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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong Gu Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang Wei ming Longfu Chen Tianliang song Moxi Yele Hao Zhang Long Yang Gegen Sarula Benliang Liang Luting Yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

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网络安全用户行为画像方案设计

通信技术 2017年第4期50卷 789-794页

作者：何雪海黄明浩宋飞卫士通信息产业股份有限公司四川成都610041

用户行为分析是近年来网络安全领域研究的热点之一,但是一直受限于相关数据存储和分析的能力而用处不大。对历史行为数据建模,是这类安全分析应用的关键。计算机用户相关的行为数据对于预测用户行为、异常检测非常有用。因此,提出一种... 详细信息

用户行为分析是近年来网络安全领域研究的热点之一,但是一直受限于相关数据存储和分析的能力而用处不大。对历史行为数据建模,是这类安全分析应用的关键。计算机用户相关的行为数据对于预测用户行为、异常检测非常有用。因此,提出一种大数据网络安全用户行为画像设计方案。该方案结合用户角色和个人用户操作行为特征,利用用户日志历史信息勾勒出用户行为画像,并给出用户行为安全画像实例。该方案能有效利用用户历史行为数据,使得安全管理系统能准实时地判断用户行为异常,提高网络安全类产品的实时响应能力。实践表明,该方案能应用于异常检测、日志审计、网络安全评估等。

关键词：用户画像用户行为分析综合监督管理系统大数据日志分析

Temperature Control of Bench-Scaled Batch Reactor Equipped with a Monofluid Heating/Cooling System

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Journal of Thermal Science 2014年第2期23卷 187-195页

作者： TENG hai-peng song Yi-ming School of Chemical Engineering Northwest University

An advanced control concept, Predictive Functional Control （PFC）, is applied for temperature control of a bench-scaled batch reactor equipped with monofluid heating/cooling system. First principles process models are developed. Based on achieved models, significant process variables, which are difficult or impossible to measure online, are estimated from easily measured variables, and cascade PFC control strategy has been projected and implemented in Matlab RI 4. The dynamics of individual subunits is explicitly taken into consideration by internal model in the control algorithms, and model uncertainty, various process disturbances are compensated by modifi- cation of internal model. The experimental results present an excellent capability of tracking the set point, and the success of PFC technique as a process control paradigm is illustratively demonstrated.

关键词： temperature control batch reactor mono-fluid heating/cooling system

Preparation and Spectroscopic Study of Different Stoichiometric Solid Supramolecular Inclusion Complexes of β-Cyclodextrin with Short Chain Aliphatic Amines

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Chinese Journal of Chemical Physics 2008年第2期21卷 174-180页

作者： Le-xin song Chuan-feng Teng hai-ming Wang Lei Bai Department of Chemistry University of Science and Technology of China Hefei 230026 China

The solid Supramolecular complexes of β-cyclodextrin （β-CD） with ethylenediamine 1, diethylenetriamine 2 and triethylamine 3 were obtained and characterized using elemental analysis, powder X-ray diffraction, infrared spectroscopy, thermogravimetric analysis, and ^1H nuclear magnetic resonance spectroscopy. Based on the results of elemental analysis and ^1H NMR, the guest-host stoichiometries of the three solid complexes were determined to be 5：2 for 1-β-CD, hl for 2-β-CD, and 1：3 for 3-β-CD. The yields were relative to the molar volume ratio of guest to β-CD cavity, and increased in the order： 1-β-CD〈2-3-CD〈3-β-CD. X-ray diffraction patterns of the inclusion complexes gave very good exhibitions not only in location of diffraction peaks but also in shape and diffraction intensity of the peaks due to the intermolecular complexations between β-CD and the guests. The formation of host-guest inclusion complexes exhibited obviously enhanced phase change temperatures of the complexed guests such as 1 and 3. The H-5 protons located at the narrower rim inside the CD cavity experienced a higher shift upon inclusion while all other protons experienced lower shifts.

关键词： β-cyclodextrin Inclusion complex Ethylenediamine Supramolecular

Synthesis and Crystal Structure of a Sodium Monosulfuron-ester (N-[2'-(4-Methyl)pyrimidinyl]-2-carbomethoxy Benzyl Sulfonylurea Sodium)

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Chinese Journal of Structural Chemistry 2006年第11期25卷 1414-1417页

作者： KOU Jun-Jie LI Zheng-ming song hai-Bin National Pesticide Engineering Research Center State Key Laboratory of Elemento-organic Chemistry Nankai University Tianjin 300071 China

Monosulfuron-ester is a novel sulfonylurea herbicide with ultra-low dosage Herein sodium monosulfuron-ester was synthesized and its crystal structure was determined by X-ray diffraction method. The title compound belongs to monoclinic, space group P21/c with a = 9.335（5）, b = 20.632（12）, c = 13.853（8） A, β = 107.193（9）°, Mr = 487.46, Z = 4, Dc = 1.270 g/cm^3, μ = 0.293 mm^-1, F（000） = 1015, R = 0.0859 and wR = 0.2633. In the title compound, Na coordinates with N（1）, O（1） and O（3） from one monosulfuron-ester molecule, N（4A） and O（5A） from the other monosulfuron-ester molecule and one oxygen atom from DMSO to give six coordination bonds.

关键词： sulfonylurea sodium monosulfuron-ester crystal structure

Intelligent Visual Media Processing： When Graphics Meets Vision

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Journal of Computer Science & Technology 2017年第1期32卷 110-121页

作者： ming-ming Cheng Qi-Bin Hou song-hai Zhang Paul L. Rosin College of Computer Science and Control Engineering Nankai University Tianjin 300071 China TNList Tsinghua University Beijing 100084 China School of Computer Science and Informatics Cardiff University Wales CF10 3EU U.K.

The computer graphics and computer vision communities have been working closely together in recent years and a variety of algorithms and applications have been developed to analyze and manipulate the visual media around us. There are three major driving forces behind this phenomenon： 1） the availability of big data from the Internet has created a demand for dealing with the ever-increasing, vast amount of resources; 2） powerful processing tools, such as deep neural networks, provide effective ways for learning how to deal with heterogeneous visual data; 3） new data capture devices, such as the Kilxect, the bridge betweea algorithms for 2D image understanding and 3D model analysis. These driving forces have emerged only recently, and we believe that the computer graphics and computer vision communities are still in the beginning of their honeymoon phase. In this work we survey recent research on how computer vision techniques benefit computer graphics techniques and vice versa, and cover research on analysis, manipulation, synthesis, and interaction. We also discuss existing problems and suggest possible further research directions.

关键词： computer graphics computer vision survey scene understanding image manipulation

Molecular Dynamics Study of Effects of Si-Doping Upon Structure and Mechanical Properties of Carbon Nanotube

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Communications in Theoretical Physics 2006年第4期45卷 741-744页

作者： song hai-Yang SUN He-ming ZHANG Guo-Xiang Department of Physics Beijing Institute of Technology Beijing 100081 China

In this paper, a Si-doped single-walled carbon nanotube （SWCNT）（7,7） and several perfect armchair SWCNTs are investigated using the classical molecular dynamics simulations method. The inter-atomic short-range interaction is represented by empirical Tersoff bond order potential. The computational results show that the axial Young＇s modulus of the perfect SWCNTs are in the range of 1.099 ± 0.005 TPa, which is in good agreement with the existing experimental results. From our simulation, the Si-doping decreases the Young＇s modulus of SWCNT, and with the increased strain levels, the effect of Si-doped layer in enhancing the local stress level increases. The Young＇s modulus of armchair SWCNTs are weakly affected by tube radius.

关键词： molecular dynamics simulation carbon nanotubes Young's modulus Si-doping

Synthesis, Crystal Structure and Biological Activity of 2-Chloro-N-{2-fluoro-5-[N-(phenylsulfonyl) phenyl-sulfonamido]phenyl}benzamide

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Chemical Research in Chinese Universities 2008年第3期24卷 295-298页

作者： LI Wen-ming WANG Jian-guo LI Zheng-ming song hai-bin Elemento-Organic Chemistry Institute State Key Laboratory of Elemento-Organic Chemistry National Pesticide Engineering Research Center Nankai University Tianjin 300071 P R. China

2-Chloro-N-{2-fluoro-5-[N-（phenylsulfonyl）phenylsulfonamido]phenyl}benzamide was synthesized and its crystal structure was also determined by X-ray single-crystal diffraction. The title compound（C25H18ClFN2O5S2） belongs to monoclinic, space group P21/n with a=0.7377（3） nm, b=1.2036（5） nm, c=2.6846（11） nm, β=90.895（9）°, V=2.3833（16） nm3, Mr=544.98, Z=4, Dc=1.519 g/cm3, μ=0.385 mm–1, F（000）=1120, R1=0.0632, and wR2=0.1438. Its crystal structure belongs to a novel class that has not been reported yet, and its preliminary herbicidal activity was also tested. Its inhibition rate to seedling growth of barnyard grass reaches 15.1% at 100 μg/mL.

关键词： X-ray diffraction Crystal structure Synthesis Biological activity