检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

《农事操作》课程现场教学法的探索与实践

高教论坛 2014年第2期 66-68页

作者：朱翠林海江波冯炜西北农林科技大学陕西杨凌712100

为了提升《农事操作》课程的实践教学效果,详细介绍了该课程运用现场教学法的具体做法:加强和改善农事操作课程所需的硬件和软件条件的建设;增加形态观察实验;有计划、灵活地安排农事操作实践活动。并分析了现场教学法运用的成效:学生... 详细信息

为了提升《农事操作》课程的实践教学效果,详细介绍了该课程运用现场教学法的具体做法:加强和改善农事操作课程所需的硬件和软件条件的建设;增加形态观察实验;有计划、灵活地安排农事操作实践活动。并分析了现场教学法运用的成效:学生更易理解和掌握专业课的内容和理论;为三年级的科研训练和四年级的毕业实习打下了坚实的科研技能基础。

关键词：农事操作现场教学法实践教学

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

《种子法规与管理》课程教学改革初探

种子 2013年第4期32卷 122-123页

作者：李晓燕谢彦周海江波高翔闵东红西北农林科技大学农学院陕西杨凌712100

种子产业的发展,要求种子专业人才要具备综合知识结构,要掌握种子科学技术和理论的专业知识。《种子法规与管理》是种子科学与工程专业培养计划中的主观专业课程。本文本着培养学生熟悉掌握种子法规及行政管理相关知识,激发学生的学习兴... 详细信息

种子产业的发展,要求种子专业人才要具备综合知识结构,要掌握种子科学技术和理论的专业知识。《种子法规与管理》是种子科学与工程专业培养计划中的主观专业课程。本文本着培养学生熟悉掌握种子法规及行政管理相关知识,激发学生的学习兴趣,培养思考问题解决问题的能力,从培养高级应用型人才角度对本课程的教学方法进行了一系列的改革。

关键词：种子法规与管理教学方法人才培养

Preparation of calcium carbonate particles coated with titanium dioxide

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2009年第5期16卷 592-597页

作者： hai Lin Ying-bo Dong Le-yong jiang School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China

The preparation of a new mineral composite material, calcium carbonate particles coated with titanium dioxide, was studied. The mechanism of the preparation process was proposed. The new mineral composite material was made by the mechanoehemieal method under the optimum condition that the mass ratio of calcium carbonate particles to titanium dioxide was 6.5：3.5. The mass ratios of two different types of titanium dioxide （anatase to rutile） and grinding media to grinded materials were 8：2 and 4：1 respectively, and the modified density was 60%. Under this condition, the new material was capable of forming after 120-min modification. The hiding power and oil absorption of this new material were 29.12 g/m^2 and 23.30%, respectively. The results show that the modification is based on surface hydroxylation. After coating with titanium dioxide, the hiding power of calcium carbonate can be improved greatly. The new mineral composite materials can be used as the substitute for titanium dioxide.

关键词： calcium carbonate mechano-chemical process titanium dioxide film hydroxylation

在线全文

学校读者我要写书评

暂无评论

积极推进体育改革树立终身体育思想

体育成人教育学刊 2003年第4期19卷 27-28页

作者：韩海波姜域湛江海洋大学体育部广东湛江524088

高校是学生树立终身体育思想的关键时期 ,我们应通过改进现有的大学体育教育模式和方法 ,使学生主动投入到体育中来 ,并最终形成终身体育的思想 ,掌握终身体育的知识和技能。针对高校体育课内外活动的现状 ,提出了高校体育课及课外体育... 详细信息

高校是学生树立终身体育思想的关键时期 ,我们应通过改进现有的大学体育教育模式和方法 ,使学生主动投入到体育中来 ,并最终形成终身体育的思想 ,掌握终身体育的知识和技能。针对高校体育课内外活动的现状 ,提出了高校体育课及课外体育活动的改革应在终生体育的理念基础上采用可行性模式的对策。

关键词：体育教学教学改革终身体育教学思想高等院校教育模式课外体育活动教学内容

SII1263,a Putative Cation Diffusion Facilitator in Synechocystis *** 6803,Plays an Essential Role in Iron Starvation Rather Than Iron Detoxification

在线全文

学校读者我要写书评

暂无评论

SII1263,a Putative Cation Diffusion Facilitator in Synechocy...

单宁酸改性互穿网络水凝胶促进断裂跟腱术后的组织重塑

中国藻类学会第八次会员大会暨第十六次学术讨论会

作者： hai-bo jiang,Wen-Jing Lou,Han-Ying Du & Bao-Sheng Qiu~* College of Life Sciences,Central China Normal University,Luoyu Road 152,Wuhan 430079, Hubei,People'' s Republic of China Hubei Key Laboratory of Genetic Regulation and Integrative Biology,Central China Normal University,Wuhan 430079,Hubei,P.R.China

＜正＞Iron plays essential roles in photosynthetic organisms while iron bioavailability in neutral pH environment is very *** are the most ancient photosynthetic organism that contributes significant percentages of total global primary *** cyanobacteria survive in iron deficiency conditions remains *** this study,six genes and one gene cluster from Synechocystis sp. strain PCC 6803 were identified to be required when cells were under iron starvation *** them,a gene slll263 encoding putative cation diffusion facilitator protein（CDF） was sharply induced by *** of slll263 in Synechocystis 6803 reduced growth and pigment contents under iron starvation condition compared to its ***-expression of slll263 resulted in increased iron-deficiency adaptation in Synechocystis 6803 but decreased growth rate in high-iron stress compared to wild-type *** putative cyanobacterial CDF protein likely plays distinctly different roles from that in bacteria,which promoted iron uptake rather than iron *** S111263 homolog in Escherichia coli,ferrous iron efflux protein（FieF）,could not complement slll263::C.K2 mutant of Synechocystis 6803 although they have 50%amino acid similarity,but S111263 itself could completely complement *** low-iron habitats and high iron demand of cyanobacteria can be the major reasons determining the role of cyanobacterial CDF protein in the homeostasis of iron uptake and efflux.

关键词： Cyanobacteria CDF protein Iron transport Iron starvation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第4期29卷 721-729页

作者：张博张振江东北京大学第三医院运动医学科北京市100191

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿... 详细信息

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿网络水凝胶,表征水凝胶的微观形貌、力学性能、黏附性能、体外释药性能与生物相容性。②取30只SD大鼠,采用随机数字表法分为假手术组、手术组与水凝胶组,每组10只,后2组建立右后肢跟腱断裂模型,手术组采用改良Kessler法将断裂跟腱重新缝合,水凝胶组采用相同术式缝合断裂跟腱后将单宁酸改性互穿网络水凝胶贴片完全缠绕包裹于断端接合处。术后4周,对断裂跟腱进行影像学检查、组织学评价、生物力学测试及炎症因子水平检测。结果与结论:①扫描电镜下可见单宁酸改性互穿网络水凝胶呈多孔微观结构,孔径为3-10μm,并且水凝胶具备良好的体外释药性能、黏附强度与拉伸强度;CCK-8检测与活/死染色显示,该水凝胶对大鼠骨髓间充质干细胞增殖活性无明显影响,具备良好的生物相容性。②MRI成像显示,与手术组比较,水凝胶组大鼠跟腱呈均一低信号,跟腱前后径厚度减小,与周围组织分界更为明确,表现更接近假手术组。苏木精-伊红与Masson染色显示,手术组大鼠跟腱纤维排列松散混乱,细胞密度增加且排布杂乱,伴有明显炎性细胞浸润,部分区域出现腱内骨化;水凝胶组大鼠跟腱纤维排列有序,细胞密度降低且排布规整,炎性细胞浸润明显减少。手术组大鼠跟腱的拉伸强度低于假手术组(P<0.05),水凝胶组大鼠跟腱的拉伸强度高于手术组(P<0.05)。与假手术组比较,手术组大鼠跟腱中白细胞介素1β、白细胞介素6及肿瘤坏死因子α质量浓度及mRNA表达升高(P<0.05);与手术组比较,水凝胶组3种炎症因子水平及mRNA表达降低。③结果表明,单宁酸改性互穿网络水凝胶可显著抑制局部炎症反应、促进断裂跟腱组织重塑。

关键词：单宁酸水凝胶互穿网络跟腱断裂组织重塑组织再生

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

国内农业用生物炭的研究脉络和趋势——基于CiteSpace的可视化分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

河西学院学报 2022年第2期38卷 77-88页

作者：卜康敏孙毅涛李文佳海江波西北农林科技大学农学院陕西杨凌712100

【目的】农业用生物炭是提高作物产量、实现农业可持续发展的重要举措.通过对我国农业用生物炭研究脉络和趋势探讨的分析,为其发展和未来研究趋势提供理论指导.【方法】文章使用CiteSpace对与“农业用生物炭”相关的870篇文献进行知识... 详细信息

【目的】农业用生物炭是提高作物产量、实现农业可持续发展的重要举措.通过对我国农业用生物炭研究脉络和趋势探讨的分析,为其发展和未来研究趋势提供理论指导.【方法】文章使用CiteSpace对与“农业用生物炭”相关的870篇文献进行知识图谱的绘制及可视化分析.【结果】我国农业用生物炭研究领域的发展主要经历了萌芽起步、加速上升、缓慢下降3个主要阶段;该领域的研究员代表主要是潘根兴、李恋卿等;该领域具有代表性的研究机构为南京农业大学和沈阳农业大学;国家层面设立了“国家自然科学基金”“国家重点研发计划”等国家重点基金提供支持;未来我国农业用生物炭的研究趋势可能主要集中在农作物品质改善及增产、农田土壤理化性质的改良及养分的提高、农业生态环境的修复及可持续发展3个方面.【结论】根据文章研究结果,可以客观、科学的看出我国生物炭在农业中应用的相关文献数量及年度变化趋势、高频关键词、高产发文作者、发文机构、主要基金支持及研究前沿,奠定了以农业用生物炭为基础的研究脉络;同时,也为从事相关领域的学者在未来进行多元化扩展提供了有利的参考信息.

关键词：生物炭农业 CiteSpace 可视化分析知识图谱