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Efficacy of intramuscular matrine in the treatment of chronic hepatitis B

Hepatobiliary & Pancreatic Diseases International 2004年第1期3卷 69-72页

作者： Yao Long, Xiao-Tian Lin, Kun-Lun Zeng and Lian Zhang zhanjiang, china Department of Infectious Diseases, Affiliated hospital of Guangdong Medical College, zhanjiang 524001, china haibin centre hospital, zhanjiang 524005, china centre of Hepatology of Nanfang hospital, First Military Medical University, Guang- zhou 510515, china Department of Infectious Diseases Affiliated Hospital of Guangdong Medical College Zhanjiang 524001 China. zjlongyao@***

BACKGROUND: Hepatitis B virus (HBV) infection, a glo- bal public health problem, is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. There are more than 350 million HBV carriers in the world and up to one million die annually due to hepatitis B associated liv- er disease. So far no optimal treatment is available for pa- tients with chronic hepatitis B. In the paper we investigated the efficacy of intramuscular matrine in the treatment of chronic hepatitis B. METHODS: One hundred and twenty patients with chronic hepatitis B were randomly divided into matrine treatment group (n =60) and control group (n =60). The patients of the matrine group were given intramuscularly with matrine (an alkaloid extracted from a traditional Chinese herb Radix Sophorae Flavescentis by Guangzhou Ming Xing Pharmaceu cal Factory, Guangzhou, china) of 100 mg daily for 90 days in addition to conventional liver-protective drugs in- cluding glucurone, inosine, compound vitamin B and caryophyllin. The control group received conventional liv- er-protective drugs alone. Clinical manifestations and labo- ratory parameters including liver biochemistry and serum hepatitis B virus markers were monitored before and after treatment in the two groups. RESULTS: Significant differences were seen between the two groups in terms of improvement of clinical symptoms and signs, recovery of liver functions, and serum conver- sion from hepatitis Be antigen to HBe antibody and from positive to negative serum HBV DNA (P <0.05-0.01). The result of the matrine group was more marked than that of the control group. Serious side-effects were not observed except mild pain at the site of injection of matrine in a few patients. CONCLUSION: These results indicate that intramuscular matrine may be an economical, efficacious, safe drug for the treatment of chronic hepatitis B.

关键词： chronic hepatitis B/therapy matrine/therapeutical effect HBV DNA hepatitis B surface antigen hepatitis Be antigen seroconversion

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High-Performance Inverted Perovskite Solar Cells with Sol-Gel-Processed Sliver-Doped NiOx Hole Transporting Layer

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Energy & Environmental Materials 2024年第4期7卷 205-214页

作者： haibin Wang Zhiyin Qin Xinjian Li Chun Zhao Chao Liang School of Advanced Technology Xi'an Jiaotong-Liverpool University Department of Electrical Engineering and Electronics University of Liverpool School of Humanities and Social Sciences Xi'an Jiaotong-Liverpool University Key Laboratory of Materials Physics of Ministry of Education School of Physics and Microelectronics Zhengzhou University MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of Physics National Innovation Platform (Center) for Industry-Education Integration of Energy Storage Technology Xi'an Jiaotong University

Nickel oxide （NiOx） has been established as a highly efficient and stable holetransporting layer （HTL） in perovskite solar cells （PSCs）.However,existing deposition methods for NiOxhave been restricted by high-vacuum processes and fail to address the energy level mismatch at the NiOx/perovskite interface,which has impeded the development of PSCs.

关键词： Ag-NiOX/NiOX hole transporting layer inverted perovskite solar cells

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Analysis of environmental selection pressure of superoxide dismutase in deep-sea sea cucumber

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Journal of Oceanology and Limnology 2024年第3期42卷 893-904页

作者： Yanan LI Zongfu CHEN haibin ZHANG Ruoyu LIU Shuichun CHEN Li LIN Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding College of Animal Sciences and TechnologyZhongkai University of Agriculture and EngineeringGuangzhou 510222China Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanya 572000China College of Marine Science Fujian Agriculture and Forestry UniversityFuzhou 350002China zhanjiang Tianli Sea Cucumber New Technology Development Co. Ltd.Zhanjiang 524000China

Manganese superoxide dismutase(MnSOD)is an antioxidant that exists in mitochondria and can effectively remove superoxide anions in *** a dark,high-pressure,and low-temperature deep-sea environment,MnSOD is essential for the survival of sea *** MnSODs were identified from the transcriptomes of deep and shallow-sea sea *** explore their environmental adaptation mechanism,we conducted environmental selection pressure analysis through the branching site model of PAML *** obtained night positive selection sites,and two of them were significant(97F→H,134K→V):97F→H located in a highly conservative characteristic sequence,and its polarity c hange might have a great impact on the function of MnSOD;134K→V had a change in piezophilic a bility,which might help MnSOD adapt to the environment of high hydrostatic pressure in the *** further study the effect of these two positive selection sites on MnSOD,we predicted the point mutations of F97H and K134V on shallow-sea sea cucumber by using MAESTROweb and *** show that 97F→H,134K→V might improve MnSOD’s efficiency of scavenging superoxide a nion and its ability to resist high hydrostatic pressure by moderately reducing its *** above results indicated that MnSODs of deep-sea sea cucumber adapted to deep-sea environments through their amino acid changes in polarity,piezophilic behavior,and local *** study revealed the correlation between MnSOD and extreme environment,and will help improve our understanding of the organism’s adaptation mechanisms in deep sea.

关键词： Holothuroidea environmental adaptation positive selection point mutation

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Refinement of α′Martensite by Oxygen in Selective Laser Melted Ti-6Al-4V

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 777-792页

作者： Hasfi FNurly Jinhu Zhang Dechun Ren Yusheng Cai haibin Ji Dongsheng Xu Zhicheng Dong Hao Wang Qingmiao Hu Jiafeng Lei Rui Yang School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials and Chemistry/Interdisciplinary centre for Additive Manufacturing University of Shanghai for Science and TechnologyShanghai 200093China centre for Adaptive System Engineering ShanghaiTech UniversityShanghai 201210China

Oxygen is crucial in influencing the microstructure evolution of selective laser melted(SLMed)Ti–6Al–4V,significantly impacting its applicability in various ***,this study investigates the influnce of oxygen on microstructure evolution,particularlyα′martensite transformation and refinement *** alloys,Ti–6Al–4V–xO(x=0.11,0.16,0.21,and 0.25 wt%),were fabricated by the SLM *** martensite start temperature(M_(s))of Ti–6Al–4V,as evaluated by computation,is 656.8°C,and oxygen was found to increase the M_(s) by about 10°C per 0.1 wt%.The SLMed alloy samples exhibit[001]_(β)growth texture along the build *** analysis of martensite morphology suggests internal twinning on{1011}planes as the lattice invariant strain,which becomes more predominant with increasing oxygen *** of α′martensite plates by oxygen is due to increased lattice distortion,reduced prior β grain size,and oxygen segregation toβgrain *** findings contribute to improving the understanding of the effect of oxygen on the transformation mechanism ofα′martensite during SLM of Ti–6Al–4V.

关键词： Selective laser melting α′Martensite Martensite start temperature Oxygen Ti-6Al-4V

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A phylogenetic approach identifies patterns of beta diversity and floristic subregions of the Qinghai-Tibet Plateau

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Plant Diversity 2024年第1期46卷 59-69页

作者： haibin Yu Man Yang Zixin Lu Weitao Wang Fangyuan Yu Yonghua Zhang Xue Yin Hongjun Yu Junjie Hu David C.Deane Key Laboratory of Conservation and Application in Biodiversity of South china School of Life SciencesGuangzhou UniversityGuangzhou 510006China School of Ecology Sun Yat-Sen UniversityShenzhen 510275China School of Geography and Remote Sensing Guangzhou UniversityGuangzhou 510006China College of Life and Environmental Science Wenzhou UniversityWenzhou 325035China centre for Future Landscapes and Department of Environment and Genetics La Trobe UniversityBundooraVIC 3083Australia

Patterns of taxonomic and phylogenetic beta diversity and their relationships with environmental correlates can help reveal the origin and evolutionary history of regional *** Qinghai-Tibet Plateau(QTP)harbors an exceptionally diverse flora,however,a phylogenetic perspective has rarely been used to investigate its beta diversity and floristic *** this study,we used a phylogenetic approach to identify patterns of beta diversity and quantitatively delimit floristic regions on the Qinghai-Tibet *** also examined the relationships between multifaceted beta diversity,geographical distance,and climatic difference,and evaluated the relative importance of various factors(i.e.,climate,topography and history)in shaping patterns of beta diversity.Sørensen dissimilarity indices indicated that patterns of species turnover among sites dominated the *** also found that patterns of both taxonomic and phylogenetic beta diversity were significantly related to geographical distance and climatic *** environmental factors that contributed most to these patterns of beta diversity include annual precipitation,mean annual temperature,climatic gradients and climatic *** dendrograms of dissimilarity and non-metric multidimensional scaling ordination based on phylogenetic beta diversity data identified ten floristic subregions in the *** results suggest that the contemporary environment and historical climate changes have filtered species composition among sites and eventually determined beta diversity patterns of plants in the QTP.

关键词： Biogeographical regionalization Phylogenetic beta diversity Seed plants Sørensen dissimilarity Qinghai-Tibet Plateau

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Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways

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Genes & Diseases 2024年第1期11卷 64-66页

作者： Ying Li Lingli Ding Yage Zhang Bingyu Zhou Gene Chi Wai Man Min Wang Jinglan Li Yamei Liu Weiping Lin haibin Wang Sien Lin Liangliang Xu Key Laboratory of Orthopaedics&Traumatology Lingnan Medical Research CenterThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong SAR 999077China Departments of Diagnostics of Traditional Chinese Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Orthopaedic Research Lab Affiliated Hospital of Guangdong Medical UniversityGuangdong Medical UniversityZhanjiangGuangdong 524001China

Fractures have an extraordinarily negative impact on individuals'quality of life and functional *** or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MSCs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new *** use of MSCs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion.

关键词： PI3K/Akt HIF1α healing

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Evolutionary divergence of subgenomes in common carp provides insights into speciation and allopolyploid success

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Fundamental Research 2024年第3期4卷 589-602页

作者： Lin Chen Chengyu Li Bijun Li Xiaofan Zhou Yulin Bai Xiaoqing Zou Zhixiong Zhou Qian He Baohua Chen Mei Wang Yaguo Xue Zhou Jiang Jianxin Feng Tao Zhou zhanjiang Liu Peng Xu State Key Laboratory of Mariculture Breeding College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Fujian Key Laboratory of Genetics and Breeding of Marine Organisms College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Integrative Microbiology Research centre South China Agricultural UniversityGuangzhou 510642China College of Fisheries Henan Normal UniversityXinxiang 453007China Henan Academy of Fishery Science Zhengzhou 450044China Department of Biology College of Arts and SciencesSyracuse UniversitySyracuse 13244USA

Hybridization and polyploidization have made great contributions to speciation,heterosis,and agricultural production within plants,but there is still limited understanding and utilization in *** structure and expression reorganization and cooperation post hybridization and polyploidization are essential for speciation and allopolyploid ***,the mechanisms have not yet been comprehensively assessed in ***,we produced a high-fidelity reference genome sequence for common carp,a typical allotetraploid fish species cultured *** genome enabled in-depth analysis of the evolution of subgenome architecture and expression *** genes were expressed with subgenome biases,with a trend of transition from the expression of subgenome A during the early stages to that of subgenome B during the late stages of embryonic *** subgenome A evolved more rapidly,subgenome B contributed to a greater level of expression during development and under stressful *** dominant patterns for homoeologous gene pairs both during development and under thermal stress suggest a potential fixed heterosis in the allotetraploid *** expressing either copy of a homoeologous gene at higher levels to confer development and response to stress indicates the dominant effect of *** plasticity of subgenomes and their shifting of dominant expression during early development,and in response to stressful conditions,provide novel insights into the molecular basis of the successful speciation,evolution,and heterosis of the allotetraploid common carp.

关键词： Allotetraploid Subgenome structural evolution Homoeologous expression Expression dominance shift Environmental adaptation

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医院图书馆人力资源的现状与建设研究

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图书馆论坛 2005年第1期25卷 64-66页

作者：张政广东省农垦中心医院图书馆广东湛江524002

人力资源是医院图书馆可持续发展的主要因素, 文章分析其重要性和影响因素, 提出树立以人为本的人力资源建设理念, 确立人才开发定位方略, 建立调动人才积极性的激励机制等相应对策。

关键词：人力资源建设可持续发展激励机制人才开发相应对策以人为本现状医院图书馆文章分析主要因素

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开架服务中书库环境的布局

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图书馆论坛 2003年第2期23卷 143-144页

作者：吴振忠广东湛江海洋大学海滨学院图书馆广东湛江524005

指出开架服务中容易产生丢书、乱架、损坏书刊等不利因素 ,探讨如何在既方便读者又减轻工作人员劳动强度的前提下 ,合理布局书库环境。

关键词：开架服不利因素书库环境布局图书排架规章制度

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A categorical interpretation of Yetter-Drinfel'd modules

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Chinese Science Bulletin 1999年第9期44卷 771-778页

作者： KAN haibin and WANG ShuanhongInstitute of Mathematics , Fudan University , Shanghai 200433 , china Department of Mathematics , Henan Normal University, Xinxiang 453002, china Institute of Mathematics Fudan Univrrsity Shanghai China Dcpartment of Mathematics Henun Normal University Xinxiang China

It is known that any strict tensor category （C, I） can determine a strict braided tensor category Z （ C）, the centre of C. When A is a finite Hopf algebra, Drinfel’d has proved that Z（AM） is equivalent to D（A）M as a braided tensor category, where AM is the left A-module category, and D （A） is the Drinfel’d double of A. This is the categorical interpretation of D （A）.Z（4M） is proved to be equivalent to the Yetter-Drinfel’ d module category AY D4 as a braided tensor category for any Hopf algebra A. Furthermore, for right A-comodule category MA , Z（MA） is proved to be equivalent to the Yetter-Drinfel’ d module category AY D4 as a braided tensor category. But, in the two cases, the Yetter-Drinfel’ d module category AY DA has different braided tensor structures.

关键词： Yetter-Drinfel’d module tensor category equivalence.

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