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Impairment of recovery of muscle function by residual rocuronium after re-transfusion of intraoperative salvaged blood

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Chinese Medical Journal 2014年第5期127卷 821-824页

作者： wang Geng wang Jia Zhou haibin Zhao Xia Wu Xinmin Department of Anesthesiology Beijing Jishuitan Hospital Beijing 100035 China

Background Recurarization has previously been described in the context of acute normovolemic hemodilution.The aim of this study was to investigate the impairment of recovery of neuromuscular function after re-transfusion of intraoperative salvaged blood in patients treated with rocuronium.Methods We enrolled 50 patients undergoing general anesthesia for lumbar surgery.Intraoperative blood salvage （IBS） was used in 30 patients （group Ⅰ）; the remaining 20 comprised a control group （group C）.Anesthesia was induced with fentanyl,midazolam,propofol and rocuronium.Rocuronium was infused to maintain neuromuscular blockade during surgery.Blood was collected from the operative field and re-transfused in the post-anesthesia care unit （PACU）.Neuromuscular function was monitored using the train-of-four ratio （TOFr）.Once the train-of-four ratio exceeded 90 in the PACU,neuromuscular function was evaluated every 5 minutes for 30 minutes.The TOFr and incremental recovery of TOFr from baseline were recorded.Salvaged blood was re-transfused at the beginning of the evaluation for patients in group Ⅰ,and afterwards for patients in group C.Blood gas analysis was assessed before anesthesia and in the PACU.Results Incremental recovery of TOFr from baseline was significantly less in group Ⅰ than controls at 25 minutes （6.1±3.2vs.9.1±3.2,respectively; P=0.001） and 30 minutes （7.1±3.2 vs.10.0±2.2,respectively; P=-0.001）.There were no significant differences in gas exchange between the groups.Conclusions In patients who had received a rocuronium infusion during anesthesia,re-transfusion of salvaged blood significantly impaired recovery of neuromuscular function recovery in the PACU,but without significant impairment of respiratory function.

关键词： intraoperative blood salvage neuromuscular blocking agents rocuronium recurarization

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牛庄洼陷页岩油大尺寸井眼优快钻井技术

石油机械 2023年第7期51卷 43-50页

作者：王海斌中石化胜利石油工程有限公司黄河钻井总公司

牛庄洼陷是胜利页岩油国家级示范区重点开发区域,该区块地质条件复杂,二开311.1 mm井眼钻进效率低的问题十分突出。为实现页岩油井大尺寸井眼的高效钻进,针对上部砾石层钻头寿命短、行程进尺少,斜井段滑动钻进“托压”严重、钻头攻击性... 详细信息

牛庄洼陷是胜利页岩油国家级示范区重点开发区域,该区块地质条件复杂,二开311.1 mm井眼钻进效率低的问题十分突出。为实现页岩油井大尺寸井眼的高效钻进,针对上部砾石层钻头寿命短、行程进尺少,斜井段滑动钻进“托压”严重、钻头攻击性与工具面稳定性矛盾突出等问题,通过对提速工艺的分段优化、井眼轨迹优化、高效钻头及提速工具研制配套、钻井液性能分析及工艺优化等技术措施,提出了优快钻井技术。该技术在牛庄洼陷页岩油国家级示范区应用20口井,取得了显著的提速提效成果,表现在:机械钻速较同区块前期提高40.8%,平均行程进尺较同区块前期提升46.35%,二开平均钻井周期较同区块前期缩短55.55%,有效解决了牛庄洼陷页岩油上部大尺寸井眼钻进效率低、行程进尺少的问题。研究结果可为胜利油田页岩油钻井提速提效提供借鉴。

关键词：胜利油田牛庄洼陷页岩油大井眼优快钻井

Grain size effect on wear resistance of WC-Co cemented carbides under different tribological conditions

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Journal of Materials Science & Technology 2019年第11期35卷 2435-2446页

作者： Haibin Wang Mark Gee Qingfan Qiu Hannah Zhang Xuemei Liu Hongbo Nie Xiaoyan Song Zuoren Nie College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaBeijing University of TechnologyBeijing 100124China National Physical Laboratory Hampton RoadTeddingtonTW110LWUK Xiamen Tungsten Co. Ltd.Xiamen 361009China

The grain-size dependence of wear resistance of WC-Co cemented carbides(with mean WC grain sizes of 2.2μm,1.6μm,0.8μm and 0.4μm,respectively)was investigated under different tribological conditions.The results showed that the grain size had opposite effects on wear resistance of the cemented carbides in dry sliding wear and microabrasion tests.In the former condition,with decrease of WC grain size hence the increase of hardness,plastic deformation,fracture,fragmentation and oxidation were all mitigated,leading to a drastic decrease in the wear rate.In the latter condition,pull-out of WC grains after Co removal dominated the wear,so that the hardness of cemented carbide was not a core factor.As a result,the wear resistance of the cemented carbide generally showed a decreasing trend with decrease of the grain size,except for a slight increase in the ultrafine-grained cemented carbide.Single-pass scratching of the cemented carbides under various loads indicated the same failure mechanism as that in the sliding wear tests.Furthermore,the reasons for severe surface oxidation of the coarse-grained cemented carbides were disclosed.

关键词： Cemented carbide Grain size Fracture Surface oxidation Grain pull-out Wear resistance

Oxygen modified CoP2 supported palladium nanoparticles as highly efficient catalyst for hydrolysis of ammonia borane

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Nano Research 2022年第4期15卷 3034-3041页

作者： Leijie Zhang Jian Ye Yi Tu Qingyu wang haibin Pan Lihui Wu Xusheng Zheng Junfa Zhu National Synchrotron Radiation Laboratory Department of Chemical Physics and Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei 230029China School of Science Anhui Agricultural UniversityHefei 230036China

Ammonia borane(AB)is regarded as a promising chemical hydrogen-storage material due to its high hydrogen content,nontoxicity,and long-term stability under ambient temperature.However,constructing advanced catalysts to further promote the hydrogen production still remains a challenge for the hydrolysis of AB.Herein,we report a novel oxygen modified CoP_(2)(O-CoP_(2))material with dispersed palladium nanoparticles(Pd NPs)as a highly efficient and sustainable catalyst for AB hydrolysis.The modification of oxygen could optimize the catalytic synergy effect between CoP_(2)and Pd NPs,achieving enhanced catalytic activity with a turnover frequency(TOF)number of 532 min^(-1)and an activation energy(E_(a))value of 16.79 kJ·mol^(-1).Meanwhile,reaction kinetic experiments prove that the activation of water is the rate-determining step(RDS).The water activation mechanism is revealed by quasi in-situ X-ray photoelectron spectroscopy(XPS)and in-situ X-ray absorption fine structure(XAFS)measurements.The activation of water leads to the production of-H and-OH groups,which are further adsorbed on the oxygen atoms in P-O bond and Pd atoms,respectively.In addition,density functional theory(DFT)calculations indicate that the introduced oxygen facilitates the adsorption and activation of water molecules.This novel modulation strategy successfully sheds new light on the development of advanced catalysts for hydrolysis of AB and beyond.

关键词： Pd-based catalysis ammonia borane hydrolysis water activation quasi in-situ X-ray photoelectron spectroscopy density functional theory(DFT)calculations

On the chemical compatibility between Zr-4 substrate and well-bonded Cr_2AlC coating

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Journal of Materials Science & Technology 2019年第1期35卷 1-5页

作者： Jie Zhang Zhilin Tian haibin Zhang Lei Zhang Jingyang wang High-Performance Ceramics Division Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics Technical Support Division Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences

Accident tolerant fuel(ATF) for the light water reactor has gained wide attentions after the Fukushima accident. To enhance the accident-tolerance of the nuclear system, one strategy is to modify the Zr-based alloy cladding surface with advanced ceramic coating. In this work, monolithic and dense Cr_2AlC coating has been synthesized by magnetron sputtering. The as-grown Cr_2AlC coating exhibits good chemical compatibility with Zr-based alloy substrate as well as mechanical integrity under both pull-off and scratch tests. The coating system also presents moderate thermochemical compatibility at 800℃ but degrades above 1000℃ under simulated loss-of-coolant accident(LOCA) conditions.

关键词： Accident tolerant fuel Cr2AlC coating Thermochemical compatibility

Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material

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Journal of Materials Science & Technology 2023年第15期146卷 211-220页

作者： Chenxi Dou Mingyang Zhang Dechun Ren haibin Ji Zhe Yi Shaogang wang Zengqian Liu Qiang wang Yufeng Zheng Zhefeng Zhang Rui Yang Liaoning Provincial Key Laboratory of Oral Diseases School and Hospital of StomatologyChina Medical UniversityShenyang 110001China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Peking UniversityBeijing 100871China Center for Adaptive System Engineering School of Creativity and ArtShanghaiTech UniversityShanghai 201210China

Mg(and Mg alloys)and Ti(and Ti alloys)are two important classes of metallic implant materials which are respectively completely degradable and non-degradable after implantation.Making composites composed of them offers the promise for combining their property advantages for bone repair.Here,we present a Mg-Ti composite fabricated by pressureless infiltration of pure Mg melt into 3D printed Ti scaffold,and demonstrate a potential of the composite for use as new partially degradable and bioactive implant materials.The composite has such architecture that the Mg and Ti phases are topologically bicontinuous and mutually interspersed in 3D space,and exhibits several advantages over its constituents,such as higher strengths than as-cast pure Mg and Ti scaffold along with lower Young’s modulus than dense Ti.Additionally,the degradation of Mg phase may induce the formation and ingrowth of new bone tissues into the Ti scaffold to form mechanical interlocking between them;in this process,the Ti scaffold provides constant support and Young’s modulus adaptively decreases toward that of bone.Despite the accelerated corrosion than pure Mg,the composite remains non-cytotoxic and does not cause obvious adverse reactions after implantation as revealed by in vitro and in vivo experiments.This study may offer a new possibility for combining mechanical durability and bioactivity in implant materials,and allow for customized and targeted design of the implant.

关键词： Mg-Ti composite Interpenetrating-phase architecture Implant Bioactivity Degradation Strength

Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation

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Journal of Molecular Cell Biology 2021年第9期13卷 646-661页

作者： Chan Zhou Meiying Lv Peike wang Chuanhui Guo Zhangli Ni Haili Bao Yedong Tang Han Cai Jinhua Lu Wenbo Deng Xiaoyu Yang Guoliang Xia Haibin Wang Chao wang Shuangbo Kong State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijingChina'2 Fujian Provincial Key Laboratory of Reproductive Health ResearchSchool of MedicineXiamen UniversityXiamenChina'3 Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese MedicineFuzhouChina'4 Department of Obstetrics and GynecologyThe First Affiliated Hospital of Xiamen UniversityXiamenChina'5 Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western ChinaCollege of Life ScienceNingXia UniversityYinchuanChina

Embryo implantation in both humans and rodents is initiated by the attachment of a blastocyst to the uterine epithelium.For blastocyst attachment,the uterine epithelium needs to transform at both the structural and molecular levels first,and then initiate the interaction with trophectoderm.Any perturbation during this process will result in implantation failure or long-term adverse pregnancy outcomes.Endocrine steroid hormones,which function through nuclear receptors,combine with the local molecules produced by the uteri or embryo to facilitate implantation.The insulin-like growth factor(IGF)signaling has been reported to play a vital role during pregnancy.However,its physiological function during implantation remains elusive.This study revealed that mice with conditional deletion of Igflr gene in uteri suffered from subfertility,mainly due to the disturbed uterine receptivity and abnormal embryo implantation.Mechanistically,we uncovered that in response to the nidatory estrogen on D4 of pregnancy,the epithelial IGF1R,stimulated by the stromal cell-produced IGF1,facilitated epithelial STAT3 activation to modulate the epithelial depolarity.Furthermore,embryonic derived IGF2 could activate both the epithelial ERK1/2 and STAT3 signaling through IGF1R,which was critical for the transcription of Cox2 and normal attachment reaction.In brief,our data revealed that epithelial IGF1R was sequentially activated by the uterine stromal IGF1 and embryonic IGF2 to guarantee normal epithelium differentiation during the implantation process.

关键词： IGF1R IGF1 IGF2 uterine epithelium implantation blastocyst

Analysis of gas-solid flow and shaft-injected gas distribution in an oxygen blast furnace using a discrete element method and computational fluid dynamics coupled model

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Particuology 2017年第3期15卷 63-72页

作者： Zeshang Dong Jingsong wang haibin Zuo Xuefeng She Qingguo Xue State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Beijing 100083 China

lronmaking using an oxygen blast furnace is an attractive approach for reducing energy consumption in the iron and steel industry. This paper presents a numerical study of gas-solid flow in an oxygen blast fur- nace by coupling the discrete element method with computational fluid dynamics. The model reliability was verified by previous experimental results. The influences of particle diameter, shaft tuyere size, and specific ratio （X） of shaft-injected gas （51G） flowrate to total gas flowrate on the SIC penetration behavior and pressure field in the furnace were investigated. The results showed that gas penetration capacity in the furnace gradually decreased as the particle diameter decreased from 100 to 40 mm. Decreasing particle diameter and increasing shaft tuyere size both slightly increased the SIG concentration near the furnace wall but decreased it at the furnace center. The value of X has a significant impact on the SIG distribution. According to the pressure fields obtained under different conditions, the key factor affecting SIG penetration depth is the pressure difference between the upper and lower levels of the shaft tuyere. If the pressure difference is small, the SIG can easily penetrate to the furnace center.

关键词： Oxygen blast furnace Discrete element method Computational fluid dynamics Shaft gas injection Gas-solid flow Pressure field

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俄日关系的进展与限度

国际问题研究 2020年第6期 57-76,137,138页

作者：王海滨陕西师范大学哲学与政府管理学院

近年来,俄日在推进双边关系方面取得了一定进展:双方确认追求构建战略伙伴关系并致力于发展全领域的双边合作;以"行动对行动"平行推进经济合作与领土谈判;逐渐拓展和升级军事安全对话与协作;积极推进及活跃人文交流;就领土及和平条约问... 详细信息

近年来,俄日在推进双边关系方面取得了一定进展:双方确认追求构建战略伙伴关系并致力于发展全领域的双边合作;以"行动对行动"平行推进经济合作与领土谈判;逐渐拓展和升级军事安全对话与协作;积极推进及活跃人文交流;就领土及和平条约问题的谈判基础达成初步共识。但是,俄日关系的进展与双方期待之间存在较大落差,这反映出两国关系发展的限度:俄日关系没有获得质的提升;经济合作的意向远多于实际落实;双方在领土及和约问题上真正达成协议仍然遥遥无期。在安倍时代,俄日关系具有明显的不稳定性与脆弱性,两国互动存在明显"温差"。展望菅义伟时代,俄日关系难有新的突破,甚至存在下滑风险;但同时,对发展相互关系的诸多需求将确保俄日关系"不脱轨"。长远来看,俄日将继续保持对话并探讨"无约"状态下推进双边关系的可能路径。

关键词：俄日关系领土争议和平条约日美同盟