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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang haibin xu xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Theoretical study on the mechanism of cycloaddition between dimethyl methylene carbene and acetone

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Chinese Science Bulletin 2005年第20期50卷 2281-2287页

作者： LU Xiuhui WU Weirong YU haibin xu Yuehua School of Chemistry and Chemical Engineering Jinan University Jinan 250022 China

The mechanism of the cycloaddition reaction of singlet dimethyl methylene carbene and acetone has been studied by using second-order Moller-Plesset perturbation and density functional theory. The geometrical parameters, harmonic vibrational frequencies and energy of stationary points on the potential energy surface are calculated by MP2/6-31G* and B3LYP/6-31G* methods. The results show that path b of the cycloaddition reaction (1) would be the major reactive channel of the cycloaddition reaction between singlet dimethyl methylene carbene and acetone, which pro- ceeds in two steps: i) The two reactants form an energy-rich intermediate (INT1b), which is an exothermic reaction of 23.3 kJ/mol with no energy barrier. ii) The intermediate INT1b isomerizes to a three-membered ring product (P1) via transition state TS1b with energy barrier of 22.2 kJ/mol. The reaction rate of this reaction and its competitive reactions do greatly differ, with excellent selectivity. In view of dynamics and thermodynamics, this reaction is suitable for occurring at 1 atm and temperature range of 300―800 K, in which the reaction will have not only the larger spontaneous tendency and equilibrium constant but also the faster reaction rate.

关键词：二甲基亚甲基碳烯丙酮环状化合物密度函数能量表面

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Numerical Simulation of Moisture Movement in Unsaturated Expansive Soil Slope Suffering Permeation

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Journal of China University of Geosciences 2005年第4期16卷 359-362页

作者： Chen Shanxiong Yu Song Liu Zhiguo xu haibin School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074 China Institute of Rock and Soil Mechanics Chinese Academy of Sciences Wuhan 430071 China Institute of Rock and Soil Mechanics Chinese Academy of Sciences Wuhan 430071 China

This study develops a way of analyzing moisture movement in unsaturated expansive soil slope. The basic equations and the integrated finite difference method for moisture movement in unsaturated soils are briefly described, and the calculation code MFUS2 has been developed. The moisture movements in unsaturated expansive soil slopes suffering precipitation were simulated numerically. The simulation results show that expansion or contraction must be taken into account in an analysis model. A simplified equivalent model for calculating rainwater infiltration into expansive soil slopes has been developed. The simplified equivalent model divides the soil slope into two layers according to the extent of weathering of the soil mass at depth. Layer Ⅰ is intensively weathered and moisture can be fully evaporated or rapidly absorbed. The moisture movement parameters take into account the greater soil permeability caused by fissures. Layer Ⅱ is unweathered and the soil is basically undisturbed. The moisture movement parameters of homogeneous soils are applicable. The moisture movements in unsaturated ex- pansive soil slopes suffering precipitation were simulated numerically using the simplified equivalent model. The simulation results show that the moisture movement in the expansive soil slope under rainfall permeation mainly takes place in the extensively weathered layer Ⅰ which closely simulates the real situation.

关键词： expansive soils unsaturated soil slope infiltration transient distribution of water content.

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Expression and responses to dehydration and salinity stresses of V-PPase gene members in wheat

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Journal of Genetics and Genomics 2009年第12期36卷 711-720页

作者： Yuezhi Wang haibin xu Guangxiang Zhang Huilan Zhu Lixia Zhang Zhengzhi Zhang Caiqin Zhang Zhengqiang Ma The Applied Plant Genomics Laboratory Crop Genomics and Bioinformatics Center & National Key Lab of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Nanjing 210095 China

Vacuolar H^＋-translocating pyrophosphatase （V-PPase） is a key enzyme related to plant growth as well as abiotic stress tolerance. In this work, wheat V-PPase genes TaVP1, TaVP2 and TaVP3 were identified. TaVP1 and TaVP2 are more similar to each other than to TaVP3. Their deduced polypeptide sequences preserve the topological structure and essential residues of V-PPases. Phylogenetic studies suggested that monocot plants, at least monocot grasses, have three VP paralogs. TaVP3 transcripts were only detected in developing seeds, and no TaVP2 transcripts were found in germinating seeds. TaVP2 was mainly expressed in shoot tissues and down-regulated in leaves under dehydration. Its expression was up-regulated in roots under high salinity. TaVP1 was relatively more ubiquitously and evenly expressed than TaVP2. Its expression level in roots was highest among the tissues examined, and was inducible by salinity stress. These results indicated that the V-PPase gene paralogs in wheat are differentially regulated spatially and in response to dehydration and salinity stresses.

关键词： vacuolar H^+-pyrophosphatase abiotic stress phylogenetic analysis

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Effect of Bath pH on the Squareness of Electroless CoNiWP Magnetic Films

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Journal of Materials Science & Technology 2008年第5期24卷 712-714页

作者： haibin CHENG Shuai xu Wenyu ZHAO Suling ZHAO Pengcheng ZHAI Zhigang SUNand Qingjie ZHANGt Pengcheng ZHAI Zhigang SUN Qingjie ZHANG State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China

Electroless CoNiWP magnetic films were prepared by varying the bath pH and then characterized by energy dispersive X-ray analysis, X-ray diffraction and magnetic force microscopy, it has been found that the microstructure and the magnetic properties of films were influenced greatly by the bath pH. At the bath pH 8.06, the grain size and coercivity of the films reach maximuml while the squareness （Mr/Ms） of MH curves reaches minimum. The Henkel plots indicates that the exchange-coupling interaction is very weak at this pH, which may be caused by phase-separation and large grain size, and then results in the lowest squareness. At pH above 8.5, obvious exchange-coupling interaction is observed because of the inexistence of phase-separation and the refinement of grain size.

关键词： CoNiWP magnetic film Bath pH Squareness Exchange-coupling interaction

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SUNKEN ANCIENT SHIP SALVAGED

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China & The World Cultural Exchange 2007年第12期73卷 4-7页

作者： Feng Lin & xu haibin and Li Bin

Editor’s words: Over the sweep of history, Chinese people have paid heavy price in their struggles with the ocean. A large number of sunken ships are evidence that testifies to the history of South China Sea as an important maritime passage linking the mainland to the outside world since the Song Dynasty dating back to more than 1000 years. In 1987 the discovery of the sunken Song-Dynasty ship "South China Sea No. 1" in the border area between Yangjiang and Taishan counties in Guangdong Province is the landmark event for China’s underwater archeologists. 20 years from then on, surveys and excavations done to this ancient ship have witnessed the development of Chinese underwater archeology. With decades of efforts by experts from various fields, the sunken ship was eventually salvaged out of water in 2007 and will be housed in the newly-built Maritime Silk Road Museum in Guangdong…

关键词：古代沉船打捞中国

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有腹筋UHPFRC梁抗剪承载力计算

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哈尔滨工业大学学报 2015年第12期47卷 80-85页

作者：徐海宾邓宗才工程抗震与结构诊治北京市重点实验室北京工业大学北京100124 工程抗震与结构诊治北京市重点实验室(北京工业大学) 北京100124

为研究有腹筋UHPFRC梁的抗剪承载力,根据超高性能纤维混凝土梁的剪切破坏机理,结合修正压力场理论,考虑梁上部受压区混凝土和下部受拉区骨料咬合力、箍筋及裂缝间钢纤维共同承受剪力,推导了有腹筋超高性能纤维混凝土梁的抗剪承载力计算... 详细信息

为研究有腹筋UHPFRC梁的抗剪承载力,根据超高性能纤维混凝土梁的剪切破坏机理,结合修正压力场理论,考虑梁上部受压区混凝土和下部受拉区骨料咬合力、箍筋及裂缝间钢纤维共同承受剪力,推导了有腹筋超高性能纤维混凝土梁的抗剪承载力计算公式.与9根超高性能纤维混凝土梁的剪切试验结果进行对比,用推导公式计算的抗剪承载力与试验结果吻合较好,且变异系数较小,可用于有腹筋超高性能纤维混凝土梁的抗剪分析和设计.

关键词：超高性能纤维混凝土腹筋梁抗剪承载力修正压力场理论

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超高性能混凝土连续梁弯矩调幅系数

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哈尔滨工程大学学报 2016年第11期37卷 1520-1525页

作者：徐海宾邓宗才河南理工大学土木工程学院河南焦作454000 北京工业大学建筑工程学院北京100124

为了研究HRB500钢筋超高性能混凝土连续梁的弯矩调幅性能,依据非线性理论分析了超高性能混凝土连续梁弯矩调幅系数的计算方法,并编制了相应的程序,通过与已有试验结果的对比验证了程序的准确性。通过对22根HRB500钢筋超高性能混凝土连... 详细信息

为了研究HRB500钢筋超高性能混凝土连续梁的弯矩调幅性能,依据非线性理论分析了超高性能混凝土连续梁弯矩调幅系数的计算方法,并编制了相应的程序,通过与已有试验结果的对比验证了程序的准确性。通过对22根HRB500钢筋超高性能混凝土连续梁的模拟分析,计算了22根模拟梁在正常使用极限状态及承载能力极限状态下的弯矩调幅系数;根据模拟结果,提出以中支座截面相对受压区高度ξ为自变量的弯矩调幅系数β的计算公式为β=-3.541ξ+0.867;最后以正常使用极限状态下裂缝宽度不大于0.2 mm为控制条件,建议ξ≤0.13时β取0.4,ξ≥0.21时β取0.1,0.13<ξ<0.21时,β值采用直线内插求得。

关键词：超高性能混凝土连续梁非线性分析弯矩调幅 HRB500钢筋裂缝

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UHPC梁开裂弯矩和裂缝试验

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哈尔滨工业大学学报 2014年第4期46卷 87-92页

作者：徐海宾邓宗才北京工业大学工程抗震与结构诊治北京市重点实验室北京100124 河南理工大学土木工程学院河南焦作454003

为研究超高性能混凝土梁的开裂弯矩和裂缝特征及评估现有规范公式计算超高性能混凝土梁开裂弯矩和裂缝宽度的适用性,进行了8根超高性能混凝土T形简支梁的受弯性能试验,观察试验梁的开裂弯矩和裂缝发展.试验结果表明:预应力水平对开裂荷... 详细信息

为研究超高性能混凝土梁的开裂弯矩和裂缝特征及评估现有规范公式计算超高性能混凝土梁开裂弯矩和裂缝宽度的适用性,进行了8根超高性能混凝土T形简支梁的受弯性能试验,观察试验梁的开裂弯矩和裂缝发展.试验结果表明:预应力水平对开裂荷载影响较大;超高性能混凝土梁的弯曲裂缝细而密,加载初期最大裂缝宽度发展较慢,纵筋屈服后最大裂缝宽度发展明显加快;利用现有规范公式计算超高性能混凝土梁开裂弯矩和最大裂缝宽度过于保守.在现行规范公式的基础上引入抗裂影响系数和裂缝修正系数,给出了超高性能混凝土梁开裂弯矩和最大裂缝宽度的建议公式,建议公式的计算值和试验值吻合良好.

关键词：超高性能混凝土开裂弯矩受弯性能裂缝宽度预应力

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超高性能混凝土梁抗剪承载力计算方法

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华中科技大学学报（自然科学版） 2015年第7期43卷 24-28,71页

作者：徐海宾邓宗才北京工业大学工程抗震与结构诊治北京市重点实验室北京100124 河南理工大学土木工程学院河南焦作454003

分别采用极限平衡法、修正压力场理论和塑性理论对超高性能混凝土梁抗剪承载力进行分析.根据超高性能混凝土的力学特性,采用简化的Rankine破坏准则推导了极限平衡法求解超高性能混凝土梁抗剪承载力的相关公式;通过对修正压力场理论的相... 详细信息

分别采用极限平衡法、修正压力场理论和塑性理论对超高性能混凝土梁抗剪承载力进行分析.根据超高性能混凝土的力学特性,采用简化的Rankine破坏准则推导了极限平衡法求解超高性能混凝土梁抗剪承载力的相关公式;通过对修正压力场理论的相关方程进行修正,得到了适合计算超高性能混凝土梁抗剪承载力的相关方程;给出了用塑性理论求解超高性能混凝土梁抗剪承载力时塑性系数的取值方法.通过对9根试验梁和其他17根试验梁进行计算,结果表明:极限平衡法、修正压力场理论和塑性理论均能较好地预测超高性能混凝土梁的抗剪承载力,其中修正压力场理论计算结果比较保守,极限平衡法计算结果最接近实测值且变异系数最小.

关键词：超高性能混凝土抗剪承载力修正压力场理论塑性理论极限平衡法

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