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Residual tumor and central lymph node metastasis after thermal ablation of papillary thyroid carcinoma: A case report and review of literature

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World Journal of Clinical Cases 2021年第1期9卷 252-261页

作者： Yu Hua Jia-Wen Yang Liu He Hua Xu hai-zhong huo Chen-Fang Zhu Department of General Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineDiscipline Construction Research Center of China Hospital Development InstituteShanghai Jiao Tong UniversityShanghai 200011China

BACKGROUND Debate exists regarding the use of thermal ablation(TA)to treat papillary thyroid carcinoma(PTC).Some studies have recommended TA as a new,efcient and safe technology for *** this article,we report one case of a residual tumor and central lymph node metastasis(CLNM)after TA for *** SUMMARY A 63-year-old female underwent bilateral ultrasound(US)-guided radiofrequency ablation for *** months later,she was diagnosed as thyroid cancer with suspected CLNM by US and contrast-enhanced computed *** subsequent fine-needle aspiration(FNA)biopsies were *** to her strong personal preference,she underwent total thyroidectomy and central lymph node *** tissue adhesion and a difficult dissection were noted during the *** pathology of the frozen sections during the operation was still *** final pathology results of paraffin-embedded sections revealed residual tumor cells at the edge of the PTC and *** TA may lead to a residual tumor in patients with ***-up using US and FNA biopsy may not be adequate to evaluate the residual *** should be carefully considered in PTC treatment.

关键词： Papillary thyroid carcinoma Thermal ablation Residual tumor Central lymph node metastasis Follow-up Case report

Treatment of leiomyomatosis peritonealis disseminata with goserelin acetate: A case report and review of the literature

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World Journal of Clinical Cases 2021年第19期9卷 5217-5225页

作者： Jia-Wen Yang Yu Hua Hua Xu Liu He hai-zhong huo Chen-Fang Zhu Department of General Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineDiscipline Construction Research Center of China Hospital Development InstituteShanghai Jiao Tong UniversityShanghai 200011China

BACKGROUND Leiomyomatosis peritonealis disseminata(LPD)is a rare condition characterized by multiple pelvic and abdominal nodules,which are composed of smoothmuscle *** date,no more than 200 cases have been *** diagnosis of LPD is difficult and there are no guidelines on the treatment of ***,surgical excision is the ***,hormone blockade therapy can be an alternative *** SUMMARY A 33-year-old female patient with abdominal discomfort and palpable abdominal masses was admitted to our *** had undergone four surgeries related to uterine leiomyoma in the past 8 *** tomography revealed multiple nodules scattered within the abdominal wall and peritoneal *** symptoms and the result of the core-needle biopsy were consistent with *** patient refused surgery and was then treated with tamoxifen,ulipristal acetate(a selective progesterone receptor modulator),and goserelin acetate(a gonadotropin-releasing hormone agonist).Both tamoxifen and ulipristal acetate were not effective in controlling the disease ***,the patient achieved an excellent response when goserelin acetate was attempted with relieved syndromes and obvious shrinkage of *** largest nodule showed a 25%decrease in the sum of the longest diameters from pretreatment to *** to now,2 years have elapsed and the patient remains asymptomatic and there is no development of further *** Goserelin acetate is effective for the management of *** long-term use of goserelin acetate is thought to be safe and *** blockade therapy can replace repeated surgical excision in recurrent patients.

关键词： Goserelin acetate Leiomyomatosis peritonealis disseminata Hormone blockade therapy Conservative treatment Disseminated peritoneal leiomyomatosis Case report

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu hai-Feng Zhou Wei Yang Di Zhu Bi-Fei Wu hai-Bin Shi Sheng Liu Wei-zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi Zheng Xiao-Sheng Li Qian-Jie Xu Wei Zhang zhong-Li Liao hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

Image Inpainting Based on Structural Tensor Edge Intensity Model

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International Journal of Automation and computing 2021年第2期18卷 256-265页

作者： Jing Wang Yan-Hong Zhou hai-Feng Sima Zhan-Qiang huo Ai-zhong Mi College of Computer Science and Technology Henan Polytechnic UniversityJiaozuo 454003China

In the exemplar-based image inpainting approach,there are usually two major problems:the unreasonable calculation of priority and only considering the color features in the patch lookup *** this paper,we propose an image inpainting approach based on the structural tensor edge intensity ***,we use the progressive scanning inpainting method to avoid the image filling order being affected by the priority ***,we use the edge intensity model to build the patches similarity function for correctly identifying the local image ***,the balance operator is used to restrict the excessive propagation of structural information to ensure the correct structural *** experimental results show that the our approach is comparable and even superior to some state-of-the-art inpainting algorithms.

关键词： Exemplar-based technique image inpainting structural tensor edge intensity model structure propagation balance operator

Chandra Observation of Point Sources in the X-Ray Elliptical Galaxy NGC 1407

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Chinese Journal of Astronomy and Astrophysics 2004年第3期4卷 221-230页

作者： zhong-LiZhang hai-GuangXu NationalAstronomicalObservatories ChineseAcademyofSciencesBeijing100012 DepartmentofPhysics ShanghaiJiaoTongUniversityShanghai200030

With the Chandra pointing observation of about 50 ks, we have detected 41 point sources in the X-ray relatively faint elliptical galaxy NGC 1407, most of which appear to be low mass X-ray binaries. In luminosity flux units, these resolved point sources contribute about 17.8 % of the total emission of the galaxy in 0.3–10 keV. Of the remaining diffuse emission, about 53.4 % (or 43.9 % of total) may arise from unresolved point sources. We find six ultraluminous X-ray sources with luminosities above 1039 erg s?1. This number is less than has been found in NGC 720, but more than in NGC 4697 and NGC 1553, so suggesting a possible correlation between the number of ULXs and the total X-ray luminosity of early-type galaxies. A central point-like source is detected whose luminosity (2.36 ± 0.14×1039 erg s?1) is the highest among all resolved sources. However, because of its relatively low hardness ratio, we speculate that it is not likely to be a low luminosity AGN.

关键词： binaries: close galaxies: elliptical and lenticular galaxies: individual:NGC 1407 X-rays: binaries X-rays: galaxies

Phosphorus status and microbial community of paddy soil with the growth of annual ryegrass (Lolium multiflorum Lam.) under different phosphorus fertilizer treatments

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第10期10卷 761-768页

作者： hai-chao GUO Guang-huo WANG Department of Resource Science College of Environmental and Resource Sciences Zhejiang University Hangzhou 310029 China

Annual ryegrass （Lolium multiflorum Lam.） was grown in paddy soil in pots under different phosphorus （P） fertilizer treatments to investigate changes of P fractions and microbial community of the soil. The treatments included Kunyang phosphate rock （KPR） applications at 50 mg P/kg （KPRs0） and 250 mg P/kg （KPR250）, mono-calcium phosphate （MCP） application at 50 mg P/kg （MCP50）, and the control without P application. The results showed that KPR50, KPR250, and MCP50 applications significantly increased the dry weight of the ryegrass by 13%, 38%, and 55%, and increased P uptake by 19%, 135%, and 324%, respectively. Compared with MCP50, the relative effectiveness of KPR50 and KPR250 treatments in ryegrass production was about 23% and 68%, respectively. After one season ofryegrass growth, the KPR50, KPR250, and MCP50 applications increased soil-available P by 13.4%, 26.8%, and 55.2%, respectively. More than 80% of the applied KPR-P remained as HC1-P fraction in the soil. Phospholipid fatty acid （PLFA） analysis showed that the total and bacterial PLFAs were significantly higher in the soils with KPR250 and MCP50 treatments compared with KPR50 and control. The latter had no significant difference in the total or bacterial PLFAs. The KPR50, KPR250, and MCP50 treatments increased fungal PLFA by 69%, 103%, and 69%, respectively. Both the principal component analysis and the cluster analysis of the PLFA data suggest that P treatments altered the microbial community composition of the soils, and that P availability might be an important contributor to the changes in the microbial community structure during the ryegrass growth in the paddy soils.

关键词： Phosphorus fractionation Phospholipid fatty acid (PLFA) Ryegrass Phosphate rock

Hot versus cold subduction initiation

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National Science Review 2024年第2期11卷 101-102页

作者： zhong-hai Li Key Laboratory of Computational Geodynamics College of Earth and Planetary SciencesUniversity of Chinese Academy of Sciences

In the framework of plate tectonics, subduction initiation(SI) indicates the birth of a plate convergent boundary, which is a key point of plate tectonics and Wilson's cycle; however, its dynamic process is not well c...

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Tailoring Morphology of PVDF-HFP Membrane via One-step Reactive Vapor Induced Phase Separation for Efficient Oil-Water Separation

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Chinese Journal of Polymer Science 2021年第5期39卷 610-619,I0007页

作者： Peng huo Cheng-Tang zhong Xiao-Peng Xiong Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005China

Poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)receives increasing attention in membrane separation field based on its advantages such as high mechanical strength,thermal and chemical ***,controlling the microporous structure is still *** this work,we attempted to tailor the morphology of PVDF-HFP membrane via a one-step reactive vapor induced phase separation ***,PVDF-HFP was dissolved in a volatile solvent and then was cast in an ammonia water vapor *** complete evaporation of solvent,membranes with adjustable porous structure were prepared,and the microstructures of the membranes were analyzed by scanning electron microscopy,Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy and X-ray diffraction *** on the results,a mechanism of dehydrofluorination induced cross-linking of PVDF-HFP has been suggested to understand the morphology *** our knowledge,this is the first report of one-step reactive vapor induced phase separation strategy to tailor morphology of PVDF-HFP *** addition,the membranes prepared in the ammonia water vapor exhibited enhanced mechanical strength and achieved satisfactory separation efficiency for water-in-oil emulsions,suggesting promising potential.

关键词： PVDF-HFP Membrane Tailoring Vapor induced phase separation Oil-water separation