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Online hierarchical recognition method for target tactical intention in beyond-visual-range air combat

Defence Technology（防务技术） 2022年第8期18卷 1349-1361页

作者： Zhen Yang Zhi-xiao Sun hai-yin piao Ji-chuan Huang De-yun Zhou Zhang Ren School of Automation Science and Electrical Engineering Beihang UniversityBeijing100191China Northwestern Polytechnical University Xi'an710072China The First Military Representative Office of the Air Force Equipment Department in Chengdu Chengdu610091China

Online accurate recognition of target tactical intention in beyond-visual-range (BVR) air combat is an important basis for deep situational awareness and autonomous air combat decision-making, which can create pre-emptive tactical opportunities for the fighter to gain air superiority. The existing methods to solve this problem have some defects such as dependence on empirical knowledge, difficulty in interpreting the recognition results, and inability to meet the requirements of actual air combat. So an online hierarchical recognition method for target tactical intention in BVR air combat based on cascaded support vector machine (CSVM) is proposed in this study. Through the mechanism analysis of BVR air combat, the instantaneous and cumulative feature information of target trajectory and relative situation information are introduced successively using online automatic decomposition of target trajectory and hierarchical progression. Then the hierarchical recognition model from target maneuver element, tactical maneuver to tactical intention is constructed. The CSVM algorithm is designed for solving this model, and the computational complexity is decomposed by the cascaded structure to overcome the problems of convergence and timeliness when the dimensions and number of training samples are large. Meanwhile, the recognition result of each layer can be used to support the composition analysis and interpretation of target tactical intention. The simulation results show that the proposed method can effectively realize multi-dimensional online accurate recognition of target tactical intention in BVR air combat.

关键词： Beyond-visual-range(BVR)air combat Tactical intention recognition Hierarchical recognition model Cascaded support vector machine(CSVM) Trajectory decomposition Maneuver element

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Hybrid gradient vector fields for path-following guidance

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Defence Technology（防务技术） 2023年第10期28卷 165-182页

作者： Yi-yang Zhao Zhen Yang Wei-ren Kong hai-yin piao Ji-chuan Huang Xiao-feng Lv De-yun Zhou School of Electronics and Information Northwestern Polytechnical UniversityXi’An710072China School of Automation Science and Electrical Engineering Beihang UniversityBeijing100191China The 93147th Unit of Chinese PLA Air Force Chengdu610091China

Guidance path-planning and following are two core technologies used for controlling un-manned aerial vehicles(UAVs)in both military and civilian ***,only a few approaches treat both the technologies *** this study,an innovative hybrid gradient vector fields for path-following guidance(HGVFs-PFG)algorithm is proposed to control fixed-wing UAVs to follow a generated guidance path and oriented target curves in three-dimensional space,which can be any combination of straight lines,arcs,and helixes as motion *** algorithm aids the creation of vector fields(VFs)for these motion primitives as well as the design of an effective switching strategy to ensure that only one VF is activated at any time to ensure that the complex paths are followed *** strategies designed in earlier studies have flaws that prevent the UAV from following arcs that make its turning angle too *** proposed switching strategy solves this problem by introducing the concept of the virtual ***,the performance of the HGVFs-PFG algorithm is verified using a reducedorder autopilot and four representative simulation *** simulation considers the constraints of the aircraft,and its results indicate that the algorithm performs well in following both lateral and longitudinal control,particularly for curved *** general,the proposed technical method is practical and competitive.

关键词： Unmanned aerial vehicle(UAV) Path-following guidance(PFG) Hybrid gradient vector field(HGVF) Switching strategy

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Mechanism underlying treatment of diabetic kidney disease using Traditional Chinese Medicine based on theory of yin and Yang balance

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Journal of Traditional Chinese Medicine 2018年第5期38卷 797-802页

作者： piao Yuanlin yin Dehai Department of Traditional Chinese Medicine Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences

The pathogenic mechanism of diabetic kidney disease(DKD) is complex. The development of DKD cannot be fully explained by a single *** Chinese Medicine(TCM) has been applied extensively for the treatment of DKD in ***, studying the mechanism of DKD using theories and methods that are appropriate for TCM characteristics and searching for theoretical bases for TCM clinical application are topics that still need to be explored and researched. Activation of the transforming growth factor(TGF)-β1/Smad and PI3 K/Akt/mTOR signaling pathways functions as a self-protection mechanism against renal microinflammation in DKD. However, the persistent abnormal overactivation of reactions causes secondary cell dysfunction, cell apoptosis, increased extracellular matrix(ECM) secretion, and eventually renal fibrosis. During this process, the dysregulation of self-balance among a variety of signaling pathways and the loss of self-feedback regulatory mecha-nisms downstream of these signaling pathways are critical causes of the occurrence and development of DKD. TCM may both inhibit the expression or activation of "hyperactive" signaling pathways(NFB, Smad3, and PI3 K/Akt/mTOR) and increase the expression or activation of "deficient" signaling pathways(Smad7 and PTEN) to restore balance to cells with an abnormal pathophysiological status and achieve the goal of DKD treatment.

关键词： Diabetic kidney disease Traditional Chinese Medicine yin and Yang theory

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Ribavirin and IFN-α combination therapy induces CD4+ T-cell proliferation and Th1 cytokine secretion in patients with chronic hepatitis B

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World Journal of Gastroenterology 2007年第41期13卷 5440-5445页

作者： Fen-Yu Ren hai Jin Xi-Xu piao Feng-Shun piao Department of Gastroenterology and Hepatology Yanbian University Hospital Yanji 133000 Jilin Province China

AIM: To investigate the anti-viral mechanism of combination therapy of interferon (IFN)-α and ribavirin in patients with chronic hepatitis B. METHODS: Twenty patients were assigned to receive either IFN-α plus ribavirin (group A,n = 14) or no treatment as a control (group B,n = 6). Patients were analyzed for T-cell proliferative responses specific for hepatitis B virus (HBV)-antigen and cytokine production by peripheral blood mononuclear cells (PBMCs). RESULTS: Combination therapy induced HBV-antigen specific CD4+ T-cell proliferative responses in four patients (28.6%). Production of high levels of HBV-specific IFN-γ,tumor necrosis factor (TNF)-α,interleukin (IL)-12 by PBMCs was found in five patients (35.7%),who showed significantly lower HBV DNA levels in serum at 12 mo after treatment ended (P = 0.038) and at 24 mo of follow-up (P = 0.004) than those without high levels of cytokine production. CONCLUSION: HBV-antigen specific CD4+ T cells may directly control HBV replication and secretion of anti-viral T helper 1 (Th1) cytokines by PBMCs during combination therapy of chronic hepatitis B with ribavirin and IFN-α.

关键词： Hepatitis B Interferon-alpha Ribavirin CD4+ T cells Th1

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Dichloroacetic acid and rapamycin synergistically inhibit tumor progression

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 397-405页

作者： Huan CHEN Kunming LIANG Cong HOU hai-long piao CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Department of Biochemistry&Molecular Biology School of Life SciencesChina Medical UniversityShenyang 110122China University of Chinese Academy of Sciences Beijing 100049China

Mammalian target of rapamycin(mTOR)controls cellular anabolism,and mTOR signaling is hyperactive in most cancer *** a result,inhibition of mTOR signaling benefits cancer *** is a US Food and Drug Administration(FDA)-approved drug,a specific mTOR complex 1(mTORC1)inhibitor,for the treatment of several different types of ***,rapamycin is reported to inhibit cancer growth rather than induce *** dehydrogenase complex(PDHc)is the gatekeeper for mitochondrial pyruvate *** inactivation has been observed in a number of cancer cells,and this alteration protects cancer cells from senescence and nicotinamide adenine dinucleotide(NAD^(+))*** this paper,we describe our finding that rapamycin treatment promotes pyruvate dehydrogenase E1 subunit alpha 1(PDHA1)phosphorylation and leads to PDHc inactivation dependent on mTOR signaling inhibition in *** inactivation reduces the sensitivity of cancer cells'response to *** a result,rebooting PDHc activity with dichloroacetic acid(DCA),a pyruvate dehydrogenase kinase(PDK)inhibitor,promotes cancer cells'susceptibility to rapamycin treatment in vitro and in vivo.

关键词： Dichloroacetic acid(DCA) Rapamycin Pyruvate dehydrogenase E1 subunit alpha 1(PDHA1) Mammalian target of rapamycin(mTOR)

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毛囊类器官研究:现状、问题与前景

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中国组织工程研究 2025年第31期29卷 6733-6742页

作者：王钊龚琳朴永君大连医科大学附属第一医院皮肤科辽宁省大连市116000

背景:毛囊体外重建依赖于毛乳头细胞及角质形成细胞3D共培养时的自组装行为,该过程与毛囊胚胎发育极为相似,因此,毛囊类器官可作为毛囊再生相关基础研究良好的体外模型,目前,通过仿生系统培养的全人源毛囊类器官已能成功移植到动物体内... 详细信息

背景:毛囊体外重建依赖于毛乳头细胞及角质形成细胞3D共培养时的自组装行为,该过程与毛囊胚胎发育极为相似,因此,毛囊类器官可作为毛囊再生相关基础研究良好的体外模型,目前,通过仿生系统培养的全人源毛囊类器官已能成功移植到动物体内。毛囊类器官研究使毛囊再生成为可能,但构建方法亦无统一定论,仍面临诸多挑战。目的:综述目前毛囊类器官的研究进展,总结毛囊类器官培养方法及表征,阐述应用前景,为后续研究提供可靠依据,以期促进其在组织工程及脱发治疗的临床转化。方法:应用计算机在中国知网(CNKI)及PubMed数据库中,以“毛囊再生,毛发再生,类器官”为中文检索词,“hair growth,hair loss,hair regeneration,hair follicle,dermal papilla cell,organoid”为英文检索词进行检索,查阅国内外关于毛囊类器官的相关文献,共纳入文献67篇进行后续分析。结果与结论:①不同来源的毛乳头细胞与角质形成细胞可在体外构建毛囊类器官,以获得鼠源、人-鼠嵌合及人源毛囊类器官,并成功用于啮齿动物移植模型;②多种重编程方法如电刺激、添加重组蛋白、解离细胞基因过表达等可用于促进毛囊类器官毛胚形成及毛钉伸长,同时,多种3D打印技术的应用已实现大小可控毛囊类器官的批量生产,极大提高了生产效率;③在解离细胞共培养体系中加入黑素细胞时,或可破译新生毛囊的色素缺失难题,而加入人脐静脉血管内皮细胞时,细胞聚集体内的新生血管可改善营养供给,减少中心部位坏死;④随着工程化类毛囊技术逐渐趋于成熟,患者自体细胞构建的毛囊类器官或可用于严重脱发的个体化医疗。

关键词：脱发毛囊再生毛乳头细胞毛囊类器官上皮-间充质交互作用 3D培养类器官组织工程工程化类器官

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Long noncoding RNA NALT1-induced gastric cancer invasion and metastasis via NOTCH signaling pathway

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World Journal of Gastroenterology 2019年第44期25卷 6508-6526页

作者： hai-Yan piao Shuai Guo Yue Wang Jun Zhang Medical Oncology Department of Gastrointestinal Cancer Liaoning Province Cancer Hospital&Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina Gastric Cancer Department Liaoning Province Cancer Hospital&Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina

BACKGROUNDLong noncoding RNAs (lncRNAs) are aberrant and play critical roles in gastriccancer (GC) progression and metastasis. Searching for coexpressed lncRNAclusters or representative biomarkers related to malignant phenotypes of GC mayhelp to elucidate the mechanism of tumor development and predict the prognosisof *** investigate the prognostic value of NOTCH1 associated with lncRNA in T cellacute lymphoblastic leukemia 1 (NALT1) in GC and the mechanism of itsinvolvement in GC invasion and *** sequencing and corresponding clinical data were downloaded from TheCancer Genome Atlas database. The significance module was studied byweighted gene coexpression network analysis. A total of 336 clinical sampleswere included in the study. Gene silencing, reverse transcription polymerasechain reaction, western blotting, scrape motility assay, and Transwell migrationassay were used to assess the function of *** the transcriptome level, 3339 differentially expressed lncRNAs were *** gene coexpression network analysis was used to obtain 15 lncRNAclusters and observe their coexpression. Pearson’s correlation showed that blue module was correlated with tumor grade and survival. NALT1 was the hublncRNAof blue module and was an independent risk factor for GC ***1 was overexpressed in GC and its expression was closely related toinvasion and metastasis. The mechanism may involve NALT1 regulation ofNOTCH1, which is associated with lncRNA in T cell acute lymphoblasticleukemia, through cis regulation, thereby affecting the expression of the NOTCHsignaling ***1 is overexpressed and promotes invasion and metastasis of GC. Themechanism may be related to regulation of NOTCH1 by NALT1 and its effect onNOTCH signaling pathway expression.

关键词： Gastric cancer Weighted gene coexpression network analysis NALT1 NOTCH1 Cancer survival

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Supermassive Primordial Black Holes for Nano-Hertz Gravitational Waves and High-redshift JWST Galaxies

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Research in Astronomy and Astrophysics 2024年第9期24卷 1-6页

作者： hai-Long Huang Yong Cai Jun-Qian Jiang Jun Zhang Yun-Song piao School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute for Astrophysics School of PhysicsZhengzhou UniversityZhengzhou 450001China International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of SciencesBeijing 100190China Taiji Laboratory for Gravitational Wave Universe(Beijing/Hangzhou) University of Chinese Academy of SciencesBeijing 100049China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China

Recently,observational hints for supermassive black holes have been accumulating,prompting the question:Can primordial black holes(PBHs)be supermassive,particularly with masses M■10^(9)M_(⊙)?A supercritical bubble,containing an inflating baby universe,that nucleated during inflation can evolve into a PBH in our observable *** find that when the inflaton slowly transitions past a neighboring vacuum,the nucleation rate of supercritical bubbles inevitably peaks,leading to a mass distribution of multiverse PBHs with a peak mass up to M■10^(11)M_(⊙).Thus,our mechanism naturally provides a primordial origin for supermassive black holes.

关键词： (cosmology:)early universe (cosmology:)inflation (galaxies:)quasars:supermassive black holes

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Coincidence Point Theorems,Intersection Theorems and Saddle Point Theorems on FC-spaces

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Communications in Mathematical Research 2009年第2期25卷 115-122页

作者： piao YONG-JIE yin ZHE Department of Mathematics Yanbian University Yanji Jilin 133002

In this paper, we first give the definitions of finitely continuous topological space and FC-subspace generated by some set, and obtain coincidence point theorem, whole intersection theorems and Ky Fan type matching t... 详细信息

关键词： FC-space FC-subspace generated by set saddle point

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Continuous Selections and Fixed Points forφ-maps with Their Applications to Section Problems

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Communications in Mathematical Research 2012年第3期28卷 225-234页

作者： piao YONG-JIE JIN hai-LAN piao GUANG-RI Department of Mathematics College of Science Yanbian Universify Yanji Jilin 133002

The concept of finitely continuous topological space is introduced and the basic properties of the space are given. Several continuous selection theorems and fixed point theorems for Ф-maps are established, and as applications of the above fixed point theorems, some section problems are discussed. The results generalize and improve many corresponding conclusions.

关键词： FC-space FC-subset Ф-map continuous selection fixed point section problem

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