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Development and validation of a nomogram model for predicting overall survival in patients with gastric carcinoma

World Journal of Gastrointestinal Oncology 2025年第2期17卷 132-143页

作者： Guan-Zhong Liang Xiao-Sheng Li Zu-hai Hu Qian-Jie Xu Fang Wu Xiang-Lin Wu hai-ke lei Chongqing key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China Research Center for Medicine and Social Development School of Public HealthChongqing Medical UniversityChongqing 400016China The Research Center of Big Data Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND The prevalence and mortality rates of gastric carcinoma are disproportionately elevated in China,with the disease's intricate and varied characteristics further amplifying its health *** forecasting of overall survival(OS)is of paramount importance for the clinical management of individuals afflicted with this *** To develop and validate a nomogram model that provides precise gastric cancer prevention and treatment guidance and more accurate survival outcome prediction for patients with gastric *** Data analysis was conducted on samples collected from hospitalized gastric cancer patients between 2018 and *** absolute shrinkage and selection operator,univariate,and multivariate Cox regression analyses were employed to identify independent prognostic factors.A nomogram model was developed to predict gastric cancer patient *** model's predictability and discriminative ability were evaluated via receiver operating characteristic *** evaluate the clinical utility of the model,Kaplan-Meier and decision curve analyses were *** A total of ten independent prognostic factors were identified,including body mass index,tumor-node-metastasis(TNM)stage,radiation,chemotherapy,surgery,albumin,globulin,neutrophil count,lactate dehydrogenase,and platelet-to-lymphocyte *** area under the curve(AUC)values for the 1-,3-,and 5-year survival prediction in the training set were 0.843,0.850,and 0.821,*** AUC values were 0.864,0.820,and 0.786 for the 1-,3-,and 5-year survival prediction in the validation set,*** model exhibited strong discriminative ability,with both the time AUC and time C-index exceeding *** with TNM staging,the model demonstrated superior clinical ***,a nomogram was developed via a web-based *** This study established and validated a novel nomogram model for predicting the OS of gastric cancer patients,which demonstrat

关键词： Gastric carcinoma Prediction Overall survival Nomogram Prospective

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Development and validation of a nomogram prediction model for overall survival in patients with rectal cancer

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 93-104页

作者： Ling Liang Xiao-Sheng Li Ze-Jun Huang Zu-hai Hu Qian-Jie Xu Yu-Liang Yuan Wei Zhang hai-ke lei Chongqing key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multiomics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Rectal cancer is prevalent and associated with substantial morbidity and *** To develop a nomogram prediction model for overall survival(OS)in patients with rectal cancer by leveraging a comprehensive analysis of demographic,clinicopathological,haematological,and follow-up data to identify independent prognostic *** We conducted a prospective cohort study in China involving rectal cancer patients and applied Cox regression and least absolute shrinkage and selection operator regression to assess the significance of various variables as independent prognostic factors for *** identified factors were integrated into a nomogram model,which was evaluated for predictive accuracy via the C-index,area under the curve(AUC),calibration curve,and decision curve analysis(DCA).RESULTS Multivariate analysis revealed independent predictors of OS,including the Karnofsky performance status,age,sex,TNM stage,chemotherapy,surgery,targeted therapy,β2-microglobulin,lactate dehydrogenase,and the neutrophil-to-lymphocyte *** nomogram demonstrated a C-index of 0.80 for the training and validation cohorts,with AUC values indicating high predictive accuracy for 1-year,3-year,and 5-year *** calibration curves confirmed the model's excellent agreement with the observed survival rates,and DCA revealed the superior clinical utility of the nomogram over the TNM staging *** In this study,a novel prognostic model that accurately predicts the OS of rectal cancer patients was *** model exhibited excellent discriminatory and calibration capabilities,thus offering a reliable tool for health care professionals to estimate patient survival.

关键词： Rectal cancer Overall survival Nomogram Prognosis

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Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi Zheng Xiao-Sheng Li Qian-Jie Xu Wei Zhang Zhong-Li Liao hai-ke lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

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Synthesis of intermetallic PtCo fuel cell catalysts from bimetallic core@shell structured nanoparticles

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Journal of Energy Chemistry 2025年第2期101卷 1-6页

作者： Le Zhang lei Tong Shuai Li Chang-Song Ma Kun-Ze Xue hai-Wei Liang Hefei National Research Center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China

The high activity and stability of intermetallic PtCo nanocatalysts toward oxygen reduction reaction make them a top candidate as low-Pt cathode catalysts in proton exchange membrane fuel cells（PEMFCs）.However,forming intermetallic structures typically requires high-temperature annealing,posing a challenge for achieving well-size control and highly ordered *** we report the design and synthesis of bimetallic co re@shell structured precursors for affording high-performance intermetallic PtCo *** fabrication of the core@shell precursor involves using a molecular ligand containing both sulfur and oxygen donors to selectively bind with Pt colloidal nanoparticles as the core and chelate Co ions as the *** high-temperature annealing,the ligand transforms into carbon coatings around alloy nanoparticles,preventing particle sintering;meanwhile,Co ions in the shell can easily diffuse into the Pt core,which helps to increase the thermodynamic driving force for forming intermetallic *** benefits enable us to obtain the catalyst with finely dispersed nanoparticles（～3.5 nm）and a high ordering degree of 72%.With 0.1 mgPt/cm2cathode loading,the catalyst delivers superior performance and durability in PEMFCs,showing an initial mass activity of 0.56 A/mgPt,an initial power density of 1.05 W/cm2at 0.67 V（H2-air）,and a voltage loss of 26 mV at 0.8 A/cm2after the accelerated durability test.

关键词： Bimetallic structure Fuel cells Intermetallic PtCo Oxygen reduction reaction

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Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

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Tungsten 2025年第1期7卷 1-31页

作者： Qiao Xie Ying-Jie Yu hai-Jun Zhang Ya-Ping Deng Wen lei The State key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词： Electrocatalytic Energy conversion High-entropy alloys Structural modulation

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High Spicy Food Intake and Risk of Cancer： A Meta-analysis of Case-control Studies

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Chinese Medical Journal 2017年第18期130卷 2241-2250页

作者： Yu-Heng Chen Xiao-Nong Zou Tong-Zhang Zheng Qi Zhou Hui Qiu Yuan-Li Chen Mei He Jia Du hai-ke lei Ping Zhao Cancer Foundation of China National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021 China National Office for Cancer Prevention and Control National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Epidemiology School of Public Health Brown University Providence RI 02912 USA Office for Cancer Prevention and Control Chongqing Cancer Hospital Chongqing 400030 China

Background：Studies on the association between spicy food intake and cancer risk have reported inconsistent *** quantitatively assessed this association by conducting a meta-analysis based on evidence from case-control ***：PubMed,EMBASE,and the Cochrane Library were searched for eligible *** odds ratios （ORs） with their 95% confidence interval （CI） were calculated using a random-or fixed-effects *** methodological quality of the included articles was assessed using the Newcastle-Ottawa scale （NOS）.All data were analyzed using STATA 1 1.0 software （version 11.0;StataCorp.,College Station,TX,USA）.Subgroup analyses were also performed with stratification by region,sex,number of cases,cancer subtype,source of the control group,and NOS ***：A total 39 studies from 28 articles fulfilled the inclusion criteria for the meta-analysis （7884 patients with cancer and 10,142 controls）.Comparison of the highest versus lowest exposure category in each study revealed a significant OR of 1.76 （95% CI =1.35-2.29） in spite of significant heterogeneity （P 〈 0.00l）.In the subgroup analyses,this positive correlation was still found for gastric cancer,different regions,different numbers of cases,different sources of the control group,and high-quality articles （NOS score of≥ 7）.However,no statistically significant association was observed for women,esophageal cancer,gallbladder cancer,or low-quality articles （NOS score of〈7）.No evidence of publication bias was ***：Evidence from case-control studies suggested that a higher level of spicy food intake may be associated with an increased incidence of cancer despite significant *** studies are warranted to clarify our understanding of the association between high spicy food intake and the risk of cancer.

关键词： Cancer Incidence: Case control Studies Meta-analysis Spicy Food

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Enhancement of bending toughness for Fe-based amorphous nanocrystalline alloy with deep cryogenic-cycling treatment

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China Foundry 2025年第1期22卷 99-107页

作者： Yi-ran Zhang Dong Yang Qing-chun Xiang Hong-yu Liu Jing Pang Ying-lei Ren Xiao-yu Li ke-qiang Qiu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Qingdao Yunlu Advanced Material Technology Co. Ltd.Qingdao 266232ShandongChina

The effects of deep cryogenic-cycling treatment(DCT)on the mechanical properties,soft magnetic properties,and atomic scale structure of the Fe_(73.5)Si_(13.5)B_(9)Nb_(3)Cu_(1)amorphous nanocrystalline alloy were *** DCT samples were obtained by subjecting the as-annealed samples to a thermal cycling process between the temperature of the supercooled liquid zone and the temperature of liquid *** flat plate bending testing,hardness measurements,and nanoindentation experiment,it is found that the bending toughness of the DCT samples is improved and the soft magnetic properties are also slightly *** are attributed to the rejuvenation behavior of the DCT samples,which demonstrate a higher enthalpy of ***,DCT is an effective method to enhance the bending toughness of Fe-based amorphous nanocrystalline alloys without degrading the soft magnetic properties.

关键词： deep cryogenic-cycling treatment Fe-based amorphous nanocrystalline alloy bending toughness rejuvenation

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Oxygen vacancies enriched Ir/WOx catalysts for the directly chem-catalytic conversion of cellulose to ethanol

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Tungsten 2025年第1期7卷 88-99页

作者： Yu-Jing Weng Zhao-Ying Ding Ying-Chao Li Yuan-Feng Wu Yuan-Yang Xu Rui Chen Xiao-lei Zhao hai-Yong Wang Da-lei Zhang Yu-Long Zhang Henan key Laboratory of Coal Green Conversion and International Joint Laboratory of Coal Clean Utilization College of Chemistry and Chemical Engineering Henan Polytechnic University key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Liaoning Institute of Energy Technology

Tungsten and its oxides are highly versatile catalysts with unique properties that hold great promise for a wide array of applications,including biological pathways and chemical *** chemo-catalysis of cellulose to ethanol presents a promising avenue for ethanol synthesis with the potential for enhanced efficiency compared to conventional methods,offering a sustainable and carbon-neutral alternative to existing petrochemical and biological ***,Ir/WOxcatalysts enriched with oxygen vacancies were meticulously prepared and demonstrated remarkable catalytic performance in converting cellulose to ethanol directly in the presence of tungstic *** catalyst achieved a high ethanol yield of 66.5%under optimal reaction conditions,approaching the theoretical yield limit of traditional ethanol *** results revealed the presence of oxygen defects,Bronsted/Lewis acidity,and Ir nanoclusters on the catalyst surface,working synergistically to facilitate the cascade catalysis of cellulose hydrolysis,sugar retro-aldol condensation reaction,and C2 intermediate hydrodeoxygenation to *** situ Fourier transform infrared spectrometer analysis confirmed the catalyst's ability to enhance the adsorption and activation of ethylene glycol for ethanol *** manipulating subtle structural features,this study offers a fresh perspective on tungsten group catalyst design and underscores the importance of synergistic effects among catalytic sites for the efficient production of ethanol from cellulose.

关键词： Cellulosic ethanol Chem-catalysis Hydrogenolysis Retro-aldol condensation Tungsten

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Latitudinal patterns of tree β-diversity and relevant ecological processes vary across spatial extents in forests of southeastern China

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Plant Diversity 2025年第1期47卷 89-97页

作者： Maochou Liu Wenxiang Wu ke Wang Xinshuai Ren Xueqin Zhang lei Wang Jing Geng Bo Yang key Laboratory of Land Surface Pattern and Simulation Institute of Geographic and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Department of Environment and Resources University of Chinese Academy of SciencesBeijing 100049China Zhai Mingguo Academician Work Station Sanya UniversitySanya 572022China

Latitudinal patterns of treeβ-diversity reveal important insights into the biogeographical processes that influence forest *** previous studies have extensively documentedβ-diversity within relatively small spatial extents,the potential drivers ofβ-diversity along latitudinal gradients are still not well understood at larger spatial *** this study,we determined whether treeβ-diversity is correlated with latitude in forests of southeastern China,and if so,what ecological processes contribute to these patterns of treeβ-*** specifically aimed to disentangle the relative contributions from interspecific aggregation and environmental filtering across various spatial *** delineated regional communities comprising multiple nearby national forest inventory(NFI)plots around random focal *** number of NFI plots in a regional community served as a surrogate for spatial *** also used a null model to simulate randomly assembled communities and quantify the deviation(β-deviation)between observed and expectedβ-*** found thatβ-diversity decreased along a latitudinal gradient and that this pattern was clearer at larger spatial *** addition,latitudinal patterns ofβ-deviation were explained by the degree of species spatial *** also identified environmental factors that driveβ-deviation in these forests,including precipitation,seasonality,and temperature *** larger spatial extents,these environmental variables explained up to 84%of theβ-*** results reinforce that ecological processes are scale-dependent and collectively contribute to theβ-gradient in subtropical *** recommend that conservation efforts maintain diverse forests and heterogeneous environments at multiple spatial extents to mitigate the adverse effects of climate change.

关键词： Environmental filtering Latitudinal pattern Forest beta diversity Spatial extent Species spatial aggregation Regional community

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Potassium ions and cyano group modified g-C_(3)N_(4) for effective generation of H_(2)O_(2) through two-electron oxygen reduction

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Science China Chemistry 2025年第1期68卷 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen ke lei Yujie Duan Linjiao Mao Xuhui Zeng Xi Luo Yuntao Zhang Yuqin Dong Jin Zhong Zhang Yan Sun School of Mechanical Engineering Chengdu UniversityChengdu 610106China Department of Chemistry and Biochemistry University of CaliforniaSanta CruzCA 95064USA

Potassium ions(K^(+))doped graphitic carbon nitride(g-C_(3)N_(4))was prepared by a thermal etching method using potassium hydroxide(KOH)as an ion *** transform infrared spectroscopy(FTIR)and X-ray photoelectron spectroscopy(XPS)results showed that the generation of the cyano group was detected while introducing K^(+).Under simulated sunlight irradiation,the sample with a K^(+)doping amount of 10%showed the highest hydrogen peroxide(H_(2)O_(2))generation rate of2,140.2μmol h^(-1)g^(-1).The apparent quantum yield(AQY)at 400 nm and the solar-to-chemical conversion(SCC)are 4.35%and1.23%,respectively.K^(+)acted as a bridge between g-C_(3)N_(4)layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons(H^(+))and promoted the yield of H_(2)O_(2).The catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals(·O_(2)^(-))were the most important active species in the reaction *** production of H_(2)O_(2)was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H_(2)O_(2)generation.

关键词： photocatalysis hydrogen peroxide oxygen reduction reaction potassium doping cyano group

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