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An open-label, multicenter, randomized, crossover study comparing sildenafil citrate and tadalahl for treating erectile dysfunction in Chinese men na＇=＇ve to phosphodiesterase 5 .inhibitor therapy

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Asian Journal of Andrology 2015年第1期17卷 61-67,I0007,I0008页

作者： Wen-jun Bai Hong-jun Li yu-Tian Dai Xue-You He Yi-Ran Huang Ji-Hong Liu Sebastian Sorsaburu Chen Ji Jian-jun Jin Xiao-Feng Wang Department of Urology People's Hospital of Peking University Beijing China Department of Urology Peking Union Medical College Hospital Beijing China Department of Andrology Nanjing Drum Tower Hospital Jiangsu China Department of Urology Chinese PLA General Hospital Beijing China Department of Urology Shanghai Renji Hospital Shanghai China Department of Urology Tongji Hospital Tengji Medical College of Huazhong University of Science and Technology Wuhan China Department of Medical Eli Lilly and Company Indianapolis IN USA Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai China.

The study was to compare treatment preference, efficacy, and tolerability of sildenafil citrate （sildenafil） and tadalafil for treating erectile dysfunction （ED） in Chinese men na＇ive to phosphodiesterase 5 （PDE5） inhibitor therapies. This multicenter, randomized, open-label, crossover study evaluated whether Chinese men with ED preferred 20-mg tadalafil or 100-mg sildenafil. After a 4 weeks baseline assessment, 383 eligible patients were randomized to sequential 20-mg tadalafil per 100-mg sildenafil or vice versa for 8 weeks respectively and then chose which treatment they preferred to take during the 8 weeks extension. Primary efficacy was measured by Question 1 of the PDE5 Inhibitor Treatment Preference Questionnaire （PITPQ）. Secondary efficacy was analyzed by PITPQ Question 2, the International Index of Erectile Function （IIEF） erectile function （EF） domain, sexual encounter profile （SEP） Questions 2 and 3, and the Drug Attributes Questionnaire. Three hundred and fifty men （91%） completed the randomized treatment phase. Two hundred and forty-two per 350 （69.1%） patients preferred 20-mg tadalafil, and 108/350 （30.9%） preferred lO0-mg sildenafil （P 〈 0.001） as their treatment in the 8 weeks extension. Ninety-two per 242 （38%） patients strongly preferred tadalafil and 37/108 （34.3%） strongly the preferred sildenafil. The SEP2 （penetration）, SEP3 （successful intercourse）, and IIEF-EF domain scores were improved in both tadalafil and sildenafil treatment groups. For patients who preferred tadalafil, getting an erection long after taking the medication was the most reported reason for tadalafil preference. The only treatment-emergent adverse event reported by 〉 2% of men was headache. After tadalafil and sildenafil treatments, more Chinese men with ED na＇ive to PDE5 inhibitor preferred tadalafil. Both sildenafil and tadalafil treatments were effective and safe.

关键词： erectile dysfunction patient preference phosphodiesterase 5 inhibitors

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菌糠替代紫花苜蓿对贵州黑山羊母羊生产性能、抗氧化能力和瘤胃微生物区系的影响

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饲料研究 2024年第16期47卷 1-7页

作者：李小冬于二汝裴成江尚以顺陈才俊洪莉平贵州省农业科学院草业研究所贵州贵阳550006 贵阳康养职业大学贵州贵阳550000

试验旨在研究饲粮中菌糠替代紫花苜蓿对贵州黑山羊母羊生产性能、抗氧化能力和瘤胃微生物区系的影响。选取18只体况相近的贵州黑山羊母羊,随机分为3组,每组6个重复,每个重复1只羊。对照组饲喂基础饲粮,试验组分别以金针菇和海鲜菇菌糠... 详细信息

试验旨在研究饲粮中菌糠替代紫花苜蓿对贵州黑山羊母羊生产性能、抗氧化能力和瘤胃微生物区系的影响。选取18只体况相近的贵州黑山羊母羊,随机分为3组,每组6个重复,每个重复1只羊。对照组饲喂基础饲粮,试验组分别以金针菇和海鲜菇菌糠等量替代基础饲粮中的紫花苜蓿,依次记为对照组(CK组)、金针菇组(JZG组)、海鲜菇组(HXG组)。预试期14 d,正式试验期60 d。结果显示,JZG组和HXG组血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)活性和总抗氧化能力(T-AOC)均显著高于CK组(P<0.05),丙二醛(MDA)含量显著低于CK组(P<0.05)。JZG组和HXG组瘤胃液中乙酸(AA)含量显著低于CK组(P<0.05)。通过高通量测序分析发现,JZG组瘤胃微生物的物种多样性和丰度显著高于HXG组和CK组(P<0.05)。聚类分析发现:在门水平上,厚壁菌门和变形菌门相对丰度在CK组中较高,而拟杆菌门、疣微菌门、浮霉菌门和螺旋菌门相对丰度在JZG组和HXG组较高;在种和属水平上,奎因氏菌属、普雷沃氏菌属、溶糊精琥珀酸弧菌等相对丰度在CK组中较高,而毛螺科菌、理研菌科、支原体_girerdii等相对丰度在JZG组和HXG组较高。研究表明,以金针菇和海鲜菇菌糠替代紫花苜蓿调制全混合日粮对贵州黑山羊母羊的育肥效果无不良影响,其中金针菇菌糠效果优于海鲜菇菌糠。

关键词：金针菇菌糠海鲜菇菌糠贵州黑山羊抗氧化能力瘤胃发酵参数瘤胃微生物区系

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Geomagnetic field absenee reduces adult body weight of a migratory insect by disrupt!ng feeding behavior and appetite regulation

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Insect Science 2021年第1期28卷 251-260页

作者： Gui-jun Wan Shou-Lin Jiang Ming Zhang Jing-yu Zhao Ying-Chao Zhang Wei-Dong Pan Gregory A.Sword Fa-jun Chen Department of Entomology Nanjing Agricultural UniversityNanjingChina Beijing Key Laboratory of Bioelectromagetics Institute of Electrical EngineeringChinese Academy of SciencesBeijingChina Department of Entomology Texas A&M UniversityCollege StationTXU.S.A.

The geomagnetic field(GMF)is well documented for its essential role as a cue used in animal orientation or *** evidence indicates that the absence of GMF(mimicked by the near-zero magnetic field,NZMF)can trigger stress-like responses such as reduced body weight,as we have previously shown in the brown planthopper,Nilaparvata *** this study,we found that consistent with the significantly decreased body weight of newly emerged female(—14.67%)and male(—13.17%)adult ***,the duration of the phloem ingestion feeding waveform was significantly reduced by 32.02%in 5th instar nymphs reared under the NZMF versus ***,5th instar nymphs that exhibited reduced feeding had significantly higher glucose levels(+16.98%and+20.05%;24 h and 48 h after molting),which are associated with food aversion,and expression patterns of their appetite-related neuropeptide genes(neuropeptide F,dow regulated overall;short neuropeptide F,dowregulated overall;adipokinetic hormone up-regulated overall;and adipokinetic hormone receptor,down-regulated overall)were also altered under the absence of GMF in a manner consistent with diminishing ***,the expressions of the potential magnetosensor croptochromes(Crys)were found significantly altered under the absence of GMF,indicating the likely upstream signaling of the Cry-mediated magnetoreception *** findings support the hypothesis that strong changes in GMF intensity can reduce adult body weight through affecting insect feeding behavior and underlying regulatory processes including appetite *** results highlight that GMF could be necessary for the maintenanee of energy homeostasis in insects.

关键词： appetite body weight feeding behavior geomagnetic field magnetoreception Nilaparvata lugens

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并列复合中空卷曲抗菌再生聚酯短纤维的制备及性能

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合成纤维 2024年第2期53卷 1-5,8页

作者：邢喜全李小军何肖姚玉元浙江余姚大发化纤有限公司浙江余姚315400 浙江理工大学纺织纤维材料与加工技术国家地方联合工程实验室浙江杭州310018

为实现废弃聚对苯二甲酸乙二醇酯(PET)的循环再生与升级利用,以废弃PET泡料为原料,制得特性黏度为0.78 dL/g和0.65 dL/g的再生聚酯(r-PET)切片,选用F220A(主要成分为纳米ZnO)和100B(季铵盐型抗菌剂)两种抗菌改性剂,经熔融并列复合纺丝... 详细信息

为实现废弃聚对苯二甲酸乙二醇酯(PET)的循环再生与升级利用,以废弃PET泡料为原料,制得特性黏度为0.78 dL/g和0.65 dL/g的再生聚酯(r-PET)切片,选用F220A(主要成分为纳米ZnO)和100B(季铵盐型抗菌剂)两种抗菌改性剂,经熔融并列复合纺丝和后整理技术得到两类并列复合中空卷曲抗菌r-PET短纤维。优化了抗菌r-PET短纤维的生产工艺参数,并对其性能进行测试分析,结果表明:在计量泵频率44~46 Hz、纺速1050~1200 m/min、总牵伸倍数3.33倍的条件下,两类抗菌r-PET短纤维均具有良好的可纺性,其中空度接近20%,卷曲数为5个/25 mm;抗菌剂F220A与r-PET可实现热力学互容,且作为基体异相结晶成核剂,有效促进了r-PET结晶;两类抗菌r-PET短纤维对金黄葡萄球菌、大肠埃希菌及白念珠菌的抑菌率均高达99.00%,抗菌效果优异。

关键词：废弃聚对苯二甲酸乙二醇酯再生聚酯短纤维复合纺丝抗菌

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3D打印聚醚醚酮假体重建锁骨恶性肿瘤切除后缺损

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中国矫形外科杂志 2024年第15期32卷 1410-1414页

作者：朱昱衡肖砚斌李凌李文忠张漾杰康建平肖渝田昌平王寒许昊俊云南省肿瘤医院昆明医科大学第三附属医院云南昆明650118

[目的]介绍3D打印聚醚醚酮(polyetheretherketone,PEEK)假体重建锁骨肿瘤切除后缺损的手术技术及初步临床效果。[方法]对5例锁骨恶性肿瘤患者行“锁骨瘤段切除+3D打印PEEK假体重建术”。其中病灶累及锁骨外侧段3例、内侧段2例,发生病理... 详细信息

[目的]介绍3D打印聚醚醚酮(polyetheretherketone,PEEK)假体重建锁骨肿瘤切除后缺损的手术技术及初步临床效果。[方法]对5例锁骨恶性肿瘤患者行“锁骨瘤段切除+3D打印PEEK假体重建术”。其中病灶累及锁骨外侧段3例、内侧段2例,发生病理性骨折2例。参照患者健侧锁骨形态使用计算机建模后,3D打印制备个性化假体及截骨导板,术中根据肿瘤部位切断胸锁韧带或肩锁韧带,另一侧使用截骨导板辅助截骨,整块切除瘤段。置入3D打印制备的个性化假体并使用锁定钢板将保留端的正常锁骨与假体紧密连接固定,使用锚钉重建切断的胸锁韧带或肩锁韧带。[结果]患者均顺利完成手术,无神经、血管损伤等并发症。术后切口均I期愈合,无感染者。随访2~26个月,术后患者肩外形、功能恢复良好,随访期内未发现局部肿瘤复发,未见明显排斥反应等并发症发生。[结论]锁骨瘤段切除+3D打印PEEK假体重建术治疗锁骨恶性肿瘤技术可行,近期疗效满意。

关键词：锁骨恶性肿瘤整块切除骨缺损 3D打印聚醚醚酮假体重建

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十溴二苯乙烷对小鼠肝脏和肾脏的毒性研究

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动物医学进展 2024年第11期45卷 45-51页

作者：姜玟冀禹彤齐凯歌周淑馨李振民何家康韦英益胡庭俊王蕾于美玲广西大学动物科学技术学院广西南宁530004 南宁市食品药品检验所广西南宁530007

为探讨作为传统溴系阻燃剂十溴二苯醚(BDE-209)替代品的新型阻燃剂十溴二苯乙烷(DBDPE)暴露对小鼠肝肾功能的影响,将60只雄性小鼠随机分为5组,每天分别给予低、中、高剂量(5、50、500 mg/kg体重)的DBDPE,对照组给予相同体积的玉米油,联... 详细信息

为探讨作为传统溴系阻燃剂十溴二苯醚(BDE-209)替代品的新型阻燃剂十溴二苯乙烷(DBDPE)暴露对小鼠肝肾功能的影响,将60只雄性小鼠随机分为5组,每天分别给予低、中、高剂量(5、50、500 mg/kg体重)的DBDPE,对照组给予相同体积的玉米油,联合染毒组每天给予50 mg/kg体重的DBDPE和BDE-209,每天灌胃1次,连续暴露60 d。试验期间观察小鼠的一般体征,测量小鼠体质量,末次染毒后测定小鼠血清生化指标、肝脏和肾脏系数,通过苏木素-伊红(HE)、油红O和刚果红染色观察小鼠肝脏和肾脏组织病理学变化。结果显示,与对照组相比,染毒组小鼠临床体征未见异常,体质量无显著变化;高剂量组小鼠肝脏系数显著升高(P<0.05),中剂量组小鼠肾脏系数极显著降低(P<0.01)。高剂量组小鼠血清中尿素(UA)含量极显著升高(P<0.01),中剂量组小鼠血清中白蛋白(ALB)含量和碱性磷酸酶(ALP)活性极显著升高(P<0.01),甘油三酯(TG)含量降低(P<0.05)。组织病理学结果可见,各攻毒组小鼠肝脏细胞均发生不同程度的脂肪变性和坏死,高剂量组小鼠肾脏间质有大量淀粉样物质沉着。结果表明,每天500 mg/kg体重DBDPE暴露导致小鼠肝肾组织结构改变,诱导小鼠肝肾组织细胞代谢紊乱和功能障碍,对肝肾具有毒性效应。

关键词：十溴二苯乙烷毒性肝肾功能小鼠

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Effects of Nb and V on Microstructural Evolution,Precipitation Behavior and Tensile Properties in Hot-rolled Mo-bearing Steel

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Journal of Iron and Steel Research International 2016年第6期23卷 559-565页

作者： Fu-ming LIU Jian-jun WANG yu-jie LIU R.D.K.MISRA Chun-ming LIU School of Materials Science and Engineering Northeastern University Key Laboratory for Anisotropy and Texture of Materials of Ministry of Education Northeastern University Laboratory for Excellence in Advanced Steel Research Department of Metallurgical and Materials EngineeringUniversity of Texas at El Paso

Microstructural evolution,precipitation behavior,and tensile properties of four experimental Mo-bearing steels were studied to elucidate the effects of Nb and V on microstructural *** results indicated that the microstructure of hot-rolled steels consisted of polygonal ferrite and degenerate pearlite,and the morphology remained same after holding at 600 ℃for *** smallest grain size was obtained in Nb-V-Mo containing steel,followed by Nb-Mo and V-Mo *** was less in the hot-rolled Mo-bearing *** maximum volume fraction of precipitates was obtained in Nb-V-Mo bearing steel,and the Nb-V-Mo complex carbonitrides were highly stable at 600℃.In the Mo-bearing steel,the yield ratio was lowest at room temperature but highest at 600℃,which was attributed to the precipitation of Mo carbides and drag effect of Mo solute on dislocation movement.

关键词： rolled steels Precipitation tensile solute attributed polygonal holding ferrite dislocation

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Detrital apatite fission track constraints on Cenozoic tectonic evolution of the northeastern Qinghai-Tibet Plateau, China： Evidence from Cenozoic strata in Lulehe section, Northern Qaidam Basin

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Journal of Mountain Science 2018年第3期15卷 532-547页

作者： DU Ding-ding ZHANG Cheng-jun MUGHAL Muhammad Saleem WANG Xiao-yu BLAISE Dembele GAO jun-ping MA yuan LUO Xin-rong School of Earth Sciences and Mineral Resources Lanzhou University Lanzhou 730000 China Key Laboratory of Western China's Mineral Resources of Gansu Prouince Lanzhou 730000 China Institute of Geology University of Azad Jammu and Kashmir Muzaffarabad 13100 Pakistan

The Northern Qaidam Basin is located at the northeastern part of the Qinghai-Tibetan Plateau. It contains very thick Cenozoic terrestrial clastic sediments, which records the formation of the northern Qaidam Basin due to compressional deformation during the Indo-Asian collision. In this paper, we used detrital apatite fission-track thermochronology, including 4 sandstones and 2 conglomerates samples from the Lulehe section, to reveal the Cenozoic evolution of the northern Qaidam Basin. Fission-track dating indicated the source region of the Lulehe section has experiencedimportant cooling and uplifting in the Late Cretaceous(at ~85.1 Ma and ~65 Ma) and the Eocene(~52 Ma), respectively. The AFT age distribution on the section suggested that the provenance of Lulehe section sediments were mainly derived from the south Qilian Shan(Qilian Mountains) and Altun Shan(Altun Mountains), and two significantly provenance changes may occur at 43.4-46.1 Ma and ~37.8 Ma, respectively. The results may have strong constrains on the Cenozoic deformation and tectonic evolution of the northern Qaidam Basin and Qinghai-Tibet Plateau.

关键词： Northern Qaidam Basin Apatite Fission-Track Tectonic evolution Provenance analysis

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Tea Polyphenols Reduce Inflammation of Orbital Fibroblasts in Graves’Ophthalmopathy via the NF-κB/NLRP3 Pathway

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Current Medical Science 2023年第1期43卷 123-129页

作者： Wei LIU Chao MA Hao-yu LI Shan-si yuAN Kai-jun LI Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China

Objective:This study aimed to explore the effects of tea polyphenols(TP)on inflammation of orbital fibroblasts in Graves’ophthalmopathy(GO)and to provide new ideas for GO ***:Primary orbital fibroblasts were extracted from orbital adipose/connective tissues of patients with and without ***-time quantitative PCR(RT-qPCR)was used to detect the expression of interleukin(IL)-6,IL-1β,and monocyte chemotactic protein(MCP)-1 in non-GO and GO orbital *** CCK-8 assay was used to determine the appropriate concentration of TP for subsequent ***-qPCR and enzyme-linked immunosorbent assay(ELISA)were performed to investigate the effects of TP on lipopolysaccharide(LPS)-induced production of inflammatory *** factor-κB(NF-κB)expression was measured using Western blotting ***-like receptor 3(NLRP3)expression was detected using both Western blotting analysis and immunofluorescence ***:The mRNA levels of IL-6,IL-1β,and MCP-1 in GO orbital fibroblasts were significantly higher than those in non-GO *** treatment significantly inhibited LPS-induced production of inflammatory factors,including IL-6,IL-1β,and *** also inhibited the expression levels of NF-κB and *** in the GO orbital fibroblasts was higher than that in non-GO *** inhibited the production of inflammatory cytokines in GO orbital fibroblasts in vitro through the NF-κB/NLRP3 ***:These findings suggest that TP may have a potential role in GO treatment.

关键词： tea polyphenols Graves’ophthalmopathy inflammation

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垄上交错种植密度对花生群体生长及产量的影响

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中国油料作物学报 2024年第3期46卷 489-497页

作者：孙日丹赫思聪李美君赵跃吕永超张志民陈小姝高华援李春雨夏雨宏杨丹吉林省农业科学院吉林长春130000 吉林省长春市农安县前岗乡综合服务中心吉林长春130208

为构建高产花生群体模式,根据花生品种类型调整垄上交错单粒种植模式下的合理种植密度。以半匍匐型花生品种扶余四粒红和直立型花生品种吉花17为材料,研究垄上交错单粒种植密度对花生植株性状、群体结构变化及产量的影响。共设置6个种... 详细信息

为构建高产花生群体模式,根据花生品种类型调整垄上交错单粒种植模式下的合理种植密度。以半匍匐型花生品种扶余四粒红和直立型花生品种吉花17为材料,研究垄上交错单粒种植密度对花生植株性状、群体结构变化及产量的影响。共设置6个种植密度M1(23.85万株/hm^(2))、M2(20.84万株/hm^(2))、M3(18.52万株/hm^(2))、M4(16.66万株/hm^(2))、M5(13.89万株/hm^(2))、M6(11.91万株/hm^(2)),以双粒播种(23.85万株/hm^(2))为对照(CK)。对不同种植密度下各花生品种的植株性状、SPAD值、单株干物质积累量及产量性状等进行测定。随着种植密度的降低,两品种主茎高和侧枝长逐渐增高,半匍匐型花生品种四粒红在M6密度下的主茎高和侧枝长最高,直立型花生品种吉花17会随着种植密度的降低而先增加后降低的趋势,在M5密度下的主茎高和侧枝长最高。随着种植密度的降低,两品种在结荚期和成熟期的SPAD值呈先下降后上升的趋势。四粒红成熟期M4、M5、M6处理的地上和地下单株干物质积累量均显著高于CK。吉花17在生育后期M4处理下的地上和地下单株干物质积累量较CK有显著提升,成熟期分别较对照提高了155.35%、23.31%。此外,随着密度的降低,四粒红的产量呈先上升后下降的趋势,单株饱果数、百果质量和单株荚果产量均呈上升后下降的趋势,千克果数各密度处理低于CK;吉花17的产量整体上呈下降的趋势,单株饱果数、单株荚果产量均呈上升趋势,千克果数各处理均小于CK。垄上交错+单粒播种种植模式相对于双粒种植模式可以增加花生株高、SPAD值、干物质积累量,同时提高了产量。应用垄上交错种植时,应根据花生品种类型选择适宜的播种密度,半匍匐型花生品种以M4密度最佳,直立型花生品种以M2密度最佳。

关键词：花生垄上交错单粒种植模式单粒精播种植密度直立型半匍匐型

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