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两种新型西地那非同系物对MCF-7/ADR细胞对阿霉素耐药的影响

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肿瘤药学 2014年第1期4卷 26-31页

作者：黄海波季恒葛如意吴冰梁英杰周俊立李晓华林海逢汪保国陈思东广东药学院药学院广东广州510310 广东药学院公共卫生学院广东广州510310

目的探讨两种新型西地那非同系物对人乳腺癌MCF-7/ADR细胞耐阿霉素的逆转作用。方法采用GENMED磷酸二酯酶5(PDE5)活性酶测定试剂盒检测两种同系物对5型磷酸二酯酶(PDE5)的抑制作用,用MTT法检测西地那非、西地那非同系物、阿霉素以及西... 详细信息

目的探讨两种新型西地那非同系物对人乳腺癌MCF-7/ADR细胞耐阿霉素的逆转作用。方法采用GENMED磷酸二酯酶5(PDE5)活性酶测定试剂盒检测两种同系物对5型磷酸二酯酶(PDE5)的抑制作用,用MTT法检测西地那非、西地那非同系物、阿霉素以及西地那非同系物与阿霉素联合作用对人乳腺癌耐药细胞MCF-7/ADR和敏感株MCF-7的抑制率及IC50值,运用Western blot检测P-gp蛋白的表达。结果两种同系物与西地那非相比具有较低的PDE5抑制活性;10μmol·L-1的两种西地那非同系物对MCF-7/ADR细胞耐药性的逆转倍数分别是6.36和5.58,20μmol·L-1的两种西地那非同系物对MCF-7/ADR细胞耐药性的逆转倍数分别是11.83和13.47;两种同系物作用对P-gp蛋白的表达无明显影响。结论两种新型西地那非同系物具有较低的PDE5抑制活性,一定浓度的西地那非同系物可显著逆转MCF-7/ADR细胞对阿霉素的耐药。

关键词：西地那非阿霉素逆转肿瘤多药耐药

Study design of deep learning based automatic detection of cerebrovascular diseases on medical imaging: a position paper from Chinese Association of Radiologists

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Intelligent Medicine 2022年第4期2卷 221-229页

作者： Longjiang Zhang Zhao Shi Min Chen Yingmin Chen jingliang Cheng Li Fan Nan Hong Wenxiao jia Guihua jiang Shenghong Ju Xiaogang Li Xiuli Li Changhong Liang Weihua Liao Shiyuan Liu Zaiming Lu Lin Ma Ke Ren Pengfei Rong Bin Song Gang Sun Rongpin Wang Zhibo Wen haibo Xu Kai Xu Fuhua Yan Yizhou Yu Yunfei Zha Fandong Zhang Minwen Zheng Zhen Zhou Wenzhen Zhu Guangming Lu Zhengyu jin on behalf of Chinese Association of Radiologists Department of Radiology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210002China Department of Radiology Beijing HospitalNational Center of GerontologyBeijing 100005China Department of Radiology Hebei General HospitalShijiazhuangHebei 050199China Department of Magnetic Resonance Imaging The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Medical Imaging and Nuclear Medicine Changzheng Hospital of Naval Medical UniversityShanghai 200072China Department of Radiology Peking University People’s HospitalBeijing 100044China Imaging Center First AffiliatedHospital of Xinjiang Medical UniversityUrumqiXinjiang Uygur Autonomous Region 830054China Department of Medical Imaging Guangdong Second Provincial General HospitalGuangzhouGuangdong 510050China Department of Radiology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 211189China Department of Radiology General Hospital of Northern Theater CommandShenyangLiaoning 110011China DeepWise AI lab.Beijing 100089 China Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 519041China Department of Radiology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Radiology Shengjing Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Radiology Chinese PLA(People’s Liberation Army)General HospitalBeijing 100853China Department of Radiology Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenFujian 361005China Department of Radiology Third Xiangya HospitalCentral South UniversityChangshaHunan 410013China Department of Radiology Functional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduSichuan 610044China Department of Nuclear Medicine 960 Hospital of PLAJi’nanShandong 250012China Department of Radiology Guizhou Provincial People’s Hosp

In recent years,with the development of artificial intelligence,especially deep learning technology,researches on automatic detection of cerebrovascular diseases on medical images have made tremendous progress and these models are gradually entering into clinical ***,because of the complexity and flexibility of the deep learning algorithms,these researches have great variability on model building,validation process,performance description and results *** lack of a reliable,consistent,standardized design protocol has,to a certain extent,affected the progress of clinical translation and technology development of computer aided detection *** reviewing a large number of literatures and extensive discussion with domestic experts,this position paper put forward recommendations of standardized design on the key steps of deep learning-based automatic image detection models for cerebrovascular *** further research and application expansion,this position paper would continue to be updated and gradually extended to evaluate the generalizability and clinical application efficacy of such tools.

关键词： Cerebrovascular diseases Deep learning Study design Medical imaging

SARS-CoV-2污染的进口冷链产品导致的一起大连本土新冠疫情

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病毒学报 2021年第6期37卷 1283-1291页

作者：王佶薄志坚毛玲玲杨世宏鲁茁壮聂凯冯晔囡赵翔姚文清孙英伟孙海波吴凡向妮娟王越宋洋马会来陈操马学军孙克许文波中国疾病预防控制中心病毒病预防控制所北京102206 大连市疾病预防控制中心大连116033 辽宁省疾病预防控制中心沈阳110005 复旦大学上海医学院上海200438 中国疾病预防控制中心北京102206 中国疾病预防控制中心中国现场流行病学培训项目北京100050 中国医科大学沈阳110001

2020年12月15日,大连市报告了4名码头冷链货物搬运工人SARS-CoV-2核酸检测呈阳性,在此之前,大连市已经连续136天没有报告本土病例。在这次大连COVID-19疫情(简称"大连新冠疫情")中,我们收集了2020年12月15日至2021年1月8日期间大连新冠... 详细信息

2020年12月15日,大连市报告了4名码头冷链货物搬运工人SARS-CoV-2核酸检测呈阳性,在此之前,大连市已经连续136天没有报告本土病例。在这次大连COVID-19疫情(简称"大连新冠疫情")中,我们收集了2020年12月15日至2021年1月8日期间大连新冠疫情中全部感染者(83)及部分接触的轮船货物样本,其中确诊病例占61.45%(51/83),无症状感染者占38.55%(32/83)。通过高通量测序,共获得76条SARS-CoV-2全基因组序列,其中72条(86.75%,72/83)来自临床样本,4条来自R国籍A货船上的冷链食品外包装样本。基因组分析数据显示,与武汉参考株(NC;45512)相比,76条全基因组分别存在12~16个核苷酸突变位点,共享12个核苷酸突变位点,符合B.1.1进化分支突变特征。结合病毒基因组学和现场流行病学调查结果综合分析表明,大连新冠疫情是一起由SARS-CoV-2污染的进口冷链产品感染码头工人导致的本土疫情,在传播过程中至少形成了3个病毒代际和3个相对独立的传播链。

关键词： COVID-19 冷链 SARS-CoV-2 基因组学现场流行病学分子流行病学

吉非替尼联合盐酸安罗替尼一线治疗EGFR突变晚期非小细胞肺癌的临床研究

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中外医学研究 2020年第28期18卷 37-39页

作者：季洪波王乐乐商迪尹胜杰王晓颖孙丽立于海波高志艳马晓云王磊赤峰市医院内蒙古赤峰024000

目的:探讨吉非替尼联合盐酸安罗替尼一线治疗EGFR突变晚期非小细胞肺癌(NSCLC)的临床效果。方法:回顾性分析笔者所在医院肿瘤内科2018年1-12月收治的30例EGFR突变晚期NSCLC患者的临床资料,所有患者均予以吉非替尼联合盐酸安罗替尼一线... 详细信息

目的:探讨吉非替尼联合盐酸安罗替尼一线治疗EGFR突变晚期非小细胞肺癌(NSCLC)的临床效果。方法:回顾性分析笔者所在医院肿瘤内科2018年1-12月收治的30例EGFR突变晚期NSCLC患者的临床资料,所有患者均予以吉非替尼联合盐酸安罗替尼一线治疗。观察临床疗效及治疗前后肿瘤标志物水平、血清脂肪酸合成酶(FAS)及肿瘤型M2丙酮酸激酶(TuM2-PK)及不良反应发生率及1年生存率。结果:30例患者中总缓解24例,总缓解率为80.00%。治疗后,患者血清癌抗原125(CA125)、癌胚抗原(CEA)、细胞角蛋白19片段抗原(CYFRA21-1)及神经烯醇化酶(NSE)水平、FAS及TuM2-PK水平均较治疗前明显降低,差异有统计学意义(P<0.05)。30例患者中共9例发生不良反应,不良反应发生率为30%;30例患者化疗结束后1年生存26例,生存率为86.67%。结论:EGFR突变晚期NSCLC患者采用吉非替尼联合盐酸安罗替尼一线治疗的效果确切,可有效缓解病症,显著改善肿瘤标志物水平,降低FAS及TuM2-PK水平,且远期生存率较高,值得临床推广使用。

关键词：非小细胞肺癌吉非替尼盐酸安罗替尼肿瘤标志物远期疗效

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黄海波教授诊疗精液病经验摭拾

中国中医药现代远程教育 2017年第17期15卷 70-72页

作者：黄震洲季雯荣宝山呼和浩特市蒙医中医医院男科内蒙古呼和浩特010030 空军易县场站医院河北保定074200 内蒙古医科大学中医学院中医临床基础教研室内蒙古呼和浩特010031

"精液病"是全国名老中医黄海波教授首次提出的精液异常类疾病的统称。黄海波教授在诊疗男性不育症中,尤为关注精液异常情况,往往从精液异常方面作为切入点,结合现代医学检查结果,运用中医理论,辨证施治,提高精液质量。治疗时强调应以补... 详细信息

"精液病"是全国名老中医黄海波教授首次提出的精液异常类疾病的统称。黄海波教授在诊疗男性不育症中,尤为关注精液异常情况,往往从精液异常方面作为切入点,结合现代医学检查结果,运用中医理论,辨证施治,提高精液质量。治疗时强调应以补肾填精为要,同时注意祛除湿、热、痰、瘀之邪,并辅以饮食、情志调摄等以提高疗效。

关键词：黄海波精液异常补肾填精临证经验不孕

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培养条件及人参对嗜酸乳杆菌外膜囊泡的影响

时珍国医国药 2022年第4期33卷 824-826页

作者：李星枚李勇敏罗吉吕元刘芳谭小宁湖南中医药大学湖南长沙410000 湖南省中医药研究院附属医院湖南长沙410000

目的探究在不同培养条件及人参对嗜酸乳杆菌分泌的外膜囊泡(OMVs)的影响。方法在厌氧培养、需氧培养环境及海博、OXOID两种不同厂家培养基的培养条件下,及人参与嗜酸乳杆菌共培养中,提取其分泌的OMVs。用透射电镜观察OMVs的大小、形态;... 详细信息

目的探究在不同培养条件及人参对嗜酸乳杆菌分泌的外膜囊泡(OMVs)的影响。方法在厌氧培养、需氧培养环境及海博、OXOID两种不同厂家培养基的培养条件下,及人参与嗜酸乳杆菌共培养中,提取其分泌的OMVs。用透射电镜观察OMVs的大小、形态;用BCA蛋白含量测定法测定其蛋白含量;SDS-PAGE测定其蛋白分布。结果经电镜鉴定,嗜酸乳杆菌OMVs为20~200nm的双层囊泡状结构;在厌氧、需氧培养条件下,嗜酸乳杆菌OMVs的蛋白含量分别为0.63mg/mL、0.45mg/mL;在海博、OXOID两种不同厂家培养基培养的嗜酸乳杆菌OMVs蛋白含量分别为0.92mg/mL、0.45mg/mL;在有无人参影响下OMVs、Gin-OMVs蛋白含量分别为0.45mg/mL、0.28mg/mL;厌氧、需氧培养的嗜酸乳杆菌OMVs在40~55KD均有两条条带,而厌氧培养的OMVs在30~40KD另有一条条带;海博、OXOID两种不同厂家培养基培养的嗜酸乳杆菌OMVs蛋白条带无明显差别;OMVs与Gin-OMVs相比Gin-OMVs的条带较浅,且40~55KD之间只有一条条带。结论嗜酸乳杆菌在不同培养条件下所分泌的OMVs是有区别的,可选出最佳提取参数;人参可能能够抑制嗜酸乳杆菌分泌OMVs及改变其内含蛋白,此实验可供后续嗜酸乳杆菌OMVs功能研究提供一定的研究价值。

关键词：嗜酸乳杆菌外膜囊泡人参提取鉴定

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen jinhui Chen ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jiNR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Notch信号通路在肺癌和肺癌干细胞中的作用及其抑制剂

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国际肿瘤学杂志 2018年第4期45卷 250-252页

作者：刘恒铫赵国丽王福文蔡海波张月英济南大学山东省医学科学院医学与生命科学学院 250200 山东省医学科学院药物研究所国家卫生和计划生育委员会生物技术药物重点实验室山东省罕少见病重点实验室山东省医学科学院基础医学研究所病理学与病理生理学研究室济宁市第一人民医院胸外科

Notch信号通路参与肺癌干细胞的异常分化和自我更新,深入研究Notch信号通路在肺癌干细胞调控中的作用,有望在肺癌的诊断及治疗中找到新的靶点.作用于Notch信号通路的抑制剂可能成为有效治疗肺癌的药物.肺癌干细胞被认为是肺癌复发的主... 详细信息

Notch信号通路参与肺癌干细胞的异常分化和自我更新,深入研究Notch信号通路在肺癌干细胞调控中的作用,有望在肺癌的诊断及治疗中找到新的靶点.作用于Notch信号通路的抑制剂可能成为有效治疗肺癌的药物.肺癌干细胞被认为是肺癌复发的主要因素,因此针对肺癌干细胞的靶向治疗可能比针对整个肿瘤的治疗更有效.

关键词：受体,Notch 肺肿瘤肿瘤干细胞抑制剂

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纤维素基气敏传感器的制备及其应用研究进展

中国造纸 2022年第8期41卷 117-126页

作者：任海波沈湘凌田宇龙李知行余文政童欣浙江科技学院环境与资源学院浙江杭州310023 齐鲁工业大学(山东省科学院)制浆造纸科学与技术教育部重点实验室山东济南250353

纤维素作为世界上来源最广、含量最丰富的可降解、可再生绿色材料,其研究价值显而易见。近年来,基于纤维素材料的气敏传感器研究受到了国内外学者的广泛关注,并取得了长足的进展。本文主要介绍了基于纳米纤维素及其复合材料的气敏传感... 详细信息

纤维素作为世界上来源最广、含量最丰富的可降解、可再生绿色材料,其研究价值显而易见。近年来,基于纤维素材料的气敏传感器研究受到了国内外学者的广泛关注,并取得了长足的进展。本文主要介绍了基于纳米纤维素及其复合材料的气敏传感器制备方法。同时,对基于纳米纤维素材料的气敏传感器在环境监测、医疗卫生、食品安全领域的应用进行了分析和总结。

关键词：纳米纤维素纤维素基复合材料气敏传感器可穿戴器件