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On the formation of couplet-style stratifications

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International Journal of Sediment Research 2008年第1期23卷 85-91页

作者： yu-hai wang1, Yan-Hong wang2, and Li-Qun TANG31 Ph.D., Engineer, Department of Sediment Research, China Institute of Water Resources and Hydropower Research, Chegongzhuangxilu 20, Beijing 100044, China, 2 Ph.D., Engineer, Nanjing Hydraulic Research Institute, Hujuguanlu 34, Nanjing 210024, China 3 Ph.D., Prof., Department of Sediment Research, China Institute of Water Resources and Hydropower Research, Chegongzhuangxilu 20, Beijing 100044, China [a]Ph.D. Engineer Department of Sediment Research China Institute of Water Resources and Hydropower Research Chegongzhuangxilu 20 Beijing 100044 China [b]Ph.D. Engineer Nanjing Hydraulic Research Institute Hujuguanlu 34 Nanjing 210024 China [c]Ph.D. Prof. Department of Sediment Research China Institute of Water Resources and Hydropower Research Chegongzhuangxilu 20 Beijing 100044 China

Couplet-style stratifications refer to the sedimentary sequences that consist of alternating coarse-grain-dominated bed and fine-grain-dominated bed, with or without a sandwiched middle-sized bed. The formation mechanism is complicated due to the interplays of varying driving force (s), sediment supply & transport and topographic configurations. This paper presents a comprehensive overview of such characteristic bedforms, which emerge during the transport and deposition of non-uniform sediments. The leading formative models include water-stage variation, gravel-overpassing process, superimposition of bedload sheets and avalanching process (inverse grading). Each process might produce similar or distinct sedimentological features with respect to grading, matrix content, grain attitude, bounding faces between beds and internal longitudinal/transverse geometry. The couplet-style stratified strata might play an active role in landscape evolution.

关键词： Couplet-style stratification Formative model Sedimentological features Landform

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RoboCup小型组控制系统设计和实现

微特电机 2004年第6期32卷 21-24页

作者：王海玉王磊孙增圻清华大学北京100084

介绍了RoboCup组在进行多智能体的设计和实现研究中使用的硬件平台。重点研究了无速度传感器的微型空心杯直流电机的速度-电流双闭环控制系统,并提出了简单有效的电机控制方案和电机参数测量的方法,对采用电流内环的优缺点进行了对比讨... 详细信息

介绍了RoboCup组在进行多智能体的设计和实现研究中使用的硬件平台。重点研究了无速度传感器的微型空心杯直流电机的速度-电流双闭环控制系统,并提出了简单有效的电机控制方案和电机参数测量的方法,对采用电流内环的优缺点进行了对比讨论和分析。最后描述了整个电机控制流程和采用的系统优化。

关键词： RoboCup 直流永磁电机双闭环控制无速度传感器

NADPH oxidase-derived superoxide mediates cardiovascular effects of UrotensinⅡin spontaneously hypertensive rats

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NADPH oxidase-derived superoxide mediates cardiovascular eff...

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Ning LU,hai-yun yu,Rui wang,Yi-Chun ZHU Department of Physiology and Pathophysiology,Shanghai Medical College,Fudan University,Shanghai 200032,China

Central UrotensinⅡ(U-Ⅱ) may participate in the regulation of cardiovascular functions by stimulating sympathy ***,their central mechanism remained *** studies have shown that brain reactive oxygen species(ROS) mediate the sympatho-excitaory *** present study,we tested the hypothesis that ROS mediate central cardiovascular effects of *** were completed in Wistar-Kyoto(WKY) rats and spontaneously hypertensive rats(SHR).The following observations were made:(1) Expressions of U-Ⅱreceptors of rostral ventrl medulla(RVLM) and Nucleus tractus solitarii(NTS) were increased in SHR rats compared with WKY rats.(2) Doubling Immunoflurescence analysis showed that U-Ⅱreceptor and NADPH oxidase subunit gp91 were co-localized in the RVLM and NTS.(3) Intracerebroventricular U-Ⅱor microinjection of U-Ⅱin RVLM significantly increased mean arterial pressure(MAP) and heart rate(HR).Tempol(a superoxide dismutase mimetic) or Apocinin(NADPH oxidase inhibitor) pretreatment eliminated these effects of U-Ⅱ.(4) Brain superoxide levels were enhanced in U-Ⅱ-treated rats compared with CSF-treated rats.(5) Intracerebroventricular UⅡsignificantly increased gp91 or p47 mRNAlevel in the *** importantly,a significant elevation in phosporylated P47 was detected 5 min after microinjection of UⅡinto the *** results indicate that superoxide mediates central cardiovascular effects of U-Ⅱand provide evidence for a novel relationship between U-Ⅱand ROS.

关键词： reactive oxygen species UrotensinⅡ central cardiovascular effects

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： hai-Luo wang Ruo-Ran Zhang Hao wang Peng Xu Jing-Kai wang Bo Chen Hao Xu Deng Pan yu-Yang Ma Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

Sporadic E responds to the 2022 Tonga volcano eruptions recorded by the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 20-28页

作者： YangYi Sun Tao yu Jin wang Chi Long School of Geophysics and Geomatics China University of Geosciences(Wuhan)Wuhan 430047China School of Physics and Electronic Science Guizhou Normal UniversityGuizhou 550001China

In this study,ionosonde observations over Fuke(19.5°N,109.1°E),Wuhan(30.5°N,114.4°E),and Mohe(53.5°N,122.3°E)were analyzed to demonstrate the responses of the sporadic E()to the severe atmospheric disturbances caused by the Tonga volcanic eruptions on January 15,*** most prominent signature was the disappearance of the layer after~10:00 UT over Wuhan and Fuke,which was attributed to the vertical drift caused by the *** occurred intermittently after 13:00 UT following the arrival of the tropospheric Lamb *** examine the causal mechanism for the intermittence,we also included data of horizontal winds in the mesosphere and lower thermosphere region recorded by the meteor radars at Wuhan and Mohe in this *** wind disturbances with periods of~20 hours contributed to the formation of the layer in the nighttime on January 15.

关键词： sporadic E Tonga eruptions neutral wind disturbances

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li Xi Liu Wenping Liang yu Li Liyong Wu Zhe wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu yu Shi Haoxue wang Lijie Huang Su Zhang Ruixin Zhang Song wang Guangxu Lu Peifu Tang Zhongyang Liu Kai wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO_(2) Nanoparticles for Tetracycline Degradation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 42-48页

作者： XU Rongqi MI Jianxin wang Shulin XU Man ZHU Li BAI Lei TANG Dandan LEI yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710100China

Cu-Mn co-doped CeO_(2) photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO_(2) without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO_(2) nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18%and maintained a stable cycling performance.

关键词： photocatalyst co-doped charge separation water treatment

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超声速混合层液滴两相流动的大涡模拟

推进技术 2009年第1期30卷 24-29页

作者：吴海燕王昱孙明波汪洪波周进国防科技大学航天与材料工程学院湖南长沙410073

为研究超声速气流中液滴与气流的混合及液滴蒸发对混合的影响,采用大涡模拟(LES)方法数值仿真了超声速混合层内液滴两相流流场结构,气相流场采用亚格子(SGS)模型和切应力输运(k-ωSST)湍流模型,液相模拟采用轨道模型和单液滴蒸发模型。... 详细信息

为研究超声速气流中液滴与气流的混合及液滴蒸发对混合的影响,采用大涡模拟(LES)方法数值仿真了超声速混合层内液滴两相流流场结构,气相流场采用亚格子(SGS)模型和切应力输运(k-ωSST)湍流模型,液相模拟采用轨道模型和单液滴蒸发模型。在混合层前缘入口处均匀持续地投放液滴,并在液滴入口处下方添加非周期小扰动,并观察液滴蒸发过程对该小扰动造成的影响。分析了入口小扰动在流场中不同的发展情况,发现液滴的蒸发过程使混合层厚度增加并加速混合层的发展,对气相流场扰动较强,可能导致流动失稳,对混合过程有很大的促进作用。

关键词：大涡模拟两相流混合层液滴