风险进行评估。方法:收集2020年4月至2022年7月675例甲状腺乳头状癌患者纳入研究,通过单因素和多因素Logistic回归分析甲状腺乳头状癌颈部淋... 详细信息

目的:探讨甲状腺乳头状癌颈部淋巴结转移的风险因素,构建临床风险预测模型对颈部淋巴结转移的风险进行评估。方法:收集2020年4月至2022年7月675例甲状腺乳头状癌患者纳入研究,通过单因素和多因素Logistic回归分析甲状腺乳头状癌颈部淋巴结转移的危险因素。按照7:3的比例随机抽样将患者分为训练集(n=474)和验证集(n=201),在训练集中构建预测模型并在验证集中进行验证。绘制列线图对模型进行可视化展示。绘制受试者工作特征曲线(ROC)、校准曲线和决策曲线分析(DCA)对预测模型的区分度、校准度和临床价值进行评估。结果:675例甲状腺乳头状癌患者中,颈部淋巴结转移212例(31.4%)。通过多因素Logistic回归分析,确定了甲状腺乳头状癌颈部淋巴结转移的独立危险因素,包括年龄1 cm、脉管侵犯和包膜侵犯。利用所得到的6个预测因子构建颈部淋巴结转移预测模型,绘制可视化的列线图,用于颈部淋巴结转移风险的评估。该模型在训练集中的曲线下面积(AUC)为0.787(95%CI=0.741~0.834),在验证集中的AUC为0.720(95%CI=0.644~0.796),DCA显示阈值概率在0.2~0.9时该模型预测甲状腺乳头状癌颈部淋巴结转移发生的风险净收益高。结论:年龄1 cm、脉管侵犯和包膜侵犯是甲状腺乳头状癌颈部淋巴结转移的独立危险因素。构建的临床预测模型表现良好,有助于甲状腺乳头状癌颈部淋巴结转移风险的评估与预测。

关键词：甲状腺乳头状癌颈部淋巴结转移预测模型列线图

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青海马场台金矿地质特征及找矿前景分析

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矿产勘查 2020年第2期11卷 243-248页

作者：晁海德陈礼标张海青何存发青海省第四地质勘查院西宁810029

马场台金矿区位于青海省湟源县境内,属于秦祁昆地层区,该区为前寒武系隆起,主要出露元古宙变质岩系。地层走向多呈北西-南东向,与区域构造方向基本一致。区内大地构造位置位于祁连造山带东段,古特提斯构造域北侧,位于中祁连铜、铁、非... 详细信息

马场台金矿区位于青海省湟源县境内,属于秦祁昆地层区,该区为前寒武系隆起,主要出露元古宙变质岩系。地层走向多呈北西-南东向,与区域构造方向基本一致。区内大地构造位置位于祁连造山带东段,古特提斯构造域北侧,位于中祁连铜、铁、非金属成矿带。该区地质构造复杂,岩浆活动强烈,成矿事实较多。本文对青海省马场台金矿地球物理化学地质特征及找矿前景进行了分析探讨,以供参考。

关键词：马场台金矿地质特征找矿前景青海省

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