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Comparison of ovarian preservation versus oophorectomy on fertility outcomes in patients with endometriosis post-laparoscopic surgery:A prospective study

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World Journal of Clinical Cases 2024年第21期12卷 4652-4660页

作者： Jin-Jin Zhou Ke Yu hai-yan mao Cen Li Department of Gynecology Affiliated Hospital of Yangzhou UniversityYangzhou 225001Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Yangzhou UniversityYangzhou 225001Jiangsu ProvinceChina

BACKGROUND Endometriosis is a chronic inflammatory condition affecting a significant proportion of women of reproductive *** laparoscopic surgery is commonly the preferred treatment,the decision to preserve or remove the ovaries remains *** studies have yielded inconsistent results regarding the impact of ovarian preservation vs oophorectomy on fertility outcomes and disease *** prospective study aimed to address this knowledge gap by comparing the effects of these surgical approaches on spontaneous pregnancy rates,time to pregnancy,recurrence rates,and postoperative pain in patients with *** To compare the reproductive outcomes and recurrence rates between ovarian preservation and oophorectomy in women undergoing laparoscopic surgery for *** This study was conducted at a tertiary care hospital between January 2019 and December 2023.A total of 312 women aged 18 to 40 years,diagnosed with endometriosis and undergoing laparoscopic surgery,were *** patients were categorized into the ovarian preservation group(n=204)and the oophorectomy group(n=108).The primary outcome measure was the achievement of spontaneous pregnancy within 24 months *** outcomes included time to spontaneous pregnancy,recurrence rates,and postoperative pain *** The ovarian preservation group exhibited a significantly higher spontaneous pregnancy rate than that in the oophorectomy group(43.6%vs 28.7%,P=0.006).Moreover,the median time to spontaneous pregnancy was shorter in the ovarian preservation group(8.2 months vs 11.4 months,P=0.018).Nonetheless,endometriosis recurrence was more prevalent in the ovarian preservation group(22.1%vs 11.1%,P=0.014).The postoperative pain scores demonstrated similar improvements in both groups,with no significant differences *** analyses indicated that the benefit of ovarian preservation on spontaneous pregnancy rates was more evident among youn

关键词： Endometriosis Ovarian Pregnancy Oophorectomy Laparoscopic Spontaneous pregnancy

Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions

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Chinese Chemical Letters 2011年第6期22卷 738-740页

作者： hai yang Liu Kun Wang hai yan Fu mao Lin Yuan Hua Chen Rui Xiang Li Key Lab of Green Chemistry and Technology Ministry of Education the Institute of Homogeneous Catalysis College of Chemistry Sichuan University Chengdu 610064 China

Amide,which is derived from proline and is inexpensive and air-stable,has been synthesized and characterized by ~1H NMR,^（13）C NMR,and *** was found to be an efficient ligand in the palladium-catalyzed Suzuki cross-coupling *** the Pd/amide catalytic system,aryl bromides can be coupled with phenylboronic acid in ethanol/water（1：2;v/v） in excellent yields even with a low Pd loading of 0.01 mol%.Moreover,the scope of the reaction is broad,and a wide variety of functional groups are tolerant.

关键词： Suzuki cross-coupling Palladium catalyst Aryl bromides Amide Water

Risk factors for avian influenza virus in backyard poultry flocks and environments in Zhejiang Province,China:a crosssectional study

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Infectious Diseases of Poverty 2018年第1期7卷 635-644页

作者： Xiao-Xiao Wang Wei Cheng Zhao Yu She-Lan Liu hai-yan mao En-Fu Chen Zhejiang Provincial Centre for Disease Control and Prevention 3399 Binsheng RoadBinjiang DistrictHangzhouZhejiang 310051People’s Republic of China

Background:Human infection of avian influenza virus(AIV)remains a great *** live poultry markets are believed to be associated with human infections,ever more infections have been reported in rural areas with backyard poultry,especially in the fifth epidemic of ***,limited information is available on backyard poultry infection and surrounding environmental ***:Two surveillance systems and a field survey were used to collect data and samples in Zhejiang *** total,4538 samples were collected by surveillance systems and 3171 from the field survey between May 2015 and May 2017,while 352 backyard poultry owners were interviewed in May 2017 by questionnaire to investigate factors influencing the prevalence of avian influenza A virus and other AIV ***-PCR was used to test the nucleic acids of *** 10.1 software was used to generate *** and logistic regression analyses were conducted to identify risk factors for AIV ***:Of the 428 poultry premises observed by the surveillance system,53(12.38%)were positive for influenza A *** the 352 samples from poultry premises observed by field survey,13(3.39%)were positive for influenza A *** prevalence of AIV was unevenly distributed and the dominant subtype differed among ***(Shaoxing and Ningbo)and southern(Wenzhou)cities exhibited a higher prevalence of AIV(16.33,8.94,and 7.30%respectively).Contamination of AIV subtypes was most severe in January,especially in 2016(23.26%,70/301).The positive rate of subtype H5/H7/H9 was 2.53%(115/4538).Subtype H5 was the least prevalent,while subtypes H7 and H9 had similar positivity rates(1.50 and 1.32%respectively).Poultry flocks and environmental samples had a similar prevalence of AIV(4.46%vs 5.06%).The type of live birds was a risk factor and the sanitary condition of the setting was a protective factor against influenza A ***:AIV subtypes were prevalent in ba

关键词： Risk factor Avian influenza virus Backyard poultry Environmental contamination

BSEC Method for Unveiling Open Clusters and its Application to Gaia DR3:83 New Clusters

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Research in Astronomy and Astrophysics 2024年第5期24卷 169-184页

作者： Zhong-Mu Li Cai-yan mao Institute of Astronomy and Information Dali UniversityDali 671003China

Open clusters(OCs) are common in the Milky Way, but most of them remain undiscovered. There are numerous techniques, including some machine-learning algorithms, available for the exploration of OCs. However, each method has its limitations and therefore, different approaches to discovering OCs hold significant values. We develop a comprehensive approach method to automatically explore the data space and identify potential OC candidates with relatively reliable membership determination. This approach combines the techniques of Hierarchical Density-Based Spatial Clustering of Applications with Noise, Gaussian mixture model, and a novel cluster member identification technique, color excess constraint. The new method exhibits efficiency in detecting OCs while ensuring precise determination of cluster memberships. Because the main feature of this technique is to add an extra constraint(EC) for the members of cluster candidates using the homogeneity of color excess,compared to typical blind search codes, it is called Blind Search-Extra Constraint(BSEC) method. It is successfully applied to the Gaia Data Release 3, and 83 new OCs are found, whose color–magnitude diagrams(CMDs) are fitted well to the isochrones. In addition, this study reports 621 new OC candidates with discernible main sequence or red giant branch. It is shown that BSEC technique can discard some false negatives of previous works, which takes about three percentage of known clusters. It shows that as an EC, the color excess(or twocolor) constraint is useful for removing fake cluster member stars from the clusters that are identified from the positions and proper motions of stars, and getting more precise CMDs, when differential reddening of member stars of a cluster is not large(e.g., ΔE(G_(BP)-G_(RP)) < 0.5 mag). It makes the CMDs of 15% clusters clearer(in particular for the region near turnoff) and therefore is helpful for CMD and stellar population studies. Our result suggests that the color excess con

关键词： Galaxy stellar content-(Galaxy:)open clusters and associations general-stars fundamental parameters

Theoretical screening of cooperative N-bridged dual-atom sites for efficient electrocatalytic nitrogen reduction with remolding insight

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Nano Research 2024年第4期17卷 3413-3422页

作者： Huimei Chen yan yang Chi Jiao Zhiwen Zhuo Junjie mao yan Liu Key Laboratory of Functional Molecular Solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China

The electrocatalytic nitrogen reduction reaction(e-NRR)is a promising alternative method for the Haber–Bosch ***,it still faces many challenges in searching for high activity,stability,and selectivity catalysts and ascertaining the catalytic mechanism with complete ***,a series of graphene-based N-bridged dual-atom catalysts(M1-N-M2/NC)are systematically investigated via first-principle calculation and a high-throughput screening *** result unveils that N_(2) adsorption on M1-N-M2/NC in bridge-on adsorption mode can effectively break the scaling relationship on single-atom catalysts(SACs).Moreover,V-N-Ru/NC and V-N-Os/NC are systematically screened out as promising e-NRR catalysts,with extremely low limiting potentials of-0.20 and-0.18 V,***,the adsorption site competition between*N_(2) and*H,as well as the competitive twin reactions of hydrogen evolution reaction(HER)on intermediates(N_(n)H_(m))during the e-NRR process,is systematically evaluated to form a remodeling insight for the reactions in mechanism,and the e-NRR of new proposed dual-atom catalysts(DACs)is strategically optimized for its high-efficiency performance potential via our remolding insight in e-NRR *** work provides new ideas and insights for the design and mechanism of e-NRR catalysts and an effective strategy for rapidly screening highly efficient e-NRR catalysts.

关键词： nitrogen reduction dual-atom catalysts high-throughput screening hydrogen evolution reaction density functional theory calculations

Carbon efficiency evaluation method for urban energy system with multiple energy complementary

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Global Energy Interconnection 2024年第2期7卷 142-154页

作者： Xianan Jiao Jiekang Wu Yunshou mao Mengxuan yan School of Automation Guangdong University of TechnologyGuangzhou 510006P.R.China Guangzhou Power Supply Bureau Guangdong Power Grid CompanySouth China Power GridGuangzhou 510660P.R.China School of Electronic Information and Electrical Engineering Huizhou UniversityHuizhou 516007P.R.China

Urban energy systems(UESs)play a pivotal role in the consumption of clean energy and the promotion of energy cascade *** the context of the construction and operation strategy of UESs with multiple complementary energy resources,a comprehensive assessment of the energy efficiency is of paramount ***,a multi-dimensional evaluation system with four primary indexes of energy utilization,environmental protection,system operation,and economic efficiency and 21 secondary indexes is constructed to comprehensively portray the *** that the evaluation system may contain a large number of indexes and that there is overlapping information among them,an energy efficiency evaluation method based on data processing,dimensionality reduction,integration of combined weights,and gray correlation analysis is *** method can effectively reduce the number of calculations and improve the accuracy of energy efficiency ***,a demonstration project for a UES in China is *** energy efficiency of each scenario is assessed using six operational *** results show that Scenario 5,in which parks operate independently and investors build shared energy-storage equipment,has the best results and is best suited for green and low-carbon *** results of the comparative assessment methods show that the proposed method provides a good energy efficiency *** study provides a reference for the optimal planning,construction,and operation of UESs with multiple energy sources.

关键词： Urban energy systems(UESs) Multiple energy complementary system Carbon efficiency evaluation Data downscaling Subjective and objective weight Gray correlation analysis

Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo FGFR1 mutations

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Asian Journal of Andrology 2024年第4期26卷 426-432页

作者： Yu-Fan yang hai-Lu Ma Xi Wang Min Nie Jiang-Feng mao Xue-yan Wu Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China.

Fibroblast growth factor receptor 1(FGFR1)mutations are associated with congenital hypogonadotropic hypogonadism(CHH)through inheritance or spontaneous *** detected FGFR1 mutations in a Chinese cohort of 210 CHH patients at Peking Union Medical College Hospital(Beijing,China)using next-generation and Sanger *** assessed missense variant pathogenicity using six bioinformatics tools and compared clinical features and treatment outcomes between inherited and de novo mutation *** 19 patients with FGFR1 mutations,three were recurrent,and 16 were novel *** of the novel mutations were likely pathogenic according to the American College of Medical Genetics and Genomics(ACMG)guidelines,with the prevalent P366L *** majority of FGFR1 mutations was inherited(57.9%),with frameshift mutations exclusive to the de novo mutation *** inherited mutation group had a lower incidence of cryptorchidism,short stature,and skeletal *** the inherited mutation group,luteinizing hormone(LH)levels were 0.5 IU l−1,follicle-stimulating hormone(FSH)levels were 1.0 IU l−1,and testosterone levels were 1.3 nmol l−*** contrast,the de novo group had LH levels of 0.2 IU l−1,FSH levels of 0.5 IU l−1,and testosterone levels of 0.9 nmol l−1,indicating milder hypothalamus–pituitary–gonadal axis(HPGA)functional deficiency in the inherited *** inherited mutation group showed a tendency toward higher spermatogenesis *** conclusion,this study underscores the predominance of inherited FGFR1 mutations and their association with milder HPGA dysfunction compared to de novo mutations,contributing to our understanding of the genetic and clinical aspects of FGFR1 mutations.

关键词： congenital hypogonadotropic hypogonadism de novo FGFR1 inherited

Research progress on natural products against hepatocellular carcinoma

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BIOCELL 2024年第6期48卷 905-922页

作者： LINGLI ZHANG yan LI JINGXIN mao Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System Chongqing Medical and Pharmaceutical CollegeChongqing400030China Provincial Key Laboratory of Pharmaceutical Bioactive Substances School of Life Sciences and BiopharmaceuticalsGuangdong Pharmaceutical UniversityGuangzhou510006China

Hepatocellular carcinoma(HCC)remains a prevalent and challenging malignancy globally,characterized by its numerous causal factors and generally unfavorable *** the relentless pursuit of effective treatment modalities,natural products have emerged as a promising and relatively non-toxic alternative,garnering signiﬁcant *** integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of *** review offers a comprehensive overview of the causal factors underlying HCC,and the diverse treatment options available,and highlights the advancements made by natural products in anti-HCC ***,we provide an outline of the various types of natural products,their corresponding nomenclature,target molecules,and mechanisms of action that exhibit anti-HCC *** products are anticipated to play a pivotal role in future comprehensive treatment plans for liver cancer,potentially offering patients improved survival rates and an enhanced quality of life.

关键词： Hepatocellular carcinoma Natural products Targets Research progress Drug

Advances in mesenchymal stem cells therapy for tendinopathies

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Chinese Journal of Traumatology 2024年第1期27卷 11-17页

作者： Xu-Feng mao Xi-Qian Zhang Zhe-Yu Yao hai-Jiao mao Department of Orthopaedic Surgery The First Affiliated Hospital of Ningbo UniversityNingbo315010Zhejiang provinceChina

Tendinopathies are chronic diseases of an unknown etiology and associated with *** stem cells(MSCs)have emerged as a viable therapeutic option to combat the pathological progression of tendinopathies,not only because of their potential for multidirectional differentiation and self-renewal,but also their excellent immunomodulatory *** immunomodulatory effects of MSCs are increasingly being recognized as playing a crucial role in the treatment of tendinopathies,with MSCs being pivotal in regulating the inflammatory microenvironment by modulating the immune response,ultimately contributing to improved tissue *** review will discuss the current knowledge regarding the application of MSCs in tendinopathy treatments through the modulation of the immune response.

关键词： Mesenchymal stem cells Tendinopathy Immunomodulation Treatment Review