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AST-to-ALT ratio and coronary artery lesions among patients with Kawasaki disease

World Journal of Pediatrics 2021年第6期17卷 659-668页

作者： Lei Cao Yun-Jia Tang Miao Gang Jin Ma Wei-Guo Qian Qiu-Qin Xu hai-tao lv Department of Cardiology Children's Hospital of Soochow UniversityNo.92Zhongnan StreetSuzhouChina Department of Pharmacy Children's Hospital of Soochow UniversityNo 92Zhongnan StreetSuzhou.China

Background The aim of this study was to explore the associations between the aspartate aminotransferase-to-alanine aminotransferase ratio(AST/ALT)and coronary artery lesions(CALs)among patients with Kawasaki disease(KD).Methods Medical records of KD patients presenting to a single center between January 2019 and December 2020 were retrospectively collected and ***,multivariable-adjusted analyses,subgroup analyses,restricted cubic spline test,and fitted curves were used to evaluate the associations between AST/ALT and *** A total of 831 patients were enrolled,of which 201(24.2%)had CALs on admission and 21(2.5%)developed CALs de novo after intravenous immunoglobulin(IVIG).Multivariable-adjusted analyses models revealed that a lower AST/ALT was associated with an increased risk of CALs on admission when AST/ALT was a continuous variable(P=0.007)and when it was a categorical variable(P for trend=0.004).Each unit increase in AST/ALT was associated with a 22%lower risk of CALs on admission(odds ratio=0.78,95%confidence interval 0.65-0.94).A negative linear relationship was noted between AST/ALT and the risk of CALs on admission in both observed and fitted ***,such associations were not observed in AST/ALT and CALs de novo after *** of the variables significantly modified the association between AST/ALT and CALs on admission and CALs de novo after IVIG(P>0.05).Conclusion Our findings suggested that AST/ALT was a risk factor of CALs,but was not associated with progressive CALs.

关键词： Alanine aminotransferase Aspartate aminotransferase Coronary artery lesions Kawasaki disease

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Effects of rosuvastatin on the production and activation of matrix metalloproteinase-2 and migration of cultured rat vascular smooth muscle cells induced by homocysteine

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 696-704页

作者： Ya-fei SHI Ju-fang CHI Wei-liang TANG Fu-kang XU Long-bin LIU Zheng JI hai-tao lv Hang-yuan GUO Department of Cardiology Shaoxing People's Hospital Shaoxing Hospital of Zhejiang University Department of Cardiology Huai'an First People's Hospital Nanjing Medical University

Objective： To test the influence of homocysteine on the production and activation of matrix metalloproteinase-2 （MMP-2） and tissue inhibitors of matrix metalloproteinase-2 （TIMP-2） and on cell migration of cultured rat vascular smooth muscle cells （VSMCs）. Also, to explore whether rosuvastatin can alter the abnormal secretion and activation of MMP-2 and TIMP-2 and migration of VSMCs induced by homocysteine. Methods： Rat VSMCs were incubated with different concentrations of homocysteine （50-5000 μmol/L）. Western blotting and gelatin zymography were used to investigate the expressions and activities of MMP-2 and TIMP-2 in VSMCs in culture medium when induced with homocysteine for 24, 48, and 72 h. Transwell chambers were employed to test the migratory ability of VSMCs when incubated with homocysteine for 48 h. Different concentrations of rosuvastatin （10^-9-10^-5 mol/L） were added when VSMCs were induced with 1 000 pmol/L homocysteine. The expressions and activities of MMP-2 and TIMP-2 were examined after incubating for 24, 48, and 72 h, and the migration of VSMCs was also examined after incubating for 48 h. Results： Homocysteine （50-1000 μmol/L） increased the production and activation of MMP-2 and expression of TIMP-2 in a dose-dependent manner. However, when incubated with 5000 pmol/L homocysteine, the expression of MMP-2 was up-regulated, but its activity was down-regulated. Increased homocysteine-induced production and ac- tivation of MMP-2 were reduced by rosuvastatin in a dose-dependent manner whereas secretion of TIMP-2 was not significantly altered by rosuvastatin. Homocysteine （50-5000 μmol/L） stimulated the migration of VSMCs in a dose-dependent manner, but this effect was eliminated by rosuvastatin. Conclusions： Homocysteine （50-1000 μmol/L） significantly increased the production and activation of MMP-2, the expression of TIMP-2, and the migration of VSMCs in a dose-dependent manner. Additional extracellular rosuvastatin can decrease the excessive expressio

关键词： Matrix metalloproteinase-2 (MMP-2) Vascular smooth muscle cells (VSMCs) Migration Rosuvastatin Homocysteine

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Insufficiency of Mrpl40 disrupts testicular structure and semen parameters in a murine model

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Asian Journal of Andrology 2023年第5期25卷 627-631页

作者： Ying Liu Long-Long Fu Hui-Zhong Xu Yi-Ming Zheng Wei-Xi Li Guang-Hui Qian Wen-Hong Lu hai-tao lv Institute of Pediatric Research Children's Hospital of Soochow UniversitySuzhou 215025China National Health Commission Key Laboratory of Male Reproductive Health National Research Institute for Family PlanningBeijing 100081China Institute for Advanced Study and School of Physical Science and Technology Soochow UniversitySuzhou 215006China

Approximately 31%of patients with 22q11.2 deletion syndrome(22q11.2DS)have genitourinary system disorders and 6%of them have undescended *** of genes on chromosome 22q11.2 might contribute to the risk of *** this study,we used mice with single-allele deletion in mitochondrial ribosomal protein L4o(Mrpl40-)as models to investigate the function of Mrpl40 in testes and spermatozoa *** penetrance of cryptorchidism in Mrpl40+-mice was found to be higher than that in wild-type(WT)*** the weight of testes was not significantly different between the WT and Mrpl40+-mice,the structure of seminiferous tubules and mitochondrial morphology was altered in the Mrpl40+-***,the concentration and motility of spermatozoa were significantly decreased in the Mrpl4O+-*** addition,data-independent acquisition mass spectrometry indicated that the expression of genes associated with male infertility was altered in Mrpl40+-*** study demonstrated the important role of Mrpl40 in testicular structure and spermatozoa motility and *** findings suggest that Mrpl4o is potentially a novel therapeutic target for cryptorchidism and decreased motility and count of spermatozoa.

关键词： cryptorchidism DiGeorge syndrome semen analysis spermatozoa

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Hyperhomocysteinemia independently causes and promotes atherosclerosis in LDL receptor-deficient mice

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Journal of Geriatric Cardiology 2014年第1期11卷 74-78页

作者： Hang-Yuan GUO Fu-Kang XU hai-tao lv Long-Bin LIU Zheng JI Xiao-Ya Zhai Wei-Liang TANG Ju-Fang CH Department of Cardiology Shaoxing Hospital of Zhejiang University Shaoxing 312000 Zhejiang Province China

Background Hyperhomocysteine is an independent risk factor of coronary heart disease （CHD）. However, whether hyperhomocys teine affects the progression of atherosclerosis is unclear. In the present study, we examined the effect of hyperhomocysteine on the forma tion of atherosclerosis in low-density lipoprotein receptor-deficient （LDLr ） mice. Methods Forty-eight 7-week-old LDLr/ mice were assigned to the following groups： mice fed a standard rodent diet （control group）, mice fed a high-methionine diet （high-methionine group）, mice fed a high-fat diet （high-fat group）, and mice fed a diet high in both methionine and fat （high-methionine and high-fat group）. At the age of 19, 23, and 27 weeks, four mice at each interval in every group were sacrificed. Results At the end of the study, mice did not show atherosclerotic lesions in the aortic sinus and aortic surface until 27 weeks old in the control group. However, atherosclerotic lesions developed in the other three groups at 19 weeks. The amount of atherosclerotic lesions on the aortic surface was lower in the high-methionine group than in the high-fat group （P 〈 0.001）. Atherosclerotic lesions on the aortic surface in the high-methionine and high-fat group were the most severe. The mean area of atherosclerotic lesions in the aortic sinus compared with atherosclerotic lesions on the aortic surface was lower in the high-methionine group than in the high-fat group （P 〈 0.001）. Atherosclerotic lesions in the aortic sinus in the high-methionine and high-fat group were the most severe. Conclusions Homocysteinemia accelerates atherosclerotic lesions and induces early atherosclerosis independently in LDLrmice. Reducing the level of homocysteinemia may be beneficial for prevention and treatment of CHD.

关键词： Atherosclerosis Homocysteine Low-density lipoprotein Hyperhomocysteinemia

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Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic

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World Journal of Pediatrics 2021年第3期17卷 263-271页

作者： Yue-Yue Ding Yan Ren Jie Qin Guang-Hui Qian Yun-Jia Tang Ye Chen Xuan Li Lei Xu Chun-Hong Qiao Ling Sun hai-tao lv Cardiology Department Children’s Hospital of Soochow UniversitySuzhou 215025China Department of Radiology Huashan Hospital of Fudan University12 Mid Wulumuqi RoadShanghai 200040China Institute of Pediatric Research Children's Hospital of Soochow UniversitySuzhou 215025China Department of Biostatistics and Computational Biology School of Life ScienceFudan UniversityShanghai 200433China

Background The aim of this study is to explore the characteristics of Kawasaki disease(KD)and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019(COVID-19)*** All patients with KD admitted between February and April in 2015-2020,were classified into before(group 1,in 2015-2019)and after(group 2,in 2020)isolation groups.A total of 4742 patients[with KD(m=98)and non-KD(n=4644)]referred to Mycoplasma pneumoniae(MP)and virus detection were analyzed in *** characteristics,laboratory data,and 13 pathogens were analyzed *** Group 2 had a significantly increased incidence of KD(0.11%)with 107 patients compared to that of group 1(0.03%)with 493 *** comparisons of oral mucosal change,strawberry tongue,desquamation of the fingertips,cervical lymphadenopathy and neutrophil percentage decreased in group 2 compared to group *** infection rate of MP increased significantly in group 2(34.7%)compared to group 1(19.3%),while the positive rate of viruses decreased significantly in group 2(5.3%)compared to group 1(14.3%).In 2020,the positive rate of MP infection increased significantly in patients with KD compared to the increase in patients with *** infection rate of MP for younger children aged less than 3 years old was higher in group 2 than in group *** Compared with the characteristics of KD from 2015 to 2019 years,the incidence of KD was increased in 2020 and was accompanied by a high incidence of MP infection,especially in younger children(less than 3 years old)during the isolation due to COVID-19 pandemic.

关键词： Kawasaki disease Concurrent pathogens Mycoplasma pneumoniae COVID-19 Isolation

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FLNB haploinsufficiency-related short stature:a new syndrome or an expanded spectrum of Larsen syndrome

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World Journal of Pediatrics 2024年第9期20卷 976-980页

作者： Qing Wang Hong-Ying Wang Shui-Yan Wu Xue-Qian Wang hai-Ying Wu Rong-Rong Xie Feng-Yun Wang Xiu-Li Chen Lin-Qi Chen hai-tao lv Ting Chen Department of Endocrinology Genetics and MetabolismChildren’s Hospital of Soochow UniversitySuzhouChina Suzhou Clinical Center for Rare Diseases in Children Children’s Hospital of Soochow UniversitySuzhouChina Intensive Care Unit Children’s Hospital of Soochow UniversitySuzhouChina Department of Cardiology Children’s Hospital of Soochow UniversitySuzhouChina Department of Pediatrics Kunshan Sixth People’s HospitalSuzhouJiangsuChina

FLNB encodes the protein filamin B(FLNB),which is expressed in chondrocytes of the human growth plate[1].To date,pathogenic mutations in the FLNB gene have solely been found to cause skeletal deformities,indicating th... 详细信息

关键词： insufficiency skeletal expanded

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Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting lv Hongfu Li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

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高效液相色谱法测定蒙药制剂敖勒盖-13中胡椒碱的含量

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中国民族医药杂志 2017年第5期23卷 42-44页

作者：张海涛吕颖赤峰市药品检验所内蒙古赤峰024050

目的:建立高效液相色谱法测定蒙药制剂敖勒盖-13中胡椒碱的含量。方法:采用Diamonsi L C18(250mm×4.6mm,5μm)色谱柱;以甲醇-水(77:23)为流动相;流速1.0 m L·min^(-1);检测波长343 nm;柱温为30℃。结果:胡椒碱在4~40μg·m L^(-1)(r=0... 详细信息

目的:建立高效液相色谱法测定蒙药制剂敖勒盖-13中胡椒碱的含量。方法:采用Diamonsi L C18(250mm×4.6mm,5μm)色谱柱;以甲醇-水(77:23)为流动相;流速1.0 m L·min^(-1);检测波长343 nm;柱温为30℃。结果:胡椒碱在4~40μg·m L^(-1)(r=0.999 9)范围内线性关系良好,平均回收率为97.94%(n=9),RSD为0.62%。结论:本方法简便准确、稳定可靠,可用于蒙药制剂敖勒盖-13的含量测定。

关键词：蒙药制剂高效液相色谱法敖勒盖-13 胡椒碱含量测定

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高效液相色谱法测定蒙药制剂色布如-9中胡椒碱的含量

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中国民族医药杂志 2017年第6期23卷 43-45页

作者：张海涛吕颖赤峰市药品检验所内蒙古赤峰024050

目的:建立高效液相色谱法测定蒙药制剂色布如-9中胡椒碱的含量。方法:采用Diamonsi L C18(250 mm×4.6mm,5μm)色谱柱;以甲醇-水(77:23)为流动相;流速1.0 mL·min^(-1);检测波长343 nm;柱温为30℃。结果:胡椒碱在4~40μg·mL^(-1)(r=0.9... 详细信息

目的:建立高效液相色谱法测定蒙药制剂色布如-9中胡椒碱的含量。方法:采用Diamonsi L C18(250 mm×4.6mm,5μm)色谱柱;以甲醇-水(77:23)为流动相;流速1.0 mL·min^(-1);检测波长343 nm;柱温为30℃。结果:胡椒碱在4~40μg·mL^(-1)(r=0.999 9)范围内线性关系良好,平均回收率为100.74%(n=9),RSD为0.18%。结论:本方法简便准确、稳定可靠,可用于蒙药制剂色布如-9的含量测定。

关键词：蒙药制剂高效液相色谱法色布如-9 胡椒碱含量测定

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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