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Prognostic significance of cytokine receptor-like factor 2 alterations in acute lymphoblastic leukemia:a meta-analysis

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World Journal of Pediatrics 2015年第2期11卷 126-133页

作者： Ming Jia Zhu-Jun Wang hai-zhao zhao He-Ping Shen Yu-Ping Cheng Ze-Bin Luo Yong-Min Tang Division of Hematology-oncology Children's HospitalZhejiang University School of MedicineKey Laboratory of Reproductive Genetics(Zhejiang University)Ministry of EducationHangzhou 310003China

Background:Cytokine receptor-like factor 2(CRLF2)has been shown to play a role in the pathogenesis of acute lymphoblastic leukemia(ALL).Studies have examined the relationship between CRLF2 alterations such as over-expression or deregulation and clinical outcome in childhood ALL,but the results are *** metaanalysis aimed to explore the association between CRLF2 alterations and survival of pediatric patients with ***:Electronic databases updated to March 2014 were searched for relevant studies.A meta-analysis was made of twelve studies including 5945 patients to evaluate the prognostic significance of CRLF2 alterations on survival in childhood *** ratios(HRs)with 95%confidence intervals(CIs)were pooled across the studies using a fixed-effects ***:CRLF2 over-expression in childhood ALL was associated with poor prognosis in terms of relapse-free survival(RFS;HR=1.70,95%CI=1.28-2.24,P=0.000),event-free survival(EFS;HR=1.78,95%CI=1.05-3.01,R=0.032),and overall survival(OS;HR=2.28,95%CI=1.42-3.65,R=0.001).The combined data also suggested that CRLF2 deregulation in childhood ALL was correlated with poor EFS(HR=1.95,95%CI=1.46-2.61,R=0.000),RFS(HR=2.20,95%CI=1.53-3.18,P=0.000),and OS(HR=1.89,95%CI=1.24-2.87,P=0.003).Subgroup analysis on multivariate HRs showed that CRLF2 deregulation independently predicted a poor prognosis for childhood ***:The present meta-analysis reveals that both CRLF2 over-expression and deregulation are associated with poor prognosis in pediatric patients with ALL.

关键词： acute lymphoblastic leukemia cytokine receptor-like factor 2 meta-analysis prognosis

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Differential Evolution Hemivariational Inequalities with Anti-periodic Conditions

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1143-1160页

作者： Jing zhao Chun Mei GAN Zhen hai LIU School of Mathematics and Quantitative Economics Guangxi University of Finance and EconomicsNanning 530003P.R.China Guangxi Colleges and Universities Key Laboratory of Optimization Control and Engineering Calculation Guangxi Minzu UniversityNanning 530006P.R.China

The goal of this paper is to deal with a new dynamic system called a differential evolution hemivariational inequality(DEHVI)which couples an abstract parabolic evolution hemivariational inequality and a nonlinear differential equation in a Banach ***,by apply ing surjectivity result for pseudomonotone multivalued mappins and the properties of Clarke's subgradient,we show the nonempty of the solution set for the parabolic hemivariational ***,some topological properties of the solution set are established such as boundedness,closedness and ***,we explore the upper semicontinuity of the solution ***,we prove the solution set of the system(DEHVI)is nonempty and the set of all trajectories of(DEHVI)is weakly compact in C(I,X).

关键词： Differential parabolic hemivariational inequality Clarke subdifferential hyperbolicparabolic system parabolic-parabolic system existence result

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Paraffin–CaCl_(2)·6H_(2)O dosage effects on the strength and heat transfer characteristics of cemented tailings backfill

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 60-70页

作者： hai Li Aibing Jin Shuaijun Chen Yiqing zhao You Ju Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mine University of Science and Technology BeijingBeijing 100083China School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China

The challenge of high temperatures in deep mining remains harmful to the health of workers and their production efficiency The addition of phase change materials (PCMs) to filling slurry and the use of the cold storage function of these materials to reduce downhole temperatures is an effective approach to alleviate the aforementioned ***–CaCl_(2)·6H_(2)O composite PCM was prepared in the *** composition,phase change latent heat,thermal conductivity,and cemented tailing backfill (CTB) compressive strength of the new material were *** heat transfer characteristics and endothermic effect of the PCM were simulated using Fluent *** results showed the following:(1) The new paraffin–CaCl_(2)·6H_(2)O composite PCM improved the thermal conductivity of native paraffin while avoiding the water solubility of CaCl_(2)·6H_(2)O.(2) The calculation formula of the thermal conductivity of CaCl_(2)·6H_(2)O combined with paraffin was deduced,and the reasons were explained in principle.(3) The“enthalpy–mass scale model”was applied to calculate the phase change latent heat of nonreactive composite PCMs.(4)The addition of the paraffin–CaCl_(2)·6H_(2)O composite PCM reduced the CTB strength but increased its heat absorption *** research can give a theoretical foundation for the use of heat storage backfill in green mines.

关键词： paraffin–CaCl_(2)·6H_(2)O heat transfer simulation heat calculation phase change material-based backfill latent heat of formula

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Strength and ductility optimization of HPDC AlSi8MgCuZn2 alloys by modifying pre-aging treatment

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China Foundry 2024年第4期21卷 343-351页

作者： Yuan-hang Jiang Hui-ting Zheng Fei Liu hai-dong zhao National Engineering Research Center of Near-net Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510641China

Considering the components produced by high pressure die casting(HPDC)process usually with ultra-large sizes and complex morphologies,high temperature solid solution treatment is not a suitable method to further improve their mechanical *** this study,two-stage aging treatment with different pre-aging times was designed and employed to further improve the mechanical properties of HPDC Al8SiMgCuZn *** characteristics of precipitates were evaluated by a transmission electron microscope(TEM),and the precipitation strengthening mechanism was *** results reveal that the strengthening is mainly contributed by the precipitation ofβ″phase after two-stage aging,and the number density and size of the precipitates are significantly depended on the pre-aging *** number density of precipitates is increased with the pre-aging time prolonged from 0 h to 4 h,and then decreases with the further increase of pre-aging time from 4 h to 6 *** precipitates with the highest density and smallest size are observed after pre-aging for 4 *** pre-aged at 100℃for 4 h and then artificial aged at 200℃for 30 min,the yield strength of 207 MPa,ultimate tensile strength of 325 MPa and elongation of 7.6%are achieved.

关键词： high pressure die cast aluminum alloy microstructural heterogeneity mechanical properties precipitation strengthening two-stage aging

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Traveling Fronts for a Time-periodic Population Model with Dispersal

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Acta Mathematicae Applicatae Sinica 2024年第4期40卷 1147-1154页

作者： hai-qin zhao School of Mathematics and Statistics Xidian UniversityXi’an 710071China

In this paper,we study a class of time-periodic population model with *** is well known that the existence of the periodic traveling fronts has been ***,the uniqueness and stability of such fronts remain *** this paper,we first prove the uniqueness of non-critical periodic traveling ***,we show that all non-critical periodic traveling fronts are exponentially asymptotically stable.

关键词： periodic integro-differential equation time-periodic traveling front uniqueness stability

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Geochronology,Geochemistry,and Sr-Nd-Hf Isotopes of the Diorite Porphyrites from the Weining Beishan Area,Ningxia Hui Autonomous Region:Constraints on Their Source and Tectonic Implications

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Journal of Earth Science 2024年第2期35卷 462-475页

作者： Anlu Liu Lianfu hai Jinke Liu Xiaojun Zhang haifeng Li Fengshun zhao Guoliang zhao Jinhe Bai Yifu Museum China University of GeosciencesWuhan430074China School of Earth Resources China University of GeosciencesWuhan430074China Mineral Geological Survey Institute of Ningxia Hui Autonomous Region Yinchuan750021China National Demonstration Center for Experimental Mineral Exploration Education China University of GeosciencesWuhan430074China Coal Geological Survey Institute of Ningxia Hui Autonomous Region Yinchuan750021China Zhuhai Engineering Investigation Institute of Guangdong Province Zhuhai519000China

The Weining Beishan area of Ningxia Hui Autonomous Region is located at on the western edge of the Helanshan tectonic belt,which is a tectonic joint among Alxa Block,Ordos Block,and North Qilian orogenic ***,the tectonic evolution of this area remains unclear due to the lack of magmatic *** paper conducted researches on geochronology,geochemistry,and Sr-Nd-Hf isotopes of the diorite porphyrites exposed in the Weining Beishan *** zircon U-Pb dating yields two ages of 145.0±1.1 and 146.2±1.5 Ma,and the whole-rock geochemical data indicate that the diorite porphyrites are metaluminous to weakly peraluminous and high-K calc-alkaline *** characteristics of highly initial^(87)Sr/^(86)Sr ratios(0.70816 to 0.71047),negativeε_(Nd)(t)(−8.9 to−8.4),and negativeε_(Hf)(t)(−13.8 to−21.2)indicate that the diorite porphyrites originated from partial melting of the middle-lower ancient crust related to the North China *** with the regional geology,we suggested that partial melting was triggered by a tectonic activity of deep faults cutting through the crust under the regional stress transformation from compressing to extension during the Late Jurassic–Early Cretaceous,which is probably related to the westward subduction of the Paleo-Pacific Plate.

关键词： zircon U-Pb dating Sr-Nd-Hf isotopes magma source diorite porphyrite Weining Beishan area Ningxia Hui Autonomous Region geochronology geochemistry

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Adaptive Trajectory Tracking Control for Nonholonomic Wheeled Mobile Robots:A Barrier Function Sliding Mode Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1007-1021页

作者： Yunjun Zheng Jinchuan Zheng Ke Shao Han zhao Hao Xie hai Wang the School of Mechanical Engineering Hefei University of TechnologyHefei 230009China the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyHawthorn VIC 3122Australia the School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072China the Shanghai Aerospace Control Technology Institute Shanghai 201109 the School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China the College of Science HealthEngineering and EducationMurdoch UniversityPerth WA6150Australia

The trajectory tracking control performance of nonholonomic wheeled mobile robots(NWMRs)is subject to nonholonomic constraints,system uncertainties,and external *** paper proposes a barrier function-based adaptive sliding mode control(BFASMC)method to provide high-precision,fast-response performance and robustness for *** with the conventional adaptive sliding mode control,the proposed control strategy can guarantee that the sliding mode variables converge to a predefined neighborhood of origin with a predefined reaching time independent of the prior knowledge of the uncertainties and disturbances *** advantage of the proposed algorithm is that the control gains can be adaptively adjusted to follow the disturbances amplitudes thanks to the barrier *** benefit is that the overestimation of control gain can be eliminated,resulting in chattering ***,a modified barrier function-like control gain is employed to prevent the input saturation problem due to the physical limit of the *** stability analysis and comparative experiments demonstrate that the proposed BFASMC can ensure the prespecified convergence performance of the NWMR system output variables and strong robustness against uncertainties/disturbances.

关键词： Adaptive sliding mode barrier function nonholonomic wheeled mobile robot(NWMR) trajectory tracking control

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Tribological and Corrosion Properties of the CoCrAlYTaSiC-xCNTs Coatings Deposited by Laser Cladding

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 726-738页

作者： hai zhao Yi Ding Wei Gao Bo Yu Jinghui Li Mingya Zhang School of Material Science and Engineering Anhui University of TechnologyMaanshan243002China Maanshan Iron&Steel Co. LtdMaanshan243000China Applied Technology Research Institute Jiujiang Vocational UniversityJiujiang332000China School of Metallurgical Engineering Anhui University of TechnologyMaanshan243002China

The MCrAlY coating has been potential candidate for the parts applied in friction and corrosion conditions, and CNTs (carbon nanotubes) are expected to improve the service performance of coatings owing to high lubrication and low chemical reactivity. In this work, a systematic investigation on the tribological and corrosion properties of CoCrAlYTaSiC-xCNTs coatings deposited by laser melting was analyzed. Results showed that the coatings had good-quality without typical metallurgical defects. The CNTs addition homogenized and refined the microstructure of coating, and also improved the tribological and corrosion properties. As the CNTs content changed from 0 to 4 wt%, the wear rate of coating decreased from 16.23 × 10^(-3) to 7.58 × 10^(-3) mg m^(−1), the jcorr of coating decreased from 4.13 × 10^(-4) to 1.23 × 10^(-4) A cm^(−2), and the Rct values increased from 12.69 to 25.07 Ω cm2.

关键词： MCrAlY coating Laser melting deposition Friction Electrochemical corrosion

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Large‑scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1466-1481页

作者： Di zhao Ranran Liu Xiaodong Tan Huimin Kang Jie Wang Zheng Ma haiquan zhao hai Xiang Zhengfen Zhang Hua Li Guiping zhao Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding School of Life Science and EngineeringFoshan UniversityFoshanChina State Key Laboratory of Animal Biotech Breeding Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijingChina Guangdong Tinoo’s Foods Group Co. Ltd.QingyuanChina

Background Carcass traits are crucial indicators of meat production ***,the molecular regulatory mechanisms associated with these traits remain *** In this study,we conducted comprehensive transcriptomic and genomic analyses on 399 Tiannong partridge chickens to identify key genes and variants associated with carcass traits and to elucidate the underlying regulatory *** on association analyses with the elastic net(EN)model,we identified 12 candidate genes(AMY1A,AP3B2,CEBPG,EEF2,EIF4EBP1,FGFR1,FOXD3,GOLM1,LOC107052698,PABPC1,SERPINB6 and TBC1D16)for 4 carcass-related traits,namely live weight,dressed weight,eviscerated weight,and breast muscle ***6 was identified as the only overlapping gene by 3 analyses,EN model analysis,weighted gene co-expression network analysis and differential expression ***-level experiments confirmed that SERPINB6 promotes the proliferation of chicken DF1 cells and primary *** expression genome-wide association study and association analysis indicated that rs317934171 is the critical site that enhances SERPINB6 ***,a dual-luciferase reporter assay proved that gga-miR-1615 targets the 3′UTR of *** Collectively,our findings reveal that SERPINB6 serves as a novel gene for chicken carcass traits by promoting fibroblast and myoblast ***,the downstream variant rs317934171 regulates SERPINB6 *** results identify a new target gene and molecular marker for the molecular mechanisms of chicken carcass traits.

关键词： Carcass traits Chicken Genome SERPINB6 Transcriptome

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Ultrafast investigation of room temperature valley polarization in“optical bilayer”WS_(2)

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Science China(Technological Sciences) 2024年第1期67卷 91-97页

作者： zhao LeYi WANG hai LIU TianYu LI FangFei ZHOU Qiang WANG haiYu Synergetic Extreme Condition High-Pressure Science Center State Key Laboratory of Superhard MaterialsCollege of PhysicsJilin UniversityChangchun 130012China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China

Monolayer transition metal dichalcogenides(TMDCs)have become a promising platform in valleytronics due to possessing the regulatable valley degrees of ***,as a result of the rapid intervalley scattering,it is difficult to measure the PL valley polarization of monolayer TMDCs at room temperature,which limits their application in valleytronics ***,we report a room temperature photoluminescence(PL)valley polarization up to 3.73%in an“optical bilayer”WS_(2)formed by transferring monolayer WS_(2)onto flat Ag ***,in the transient absorption(TA)measurements,a remarkably long valley depolarization lifetime is ***,we demonstrate the valley properties of such“optical bilayer”WS_(2)resemble actual bilayer WS_(2),in which the robust valley polarization can be attributed to the phonons depletion effect and the blocked interlayer hopping *** peculiar valley features in“optical bilayer”WS_(2)provide a particularly simple method to enhance valley control at room temperature.

关键词： valleytronics optical bilayer transient absorption tungsten disulfide

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