检索结果-南通市图书馆

Journal of Integrative Plant Biology 2009年第6期51卷 537-544页

作者： hai-lin qin an-jun deng guan-hua du peng wang jin-lan zhang zhi-hong li Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Key Laboratory of Bioactive Substances and Resources of Chinese Herbal Medicine Ministry of Education Beijing 100050 China

The ^1 H nuclear magnetic resonance （^1 H NMR） fingerprints of fractionated non-polar extracts （control substance for a plant drug （CSPD） A） from Rhizoma chuanxiong, the rhizomes of ligusticum chuanxiong Hort., of seven specimens from different sources were measured on Fourier Transform （FT）-NMR spectrometer and assigned by comparing them with the ^1 H NMR spectra of the isolated pure compounds. The ^1 H NMR fingerprints showed exclusively characteristic resonance signals of the major special constituents of the plant. Although the differences in the relative intensity of the ^1H NMR signals due to a discrepancy in the ratio of the major constituents among these samples could be confirmed by high performance liquid chromatography analysis, the general features of the ^1H NMR fingerprint established for an authentic sample of the rhizomes of L. chuanxiong e. hibited exclusive data from those special compounds and can be used for authenticating L. Chuanxiong species.

关键词： control substance for a plant drug A ^1 H nuclear magnetic resonance fingerprint high performance liquid chromatography ligusticumchuanxiong phenylpropenoid phthalides.

Genetic variation of yellow pigment and its components in foxtail millet(Setaria italica(L.) ***.) from different eco-regions in China

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Journal of Integrative Agriculture 2017年第11期16卷 2459-2469页

作者： YANG Yan-bing JIA guan-qing deng li-gang qin ling CHEN Er-ying CONG Xin-jun ZOU Ren-feng wang hai-lian zhang hua-wen liU Bin guan Yan-an DIAO Xian-min YIN Yan-ping College of Agronomy Shandong Agricultural University/State Key Laboratory of Crop Biology Crop Research Institute Shandong Academy of Agricultural Sciences Institute of Crop Sciences Chinese Academy of Agricultural Sciences Institute of Quality Standard and Testing Technology for Agro-Products Shandong Academy of Agricultural Sciences Institute of Minor Crops Tai'an Academy of Agricultural Sciences

Kernel color is an important trait for assessing the commercial and nutritional quality of foxtail millet. Yellow pigment content （YPC） and carotenoid components （lutein and zeaxanthin） of 270 foxtail millet accessions, including 50 landraces and 220 improved cultivars, from four different eco-regions in China were surveyed using spectrophotometry and high performance liquid chromatography methods. Results indicated that YPC had rich variance, ranging from 1.91 to 28.54 mg kg-1, with an average value of 17.80 mg kg-1. The average YPC of improved cultivars （18.31 mg kg-1） was significantly higher than that of landraces （15.51 mg kg-l）. The YPC in cultivars from the Loess Plateau spring sowing region （LPSSR） was the highest （20.59 mg kg-~）, followed by the North China summer sowing region （NCSSR, 18.25 mg kg-1）, the northeast spring sowing region （NSSR, 17.25 mg kg-1）, and the Inner Mongolia Plateau spring sowing region （IMPSSR, 13.92 mg kg-1）. The variation coefficients of YPC in cultivars from NSSR, LPSSR, and IMPSSR were higher than that from NCSSR. A similar carotenoid profile was also obtained for 270 foxtail millet cultivars. Lutein and zeaxanthin accounted for approximately 55-65% of YPC in accessions. The lutein content was higher than zeaxanthin content in all cultivars. The ratio of lutein to zeaxanthin ranged from 1.51 to 6.06 with an average of 3.34. YPC was positively correlated with lutein （r=0.935, P〈0.01）, zeaxanthin （r=0.808, P〈0.01 ）, and growth duration （t=0.488, P〈0.01 ）, whereas it was negatively correlated with grain protein （t=-0.332, P〈0.01） and 1 000-kernel weight （t=-0.153, P〈0.05）. Our study is useful for screening and selecting cultivars with high levels of yellow pigment and for enhancing phytochemical concentrations in breeding programs.

关键词： foxtail millet yellow pigment lutein zeaxanthin eco-regions

Prediction of energy resolution in the junO experiment

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Chinese Physics C 2025年第1期49卷 35-59页

作者： Angel Abusleme Thomas Adam Kai Adamowicz Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Joao Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Marco Beretta Antonio Bergnoli Daniel Bick Lukas Bieger Svetlana Biktemerova Thilo Birkenfeld Iwan Blake David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai zhiyan Cai Stéphane Callier Steven Calvez Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao jun Cao Rossella Caruso Cédric Cerna Vanessa Cerrone jinfan Chang Yun Chang Auttakit Chatrabhuti Chao Chen Guoming Chen Pingping Chen Shaomin Chen Xin Chen Yiming Chen Yixue Chen Yu Chen Zelin Chen zhangming Chen zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng YuChin Cheng Alexander Chepurnov Alexey Chetverikov Davide Chiesa Pietro Chimenti Yen-Ting Chin Po-lin Chou Ziliang Chu Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Marta Colomer Molla Selma Conforti Di Lorenzo Alberto Coppi Daniele Corti Simon Csakli Chenyang Cui Flavio Dal Corso Olivia Dalager Jaydeep Datta Christophe De La Taille zhi deng Ziyan deng Xiaoyu Ding Xuefeng Ding Yayun Ding Bayu Dirgantara Carsten Dittrich Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Wei Dou Marcos Dracos Frédéric Druillole Ran du Shuxian du Katherine dugas Stefano dusini hongyue duyang Jessica Eck Timo Enqvist Andrea Fabbri Ulrike Fahrendholz Lei Fan Jian Fang Wenxing Fang Dmitry Fedoseev li-Cheng Feng Qichun Feng Federico Ferraro Amélie Fournier Fritsch Fritsch Haonan Gan Feng Gao Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar guanghua Gong Hui Gong Yuri Gornushkin Marco Grassi Maxim Gromov Vasily Gromov Minghao G Yerevan Physics Institute YerevanArmenia Université libre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Millennium Institute for SubAtomic Physics at the High-energy Frontier(SAPHIR) ANIDChile Pontificia Universidad Católica de Chile SantiagoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina jinan University GuangzhouChina Sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Nanjing University NanjingChina guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National

This paper presents an energy resolution study of the junO experiment,incorporating the latest knowledge acquired during the detector construction *** determination of neutrino mass ordering in junO requires an exceptional energy resolution better than 3% at 1 *** achieve this ambitious goal,significant efforts have been undertaken in the design and production of the key components of the junO *** factors affecting the detection of inverse beta decay signals have an impact on the energy resolution,extending beyond the statistical fluctuations of the detected number of photons,such as the properties of the liquid scintillator,performance of photomultiplier tubes,and the energy reconstruction *** account for these effects,a full junO simulation and reconstruction approach is *** enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy *** results of this study reveal an energy resolution of 2.95% at 1 ***,this study assesses the contribution of major effects to the overall energy resolution *** analysis serves as a reference for interpreting future measurements of energy resolution during junO data ***,it provides a guideline for comprehending the energy resolution characteristics of liquid scintillator-based detectors.

关键词： energy resolution liquid scintillator detector junO simulation reconstruction

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai deng Xiao-Wei liu Yi-peng jing Gang wang Hao-Tong zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin hai-Yuan Chen Jian-jun Chen Kun-Xin Chen li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing du Dong-Wei Fan Lei Feng Jian-Ning Fu peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-liang He jin-liang Hou Yong-Hui Hou Wen Hou hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu zhi-Ying Huo Lei Jia Fang-hua Jiang Xiang Jiang zhi-Bo Jiang Ge jin Xiao Kong Xu Kong Ya-Juan Lei Ai-hua li Chang-hua li guang-Wei li hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-Ping li Yuan liang Chien-Cheng lin Chao liu Gen-Rong liu guan-Qun liu zhi-Gang liu Wen-zhi Lu Yu Luo Yin-dun Mao Heidi Newberg Ji-jun Ni Zhao-Xiang Qi Yong-jun Qi Shi-Yin Shen Huo-Ming Shi jing Song Yi-Han Song Ding-Qiang Su hong-jun Su Zheng-hong Tang qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang hai wang hong-Chi wang Jian wang Jia-Ning wang Jian-ling wang Jian-Ping wang jun-Xian wang Lei wang Meng-Xin wang Shou-guan wang Shu-qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang peng Wei Ming-zhi Wei hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-hua Yang hai-Feng Yang Hui-qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan hai-Bo Yuan hai-Long Yuan Wei-Min Yuan Chao Zhai En-peng zhang hua-Wei zhang Jian-Nan zhang li-Pin zhang Wei zhang Yong zhang Yan-Xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3142-3154页

作者： Jiejie Geng liang Chen Yufeng Yuan Ke wang Youchun wang Chuan qin Guizhen Wu Ruo Chen Zheng zhang Ding Wei peng du jun zhang peng lin Kui zhang Yongqiang deng Ke Xu Jiangning liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang ling li Kun zhang Zhe wang jing zhang qingguo Yan hua Zhu Zhaohui Zheng jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue liang Yatao wang qingyi wang Wen Xie Yirong li Mingyan Shi Huijie Bian Ping Zhu zhi-Nan Chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi'an 710032China School of Medicine Shanghai UniversityShanghai 200444China Zhongnan Hospital of Wuhan University Wuhan 430071China Division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)and WHO Collaborating Center for Standardization and Evaluation of BiologicalsBeijing 102629China Institute of Laboratory Animals Science Chinese Academy of Medical SciencesBeijing 100071China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 100871China Beijing Institute of Biotechnology Beijing 100871China Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'an 710032China Beijing Institute of Microbiology and Epidemiology Beijing 100071China School of Basic Medicine Fourth Military Medical UniversityXi'an 710032China Jiangsu Pacific Meinuoke Biopharmceutical Co.Ltd Changzhou 213022China

SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing *** in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 ***,we identified CD147 as a universal receptor for SARS-CoV-2 and its ***,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,***,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and *** infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling ***,we proposed that severe COVID-19-related cytokine storm is induced by a"spike protein-CD147-CyPA signaling axis":Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK ***,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine ***,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its ***,our findings provided a new perspective for severe COVID-19-related ***,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment.

关键词： CD147 cytokine storm

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu Yue huang guang-Cheng Xiao qing-Cui Bu jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei Jia Fang-jun Lu Xiang Ma lian Tao Wei zhang li Chen li-Ming Song Ti-Pei li Yu-peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen Yu-peng Chen Wei Cui Wei-Wei Cui jing-Kang deng Yong-Wei Dong Yuan-Yuan du Min-Xue Fu guan-hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-hua Jiang Wei-Chun Jiang jing jin Yong-Jie jin ling-Da Kong Bing li Cheng-Kui li Gang li Mao-Shun li Wei li Xian li Xiao-Bo li Xu-Fang li Yang-Guo li Zheng-Wei li Xiao-hua liang jing-Yuan liao Bai-Sheng liu Guo-qing liu hong-Wei liu Xiao-jing liu Yi-Nong liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song liang Sun Ying Tan You-li Tuo Chen wang Guo-Feng wang Juan wang ling-jun wang Weng-Shuai wang Yu-Sa wang Xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-lin Xiong He Xu Jia-Wei Yang Sheng Yang Yan-Ji Yang Yi-jung Yang Qi-Bin Yi Qian-qing Yin Yuan You Ai-Mei zhang Cheng-Mo zhang Fan zhang hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang Yong-Jie zhang Yuan-Hang zhang Yue zhang Zhao zhang zhi zhang Zi-liang zhang hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-guang Zheng deng-Ke Zhou Jian-Feng Zhou Yu-Xuan Zhu Ren-lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Immunogenicity and safety of a recombinant fusion protein vaccine(V-01)against coronavirus disease 2019 in healthy adults:a randomized,double-blind,placebo-controlled,phaseⅡtrial

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Chinese Medical Journal 2021年第16期134卷 1967-1976页

作者： Ya-jun Shu Jian-Feng He Rong-Juan Pei peng He Zhu-Hang huang Shao-Min Chen zhi-Qiang Ou jing-Long deng Pei-Yu Zeng Jian Zhou Yuan-qin Min Fei deng hua peng Zheng zhang Bo wang Zhong-Hui Xu Wu-Xiang guan Zhong-Yu Hu Ji-Kai zhang guangdong Provincial Institute of Biological Products and Materia Medica GuangzhouGuangdong 510440China guangdong Provincial Center for Disease Control and Prevention GuangzhouGuangdong 511430China Wuhan Institute of Virology Chinese Academy of SciencesWuhanHubei 430071China National Institutes for Food and Drug Control Beijing 100050China Gaozhou Center for Disease Control and Prevention MaomingGuangdong 525000China livzon Bio Inc. ZhuhaiGuangdong 519045China Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalShenzhenGuangdong 518112China.

Background:Innovative coronavirus disease 2019(COVID-19)vaccines,with elevated global manufacturing capacity,enhanced safety and efficacy,simplified dosing regimens,and distribution that is less cold chain-dependent,are still global imperatives for tackling the ongoing pandemic.A previous phase I trial indicated that the recombinant COVID-19 vaccine(V-01),which contains a fusion protein(IFN-PADRE-RBD-Fc dimer)as its antigen,is safe and well tolerated,capable of inducing rapid and robust immune responses,and warranted further testing in additional clinical ***,we aimed to assess the immunogenicity and safety of V-01,providing rationales of appropriate dose regimen for further efficacy ***:A randomized,double-blind,placebo-controlled phaseⅡclinical trial was initiated at the Gaozhou Municipal Centre for Disease Control and Prevention(guangdong,China)in March *** younger(n=440;18–59 years of age)and older(n=440;≥60 years of age)adult participants in this trial were sequentially recruited into two distinct groups:two-dose regimen group in which participants were randomized either to follow a 10 or 25 mg of V-01 or placebo given intramuscularly 21 days apart(allocation ratio,3:3:1,n=120,120,40 for each regimen,respectively),or one-dose regimen groups in which participants were randomized either to receive a single injection of 50 mg of V-01 or placebo(allocation ratio,3:1,n=120,40,respectively).The primary immunogenicity endpoints were the geometric mean titers of neutralizing antibodies against live severe acute respiratory syndrome coronavirus 2,and specific binding antibodies to the receptor binding domain(RBD).The primary safety endpoint evaluation was the frequencies and percentages of overall adverse events(AEs)within 30 days after full ***:V-01 provoked substantial immune responses in the two-dose group,achieving encouragingly high titers of neutralizing antibody and anti-RBDimmunoglobulin,which peaked at day 35(161.9[95%

关键词： COVID-19 PhaseⅡ Clinical trial Recombinant fusion protein vaccine Safety Immunogenicity

Efficacy and Safety of All-oral,12-week Ravidasvir Plus Ritonavir-boosted Danoprevir and Ribavirin in Treatment-naive Noncirrhotic HCV Genotype 1 Patients:Results from a Phase 2/3 Clinical Trial in China

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Journal of Clinical and Translational Hepatology 2019年第3期7卷 213-220页

作者： Xiaoyuan Xu Bo Feng Yujuan guan Sujun Zheng Jifang Sheng Xingxiang Yang Yuanji Ma Yan huang Yi Kang Xiaofeng Wen jun li Youwen Tan qing He qing Xie Maorong wang Ping An Guozhong Gong Huimin liu qin Ning Rui hua Bo Ning Wen Xie Jiming zhang Wenxiang huang Yongfeng Yang Minghua lin Yingren Zhao Yanhong Yu Jidong Jia Dongliang Yang liang Chen Yinong Ye Yuemin Nan Zuojiong Gong Quan zhang peng Hu Fusheng wang Yongguo li Dongliang li Zhansheng Jia jinlin Hou Chengwei Chen jinzi JWu Lai Wei Peking University First Hospital BeijingChina Peking University People's Hospital BeijingChina guangzhou Eighth People's Hospital GuangzhouChina Beijing YouAn Hospital Capital Medical UniversityBeijingChina The First Affiliated Hospital of Medical School of Zhejiang University HangzhouChina Sichuan Provincial People's Hospital ChengduChina West China Hospital Sichuan UniversityChengduChina Xiangya Hospital Central South UniversityChangshaChina Henan Provincial People's Hospital ZhengzhouChina liuzhou People's Hospital LiuzhouChina Jiangsu Province Hospital NanjingChina Zhenjiang No.3 People's Hospital ZhenjiangChina The Third People's Hospital of Shenzhen ShenzhenChina Ruijin Hospital Shanghai Jiaotong University School of MedicineShanghaiChina People's liberation Army Bayi Hospital NanjingChina Shenyang Sixth People's Hospital ShenyangChina The 2nd Xiangya Hospital of Central South University ChangshaChina Xixi Hospital of Hangzhou HangzhouChina Tongji Medical College of huazhong University of Science&Technology WuhanChina The First Hospital of Jilin University ChangchunChina Baoji Center Hospital BaojiChina Beijing Ditan Hospital BeijingChina huashan Hospital Affiliated to Fudan University ShanghaiChina Chongqing Medical University No.1 Affiliated Hospital ChongqingChina The Second Hospital of Nanjing NanjingChina Fujian Fuzhou Municipal Infectious Disease Hospital FuzhouChina No.1 Affiliated Hospital of Xi'an Jiaotong University Xi'anChina The First Affiliated Hospital of guangxi Medical University NanningChina Beijing Friendship Hospital Capital Medical UniversityBeijingChina Wuhan Union Hospital WuhanChina Shanghai Public Health Clinical Center ShanghaiChina Foshan No.1 People's Hospital FoshanChina The Third Hospital of Hebei Medical University ShijiazhuangChina Wuhan University Renmin Hospital WuhanChina The Affiliated Hospital of Guizhou Medical University GuiyangChina The Second Affiliated Hospital of Chongqing Medical University ChongqingChina PLA 302 Hospital Be

Background and Aims:Ravidasvir(RDV)is a new generation pangenotypic hepatitis C virus(HCV)NS5A inhibitor,with high barrier to baseline resistance-associated *** is the first phase 2/3 study conducted in China's Mainland confirming the efficacy and safety of RDV+ritonavir-boosted danoprevir+ribavirin for 12 weeks in treatment-naive noncirrhotic patients with genotype 1 infection in a large ***:In this multicenter,randomized,doubleblinded,placebo-controlled phase 2/3 trial(NCT03362814),we enrolled 424 treatment-nafve,noncirrhotic adult HCV genotype 1 *** patients were randomized at 3∶1 ratio to receive a combination of RDV 200mg once daily plus ritonavir-boosted danoprevir 100mg/100mg twice daily and oral ribavirin 1000/1200mg/day(body weightline NS5A resistance-associated species in the treatment group(76/76,per protocol set)achieved sustained virological response at 12 weeks after *** treatment-related serious adverse events were *** abnormalities showed mild or moderate severity(grade 1 and grade 2)in liver function ***:In treatment-na(i)ve,noncirrhotic HCV Chinese patients infected with HCV genotype 1,all-oral regimen of RDV+ritonavir-boosted danoprevir+ribavirin for 12 weeks was highly efficacious,safe,and well tolerated.

关键词： Ravidasvir Danoprevir HCV SVR Treatment-naive Noncirrhotic GT1

Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen Yan-Fen Chai Xiao-Hui Chen Yu-Guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding Yang deng Jie Fu Bang-Jiang Fang Mai-Ying Fan li Gui Ping Gong Wei Guo Shu-Bin Guo liang huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji hong-Xu jin Xin-jun Jiang wang-Xiang Jiang Jia-liang liu Xiao-Ran liu zhi liu Chuan-Zhu Lv Feng Lu Tan-Shi li Xin li Yong li Shang-Lun li Shuang-Ming li Xiao-Gang li Bao-jun li Pei-Wu li Chun-Sheng li zhi-jun li Chang-Luo li Xiang-Min li Yin-Ping li Zong-jun Lu Zu-Xun Lu Zhong-Qiu Lu zhi-Qian Luo Xiao-Xing liao Jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma qing-Bian Ma lin-Hao Ma jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-Yang peng peng Qiao Pei Shu-Ming Pan Guo-Zhong qing li-Jie qin Wu-Ying Qiao Fei Shao Wei Song Xing-Yue Song Zhen-Ju Song Rong-Ju Sun De-Ya Shang du-Juan Sha Gui-lan Tao Guo-Gang Tian Ying-Ping Tian Jian-guang Tian Chao-Yang Tong Zi-Ren Tang Meng-Xiong Tang Guo-Ping Wu zhi Wan Tao wang Xin wang peng wang Zhong wang Tong wang Ri-Xing wang Yi-Xin wang Xiao-Dan wang ling Wu Wei Wei hua Xiang Feng Xu jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu Wen Yi li-Shan Yang Shi-Jiao Yan jin-Jian Yao Shou-Chun Yan Xue-Zhong Yu Xian-zhi Ye Xian-liang Yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou Qiang Zhou jin Zhou Ping Zhou Chang-Ju Zhu hua-Dong Zhu Ji-hong Zhu hong zhang Mao zhang hua zhang Na zhang Guo-Qiang zhang Guo-Xiu zhang jin-Song zhang Wen-Wu zhang Wen-Zhong zhang Jian-Feng zhang Yi-Min Zhu jun Zeng Yuan Zheng zhi-Jie Zheng Shen Zhao Yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-jing Zhao hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of hainan Trauma and Disaster Rescue Key Laboratory of Trauma of hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai haiying Cai huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen Huirun Chen jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue deng Wei-Tian deng zhi deng Ziyan deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jinR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise