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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang liao Mengru Cai Dongge Yin Tingting Fu Jing liu Yuji Du Jiahui Kong Rongrong Chang Jian Ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

Gastric intramural hematoma accompanied by severe epigastric pain and hematemesis after endoscopic mucosal resection

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World Journal of Gastroenterology 2012年第47期18卷 7127-7130页

作者： Peng Sun Shi-Yun Tan Guo-hai liao Department of Gastroenterology Renmin Hospital of Wuhan University

Gastric intramural hematoma is a rare injury of the stomach,and is most often seen in patients with underlying *** injury following endoscopic therapy is even rarer,and there are no universally accepted guidelines for its *** this case report,we describe a gastric intramural hematoma which occurred within 6 h of endoscopic mucosal resection(EMR).Past medical history of this patient was negative,and laboratory examinations revealed normal coagulation profiles and platelet *** EMR,the patient experienced severe epigastric pain and vomited 150 mL of gastric contents which were bright red in *** emergency endoscopy showed a 4 cm × 5 cm diverticulum-like defect in the anterior gastric antrum wall and a 4 cm × 8 cm intramural hematoma adjacent to the endoscopic submucosal dissection *** unsatisfactory temporary conservative management,the patient was treated surgically and made a complete ***,one possible reason for the patient's condition is that the arterioles in the submucosa or muscularis may have been damaged during deep and massive submucosal ***,endoscopists should be aware of this potential complication and improve the level of surgery,especially the skills required for submucosal injection.

关键词： Gastric intramural hematoma Endoscopic mucosal resection Complication

Host-guest co-assembly triggered turn-on and ratiometric sensing of berberine and its detoxicating

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Chinese Chemical Letters 2021年第4期32卷 1385-1389页

作者： Chuanfeng liu Zhixin li hai Yu Naibin Cui Xiaoyu liao haibin Zhang Zhengning Shu Peng Yang Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China

Fluorescent sensing for specific detection of berberine is an important issue in view of its potential jeopardization to food safety and human health,but remains less *** the best of our knowledge,there is no fluorescence turn-on and ratiometric sensors available for specific detection of *** this study,calix[4]carbazole(3)has been synthesized and its property of recognizing berberine ha s been evaluated by UV-vis,fluorescence,NMR,DLS and TEM *** results show that 3 selectively recognizes berberine among the tested drugs and detects it with turn-on and ratiometric fluorescence due to their co-assembly ***,3 is not only low toxic and can reduce toxicity of berberine to human normal liver L02 cell,but also can release berberine to tumor HepG2 cells at acid *** therefore holds a great potential for further exploration。

关键词： Recognition Macrocycle Host-guest Sensor Carbazole

Physical-Layer Authentication via a Dynamic Scaling

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Chinese Journal of Electronics 2020年第4期29卷 651-659页

作者： li Min JIANG Shaoquan liao Yongjian Institute of Information Security Mianyang Normal University School of Information and Software Engineering University of Electronic Science and Technology of China

Message authentication is a process that allows sender Alice to transmit a source state to receiver Bob such that the latter is assured of the *** study this problem in the physical-layer where the channel is degraded by a Rayleigh fading and a Gaussian *** propose an efficient construction for our *** idea is to amplify a basic codeword of the source state with a small but dynamic scaling *** scaling factor is asymptotically *** thus essentially incurs no power *** authentication is achieved through a statistical *** scheme is provably secure and performs better than the related existing ***,our error analysis allows it to be realized with very practical parameters.

关键词： Physical-layer authentication Information security Message authentication code

A perspective on recent methods on testing predictability of asset returns

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Applied Mathematics(A Journal of Chinese Universities) 2018年第2期33卷 127-144页

作者： liao Xiao-sai CAI Zong-wu CHEN hai-qiang The Wang Yanan Institute for Studies in Economics MOE Key Laboratory of Econometrics (Xiamen University) Fujian Provincial Key Laboratory of Statistical Science Xiamen University Department of Economics University of Kansas

This paper highlights some recent developments in testing predictability of asset returns with focuses on linear mean regressions, quantile regressions and nonlinear regression models. For these models, when predictors are highly persistent and their innovations are contemporarily correlated with dependent variable, the ordinary least squares estimator has a finite-sample bias, and its limiting distribution relies on some unknown nuisance parameter, which is not consistently estimable. Without correcting these issues, conventional test statistics are subject to a serious size distortion and generate a misleading conclusion in testing pre- dictability of asset returns in real applications. In the past two decades, sequential studies have contributed to this subject and proposed various kinds of solutions, including, but not limit to, the bias-correction procedures, the linear projection approach, the IVX filtering idea, the variable addition approaches, the weighted empirical likelihood method, and the double-weight robust approach. Particularly, to catch up with the fast-growing literature in the recent decade, we offer a selective overview of these methods. Finally, some future research topics, such as the econometric theory for predictive regressions with structural changes, and nonparametric predictive models, and predictive models under a more general data setting, are also discussed.

关键词： asset returns Heteroskedasticity high persistency nonlinearity predictability quantile regressions

Regioselective Polymerizations of α-Olefins with an α-Diamine Nickel Catalyst

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Chinese Journal of Polymer Science 2019年第10期37卷 959-965,I0003页

作者： Heng liao Jie Gao liu Zhong hai-Yang Gao Qing Wu School of Materials Science and Engineering PCFM Lab GD HPPC Lab Sun Yat-sen University

Polymerizations of linear α-olefins(CnH2n, CH2=CH―R, R = Cn-2) catalyzed by early transition metals typically afford amorphous polymers with alkyl chains(Cn-2), while chain-straightening polymerizations of α-olefins with nickel-based catalysts produce semicrystalline polyolefins. Polymerizations of various α-olefins were carried out using an α-diamine nickel catalyst with a significantly distorted chelating ring. The influences of temperature, monomer concentration, and chain length of α-olefins on polyolefin microstructure were examined in detail. The α-diamine nickel catalyst realized highly regioselective 2,1-insertion of α-olefins regardless of reaction temperature and monomer concentration. Increased chain length of α-olefins led to the formation of more linear *** polyolefins with high melting temperatures(Tm) were made from α-olefins through highly regioselective 2,1-insertion and precise chain-straightening.

关键词： Nickel catalyst α-Olefin Polymerization Regioselectivity Chain walking

Efficient enrichment and selective recovery of rare earths from sulfate leachate of ion-adsorption type rare earth ore by extraction with HPOAc

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Journal of Rare Earths 2024年第11期42卷 2156-2165,I0006页

作者： Jinglu Han Yanling li Songsong li Wuping liao State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341000China

The efficient enrichment and separation of rare earth elements(REEs) from sulfate leachates of ionadsorption type rare earth ore(IATREO) is still a *** work presents a novel extractant 2-(bis((2-ethylhexyl)oxy)phosphoryl)-2-hydroxyacetic acid(HPOAc) for the selective extraction and efficie nt enrichment of REEs from sulfate leachates of *** exhibits higher extraction ability for all fifteen REEs(Ⅲ) than naphthenic acid(NA) at pH_(ini)=1,***,it has no drawbacks of di-(2-ethylhexyl) phosphoric acid(P204) and 2-ethylhexyl phosphoric acid mono-2-ethylhexylester(P507)such as weak extraction ability towards light REEs(Ⅲ) and high stripping acidity for heavy REEs(Ⅲ).It has better separation performance for metal ion impurities than P204 and P507,especially for the typical impurity Al(Ⅲ).Furthermore,the HPOAc system has better phase separation behavior and extraction pheno mena.A simulated operation with two-stage counte r-current extraction and single-stage stripping of REEs was carried out using unsaponified *** recovery of REEs reaches 98.7%.The concentration of REEs increases from 0.44 to 130.35 g/L,indicating a nearly 300-fold ***,the content of REEs increases from 77.8 wt% to 97.6 wt%.So HPOAc has the potential to selectively recover REEs from sulfate leachates of IATREO.

关键词： Rare earths Solvent extraction Enrichment Separation Extractants

Research Progresses on Auxin Response Factors

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Journal of Integrative Plant Biology 2006年第6期48卷 622-627页

作者： hai-Bin Wei Bai-Ming Cui Yan-li Ren Juan-Hua li Wei-Bin liao Nan-Fei Xu Ming Peng State Key Laboratory of Tropical Crop Biotechnology Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 571101 China College of life Sciences Shihezi University Shihezi 832000 China BASF Plant Science L.L.C. Research Triangle Park North Carolina 27709-3528 USA 不详

Auxin response factors （ARFs）, a family of transcription factors, have been discovered recently. The ARFs bind specifically to the auxin response elements （AuxREs） within promoters of primary auxin responsive genes and function as activators or repressors. The ARFs contain three domains, namely a conserved Nterminal DNA-binding domain, a non-conserved middle region, and a conserved C-termlnal dlmerlzatlon domaln. The ARFs can form a protein complex with auxin/indoleacetic acid through homodimerization or heterodlmerization. The particular protein-protein interaction may play a key role in moduiating the expression of early auxin responsive genes. The identification of ARF mutations in Arabidopsis helps to demonstrate/dissect the function of ARFs in the normal growth and development of plants. Phylogenetic analysis also reveals some interesting protein evolution points in the ARF family.

关键词： auxin/indoleacetic acid auxin response elements auxin response factors auxin responsive genes.

An analysis of correctness for API recommendation:are the unmatched results useless?

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Science China(Information Sciences) 2020年第9期63卷 43-57页

作者： Xianglong KONG Weina HAN li liao Bixin li School of Computer Science and Engineering Southeast University

API recommendation is a promising approach which is widely used during software development. However, the evaluation of API recommendation is not explored with sufficient rigor. The current evaluation of API recommendation mainly focuses on correctness, the measurement is conducted by matching recommended results with ground-truth results. In most cases, there is only one set of ground-truth APIs for each recommendation attempt, but the object code can be implemented in dozens of ways. The neglect of code diversity results in a possible defect in the evaluation. To address the problem, we invite15 developers to analyze the unmatched results in a user study. The online evaluation confirms that some unmatched APIs can also benefit to programming due to the functional correlation with ground-truth *** we measure the API functional correlation based on the relationships extracted from API knowledge graph, API method name, and API documentation. Furthermore, we propose an approach to improve the measurement of correctness based on API functional correlation. Our measurement is evaluated on a dataset of 6141 requirements and historical code fragments from related commits. The results show that 28.2% of unmatched APIs can contribute to correctness in our experiments.

关键词： API recommendation onsite programming correctness evaluation of recommendation