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Pd-catalyzed asymmetric carbonyl alkynylation:Synthesis of axial chiral ynones

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Chinese Chemical Letters 2024年第6期35卷 293-297页

作者： Long Jin Jian han Dongmei Fang Min Wang Jian liao Natural Products Research Center Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China College of Chemical Engineering Sichuan UniversityChengdu 610065China University of Chinese Academy of Sciences Beijing 100049China

Ynones are important skeletons in bioactive molecules and valuable building blocks for organic synthesis,thus great efforts have been devoted to their ***,introducing prochiral substrates to construct ynones bearing a chiral framework is unrealized to ***,we reported the first example of Pd/SOP-catalyzed asymmetric carbonylative alkynylation via a non-classical carbonylative Sonogashiratype approach(acyl-Pd(Ⅱ)species generated from nucleophiles).By using cyclic diaryliodonium salts as prochiral substrates,various axial chiral ynones with good functional group tolerance(39 examples),satisfied yields(71%-96%)and excellent enantioselectivities(generally 94%-99%ee)were *** of bioactive compounds,scale-up experiment and useful transformations were also conducted to demonstrate the utility of this process.

关键词： Pd-catalyzed Axial chiral ynones Cyclic diaryliodonium High-valent palladium catalyzed Asymmetric carbonyl alkynylation

Bcl6 Suppresses Cardiac Fibroblast Activation and Function via Directly Binding to Smad4

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Current Medical Science 2019年第4期39卷 534-540页

作者： Jian NI Qing-qing WU hai-han liao Di FAN Qi-zhu TANG Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Cardiovascular Research Institute of Wuhan University Wuhan 430060China Hubei Key Laboratory of Cardiology Wuhan 430060China

Bcl6,a critical pro-oncogene of human B-cell lymphomas,can promote tumor *** studies have found that Bcl6 participates in hypoxia injury in ***,the effect of Bcl6 on cardiac fibroblasts is still *** aim of this study was to elucidate the functional role of Bcl6 in cardiac fibroblast activation and *** neonatal rat cardiac fibroblasts were isolated and ***,transforming growth factor β1 (TGFβ1) was used to stimulate fibroblast activation.A decreased expression level of Bcl6 was observed in fibroblasts after stimulation with TGFβ***,cells were transfected with adenovirus Bcl6 to overexpress *** results showed that Bcl6 overexpression induced decreased proliferation and reduced activation of fibroblasts which were stimulated with TGFβ*** was found that activated smad2 and smad3 were not changed by overexpressing Bcl6,but smad4 was ***,co-immunoprecipitation results showed that Bcl6 directly bound to smad4,and induced down-regulation of *** last,smad4 activator could counteract the anti-fibroblast effects of *** conclusion,Bcl6 may negatively regulate cardiac fibroblast activation and function by directly binding to smad4.

关键词： Bcl6 cardiac fibroblast transforming growth factor β1 smad4

Well-designed g-C_(3)N_(4)nanosheet incorporated Ag loaded Er_(0.05)La_(0.95)FeO_(3)heterojunctions for isoamyl alcohol detection

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Journal of Advanced Ceramics 2024年第6期13卷 736-745页

作者： Kaichun Xu Mengjie han Zichen Zheng Zexin Yu hanlin liao Hui Sun Chao Zhang College of Mechanical Engineering Yangzhou UniversityYangzhou 225127China Institute for Manufacturing Technologies of Ceramic Components and Composites(IMTCCC) University of StuttgartStuttgart 70569Germany ICB UMR 6303 CNRSUniv.Bourgogne Franche-ComtéUTBMBelfort 90010France School of Space Science and Physics Shandong UniversityWeihai 264209China

Because the volatile content of isoamyl alcohol increases sharply on the seventh day of wheat mildew infection,isoamyl alcohol can be used as an early biomarker of wheat mildew ***,only a few sensors for isoamyl alcohol detection have been reported,and these sensors still suffer from low sensitivity and poor moisture ***,the isoamyl alcohol sensitivity of 5 at%Er@LaFeO_(3)(ELFO)was enhanced by loading Ag nanoparticles on the surface of the ELFO microspheres,while the optimal operating temperature was *** moisture resistance of Ag/ELFO was improved by the incorporation of g-C_(3)N_(4)nanosheets(NSs)on the surface of Ag/ELFO through electrostatic *** the requirements for practical applications in grain granaries,the sensing behavior of a Ag/ELFO-based sensor incorporating g-C_(3)N_(4)NSs at 20%relative humidity(RH)was systematically studied,and the sensor demonstrated excellent repeatability,long-term stability,and superior selectivity(791 at 50 ppm)for isoamyl alcohol with a low limit of detection(LOD=75 ppb).Furthermore,the practical results obtained for wheat at different mildew stages further confirmed the potential of the g-C_(3)N_(4)/Ag/ELFO-based sensor for monitoring the early mildew stage of *** work may offer guidance for enhancing the moisture resistance of gas-sensitive materials through the strategy of employing composite nanomaterials.

关键词： Ag gas sensor moisture resistance isoamyl alcohol Er@LaFeO_(3)(ELFO) g-C_(3)N_(4)nanosheet(NS)

A New Method to Identify the Maximum Time Interval between Individual Events in Compound Rainstorm and Heatwave Events

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International Journal of Disaster Risk Science 2024年第3期15卷 453-466页

作者： Junlin Zhang Wei Xu Yu Qiao Xinli liao Chenna Meng Qinmei han Key Laboratory of Environmental Change and Natural Disaster of Ministry of Education Faculty of Geographical Science Beijing Normal University Academy of Disaster Reduction and Emergency Management Ministry of Emergency Management and Ministry of Education Beijing Normal University State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University National Climate Center China Meteorological Administration

Growing evidence indicates that extreme heat and rain may occur in succession within short time periods and cause greater impacts than individual events separated in time and space. Therefore, many studies have examined the impacts of compound hazard events on the social-ecological system at various scales. The definition of compound events is fundamental for such research. However, there are no existing studies that support the determination of time interval between individual events of a compound rainstorm and heatwave(CRH) event, which consists of two or more potentially qualifying component heatwave and rainstorm events. To address the deficiency in defining what individual events can constitute a CRH event, this study proposed a novel method to determine the maximum time interval for CRH events through the change in CRH event frequency with increasing time interval between individual events, using southern China as a case study. The results show that the threshold identified by the proposed method is reasonable. For more than 90% of the meteorological stations, the frequency of CRH events has reached a maximum when the time interval is less than or equal to the threshold. This study can aid in time interval selection, which is an important step for subsequent study of CRH events.

关键词： Compound extreme weather event Rainstorm and heatwave Southern China Threshold Time interval

Myocardial injury caused by Amanita pseudoporphyria Hongo

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World Journal of Emergency Medicine 2024年第5期15卷 401-403页

作者： Junliang Xiao Chengliang liao Xiquan Yan Xiaotong han Maiying Fan Department of Emergency Medicine the First Affi liated Hospital of Hunan Normal University(People's Hospital of Hunan Province)Changsha 410005China Clinical Research Center For Emergency and Critical Care in Hunan Province Changsha 410005China Hunan Provincial Institute of Emergency Medicine Changsha 410005China Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics Changsha 410005China

Amanita pseudoporphyria Hongo(APH)is a toxic mushroom containing Amanita toxin that is notably associated with liver and kidney function impairment.[1]Acute myocardial infarction(AMI)is a severe stage of coronary heart disease that can cause sudden death and is the leading cause of mortality and morbidity across the world.[2]The incidence rate of myocardial injury caused by accidental ingestion of APH is very *** this study,we aimed to report 11 patients who had varying degrees of myocardial injury,reduced heart function,and even cardiac arrest after accidental ingestion of APH.

关键词： mortality injury coronary

Theoretical probe into universal tetrad effect for complexation discrepancy between lanthanide elements and organophosphoric extractant diethyl phosphoric acid

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Journal of Rare Earths 2024年第6期42卷 1142-1148,I0006页

作者： haifeng Zheng Yanling Li Xuyi Zhang Jinglu han Songsong Li Guolong Wu Qingshi Liu Xiaojuan Liu Wuping liao State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang330031China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341000China

The deep understanding of 4f-correlated electron motion behavior is experimentally limited due to similar physicochemical properties of rare earth elements(REEs).While the solvent extraction behavior originating from the continuous occupation of 4f electrons along the lanthanide family provides a particular platform to probe the 4f electrons motion behavior and its correlations to their versatile ***,the complexation between REEs and the prototypical extractant of diethyl phosphoric acid(DEP)was substantially studied based on quantum mechanical *** results firstly show that the average bond lengths between Ln and six coordinated oxygen atoms are consistent with lanthanide contraction phenomenon,and gadolinium break effect is also obviously ***,the"tetrad effect"is figured out based on the subtle discrepancy of 4f electrons occupation,namely La-Nd,Sm-Eu,Gd-Dy and ***,the main composition is 4f5d6p for La-Nd,while the discrepancy is due to the increasing electrons in the 5d shell,while it is 4f5d for *** Gd-Dy,their 4f orbitals accept little electrons and the donating electrons flow into 6s5d subshells due to the half-filled stability and the enhancement of shielding *** electrons donate into 5d6p subshells due to multiply electrons occupation of 4f orbitals for *** detailed analyses obviously clarify the"tetrad effect"along the lanthanide family due to the different variation of 4f orbital *** is expected that these microscopic understandings provide important guidance for the separation of REEs and the design of new extractants.

关键词： Theoretical calculation Rare earths 4f electron Tetrad effect Gadolinium break

Inonotus obliquus(Chaga)against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway

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Chinese Journal of Natural Medicines 2024年第7期22卷 619-631页

作者： FENG Yating LIU Jing GONG Le han Zhaodi ZhanG Yan LI Rongshan liao Hui School of Pharmacy Shanxi Medical UniversityTaiyuan 030001China Drug Clinical Trial Institution The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)Taiyuan 030012China Department of Nephrology The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)Taiyuan 030012China

Our prior investigations have established that Inonotus obliquus(Chaga)possesses hypoglycemic *** hyperglycemia is known to precipitate renal function *** functionality of the kidneys is intricately linked to the levels of cyclic guanosine-3',5'-monophosphate(cGMP),which are influenced by the activities of nitric oxide synthase(NOS)and phosphodiesterase(PDE).Enhanced cGMP levels can be achieved either through the upregulation of NOS activity or the downregulation of PDE *** objective of the current study is to elucidate the effects of Chaga on disorders of glucolipid metabolism and renal abnormalities in rats with type 2 diabetes mellitus(T2DM),while concurrently examining the NOS-cGMP-PDE5 signaling pathway.A model of T2DM was developed in rats using a high-fat diet(HFD)combined with streptozotocin(STZ)administration,followed by treatment with Chaga extracts at doses of 50 and 100 mg·kg^(−1)for eight *** findings revealed that Chaga not only mitigated metabolic dysfunctions,evidenced by improvements in fasting blood glucose,total cholesterol,triglycerides,and insulin resistance,but also ameliorated renal function markers,including serum creatinine,urine creatinine(UCr),blood urea nitrogen,24-h urinary protein,and estimated creatinine ***,enhancements in glomerular volume,GBM thickness,podocyte foot process width(FPW),and the mRNA and protein expressions of podocyte markers,such as nephrin and wilms tumor-1,were *** was found to elevate cGMP levels in both serum and kidney tissues by increasing mRNA and protein expressions of renal endothelial NOS and neural NOS,while simultaneously reducing the expressions of renal inducible NOS and *** summary,Chaga counteracts HFD/STZ-induced glucolipid metabolism and renal function disturbances by modulating the NOS-cGMP-PDE5 signaling *** research supports the potential application of Chaga in the clinical prevention and treatment of T2DM and

关键词： Inonotus obliquus Diabetic nephropathy Glucolipid metabolism disorders Renal functions NOS-cGMP-PDE5 signaling

A novel nano-grade organosilicon polymer:Improving airtightness of compressed air energy storage in hard rock formations

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International Journal of Mining Science and Technology 2024年第3期34卷 305-321页

作者： Zhuyan Zheng Guibin Wang Chunhe Yang Hongling Ma Liming Yin Youqiang liao Kai Zhao Zhen Zeng hang Li Yue han Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Geomechanics and Geotechnical Engineering Wuhan 430071China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China PowerChina Huadong Engineering Corporation Limited Hangzhou 310014China

Enhancing cavern sealing is crucial for improving the efficiency of compressed air energy storage(CAES)in hard rock *** study introduced a novel approach using a nano-grade organosilicon polymer(NOSP)as a sealant,coupled with an air seepage evaluation model that incorporates Knudsen ***,the initial coating application methods were outlined,and the advantages of using NOSP compared to other sealing materials,particularly regarding cost and construction techniques,were also examined and *** results indicated a significant reduction in permeability of rock specimens coated with a 7–10μm thick NOSP ***,under a 0.5 MPa pulse pressure,the permeability decreased to less than 1 n D,and under a 4 MPa pulse pressure,it ranged between4.5×10^(-6)–5.5×10^(-6)m D,marking a 75%–80%decrease in granite *** sealing efficacy of NOSP surpasses concrete and is comparable to rubber *** optimal viscosity for application lies between 95 and 105 KU,and the coating thickness should ideally range from 7 to 10μm,applied to substrates with less than 3%*** study provides new insights into air transport and sealing mechanisms at the pore level,proposing NOSP as a cost-effective and simplified solution for CAES applications.

关键词： Compressed air energy storage Lining Permeability Transient pulse method Hard rock cavern Nano-grade organosilicon polymer coating

An intrinsically self-healing and anti-freezing molecular chains induced polyacrylamide-based hydrogel electrolytes for zinc manganese dioxide batteries

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Journal of Energy Chemistry 2024年第2期89卷 565-578,I0013页

作者： haiyang liao Wenzhao Zhong Chen Li Jieling han Xiao Sun Xinhui Xia Ting Li Abolhassan Noori Mir F.Mousavi Xin Liu Yongqi Zhang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of Mechanical Engineering Hunan University of TechnologyZhuzhou 412007HunanChina School of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina Department of Chemistry Faculty of Basic SciencesTarbiat Modares UniversityTehran 14117-13116Iran State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina

The anti-freezing strategy of hydrogels and their self-healing structure are often contradictory,it is vital to break through the molecular structure to design and construct hydrogels with intrinsic anti-freezing/self-healing for meeting the rapid development of flexible and wearable devices in diverse service ***,we design a new hydrogel electrolyte(AF/SH-Hydrogel)with intrinsic anti-freezing/self-healing capabilities by introducing ethylene glycol molecules,dynamic chemical bonding(disulfide bond),and supramolecular interaction(multi-hydrogen bond)into the polyacrylamide molecular *** to the exceptional freeze resistance(84%capacity retention at-20℃)and intrinsic self-healing capabilities(95%capacity retention after 5 cutting/self-healing cycles),the obtained AF/SH-Hydrogel makes the zinc||manganese dioxide cell an economically feasible battery for the state-of-the-art *** Zn||AF/SH-Hydrogel||MnO_(2)device offers a near-theoretical specific capacity of 285 m A h g^(-1)at 0.1 A g^(-1)(Coulombic efficiency≈100%),as well as good self-healing capability and mechanical flexibility in an ice *** work provides insight that can be utilized to develop multifunctional hydrogel electrolytes for application in next generation of self-healable and freeze-resistance smart aqueous energy storage devices.

关键词： Flexible aqueous battery Hydrogel electrolyte Anti-freezing Self-healing Dual-dynamic reversible bond