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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-Xiang Gu Xian-Xia Yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao Xiao-Die Liu Bao-Juan Li Ming-Hui Wang hai-long dong Hao-Hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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Understanding sequence effect in DNA bending elasticity by molecular dynamic simulations

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Communications in Theoretical Physics 2021年第7期73卷 127-135页

作者： Xiao-Wei Qiang hai-long dong Kai-Xin Xiong Wenbing Zhang Zhi-Jie Tan Department of Physics and Key Laboratory of Artificial Micro&Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan 430072China

Structural elasticity of double-strand DNAs is very important for their biological functions such as DNA-ligand binding and DNA-protein *** all-atom molecular dynamics simulations,we investigated the bending elasticity of DNA with three typical sequences including poly(A)-poly(T)(AA-TT),poly(AT)-poly(TA)(AT-TA),and a generic sequence(GENE).Our calculations indicate that,AA-TT has an apparently larger bending persistence length(P~63 nm)than GENE(P~49 nm)and AT-TA(P~48 nm)while the persistence length of AT-TA is only very slightly smaller than that of GENE,which agrees well with those from existing ***,through extensive electrostatic calculations,we found that the sequence-dependent bending elasticity is attributed to the sequence-dependent electrostatic bending energy for AA-TT,AT-TA and GENE,which is coupled to their backbone ***,the apparently stronger bending stiffness of AA-TT is attributed to its narrower minor ***,for the three DNAs,we predicted the non-electrostatic persistence length of~17 nm,thus electrostatic interaction makes the major contribution to DNA bending *** mechanism of electrostatic energy dominating sequence effect in DNA bending elasticity is furtherly illustrated through the electrostatic calculations for a grooved coarse-grained DNA model where minor groove width and other microscopic structural parameters can be artificially adjusted.

关键词： DNA elasticity molecular dynamic simulation persistence length electrostatic interaction

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The diagnostic value of tenascin-C in acute aortic syndrome

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Journal of Geriatric Cardiology 2024年第3期21卷 359-368页

作者： Ming MA Wei CHEN hai-long CAO Jun PAN Qing ZHOU Xin-long TANG dong-Jin WANG Department of Thoracic and Cardiovascular Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina Department of Thoracic and Cardiovascular Surgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingChina Department of Thoracic surgery Kunshan Hospital of Traditional Chinese MedicineJiangsuChina

OBJECTIVES Misdiagnosis of acute aortic syndrome(AAS)significantly increases ***-C(TN-C)is an extracellular matrix glycoprotein related to cardiovascular *** elevation of TN-C in AAS and whether it can discriminate suddenonset of acute chest pain in Chinese remains *** We measured the plasma concentration of TN-C by ELISA in a cohort of 376 patients with chest or back *** to discriminate AAS from acute coronary syndrome(ACS)were compared and *** From October 2016 to September 2021,376 undiagnosed patients with chest or back pain were enrolled.166 of them were finally diagnosed as AAS,100 were ACS and 110 without cardiovascular diseases(NCV).TN-C was significantly elevated in AAS at 18.18 ng/mL(IQR:13.10–27.68)compared with 7.51 ng/mL(IQR:5.67–11.38)in ACS(P<0.001)and 3.68 ng/mL(IQR:2.50–5.29)in NCV(P<0.001).There was no significant difference in TN-C level among the subtypes of *** the 166 AAS patients,the peaked level of TN-C was at acute stage(P=0.012),then a slight of decrease was observed at subacute *** area under receiver operating characteristic curve for AAS patients versus NCV was 0.979(95%CI:0.964-0.994)for *** a cutoff level of 11.474 ng/mL,TN-C has a sensitivity of 76.0%,specificity of 85.5%,accuracy of 82.0%,positive predictive value(PPV)of 76.0%,negative predictive value(NPV)of 85.5%.Diagnostic performance of TN-C was superior to D-dimer and *** The concentration of serum TN-C in AAS patients was significantly higher than that in ACS patients and ***-C could be a new biomarker to distinguish AAS patients in the early stage after symptoms onset from other pain diseases.

关键词： acute cardiovascular elevated

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Comprehensive study on the spatial distribution of heavy metals and their environmental risks in high-sulfur coal gangue dumps in China

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Journal of Environmental Sciences 2024年第2期136卷 486-497页

作者： Yingbo dong Huan Lu hai Lin School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

The accumulation of coal gangue(CG)from coal mining is an important source of heavy metals(HMs)in *** spatial distribution and environment risk assessment are extremely important for the management and remediation of *** soil samples were collected from the high-sulfur CG site in northern China and analyzed for six *** results showed that the soil was heavily contaminated by Mn,Cr and Ni based on the Nemerow index,and posed seriously ecological risk depended on the geo-accumulation index,potential ecological risk index and risk assessment *** semi-variogram model and ordinary kriging interpolation accurately portrayed the spatial distribution of ***,Mn,and Cr were distributed by band diffusion,Ni was distributed by core,the distribution of Cu had obvious patchiness and Zn was more *** spatial autocorrelation indicated that all HMs had strong spatial *** BCR sequential extraction was employed to qualify the geochemical fractions of *** data indicated that Fe and Cr were dominated by residual fraction;Cu,Ni and Zn were dominated by reducible and oxidizable fractions;Mn was dominated by reducible and acid-extractable(25.38%-44.67%)*** correlation analysis showed that pH was the main control factor affecting the non-residue fractions of ***,acid production from high sulfur CG reduced soil pH by 2-3,which indirectly promoted the activity of ***,the conceptual model of HMs contamination at the CG site was proposed,which can be useful for the development of ecological remediation strategies.

关键词： High-sulfur coal gangue Soil contamination Heavy metals Spatial distribution Geochemical fractions Risk assessment

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Rapid and chemoselective imidation of sulfides in aqueous buffer enabled by a novel guanidine-derived N-O reagent

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Science China Chemistry 2024年第6期67卷 1929-1934页

作者： Hanzheng Li long Xu Jiajia dong Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200032China Institute of Translational Medicine National Facility for Translational Medicine(Shanghai)Shanghai Jiao Tong UniversityShanghai200240China School of Chemistry and Chemical Engineering Zhangjiang Institute for Advanced StudyShanghai Jiao Tong UniversityShanghai200240China Shanghai Artificial Intelligence Laboratory Shanghai200232China

Herein we report the facile synthesis of a series of novel N-O reagents and identify N′-di-Boc-N′′-[(mesitylsulfonyl)oxy]-guanidine as an efficient imidating *** reagent is synthetically scalable and bench-stable,yet it shows unprecedented reactivity and chemoselectivity towards S(II)in buffer/hexafluoroisopropanol(HFIP)system,to generate a new class of Nguanyl *** transformation of N-guanyl sulfilimines to N-guanyl sulfoximines provides us a chance to investigate these rarely reached compounds,which are shown to be versatile precursors to a variety of N-heterocyclic and *** work provides an addition to the tool box of both sulfur imidation and guanidine synthesis,especially for the need of rapid and selective modifications of sulfur(II)center under biocompatible conditions.

关键词： sulfur imidation N-O reagent

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Bioleaching of vanadium from stone coal vanadium ore by Bacillus mucilaginosus:Influencing factors and mechanism

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1828-1838页

作者： Yingbo dong Jinyu Zan hai Lin School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

Vanadium and its derivatives are used in various industries,including steel,metallurgy,pharmaceuticals,and aerospace *** China has massive reserves of stone coal resources,these resources have low ***,the effective extraction and recovery of metallic vanadium from stone coal is an important way to realize the efficient resource utilization of stone coal vanadium ***,Bacillus mucilaginosus was selected as the leaching *** vanadium leaching rate reached 35.5%after 20 d of bioleaching under optimal operating *** cumulative vanadium leaching rate in the contact group reached 35.5%,which was higher than that in the noncontact group(9.3%).The metabolites of ***,such as oxalic,tartaric,citric,and malic acids,dominated in bioleaching,accounting for 73.8%of the vanadium leaching ***,during leaching,the presence of stone coal stimulated the expression of carbonic anhydrase in bacterial cells,and enzyme activity increased by 1.335-1.905 *** activity positively promoted the production of metabolite organic acids,and total organic acid content increased by 39.31 mg·L^(-1),resulting in a reduction of 2.51 in the pH of the leaching system with stone *** effect favored the leaching of vanadium from stone *** force microscopy illustrated that bacterial leaching exacerbated corrosion on the surface of stone coal beyond 10 *** study provides a clear and promising strategy for exploring the bioleaching mechanism from the perspective of microbial enzyme activity and metabolites.

关键词： Bacillus mucilaginosus stone coal vanadium ore bioleaching carbonic anhydrase organic acids

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Risk assessment of rockburst using SMOTE oversampling and integration algorithms under GBDT framework

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Journal of Central South University 2024年第8期31卷 2891-2915页

作者： Wang, Jia-chuang dong, long-jun School of Resources and Safety Engineering Central South University Changsha China

Rockburst is a common geological disaster in underground engineering, which seriously threatens the safety of personnel, equipment and property. Utilizing machine learning models to evaluate risk of rockburst is gradually becoming a trend. In this study, the integrated algorithms under Gradient Boosting Decision Tree (GBDT) framework were used to evaluate and classify rockburst intensity. First, a total of 301 rock burst data samples were obtained from a case database, and the data were preprocessed using synthetic minority over-sampling technique (SMOTE). Then, the rockburst evaluation models including GBDT, eXtreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), and Categorical Features Gradient Boosting (CatBoost) were established, and the optimal hyperparameters of the models were obtained through random search grid and five-fold cross-validation. Afterwards, use the optimal hyperparameter configuration to fit the evaluation models, and analyze these models using test set. In order to evaluate the performance, metrics including accuracy, precision, recall, and F1-score were selected to analyze and compare with other machine learning models. Finally, the trained models were used to conduct rock burst risk assessment on rock samples from a mine in Shanxi Province, China, and providing theoretical guidance for the mine’s safe production work. The models under the GBDT framework perform well in the evaluation of rockburst levels, and the proposed methods can provide a reliable reference for rockburst risk level analysis and safety management.

关键词： confusion matrix K-fold cross-validation random search grid rockburst evaluation SMOTE oversampling

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Strength and ductility optimization of HPDC AlSi8MgCuZn2 alloys by modifying pre-aging treatment

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China Foundry 2024年第4期21卷 343-351页

作者： Yuan-hang Jiang Hui-ting Zheng Fei Liu hai-dong Zhao National Engineering Research Center of Near-net Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510641China

Considering the components produced by high pressure die casting(HPDC)process usually with ultra-large sizes and complex morphologies,high temperature solid solution treatment is not a suitable method to further improve their mechanical *** this study,two-stage aging treatment with different pre-aging times was designed and employed to further improve the mechanical properties of HPDC Al8SiMgCuZn *** characteristics of precipitates were evaluated by a transmission electron microscope(TEM),and the precipitation strengthening mechanism was *** results reveal that the strengthening is mainly contributed by the precipitation ofβ″phase after two-stage aging,and the number density and size of the precipitates are significantly depended on the pre-aging *** number density of precipitates is increased with the pre-aging time prolonged from 0 h to 4 h,and then decreases with the further increase of pre-aging time from 4 h to 6 *** precipitates with the highest density and smallest size are observed after pre-aging for 4 *** pre-aged at 100℃for 4 h and then artificial aged at 200℃for 30 min,the yield strength of 207 MPa,ultimate tensile strength of 325 MPa and elongation of 7.6%are achieved.

关键词： high pressure die cast aluminum alloy microstructural heterogeneity mechanical properties precipitation strengthening two-stage aging

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The Emergence of Functional Ultrasound for Noninvasive Brain-Computer Interface

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Research 2024年第2期6卷 301-317页

作者： hairong Zheng Lili Niu Weibao Qiu dong Liang Xiaojing long Guanglin Li Zhiyuan Liu long Meng Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Shenzhen Institute of Advanced Integration Technology Chinese Academy of Sciences and The Chinese University of Hong KongShenzhen518055China

A noninvasive brain-computer interface is a central task in the comprehensive analysis and understanding of the brain and is an important challenge in international brain-science *** implanted brain-computer interfaces are cranial and invasive,which considerably limits their *** development of new noninvasive reading and writing technologies will advance substantial innovations and breakthroughs in the field of brain-computer ***,we review the theory and development of the ultrasound brain functional imaging and its ***,we introduce latest advancements in ultrasound brain modulation and its applications in rodents,primates,and human;its mechanism and closed-loop ultrasound neuromodulation based on electroencephalograph are also ***,high-frequency acoustic noninvasive brain-computer interface is prospected based on ultrasound super-resolution imaging and acoustic tweezers.

关键词： breakthrough computer Computer

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Investigation on the vortical structures by the Liutex method in turbulent channels at Re_(τ)=180 with scalloped and triangular riblet control

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Journal of Hydrodynamics 2024年第1期36卷 35-52页

作者： Zhang-dan Yu Shang Jiang hai-dong Yu Bi-yu Pang Xin dong Yi-qian Wang School of Mathematical Sciences Soochow UniversitySuzhou215006China Beijing Institute of Astronautical System Engineering Beijing100076China

Riblets are a series of small protrusions formed along the flow direction,which have been extensively studied as a passive turbulent drag reduction *** and numerical simulations have shown that well-designed riblets can significantly reduce drag in turbulent flows,making them highly promising and valuable for various *** this study,we focus on a scalloped riblet,which is designed by smoothly connecting two third-order polynomials,and thus the sharpness of the tip and the curvature of the valley can be well *** conduct direct numerical simulations of turbulent channel with smooth plate,scalloped riblet-mounted and triangular riblet-mounted *** in wall units of W^(+)=20 and height-width ratio ofγ=0.5 are selected for both riblet *** with the smooth plate case,the scalloped riblet case achieves an 8.68%drag reduction,while the triangular riblet case achieves a 4.79%drag *** obtained drag reduction rate of the triangular riblet is consistent with previous experiments and simulations,and the results indicate that the scalloped riblet is more effective in reducing drag and deserves further *** compare turbulent statistics of the scalloped riblet case with those of the triangular riblet *** mean velocity profiles of riblets are similar,but both the Reynolds shear stress and second-order statistics of velocity fluctuations and Liutex are significantly reduced in the scalloped riblets controlled turbulent channel,indicating that the scalloped riblet can more effectively suppress the spanwise and wall-normal turbulent intensity near the *** also compare the pre-multiplied spectra of streamwise velocity and streamwise Liutex component for the three cases to investigate the energy distribution and characteristics of Liutex *** Liutex vortex identification method is also utilized to analyze the instantaneous flow field,which provides insights into the flow field and could be bene

关键词： Liutex vector riblet drag reduction tip sharpness turbulent channel scalloped

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