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Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy

Nano Research 2024年第1期17卷 270-281页

作者： Zichen ye yun Li Jingchao Li Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao Zhu Zhide Guo Xiaolan Chen State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen UniversityXiamen 361102China The High Educational Key Laboratory for Biomedical Engineering&Key Laboratory of Fire Retardant Materials of Fujian Province Department of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361102China

Lactic acid(LA)plays a major role in the occurrence,development,and spread of *** by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-LOD,PIL)was fabricated to combine cascade reaction with photothermal for tumor *** detail,the overexpressed LA in tumor microenvironment(TME)was a key factor to activate the PIL-based cascade reaction:(1)Plenty of H_(2)O_(2)could be generated from LA by the catalysis of LOD with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-like activity of PIL;(3)meantime,PIL’s catalase(CAT)-like activity could decompose part H_(2)O_(2)into O_(2)to achieve the purpose of LA cyclic ***,the reduced glutathione(GSH)scavenging capability of PIL might protect the produced reactive oxygen species(ROS)from being cleared to further improve the cascade therapeutic *** importantly,PIL had excellent photothermal conversion efficiency(37.35%)and manifested a surprising temperature rising effect in *** together,the decreasing LA concentration,accumulation of high-toxic ROS,the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor ***,a promising therapeutic tactic based on PIL integrating endogenous LA consumption,chemodynamic therapy(CDT),and photothermal therapy(PTT)has been put forward.

关键词： lactate oxidase chemodynamic therapy photothermal therapy cascade reaction tumor microenvironment

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Photoswitchable Molecular Recognition Enabled by Dithienylethene-Mediated Structural Changes of Dynamic Covalent Hydrazone Bonds

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CCS Chemistry 2024年第2期6卷 497-506页

作者： Lifeng Wang Hanxun Zou Hebo ye Yu hai Hanwei Lu Junmiao Deng Lei You State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002 College of Chemistry and Material Science Fujian Normal UniversityFuzhou 350007 University of Chinese Academy of Sciences Beijing 100049 Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108

Light-induced recognition,assemblies,and materials are intensive areas of research due to their high spatiotemporal ***,we demonstrated photoswitchable molecular recognition via dithienylethene-triggeredreversible structural regulation of dynamic covalent hydrazone *** combining dithienylethenes and cyclic hemiacetals,the photochemical open-ring and closed-ring forms enabled turningoff and on the creation of awide range of hydrazones when ***-induced bidirectional switching between hydrazones and their cyclization structures promoted by a neighboring carboxyl group was further *** taking advantage of reversible structural changes totoggleon andoff the binding pocket,photoswitchable recognitionofmetal ionswas ***,the construction of an acylhydrazone polymer offered a facile way for light-mediated selective extraction/*** strategies and results reported here should find applications in many contexts,such asdynamicassemblies,molecular switches,and smart materials.

关键词： molecular recognition photoswitch dynamic covalent chemistry hydrazone selective extraction/release

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吲哚青绿在年龄相关性黄斑变性的应用新进展

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国际眼科杂志 2009年第12期9卷 2391-2394页

作者：叶海昀金陈进中山大学中山眼科中心中国广东省广州市510060

吲哚青绿(indocyanine green,ICG)是一种较安全的吲哚染料,在眼科的应用逐渐受到关注,已在血管造影和吲哚青绿介导的激光治疗等方面得到应用。我们现对吲哚青绿的发展历史、在年龄相关性黄斑变性(age related macular degeneration,AMD... 详细信息

吲哚青绿(indocyanine green,ICG)是一种较安全的吲哚染料,在眼科的应用逐渐受到关注,已在血管造影和吲哚青绿介导的激光治疗等方面得到应用。我们现对吲哚青绿的发展历史、在年龄相关性黄斑变性(age related macular degeneration,AMD)中的应用现状及进展进行综述。

关键词：吲哚青绿血管造影年龄相关性黄斑变性脉络膜新生血管光栓疗法

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The Immense Impact of Reverse Edges on Large Hierarchical Networks

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Engineering 2024年第5期36卷 240-249页

作者： Haosen Cao Bin-Bin Hu Xiaoyu Mo Duxin Chen Jianxi Gao ye Yuan Guanrong Chen Tamás Vicsek Xiaohong Guan hai-Tao Zhang MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems State Key Laboratory of Intelligent Manufacturing Equipment and TechnologySchool of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhan 430074China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Jiangsu Key Laboratory of Networked Collective Intelligence School of MathematicsSoutheast UniversityNanjing 210096China Department of Computer Science Rensselaer Polytechnic InstituteTroyNY 12180USA Department of Electronic Engineering City University of Hong KongHong Kong 999077China Department of Biological Physics Eötvös UniversityBudapest 1117Hungary MOE Key Laboratory for Intelligent Networks and Network Security School of Automation Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Hierarchical networks are frequently encountered in animal groups,gene networks,and artificial engineering systems such as multiple robots,unmanned vehicle systems,smart grids,wind farm networks,and so *** structure of a large directed hierarchical network is often strongly influenced by reverse edges from lower-to higher-level nodes,such as lagging birds’howl in a flock or the opinions of lowerlevel individuals feeding back to higher-level ones in a social *** study reveals that,for most large-scale real hierarchical networks,the majority of the reverse edges do not affect the synchronization process of the entire network;the synchronization process is influenced only by a small part of these reverse edges along specific *** surprisingly,a single effective reverse edge can slow down the synchronization of a huge hierarchical network by over 60%.The effect of such edges depends not on the network size but only on the average in-degree of the involved *** overwhelming majority of active reverse edges turn out to have some kind of“bunching”effect on the information flows of hierarchical networks,which slows down synchronization *** finding refines the current understanding of the role of reverse edges in many natural,social,and engineering hierarchical networks,which might be beneficial for precisely tuning the synchronization rhythms of these *** study also proposes an effective way to attack a hierarchical network by adding a malicious reverse edge to it and provides some guidance for protecting a network by screening out the specific small proportion of vulnerable nodes.

关键词： Synchronizability Large hierarchical networks Reverse edges Information flows Complex networks

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Detection of astrophysical gravitational wave sources by TianQin and LISA

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 123-163页

作者： Alejandro Torres-Orjuela Shun-Jia Huang Zheng-Cheng Liang Shuai Liu hai-Tian Wang Chang-Qing ye Yi-Ming Hu Jianwei Mei MOE Key Laboratory of Tian Qin Mission Tian Qin Research Center for Gravitational PhysicsSchool of Physics and AstronomyFrontiers Science Center for Tian QinGravitational Wave Research Center of CNSASun Yat-Sen University(Zhuhai Campus)Zhuhai 519082China Department of Physics The University of Hong KongHong Kong 999077China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing100871China

TianQin and LISA are space-based laser interferometer gravitational wave(GW)detectors planned to be launched in the *** detectors will detect low-frequency GWs around 10^(-2)Hz;however,Tian Qin is more sensitive to frequencies above this common sweet-spot while LISA is more sensitive to frequencies below 10^(-2)***,Tian Qin and LISA will be able to detect the same sources but with different accuracy depending on the source and its *** consider some of the most important astrophysical sources—massive black hole binaries,stellar-mass black hole binaries,double white dwarfs,extreme mass ratio inspirals,light and heavy intermediate mass ratio inspirals,as well as the stochastic gravitational background of astrophysical origin—that Tian Qin and LISA will be able to *** each of these sources,we analyze how far they can be detected(detection distance)and how well their parameters can be measured(detection accuracy)using a Fisher Matrix *** compare the results obtained by the three detection scenarios(Tian Qin alone,LISA alone,and joint detection by LISA and Tian Qin)highlighting the gains from joint detection as well as the contribution of Tian Qin and LISA to a combined study of astrophysical *** particular,we consider the different orientations,lifetimes,and duty cycles of the two detectors to explore how they can give a more complete picture when working together.

关键词： wave extreme stochastic

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An assessment of the CMIP6 performance in simulating Arctic sea ice volume flux via Fram Strait

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Advances in Climate Change Research 2024年第4期15卷 584-595页

作者： Hui-Yan KUANG Shao-Zhe SUN Yu-Fang ye Shao-Yin WANG hai-Bo BI Zhuo-Qi CHEN Xiao CHENG School of Geospatial Engineering and Science Sun Yat-sen UniversitySouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China CAS Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of Sciences(CAS)Qingdao 266071China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China

Numerical models serve as an essential tool to investigate the causes and effects of Arctic sea ice *** the simulation capabilities of the most recent CMIP6 models in sea ice volume flux provides references for model applications and ***,reliable long-term simulation results of the ice volume fux contribute to a deeper understanding of the sea ice response to global climate *** this study,the sea ice volume flux through six Arctic gateways over the past four decades(1979-2014)were estimated in combination of satellite observations of sea ice concentration(SIC)and sea ice motion(SIM)as well as the Pan-Arctic Ice-Ocean Modeling and Assimilation System(PIOMAS)reanalysis sea ice thickness(SIT)*** simulation capability of 17 CMIP6 historical models for the volume flux through Fram Strait were quantitatively *** ice volume flux simulated from the ensemble mean of 17 CMIP6 models demonstrates better performance than that from the individual model,yet IPSL-CM6A-LR and EC-Earth3-Veg-LR outperform the ensemble mean in the annual volume flux,with Taylor scores of 0.86 and 0.50,***6 models display relatively robust capability in simulating the seasonal variations of volume *** them,CESM2-WACCM performs the best,with a correlation coefficient of 0.96 and a Taylor score of ***,NESM3 demonstrates the largest devi-ation from the observation/reanalysis data,with the lowest Taylor score of *** variability of sea ice volume flux is primarily influenced by SIM and SIT,followed by *** extreme large sea ice export through Fram Strait is linked to the occurrence of anomalously low air temperatures,which in turn promote increased SIC and SIT in the corresponding ***,the intensified activity of Arctic cyclones and Arctic dipole anomaly could boost the southward sea ice velocity through Fram Strait,which further enhance the sea ice outflow.

关键词： Sea ice volume flux CMIP6 models Fram Strait Attribution analysis

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Sodium Sulfite as a Novel Hypoxia Revulsant Involved in Hypoxic Regulation in Escherichia coli

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Biomedical and Environmental Sciences 2024年第2期37卷 228-232页

作者： ye Qiao HUO Jia Nan LUO Yuan MEI Zhu Song FANG Long Mei GUO Bing Qian WANG Guang yun Laboratory of clinical medicine Air Force Medical CenterAir Force Medical UniversityBeijing 100142China

As a reducing salt,sodium sulfite could deprive oxygen in solution,which could mimic hypoxic stress in Caenorhabditis *** this study,the wildtype Escherichia coli strain MG1655 was used to examine the inhibition of so... 详细信息

关键词： hypoxic Sodium observing

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Evaluation of the injection and plugging ability of a novel epoxy resin in cement cracks

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Petroleum Science 2024年第2期21卷 1211-1220页

作者： Guang-Yao Leng Wei Yan hai-Mu ye Er-Dong Yao Ji-Bin Duan Zheng-Xian Xu Ke-Pei Li Jing-Ru Zhang Zhong Li State Key Laboratory of Petroleum Resource&Prospecting China University of Petroleum(Beijing)Beijing102249China CNPC Liaohe Oilfield Gas Storage Co.LTD Panjin124000LiaoningChina CNOOC Research Institute Co. Ltd.Beijing100028China

Sustained casing pressure(SCP)is a crucial issue in the oil and gas production *** resins,exhibiting exceptional compressive strength,ductility,and shear bonding strength,have the potential to form reliable *** injectivity and sealing capacity of the epoxy resin is crucial parameters for the success of shallow remediation *** study aimed to develop and assess a novel solid-free resin sealant as an alternative to Portland cement for mitigating fluid *** investigation evaluated the viscosity,compressive strength,and brittleness index of the epoxy resin sealant,as well as its tangential and normal shear strengths in conjunction with casing *** flow characteristics and sealing abilities of conventional cement and epoxy resin were comparatively analyzed in *** results showed that the application of a viscosity reducer facilitated control over the curing time of the epoxy resin,ranging from 1.5 to 6 h,and reduced the initial viscosity from 865.53 to 118.71 m Pa,*** mechanical properties of the epoxy resin initially increased with a rise in curing agent content before experiencing a minor *** epoxy resin containing 30%curing agent exhibited optimal mechanical *** a 14-day curing period,the epoxy resin's compressive strength reached81.37 MPa,2.12 times higher than that of cement,whereas the elastic modulus of cement was 2.99 times greater than that of the epoxy *** brittleness index of epoxy resin is only 3.42,demonstrating high flexibility and *** tangential and normal shear strengths of the epoxy resin exceeded those of cement by 3.17 and 2.82 times,*** a 0.5 mm-wide crack,the injection pressure of the epoxy resin remained below 0.075 MPa,indicating superior injection and flow ***,the injection pressure of cement surged dramatically to 2.61 MPa within 5 *** breakthrough pressure of0.5 PV epoxy resin reached 7.53 MPa,decreasing the crack's perme

关键词： Sustained casing pressure Epoxy resin sealant Curing agent Viscosity reducer Mechanical properties Crack sealing

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In-situ growth of MIL-53(Fe)on charcoal sponge as a highly efficient and recyclable photocatalyst for removal of Cr(Ⅵ)

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Rare Metals 2024年第9期43卷 4344-4355页

作者： Zhuo-Fan Yu ye Yang hai-Feng Zhuang Sheng-Dao Shan Mihail-Simion Beldean-Galea Qing-Quan Xue Xiao-Feng Shen Shi-Jie Li Key Laboratory of Recycling and Eco-Treatment of Waste Biomass of Zhejiang Province School of Environmental and Natural ResourcesZhejiang University of Science and TechnologyHangzhou 310023China Faculty of Environmental Science and Engineering Babes-Bolyai University400294 Cluj-NapocaRomania Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province Interdisciplinary Research Academy(IRA)Zhejiang Shuren UniversityHangzhou 310015China National Engineering Research Center for Marine Aquaculture Institute of Innovation&ApplicationZhejiang Ocean UniversityZhoushan 316022China

The application of metalDorganic frameworks(MOFs)is hindered by several crucial factors,including low photocatalytic efficiency,poor stability and challenges in *** this study,MIL-53(Fe)was grown in situ on a charcoal sponge(CS)with a large surface area,excellent mechanical properties,and high photocatalytic efficiency using a solvothermal method,thus addressing the above-mentioned shortcomings of MOF ***,CS/MIL-53(Fe)has an amazing light-harvesting capacity in the visible range,leading to a significant improvement in the utilization of *** results of the experiments indicate that CS/MIL-53(Fe)displays a higher photocatalytic activity(87%Cr(Ⅵ))when exposed to visible light than CS(58%)or MIL-53(Fe)(27%),attributing to the increased separation of photogenerated carriers.e-is the main reactive radical and dominates the photocatalytic reduction process,rooting from that e-can reduce Cr(Ⅵ)to low-toxicity Cr(Ⅲ).This study presents a novel method for constructing photocatalysts with large surface areas,superior mechanical characteristics,and enhanced photocatalytic ***,it achieves the resource utilization of agricultural and forestry waste.

关键词： Cr(Ⅵ) Charcoal sponge MIL-53(Fe) Photocatalysis Light absorption

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Artificial synthesis of polyesters at ambient condition via consecutive CO_(2)electrolysis and fermentation

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Nano Research 2024年第7期17卷 6016-6025页

作者： Guiru Zhang Ning Ji Shiheng Lyu Baoxin Ni Peng Shen Ke ye Yuting Wang Xuheng Jiang hai Zhang Xi Liu Yongcheng Wang Kun Jiang Department of Laboratory Medicine of The First Affiliated Hospital&Liangzhu Laboratory Zhejiang University School of MedicineHangzhou 310058China Interdisciplinary Research Center School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China In-situ Centre for Physical Sciences Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Electrochemically converting CO_(2)into value-added chemicals is a promising approach to mitigate anthropogenic carbon emissions,yet largely limited to short-chained C_(1)–C_(3)***,we demonstrate a tandem artificial synthesis of biodegradable polyhydroxybutyrate(PHB)plastic from CO_(2)building *** synthesis of defects-enriched Bi catalyst is firstly demonstrated by plasma bombardment and following in situ electrochemical reduction,which delivers a HCOOH Faradaic efficiency above 80%at tunable concentration from 2 to 250 mM,an energy efficiency up to 41%,and a single-pass carbon conversion efficiency up to 60%.Annular dark field and second electron microscopic analysis,density functional theory(DFT)calcualtions,coupled with H-type and solid-state electrolyzer assessments,point out the vital role of defective and/or stepped Bi surface sites in promoting CO_(2)-to-HCOOH ***,as-synthesized high-purity HCOOH is used as the sole carbon source for C-chain growth within microbial fermentation reactor with Ralstonia eutropha,where activated formate dehydrogenase and increased metabolites related to Calvin–Benson–Bassham cycle are found to be responsible for the enhanced polyester accumulation.

关键词： CO_(2)electrolysis Bi catalyst vacancy site formic acid fermentation

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