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Fas/FasL and Complement Activation are Associated with Chronic Active Epstein-Barr Virus Hepatitis

Journal of Clinical and Translational Hepatology 2023年第3期11卷 540-549页

作者： Jing lin Miao-Fang su Jiao-Long Zheng Lei Gu hai-Cong Wu Xia Wu hai-Yan lin Zhi-Xian Wu Dong-Liang Li Department of Hepatobiliary Medicine Fuzong Clinical Medical College of Fujian Medical University900TH Hospital of the Joint Logistic Support ForcePLAFuzhouFujianChina Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Background and Aims:Chronic active Epstein-Barr virus hepatitis(CAEBVH)is a rare and highly lethal disease char-acterized by hepatitis and *** study aimed to investigate the clinicopathological features and pathogenic mechanisms of ***:Ten patients with con-firmed Epstein-Barr virus hepatitis infection were *** clinicopathological characteristics of these patients were summarized and *** cytometry was utilized to detect peripheral blood immune cell phenotypes and whole exome sequencing was used to explore pathogenic genetic ***,immunohistochemical staining was em-ployed to verify pathogenic ***:Clinical features observed in all Epstein-Barr virus hepatitis patients included fever(7/10),splenomegaly(10/10),hepatomeg-aly(9/10),abnormal liver function(8/10),and CD8+T cell lymphopenia(6/7).Hematoxylin and eosin staining revealed lymphocytic infiltration in the *** Epstein-Barr vi-rus-encoded small RNA in-situ hybridization(EBER-ISH)of lymphocytes of liver tissues was *** exome se-quencing indicated that cytotoxic T lymphocytes and the complement system were *** expression of CD8,Fas,FasL,and Caspase-8 expression as well as apoptotic markers was enhanced in the Epstein-Barr virus hepatitis group relative to the controls(p<0.05).Lastly,Complement 1q and complement 3d expression,were higher in CAEBVH patients relative to controls(p<0.05).Conclusions:CAE-BVH patients developed fever,hepatosplenomegaly,and *** changes were a diffuse lymphocytic sinusoidal infiltrate with EBER-ISH ***/FasL and complement activation were involved in CAE-BVH patients.

关键词： Chronic active EB virus hepatitis Fas/FasL Complement

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Design of Self‑Reconfigurable Multiarm Robot Mechanism Based on Deployable Kinematic Chains

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Chinese Journal of Mechanical Engineering 2020年第5期33卷 34-50页

作者： Fu‑Qun Zhao Sheng Guo hai‑Jun su hai‑Bo Qu Ya‑Qiong Chen School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China

As the structures of multiarm robots are serially arranged,the packaging and transportation of these robots are often *** ability of these robots to operate objects must also be *** this issue,this paper presents a type of multiarm robot that can be adequately folded into a designed *** robot can achieve different operation modes by combining different arms and ***,deployable kinematic chains(DKCs)are designed,which can be folded into a designated area and be used as an arm structure in the multiarm robot *** strategy of a platform for storing DKCs is *** on the restrictions in the storage area and the characteristics of parallel mechanisms,a class of DKCs,called base assembly library,is ***,an assembly method for the synthesis of the multiarm robot mechanism is proposed,which can be formed by the connection of a multiarm robot mechanism with an operation object based on a parallel mechanism *** formed parallel mechanism can achieve a reconfigurable characteristic when different DKCs connect to the operation *** this method,two types of multiarm robot mechanisms with four DKCs that can switch operation modes to perform different tasks through autonomous combination and release operation is *** obtained mechanisms have observable advantages when compared with the traditional mechanisms,including optimizing the occupied volume during transportation and using parallel mechanism theory to analyze the switching of operation modes.

关键词： Design Multiarm robot Deployable kinematic chain Parallel mechanism Motion set

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Formation and impact-induced separation of tandem EFPs

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Defence Technology（防务技术） 2020年第3期16卷 668-677页

作者： Hong-bing Ma Yuan-feng Zheng hai-fu Wang Chao Ge Cheng-hai su State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

The formation and separation behaviors of tandem EFPs are studied by the combination of experiments and *** results show that different formation and separation processes can be obtained by adjusting the double-layer liners,and simulations agree with experiments ***,the interaction process between the two liners is discussed in details,and the formation and separation mechanism are *** can be found that there are four phases in the formation and separation processes,including impact phase,propulsion phase,slide phase and free flight *** the impact phase,the velocities of two liners rise in turns with kinetic energy *** the propulsion phase,the axial impact becomes insignificant,but the radial interaction between two liners influences the appearance of tandem ***,it should be mentioned that the inner surface of foregoing EFP remains to be in contact with the outer surface of following EFP in the propulsion phase,and the following one would continue to push the foregoing one for about 10μ to 20 μs,causing the velocities of following and foregoing EFPs gradually decreasing and increasing *** the slide phase,an obvious relative movement occurs between the two EFPs,and there would be barely kinetic energy ***,the two EFPs separate gradually and get into the phase of free ***,if the outer and inner liners have the same thickness,the outer copper-inner copper liners form two long EFPs,the outer copper-inner steel liners become a foregoing short steel EFP and a following long copper EFP,and the outer steel-inner copper liners produce a foregoing long copper EFP and a following conical steel *** addition,thickness match also has an important impact on formation appearance and separation process for both outer copperinner copper liners and outer steel-inner copper *** the thickness ratio of outer liner to inner liner decreasing,the length and length-diameter ratio of both foreg

关键词： Shaped charge liner Tandem EFPs Formation Separation

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Insight into the particle shape on the impact of dry granular flow against a rigid barrier: A DEM study

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Journal of Earth Science 2025年

作者： Rui-Xiao Zhan Dong su Xiang-Sheng Chen Yuan-Jun Jiang Guo-Ping Lei Jing-Jing Yu Key Laboratory for Resilient Infrastructures of Coastal Cities (MOE)， Shenzhen University College of Civil and Transportation Engineering， Shenzhen University School of Architecture and Urban Planning， Shenzhen University Shenzhen Key Laboratory of Green， Efficient and Intelligent Construction of Underground Metro Station， Shenzhen University Institute of Mountain Hazards and Environment， Chinese Academy of Sciences School of Transportation， Civil Engineering & Architecture， Foshan University

The effect of particle shape on the impact of dry granular flow remains an open area for further investigation. Five distinct particle shapes were examined in this study using discrete element simulations after calibrating the numerical model using a published work. The findings indicated that the particle shape had a significant influence on granular mobility. With negligible variations in normalized kinetic energy between particles of different shapes， the effect of particle shape on the increasing rate of kinetic energy became more obvious. All irregular particle scenarios had longer accumulated particle lengths down the channel than spherical particles. Variations in particle shape led to adjustments in the distribution of impact forces on the barrier. These findings substantially enhance our understanding of the distinctive effects of particle shapes on the impact mechanism of dry granular flow.

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Effect of pouring time on microstructure and mechanical properties of centrifugal cast Ti-46Al alloy tubes

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China Foundry 2025年

作者： Gang Huang Qian Dang Cong-cong su Jing Zhao Chi Zhang Guo-huai Liu Zhao-dong Wang The State Key Laboratory of Rolling and Automation Northeastern University School of Materials Science and Engineering Shenyang University of Technology

The grain size of TiAl alloy castings prepared by traditional casting process is coarse, thus showing poor mechanical properties. In this study, a new type of high performance Ti-46Al alloy tube prepared by vacuum centrifugal casting technology was introduced. This research comprehensively examined the influence of pouring time on the microstructure and mechanical performance of the castings, employing both experimental approaches and ProCast simulation methodologies. The findings indicate that prolonging the pouring time facilitates a microstructural evolution from coarse columnar grains to refined equiaxed grains. Under the condition of pouring temperature of 1,600 °C, rotation speed of 800 r·min-1and pouring time of 6 s, the tensile strength of Ti-46Al alloy at room temperature reaches 650 MPa, and the tensile strength at 800 °C reaches 705 MPa, which is significantly higher than that of traditional as-cast Ti-Al alloy.

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UBP12/UBP13-mediated deubiquitination of salicylic acid receptor NPR3 suppresses plant immunity

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Molecular Plant 2023年第1期16卷 232-244页

作者： Yu Zhou su-Hyun Park Nam-hai Chua Temasek Life Sciences Laboratory National University of Singapore1 Research LinkSingapore 117604Singapore Disruptive&sustainable Technologies for Agricultural Precision Singapore-MIT Alliance for Research and Technology1 CREATE WaySingapore 138602Singapore

Salicylic acid(SA),a defense hormone produced after pathogen challenge,is critical for plant *** NONEXPRESSER OF PR GENES 1(NPR1)and its paralogs NPR3 and NPR4 can bind SA and mediate SA signal ***1 functions as a transcriptional co-activator to promote defense gene expression,whereas NPR3 and NPR4 have been shown to function as negative regulators in the SA signaling *** the mechanism about NPR1 regulation has been well studied,how NPR3/NPR4 proteins are regulated in immune responses remains largely ***,we show that the stability of NPR3/NPR4 is enhanced by *** the absence of pathogen challenge,NPR3/NPR4 are unstable and degraded by the 26S proteasome,whereas the increase in cellular SA levels upon pathogen infection suppresses NPR3/NPR4 *** found that UBP12 and UBP13,two homologous deubiquitinases from a ubiquitin-specific protease subfamily,negatively regulate plant immunity by promoting NPR3/NPR4 *** genetic results further showed that UBP12/UBP13-mediated immunity suppression is partially dependent on NPR3/NPR4 *** interacting with NPR3 in the nucleus in an SA-dependent manner,UBP12 and UBP13 remove ubiquitin from polyubiquitinated NPR3 to protect it from being *** stabilization of NPR3/NPR4 promoted by UBP12/UBP13 is essential for negative regulation of basal and SA-induced immunity.

关键词： plant immunity salicylic acid NPR3 UBP12/UBP13

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Theoretical Study on the Intermolecular Interactions of Tetrazole Dimers

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Chinese Journal of Structural Chemistry 2005年第10期24卷 1203-1210页

作者： ZHOU su-Qin JU Xue-hai XIAO He-Ming Department of Chemistry Nanjing University of Science and Technology Nanjing 210094 China

Tetrazole monomers （Ⅰ, Ⅱ） and all of their possible stable dimers （1, 2, 3, 4, 5, 6, 7 and 8） were fully optimized by DFT method at the B3LYP/6-311＋＋G^＊＊ level. Among the eight dimers, there were two 1H-tetrazole dimers, three 2H-tetrazole dimers and three hetero dimers of 1H-tetrazole and 2H-tetrazole. Vibrational frequencies were calculated to ascertain that each structure was stable （no imaginary frequencies）. The basis set superposition errors （BSSE） are 2.78, 2.28, 2.97, 2.75, 2.74, 2.18, 1.23 and 3.10 kJ/mol, and the zero point energy （ZPE） corrections for the interaction energies are 4.88, 4.18, 3.87, 3.65, 3.54, 3.22, 2.87 and 4.34 kJ/mol for 1, 2, 3, 4, 5, 6, 7 and 8, respectively. After BSSE and ZPE corrections, the greatest corrected intermolecular interaction energy of the dimers is -43.71 kJ/mol. The charge redistribution mainly occurs on the adjacent N-H…N atoms between submolecules. The charge transfer between two subsystems is very small. Natural bond orbital （NBO） analysis was performed to reveal the origin of the interaction. Based on the statistical thermodynamic method, the standard thermodynamic functions, heat capacities （C^0P）, entropies （S^0T） and thermal corrections to enthalpy （H^0T）, and the changes of thermodynamic properties from monomer to dimer in the temperature range of 200.00 K to 700 K have been obtained. 1H-tetrazole monomer can spontaneously turn into two stable dimers at 298.15 K.

关键词： tetrazole dimer intermolecular interaction DFT natural bond orbital,thermodynamic properties

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Chain damage effects of multi-spaced plates by reactive jet impact

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Defence Technology（防务技术） 2021年第2期17卷 393-404页

作者： Yuan-feng Zheng Cheng-hai su Huan-guo Guo Qing-bo Yu hai-fu Wang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

Chain damage is a new phenomenon that occurs when a reactive jet impacts and penetrates multispaced *** reactive jet produces mechanical perforations on the spaced plates by its kinetic energy(KE),and then results in unusual chain rupturing effects and excessive structural damage on the spaced plates by its deflagration *** the present study,the chain damage behavior is initially demonstrated by *** reactive liners,composed of 26 wt%Al and 74 wt%PTFE,are fabricated through a pressing and sintering *** reactive liner thicknesses of 0.08 CD,0.10 CD and 0.12 CD(charge diameter)are chosen to carry out the chain damage *** results show a chain rupturing phenomenon caused by reactive *** constant reaction delay time and the different penetration velocities of reactive jets from liners with different thicknesses result in the variation of the deflagration position,which consequently determines the number of ruptured plates behind the ***,the finite-element code AUTODYN-3D has been used to simulate the kinetic energy only-induced rupturing effects on plates,based on the mechanism of behind armor debris(BAD).The significant discrepancies between simulations and experiments indicate that one enhanced damage mechanism,the behind armor blast(BAB),has acted on the ruptured ***,a theoretical model is used to consider the BAB-induced enhancement,and the analysis shows that the rupturing area on aluminum plates depends strongly upon the KE only-induced pre-perforations,the mass of reactive materials,and the thickness of plates.

关键词： Reactive materials Reactive jet Chain damage Behind armor blast

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New coordination scheme for multi-robot systems based on state space models

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Journal of Systems Engineering and Electronics 2008年第4期19卷 722-734页

作者： Xie Wenlong su Jianbo lin Zongli Dept. of Automation Shanghai Jiaotong Univ. Shanghai 200240 P. R. China Charles L. Brown Dept. of Electrical and Computer Engineering Univ of Virginia Charlottesville VA 22904-4743 USA

A new coordination scheme for multi-robot systems is proposed. A state space model of the multi- robot system is defined and constructed in which the system＇s initial and goal states are included along with the task definition and the system＇s internal and external constraints. Task accomplishment is considered a transition of the system state in its state space （SS） under the system＇s constraints. Therefore, if there exists a connectable path within reachable area of the SS from the initial state to the goal state, the task is realizable. The optimal strategy for the task realization under constraints is investigated and reached by searching for the optimal state transition trajectory of the robot system in the SS. Moreover, if there is no connectable path, which means the task cannot be performed successfully, the task could be transformed to be realizable by making the initial state and the goal state connectable and finding a path connecting them in the system＇s SS. This might be done via adjusting the system＇s configuration and/or task constraints. Experiments of multi-robot formation control with obstacles in the environment are conducted and simulation results show the validity of the proposed method.

关键词： multi-robot system coordination state space formation maneuver subgoal

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Coinfection of SARS-CoV-2 Omicron variant and other respiratory pathogens in children

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World Journal of Pediatrics 2024年第1期20卷 92-96页

作者： Wei Li Bing-Han Wang Bao-hai Chen Yi sun lin Li Wen-Qing Xiang Ahmed Faisal Ali lin-Xuan su hai-Yan Mao Hong-Qiang Shen Qiang Shu Department of Clinical Laboratory Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina School of Public Health Zhejiang University School of MedicineHangzhouChina Department of Information Center Children's HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouChina Department of Thoracic&Cardiovascular surgery Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina

Since the outbreak of coronavirus disease 2019(COVID-19),the entire world has been affected by the epidemic[1,2].On November 9,2021,a variant of the novel coronavirus B.1.1.529 was detected for the first time from case samples in South *** Omicron strain spread and mutated significantly *** variant has the characteristics of escape immunity,which can induce relatively extreme disease and reduce the neutralization of antibodies in vaccinators,and is more likely to be reinfected[3,4].The clinical presentation of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)in children has mild symptoms and a lower risk of hospitalization and death.

关键词： respiratory immunity acute

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