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IN783低膨胀高温合金的热变形行为和组织演变

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稀有金属材料与工程 2024年第7期53卷 2006-2017页

作者：苏海王晨罗通黄海亮张华张尚洲江亮周鑫烟台大学精准材料高等研究院山东烟台264005 贵州安大航空锻造有限责任公司贵州安顺561005

通过热压缩试验研究了IN783低膨胀高温合金在温度为1000~1120℃、应变速率为0.01~10 s^(-1)条件下的热变形行为,并采用电子背散射衍射(EBSD)研究了不同变形参数下合金的组织演变规律。结果表明,IN783合金的流变应力随着温度的升高和应... 详细信息

通过热压缩试验研究了IN783低膨胀高温合金在温度为1000~1120℃、应变速率为0.01~10 s^(-1)条件下的热变形行为,并采用电子背散射衍射(EBSD)研究了不同变形参数下合金的组织演变规律。结果表明,IN783合金的流变应力随着温度的升高和应变速率的减小而显著降低。基于Arrhenius方程和Zener-Hollomon参数模型,建立了该合金的本构方程为:ε=3.58237×10^(15)[sinh(0.00495724σ)]^(3.99121)exp(-417.146551/RT),可以很好地描述热变形过程中流变应力与变形温度和应变速率的关系。基于动态材料模型绘制了IN783合金的热加工图,并根据热加工图和微观组织分析,确定IN783镍基高温合金热加工的安全区间为:1000~1080℃/0.1~10 s^(-1),以及1000~1040℃/0.01~0.1 s^(-1)。此外,在高温低速率条件下(1060~1120℃、0.01 s^(-1)),尽管合金具有较高的功率耗散值,但会出现混晶组织和晶粒粗化现象,也不适合作为IN783合金的热加工区间。

关键词： IN783高温合金热变形行为热加工图组织演变

生物医学领域碳纳米材料10年研究前沿与热点

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中国组织工程研究 2025年第4期29卷 752-760页

作者：党小雯黄海量黄雷王亚洁山东中医药大学康复医学院山东省济南市250355

背景:生物医学领域碳纳米材料的研究蓬勃发展,相关科研成果逐年增加,但此领域的年发文量、国家、机构、作者的研究情况及研究热点与趋势等内容的可视化分析相对匮乏。目的:展现生物医学领域碳纳米材料研究现状,揭示主要的研究主体,探索... 详细信息

背景:生物医学领域碳纳米材料的研究蓬勃发展,相关科研成果逐年增加,但此领域的年发文量、国家、机构、作者的研究情况及研究热点与趋势等内容的可视化分析相对匮乏。目的:展现生物医学领域碳纳米材料研究现状,揭示主要的研究主体,探索研究热点及发展趋势,为此领域未来发展提供参考。方法:以Web of Science核心集数据库为文献来源,检索2012-2023年生物医学领域碳纳米材料的相关文献,运用Citespace软件以国家、机构、作者、关键词、共被引为节点生成知识图谱并进行可视化分析。结果与结论:①共纳入2932篇文献,碳纳米材料在医学领域年发文量多且增长速度较快;美国发文量较多;中国是该领域的新兴力量,发文量虽然最多,但研究水平和影响力还有待提高;中国科学院是最大的合作网络机构,主要以国内机构为合作对象,缺少与国外知名单位的合作。②关键词分析显示,碳点的绿色合成方式及应用是近年来的研究热点;其次碳纳米材料与癌症光疗、免疫疗法相结合的新方法是未来研究中的重点方向。③共被引动态发展趋势提示,组织工程是生物医学领域碳纳米材料的热点研究主题,主要包括碳纳米材料对于心脏和神经组织修复和再生的研究以及作为3D和4D生物打印的生物墨水添加剂。④未来随着生物医学领域朝着以治疗为中心的精准方向发展,科研人员应加快创建科学有效的碳纳米材料与科技、新型聚合物或有机分子及新治疗方法等结合形成的碳基体系,发挥碳纳米材料的最大效应。

关键词：碳纳米材料生物医学可视化共被引文献计量学生物安全性研究热点癌症组织工程 Citespace

Availability modeling for periodically inspection system with different lifetime and repair-time distribution

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Chinese Journal of Aeronautics 2019年第7期32卷 1667-1672页

作者： Junliang LI Yueliang CHEN Yong ZHANG hailiang huang Qingdao Campus Naval Aviation UniversityQingdao266041China The92635th Unit of Navy Qingdao266041China

Availability is a main feature of design and operation of all engineering system. Recently,availability evaluation of periodical inspection systems with different structures is at the center of attention due to the wide application in engineering. In this paper, an analytical and probabilistic availability model for periodical inspection system is proposed by a new recursively algorithm,which can achieve limiting average availability and instantaneous availability of periodical inspection system under arbitrary lifetime and repair-time distributions. Then three application examples are presented, the systems lifetime and repair-time are respectively fellow exponential/exponential,Weibull/normal and Weibull/lognormal distribution. Finally, a Weibull/lognormal system is studied to analyze the dynamic relationship between inspection period and availability. The results indicate that the proposed approach can provide the technology support for improving system availability and determining reasonable inspection period.

关键词： Availability Inspection period Lifetime distribution Reliability Repair-time distribution

基于Nrf2/GPX4信号通路探讨半夏泻心汤诱导胃癌细胞铁死亡的机制

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中国实验方剂学杂志 2024年第6期30卷 10-19页

作者：李灵李亚星王雪邱啸郭炜黄海量刘西建韩涛山东中医药大学中医学院济南250355 山东中医药大学实验中心济南250355 山东中医药大学康复学院济南250355

目的:观察半夏泻心汤(BXT)对人胃癌HGC-27、MKN-45、AGS细胞增殖的影响及其作用机制。方法:采用细胞增殖与活性检测法(CCK-8)检测不同浓度的BXT含药血清(5%、10%、20%)对HGC-27、MKN-45、AGS细胞增殖的影响;线粒体膜电位探针(TMRE)检测... 详细信息

目的:观察半夏泻心汤(BXT)对人胃癌HGC-27、MKN-45、AGS细胞增殖的影响及其作用机制。方法:采用细胞增殖与活性检测法(CCK-8)检测不同浓度的BXT含药血清(5%、10%、20%)对HGC-27、MKN-45、AGS细胞增殖的影响;线粒体膜电位探针(TMRE)检测细胞内线粒体膜电位表达,采用试剂盒对铁离子(Fe^(2+))含量、脂质过氧化物(LPO)与超氧化物歧化酶(SOD)活性进行检测,采用蛋白免疫印迹法(Western blot)检测糖原合成激酶3β(GSK3β)、磷酸化GSK3β(p-GSK3β)、核转录因子E2相关因子2(Nrf2)和谷胱甘肽过氧化物酶4(GPX4)的蛋白表达水平,实时荧光定量聚合酶链式反应(Real-time PCR)检测胱氨酸/谷氨酸逆向转运蛋白溶质载体家族7成员11(SLC7A11)、重链溶质载体家族3成员2(SLC3A2)、转铁蛋白受体3(TFRC)和肿瘤蛋白P53(TP53)mRNA表达。结果:CCK-8结果显示含药血清干预3种胃癌细胞24 h,与空白组比较,BXT组与卡培他滨组均可显著降低胃癌细胞存活率(P<0.01);含药血清干预胃癌细胞48 h,与空白组比较,卡培他滨组与BXT组均可明显降低3种胃癌细胞存活率,BXT组呈现剂量依赖,以20%效果最明显(P<0.01)。在铁死亡生化指标方面,与空白组比较,BXT组与卡培他滨组可以显著降低胃癌细胞中线粒体膜电位表达、SOD活性(P<0.01),显著提高LPO、Fe^(2+)的含量(P<0.01),从而提高胃癌细胞对铁死亡的敏感。在Nrf2/GPX4通路方面,与空白组比较,BXT组可以通过降低胃癌细胞中p-GSK3β、Nrf2、GPX4蛋白表达(P<0.01),提高SLC7A11、SLC3A2 mRNA表达(P<0.05),提高胃癌细胞中GSK3β的蛋白表达(P<0.01),提高TP53、TFRC mRNA表达(P<0.05,P<0.01),抑制Nrf2/GPX4通路诱导胃癌细胞发生铁死亡。与卡培他滨组比较,20%BXT组效果更为明显。结论:半夏泻心汤可以通过抑制Nrf2/GPX4通路的诱导胃癌细胞HGC-27、MKN-45、AGS发生铁死亡。

关键词：半夏泻心汤胃癌铁死亡核因子E2相关因子2(Nrf2) 谷胱甘肽过氧化物酶4(GPX4)

激光增材制造Al_(x)CoCrFeNi高熵合金的组织与性能

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材料工程 2024年第1期52卷 220-230页

作者：于丽莹王晨朱礼龙张华黄海亮阮晶晶张尚洲江亮周鑫烟台大学精准材料高等研究院山东烟台264005 中南大学粉末冶金国家重点实验室长沙410083

为了研究Al含量对FeCoCrNi合金组织性能的影响,采用多路送粉激光熔覆设备高通量制备Al_(x)CoCrFeNi高熵合金(0≤x≤0.9),通过X射线衍射仪、金相显微镜、扫描电子显微镜、电子探针和显微硬度计测试合金的相组成、显微组织结构、成分和硬... 详细信息

为了研究Al含量对FeCoCrNi合金组织性能的影响,采用多路送粉激光熔覆设备高通量制备Al_(x)CoCrFeNi高熵合金(0≤x≤0.9),通过X射线衍射仪、金相显微镜、扫描电子显微镜、电子探针和显微硬度计测试合金的相组成、显微组织结构、成分和硬度。结果表明:随着Al含量的增加,Al_(x)CoCrFeNi高熵合金由单一FCC相(x≤0.35)转变为FCC+BCC双相结构(0.35

关键词：激光熔覆高熵合金 Al_(x)CoCrFeNi 相组成微观组织

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Gap-plasmon of Fe3O4@Ag Core-shell Nanostructures for Highly Enhanced Fluorescence Detection of Rhodamine B

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Journal of Wuhan University of Technology(Materials Science) 2017年第2期32卷 264-271页

作者：王运佳俎喜红易国斌 LUO Hongsheng huang hailiang School of Chemical Engineering and Light Industry Guangdong University of Technology

A novel gap-plasmon of Fe3O4@Ag core-shell nanoparticles for surface enhanced fluorescence detection of Rhodamine B（RB） was developed. Fe3O4@Ag core-shell nanostructures with Ag shell and Fe3O4 core were synthetized by self-assembled method with the assistance of 3-mercaptopropyl trimethoxy silane（MPTS）. To study the RB fluorescence enhanced by gap-plasmon, the fluorescence properties of RB on the substrates with different nanogap densities were systematically investigated, and the results showed that the fluorescence intensity of RB on Fe3O4@Ag core-shell NPs substrate was much stronger than that on bare glass substrate, and the fluorescence intensity was further improved by using multilayer Fe3O4@Ag core-shell NPs substrate which had higher nanogap density. Different from the mechanism that is based on the maximum overlap of the surface plasmon resonance（SPR） band and emission band, the mechanism of the fluorescence enhancement in our work is based on the localized surface plasmon（LSP） and the gap plasmon near-field coupling with the Fe3O4@Ag core-shell NPs. Besides, the detection limit obtained was as low as 1×10^（-7） mol/L, and the Fe3O4@Ag core-shell NPs substrate had high selectivity for RB fluorophores. It was demonstrated that the Fe3O4@Ag core-shell NPs substrate had activity, good stability, and selectivity for fluorescence detection of RB. And the detection of RB by the surface plasmon enhanced fluorescence was more convenient and rapid than the traditional detection methods in previous works.

关键词： gap-plasmon self-assembled Fe3O4@Ag nanoparticles core-shell fluorescence enhancement

Nanopattern Transformation ofABC Triblock Copolymer Thin Films Induced by Strong Solvent Selectivity and Annealing

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Chemical Research in Chinese Universities 2017年第4期33卷 684-688页

作者： huang hailiang ZU Xihong YI Guobin ZHONG Benbin LUO Hongsheng School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510006 P. R. China

Nanopattem transformation behaviors of polyisoprene-block-polystyrene-block-poly（2-vinylpyridine）（PI-b-PS-b-P2VP） asymmetric ABC triblock copolymer were investigated systematically with various control para- meters, including different solvents for polymer solution and annealing conditions in this paper. Ordered nanopattern of PI-b-PS-b-P2VP with hexagonal cylinders could be obtained when PI-b-PS-b-P2VP toluene solution was spin-coated on silicon substrate followed by toluene vapor annealing process. When the film with hexagonal and cylindrical nanopattern was exposed to saturated toluene vapor, the order-order transition of cylindrical nanopattern to parallel nanopattern was observed due to the strong selectivity of toluene to PS and PI blocks. Furthermore, fingerprint nanopattern could also be obtained by solvent annealing in tetrahydrofuran vapor. The nanopattern trans- formation was due to different selectivity of solvents and incompatibilities of the three blocks of PI-b-PS-b-P2VP under various solvent annealing conditions.

关键词： Triblock copolymer Nanopattern Self-assembly Solvent vapor annealing

Potential diagnostic biomarkers for schizophrenia

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Medical Review 2022年第4期2卷 385-416页

作者： Weihua Yue hailiang huang Jubao Duan Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder Chinese Academy of Medical Sciences(2018RU006)Institute of Mental HealthPeking University Sixth HospitalNo.51 Hua Yuan Bei RoadBeijing100191China National Clinical Research Center for Mental Disorders&NHC Key Laboratory of Mental Health(Peking University) Beijing100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing100871China Chinese Institute for Brain Research Beijing102206China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMAUSA Stanley Center for Psychiatric Research Broad Institute of MIT and HarvardCambridgeMAUSA Department of Medicine Harvard Medical SchoolBostonMAUSA Center for Psychiatric Genetics NorthShore University Health SystemEvanstonILUSA Department of Psychiatry and Behavioral Neurosciences University of ChicagoChicagoILUSA

Schizophrenia(SCH)is a complex and severe mental disorder with high prevalence,disability,mortality and carries a heavy disease burden,the lifetime prevalence of SCH is around 0.7%–1.0%,which has a profound impact on the individual and *** the clinical practice of SCH,key problems such as subjective diagnosis,experiential treatment,and poor overall prognosis are still *** recent years,some exciting discoveries have been made in the research on objective biomarkers of SCH,mainly focusing on genetic susceptibility genes,metabolic indicators,immune indices,brain imaging,electrophysiological *** review aims to summarize the biomarkers that may be used for the prediction and diagnosis of SCH.

关键词： accurate diagnosis multi-omics data objective biomarkers personalized treatment schizophrenia

Ag Nanowire-Ag Nanoparticle Hybrids for the Highly Enhanced Fluorescene Detection of Protoporphyrin IX Based on Surface Plasmon-Enhanced Fluorescence

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Chinese Journal of Chemistry 2016年第12期34卷 1321-1328页

作者： Yunjia Wang Xihong Zu Guobin Yi Hongsheng Luo hailiang huang Xuliang Song School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou Guangdong 510006 China

In this study, we developed an approach to fabricate novel 1D Ag NWs-Ag NPs hybrid substrate for enhanced fluorescene detection of protoporphyrin 1X （PplX） based on surface plasmon-enhanced fluorescence. The Ag NWs-Ag NPs hybrid was synthesized by combining the hydrothermal method and self-assembly method with the asisstance of polyvinylpyrrolidone （PVP）. When the Ag NWs-Ag NPs hybrid was deposited on the glass substrate and employed as active substrate to detect PplX, the fluorescence intensity of PplX was enhanced greatly due to the coupling effect of localized surface plasmon-localized surface plasmon （LSP-LSP） and localized surface plasmon- surface plasmon propagation （LSP-SPP） which induced great enhancement of the electromagnetic field. Furthermore, the enhancement effect was approximately linear when the concentration of PpIX was ranged from 1×10^-7 mol/L to 2×10^-5 mol/L, and the photobleaching phenomenon of PplX was reduced greatly, indicating that the fab- ricated Ag NWs-Ag NPs hybrid substrate had well performance for PplX imaging. This work provides an effective approach to prepare highly sensitive and stable fluorescence enhancement substrate, and has great potential application in fluorescence imaging.

关键词： hybrid localized surface plasmon coupling surface plasmon resonance fluorescence enhancement