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Effects of adenosine agonist R-phenylisopropyl-adenosine on halothane anesthesia and antinociception in rats

Acta Pharmacologica Sinica 2005年第2期26卷 181-185页

作者： hai-chun ma~(2,4),yan-fen wang~3.chun-sheng feng~2,hua zhao~(4,5),{3.,the first hospital of jilin university,changchun 13.021,China ~3.6} of Digestive Disease,the Secondhospital of jilin university,changchun 13.041,China ~4department of Physiology,Basic Medical School,jilin university,changchun 13.021,China ~6department of anesthesiology,School of Medicine,Gifu university,Gifu 5008705,Japan department of anesthesiology the First Hospital of Jilin University Changchun China department of Physiology Basic Medical School Jilin University Changchun China department of Digestive Disease the Second Hospital of Jilin University Changchun China department of anesthesiology School of Medicine Gifu University Gifu Japan

Aim:To investigate the antinociceptive effect of adenosine agonist R-phenylisopropyl-adenosine（R-PIA）given to conscious rats by intracerebro-ventricular（ICV）and intrathecal（IT）,and identify the effect of R-PIA on minimumalveolar concentration（maC）of halothane with pretreatment of A1receptor an-tagonist 8-cyclopentyl-1,3.dipropylxanthine（DPCPX）or K+channel blocker4-aminopyridine（4-AP）.Methods:Sprague-Dawley rats were implanted with 24-gauge stainless steel guide cannula using stereotaxic apparatus and ICV method,and an IT catheter（PE-10,8.5cm）was inserted into the lumbar subarachnoidspace,while the rats were under pentobarbital *** one week ofrecovery from surgery,rats were randomly assigned to one of the followingprotocols:maC of halothane,or tail-flick *** measurements were per-formed after R-PIA（0.8-2.0μg）microinjection into ICV and IT with or withoutpretreatment of DPCPX or ***:Microinjection of adenosine agonist R-PIA in doses of 0.8-2.0μg into ICV and IT produced a significant dose-and time-dependent antinociceptive action as reflected by increasing latency times andICV administration of adenosine agonist R-PIA（0.8μg）reducing halothane anes-thetic requirements（by 29%）.The antinociception and reducing halothane re-quirements effected by adenosine agonist R-PIA was abolished by DPCPX ***:ICV and IT administration of adenosine agonist R-PIA pro-duced an antinociceptive effect in a dose-dependent manner and decreased hal-othane maC with painful stimulation through activation of A1receptor subtype,and the underlying mechanism involves K+channel activation.

关键词： adenosine inhalation anesthesia analgesia potassium channels subarachnoid space cerebral ventricles

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Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： ZHU Yuan Yue ZHENG Rui Zhi wang Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue feng yan Li wang Tian Ge {3. Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao wang You Min WU sheng Li yanG Tao DENG hua Cong {3. Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying wang Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China the first hospital of jilin university Changchun 130021JinlinChina Qilu hospital of Shandong university Jinan 250012ShandongChina Affiliated hospital of Guiyang Medical College Guiyang 550004GuizhouChina Xinhua hospital Affiliated to Shanghai Jiaotong {3. School of Medicine Shanghai 200092China Tongji hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The first Affiliated hospital of Zhengzhou university Zhengzhou 450052HenanChina The Affiliated hospital of Southwest Medical university Luzhou 646099SichuanChina Fujian Provincial hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central hospital Dalian 116003LiaoningChina The first Affiliated hospital of Wenzhou Medical university Wenzhou 325000ZhejiangChina The first Affiliated hospital of Guangxi Medical university Nanning 530021GuangxiChina Jiangxi Provincial People's hospital Affiliated to Nanchang university Nanchang 330006JiangxiChina The Second Affiliated hospital of Harbin Medical university Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central hospital of Shanghai Jiading District Shanghai 201800China Jiangsu Province hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The first Affiliated hospital of Anhui Medical university Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 3.,941 men and 62,3.1 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

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微课在麻醉学教学中的探索

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高校医学教学研究（电子版） 2018年第1期8卷 10-12页

作者：朴美花卢英刘楠张松灵杜玉君冯春生吉林大学白求恩第一医院长春130021

随着数字技术的飞速发展,微课作为一种新型的教学资源和教学方式已悄然成为医学教育的重要手段,"短小、简洁"的微课使学生在获取知识时更具直接性、需要性、便捷性和有效性,便于学生利用"碎片化"时间进行自主学习。本文以"全身麻醉"的... 详细信息

随着数字技术的飞速发展,微课作为一种新型的教学资源和教学方式已悄然成为医学教育的重要手段,"短小、简洁"的微课使学生在获取知识时更具直接性、需要性、便捷性和有效性,便于学生利用"碎片化"时间进行自主学习。本文以"全身麻醉"的微课为例,阐述在麻醉学教学中微课的设计思路,以期为微课的开发建设提供参考。

关键词：微课麻醉学教学全身麻醉

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新型冠状病毒感染者脊柱外科急诊手术的围手术期管理专家共识

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脊柱外科杂志 2020年第6期18卷 361-368页

作者：华文彬郜勇李危石仉建国朱泽章王冰李方财何达马真胜魏欣杨磊任东平张雪松李利吴继功徐宝山宁广智武汉杨群戈朝晖康学文夏磊高延征刘新宇刘浩初同伟熊伟夏平陈雄生白玉树殷国勇王向阳刘向阳杨军林万勇董健文丁文元陶惠人王迎松吴星火张宇坤郑东潘海涛吴永超曾宪林李锋邵增务杨述华邱海波王征杨操华中科技大学同济医学院附属协和医院骨科武汉430022 北京大学第三医院骨科北京100191 北京协和医院骨科北京100032 南京大学医学院附属鼓楼医院骨科南京210008 中南大学湘雅二医院骨科长沙410011 浙江大学医学院附属第二医院骨科杭州310056 北京积水潭医院骨科北京100035 空军军医大学西京医院骨科西安710032 华中科技大学同济医学院附属协和医院麻醉科武汉430022 华中科技大学同济医学院附属协和医院手术室武汉430022 中国人民解放军总医院骨科北京100853 中国人民解放军战略支援部队特色医学中心骨科北京100010 天津医院骨科天津300211 天津医科大学总医院骨科天津300052 吉林大学中日联谊医院骨科长春130033 大连医科大学附属第一医院骨科大连116011 宁夏医科大学总医院骨科银川750004 兰州大学第二医院骨科兰州730000 郑州大学第一附属医院骨科郑州450052 河南省人民医院骨科郑州450003 山东大学齐鲁医院骨科济南250012 四川大学华西医院骨科成都610041 陆军军医大学新桥医院骨科重庆400037 华中科技大学同济医学院附属同济医院骨科武汉430030 武汉市第一医院骨科武汉430022 海军军医大学附属长征医院骨科上海200003 海军军医大学附属长海医院骨科上海200433 南京医科大学第一附属医院骨科南京210029 温州医科大学附属第二医院骨科温州325000 湖南省人民医院骨科长沙410002 上海交通大学医学院附属新华医院骨科上海200092 中山大学附属第一医院骨科广州510080 中山大学附属第三医院骨科广州510630 河北医科大学第三医院骨科石家庄050091 深圳大学总医院骨科深圳518055 昆明医科大学附属第二医院骨科昆明650031 东南大学附属中大医院重症医学科南京210009

自2019年12月以来,已有200余个国家和地区相继报道了新型冠状病毒感染病例,世界卫生组织(WHO)于2020年3.12日宣布新型冠状病毒全球大流行,截至6月18日,全球已累计有824万余人感染,44万余人死亡,对全世界医疗、政治和经济领域影响巨大[1... 详细信息

自2019年12月以来,已有200余个国家和地区相继报道了新型冠状病毒感染病例,世界卫生组织(WHO)于2020年3.12日宣布新型冠状病毒全球大流行,截至6月18日,全球已累计有824万余人感染,44万余人死亡,对全世界医疗、政治和经济领域影响巨大[1-2]。WHO将其命名为“2019冠状病毒感染性疾病”(COVID-19),病原体被命名为重症急性呼吸综合征冠状病毒2(SARS-CoV-2)[3.6]。按照《中华人民共和国传染病防治法》,COVID-19被纳入乙类传染病,采取甲类传染病的预防控制措施[7]。

关键词：脊柱疾病冠状病毒感染肺炎,病毒性急诊处理外科手术

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