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Optimal timing of endoscopic biliary drainage for bile duct leaks:A multicenter,retrospective,clinical study

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 139-149页

作者： De-Xin Chen Kai-Xuan Fang Sheng-Xin Chen Sen-Lin Hou Gui-hai Wen hai-Kun Yang Da-Peng Shi qing-Xin Lu Ya-qi Zhai Ming-Yang Li Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Graduate School Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The 960th Hospital of PLAJinan 050035Shandong ProvinceChina Department of Gastroenterology and Hepatology The Second Hospital of Hebei Medical UniversityHebei 050035China Department of Gastroenterology and Hepatology Handan Central HospitalHebei 056001China Department of Gastroenterology and Hepatology Shanxi Provincial People’s HospitalShanxi 030012China Department of Gastroenterology and Hepatology First Affiliated Hospital of Army Medical University of PLAChongqing 400042China Department of Gastroenterology and Hepatology Second Affiliated Hospital of Army Medical University of PLAChongqing 400042China Department of Gastroenterology Chinese PLA General HospitalBeijing 100853China

BACKGROUND Bile duct leaks(BDLs)are serious postsurgical adverse ***,conservative management with ab-dominal drainage is the initial treatment ***,prolonged abdominal drainage without improvement can lead to biliary stricture and delay the optimal timing of endoscopic retrograde cholangiopancreatography(ERCP).AIM To identify the optimal timing for ERCP and the period during which clinical observation with conservative management is acceptable,balancing ERCP success and the risk of biliary *** We conducted a multicenter retrospective study involving 448 patients with BDLs between November 2002 and November *** patients were divided into four groups based on the timing of ERCP:3 days,7 days,14 days,and 21 *** primary outcome was clinical success,defined as the resolution of BDL and related symptoms within 6 months without additional percutaneous drainage,surgery,or *** secondary outcome was incidence of biliary *** and multivariate logistic regression analyses were performed to identify factors associated with ERCP success and biliary stricture *** In a cohort of 448 consecutive patients diagnosed with BDLs,354 were excluded,leaving 94 patients who underwent *** success was achieved in 84%of cases(79/94),with a median ERCP timing of 20 days(9.5-35.3 days).Biliary strictures were identified in 29(30.9%)*** ERCP within 3 weeks,compared to after 3 weeks,was associated with higher success rates[92.0%(46/50)vs 75.0%(33/44),P=0.032]and a lower incidence of biliary stricture incidence[18.0%(9/50)vs 45.5%(20/44),P=0.005].Subsequent multivariate analysis confirmed the association with higher success rates(odds ratio=4.168,P=0.045)and lower biliary stricture rates(odds ratio=0.256,P=0.007).CONCLUSION Performing ERCP for BDLs within 3 weeks may be associated with a higher success rate and a lower biliary stricture *** patients with BDLs do not respond to conserva

关键词： Endoscopic retrograde cholangiopancreatography Bile duct leaks Endoscopic nasobiliary drainage Endoscopic biliary stent drainage Optimal timing Biliary stricture

Anisotropy characterization of upper shanghai clays: Shear strength and small-strain stiffness

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 493-508页

作者： Lixin Lan Wenxuan Zhu Guanlin Ye qi Zhang Tongshuai Yang Department of Civil Engineering State Key Laboratory of Ocean EngineeringShanghai Key Laboratory for Digital Maintenance of Buildings and InfrastructureShanghai Jiao Tong UniversityShanghai200240China Department of Civil Engineering Shanghai Jiao Tong UniversityShanghai200240China The Fourth Construction Co. Ltd.of China Construction Eighth Engineering DivisionQingdao266100China

Comprehensive investigations have been conducted to study the structure and overconsolidation of upper Shanghai clays, i.e. Layers 2–6 clays, typically located at depths of 30–40 m. However, limited information is available on their anisotropy, and even less is known about the correlation between structure, overconsolidation, and anisotropy. In this study, the undrained anisotropy characteristics of shear strength and small-strain shear stiffness in upper Shanghai Layers 2–6 clays were thoroughly assessed using a series of K0-consolidated undrained triaxial compression (TC) and triaxial extension (TE) tests (K0 is the coefficient of lateral earth pressure at rest). The effective stress paths, shear strength, and small-strain shear stiffness from the undrained TC and TE tests demonstrate the anisotropic behaviors in upper Shanghai clays. Analyses of data from upper Shanghai clays and other clays worldwide indicate that the shear strength anisotropy ratio (Ks) converges at 0.8 as the overconsolidation ratio (OCR) and plasticity index (Ip) increase, while the small-strain shear stiffness anisotropy ratio (Re) converges at 1.0. The influence of OCR on Ks and Re is more pronounced than that of Ip and sensitivity (St). Nevertheless, no clear correlation between Ks and Re is observed in upper Shanghai clays.

关键词： Shanghai clays Anisotropy Shear strength Small-strain stiffness

Spatial Patterns and Controlling Factors of Soil Organic Carbon and Total Nitrogen in the Three River Headwaters Region,China

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Chinese Geographical Science 2025年第1期35卷 131-148页

作者： CUI qiao LI Zongxing FENG qi ZHANG Baijuan ZHAO Yue Observation and Research Station of Eco-Hydrology and National Park by Stable Isotope Tracing in qilian Mountains/Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China

The alpine ecosystem has great potential for carbon *** organic carbon(SOC)and total nitrogen(TN)are highly sensitive to climate change,and their dynamics are crucial to revealing the effect of climate change on the structure,function,and services of the ***,the spatial distribution and controlling factors of SOC and TN across various soil layers and vegetation types within this unique ecosystem remain inadequately *** this study,256 soil samples in 89 sites were collected from the Three River Headwaters Region(TRHR)in China to investigate SOC and TN and to explore the primary factors affecting their distribution,including soil,vegetation,climate,and geography *** results show that SOC and TN contents in 0-20,20-40,40-60,and 60-80 cm soil layers are 24.40,18.03,14.04,12.40 g/kg and 2.46,1.90,1.51,1.17 g/kg,respectively;with higher concentrations observed in the southeastern region compared to the northwest of the ***-way analysis of variance reveals that SOC and TN levels are elevated in the alpine meadow and the alpine shrub relative to the alpine steppe in the 0-60 cm soil *** structural equation model explores that soil water content is the main controlling factor affecting the variation of SOC and ***,the geography,climate,and vegetation factors notably indirectly affect SOC and TN through soil ***,it can effectively improve soil water and nutrient conditions through vegetation restoration,soil improvement,and grazing management,and the change of SOC and TN can be fully understood by establishing monitoring networks to better protect soil carbon and nitrogen.

关键词： controlling factors different soil layers soil organic carbon(SOC) soil total nitrogen(TN) alpine ecosystem the Three River Headwaters Region(TRHR),China

Dynamic Collaborative Data Download in Heterogeneous Satellite Networks

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China Communications 2025年第2期22卷 26-46页

作者： Wu qi Li Xintong Zhu Lidong National Key Laboratory of Wireless Communications University of Electronics of Science and Technology of ChinaChengdu 611731China

Low-earth-orbit(LEO)satellite network has become a critical component of the satelliteterrestrial integrated network(STIN)due to its superior signal quality and minimal communication ***,the highly dynamic nature of LEO satellites leads to limited and rapidly varying contact time between them and Earth stations(ESs),making it difficult to timely download massive communication and remote sensing data within the limited time *** address this challenge in heterogeneous satellite networks with coexisting geostationary-earth-orbit(GEO)and LEO satellites,this paper proposes a dynamic collaborative inter-satellite data download strategy to optimize the long-term weighted energy consumption and data downloads within the constraints of on-board power,backlog stability and time-varying ***,the Lyapunov optimization theory is applied to transform the long-term stochastic optimization problem,subject to time-varying contact time and on-board power constraints,into multiple deterministic single time slot problems,based on which online distributed algorithms are developed to enable each satellite to independently obtain the transmit power allocation and data processing decisions in ***,the simulation results demonstrate the superiority of the proposed scheme over benchmarks,e.g.,achieving asymptotic optimality of the weighted energy consumption and data downloads,while maintaining stability of the on-board backlog.

关键词： backlog stability data download heterogeneous satellite networks Lyapunov optimization power allocation

Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-Man Chen Shuo Zhang Shi-qi Gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

Investigations of liquid-liquid transitions in metallic melts by fast differential scanning calorimetry

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： qi Cheng Yonghao Sun Weihua Wang Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Peking University School of Physics and Electronic Information Anhui Normal University Institute of Physics Chinese Academy of Sciences Songshan Lake Materials Lab

Liquid-liquid transition in metallic melts is an intriguing phenomenon often confused with liquid-liquid separation, oxidation or precipitation. Here, we employ a state-of-the-art ultrafast chip-based differential scanning calorimeter to investigate the thermal behavior of six metallic melts, ranging from unary to quinary systems, at temperatures above their liquidus. Calorimetric signals of liquid-liquid transition vary across systems: Sn melts showed no direct endothermic or exothermic events, though liquid-liquid transition influenced solidification and melting temperatures, while Yb-Zn melts exhibited an exothermic peak during cooling,indicating liquid-liquid transition. Thermal signals in other systems including Li, Pd-Ni-P, Yb-Mg-Zn-Cu and Au-Ag-Pd-Cu-Si,are primarily driven by compositional changes. Our in-situ analysis provides new insights into the structural and compositional evolution of metallic melts, offering significant implications for the design and processing of novel materials.

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Efficacy and safety of radiotherapy in patients with microsatellite stable or proficient mismatch repair colorectal cancer liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 59-68页

作者： Jie Ni Chu-Gen Wan Zi-qi Sui Department of Gastroenterology The First People’s Hospital of Linping DistrictHangzhou 311100Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310005Zhejiang ProvinceChina

BACKGROUND Colorectal cancer is one of the malignant tumors with a high incidence and mortality rate globally,and the occurrence of liver metastasis significantly affects patient survival *** recent years,the application of immune checkpoint inhibitors(ICIs)in cancer treatment has made important progress,especially showing good therapeutic effects in patients with high microsatellite instability or mismatch repair ***,for the majority of patients with microsatellite stable(MSS)or proficient mismatch repair(pMMR)colorectal cancer,the efficacy of ICIs is limited,prompting researchers to explore combination therapy strategies to improve *** drugs such as tyrosine kinase inhibitors(TKIs)and radiotherapy are believed to work synergistically with ICIs by modifying the tumor microenvironment and enhancing antigen *** To investigate the efficacy and safety of the combination therapy of radiotherapy,ICIs,and TKIs in patients with MSS or pMMR colorectal cancer liver metastasis(CCLM),in order to provide new clinical treatment *** A retrospective analysis was conducted on the clinical data of 43 MSS or pMMR CCLM patients treated at our hospital from September 2021 to July *** on the treatment interventions received,the patients were divided into a control group(n=21,receiving ICIs and TKIs combination therapy)and an observation group(n=22,receiving radiotherapy,ICIs,and TKIs triple therapy).The therapeutic effects,serum tumor markers(carcinoembryonic antigen and RESULTS The disease control rate in the observation group(63.64%)was significantly higher than that of the control group(23.81%)(P<0.05)).Both groups showed a decrease in carcinoembryonic antigen and carbohydrate antigen 199 levels post-treatment,with the observation group demonstrating a more significant change(P<0.05).The median progression-free survival and median overall survival in the control group were 5.1 months and 7.6 months,respectively,

关键词： Microsatellite stability Proficient mismatch repair Colorectal cancer Liver metastasis Radiotherapy Immune checkpoint inhibitors Tyrosine kinase inhibitor Efficacy Safety

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

基于关联规则分析的献血相关迷走神经反应影响因素研究

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中国实验血液学杂志 2025年第1期33卷 230-235页

作者：孟立宁杨琪田龙张家口市中心血站河北张家口075000

目的:以Logistic回归分析为参考,对献血相关迷走神经反应(DRVR)影响因素行关联规则分析并评价其结果的临床价值。方法:筛选2019年6月至2021年6月张家口市中心血站无偿献血者10 000例,收集其基线资料进行回顾性研究。将献血者分为发生DRV... 详细信息

目的:以Logistic回归分析为参考,对献血相关迷走神经反应(DRVR)影响因素行关联规则分析并评价其结果的临床价值。方法:筛选2019年6月至2021年6月张家口市中心血站无偿献血者10 000例,收集其基线资料进行回顾性研究。将献血者分为发生DRVR的试验组(n=386)和未发生DRVR的对照组(n=9 614)。对全部献血者行Logistic回归分析,预测导致DRVR的独立风险因素。对试验组行关联规则分析,计算包含DRVR的有效强关联规则。以Logistic回归分析预测为参考,评价关联规则分析结果。结果:Logistic回归分析预测显示,年龄20-29岁、性别(女)、BMI(≤18 kg/m^(2))、血压(偏低)、血红蛋白水平(偏低)均为导致DRVR的独立风险因素(P<0.05)。包含DRVR的有效强关联规则共8项:二项规则分别为“年龄(20-29岁)、DRVR”、“性别(女)、DRVR”、“BMI(≤18 kg/m^(2))、DRVR”、“血压(偏低)、DRVR”、“血红蛋白水平(偏低)、DRVR”;三项规则分别为“年龄(20-29岁)、性别(女)、DRVR”、“BMI(≤18 kg/m^(2))、血压(偏低)、DRVR”、“BMI(≤18 kg/m^(2))、献血量(400 mL)、DRVR”。关联规则分析中二项规则结果涵盖了导致DRVR的全部独立风险因素和相似的DRVR发生率变化,三项规则结果确定了DRVR高危群体范围。结论:相较于Logistic回归分析,关联规则分析结果更具临床价值,为进一步提高DRVR预测准确度提供了方法参考。

关键词：关联规则分析 Logistic回归分析献血迷走神经反应影响因素