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一个改进的堆石料广义塑性模型

岩土工程学报 2017年第10期39卷 1936-1942页

作者：卞士海李国英魏匡民周健同济大学地下建筑与工程系上海200092 南京水利科学研究院岩土工程研究所江苏南京210024 水利部土石坝破坏机理与防控技术重点试验室江苏南京210024

在广义塑性理论框架下,通过引入两个修正系数修正塑性模量,增强了广义塑性模型在高围压条件下的适应性,成功地将砂土广义塑性模型改造成堆石料广义塑性模型。提出的修正广义塑性模型参数较少,容易确定,具有一定的实用性,并且可以推广至... 详细信息

在广义塑性理论框架下,通过引入两个修正系数修正塑性模量,增强了广义塑性模型在高围压条件下的适应性,成功地将砂土广义塑性模型改造成堆石料广义塑性模型。提出的修正广义塑性模型参数较少,容易确定,具有一定的实用性,并且可以推广至状态相关情况。模型中塑性模量公式简洁,可以退化成等向压缩塑性模量。模型可以很好地预测堆石料常规三轴加载应力应变关系,对等P以及等应力比路径也具有一定适应性。

关键词：广义塑性模型塑性模量修正系数应力路径模型验证

Overexpression of Wnt5a inhibits the telogen-to-anagen transition of hair follicles in mice

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Overexpression of Wnt5a inhibits the telogen-to-anagen trans...

细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉

作者： Yi-Zhan Xing Rui-Min Wang Ke Yang hai-ying guo Fang Deng Xiao-Hua Lian Tian Yang Department of Cell Biology College of Basic Medical SciencesThird Military Medical University Experimental Center of Basic Medicine Chongqing Medical University

The canonical Wnt/β-catenin pathway plays an important role in hair cycle ***5a is a non-canonical Wnt family member that generally antagonizes canonical Wnt signaling in other systems. In hair follicles,Wnt5a and canonical Wnt are both expressed in cells in the telogen ***5a has been shown to be critical for controlling hair cell ***,the role that Wnt5a plays in the

关键词： Wnt5a hair growth Wnt signaling pathway hair cycle

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进化机器人

机器人 2003年第1期25卷 92-96页

作者：陈海英郭巧北京理工大学机器人研究中心北京100081

进化机器人 (evolutionary robots)是一种基于进化思想设计的机器人系统 ,是机器人设计领域的新方向 ,它把人工生命的概念和思路引入到这个领域 .本文介绍了进化机器人的基本概念、设计方法、发展历程、研究现状、发展前景。

关键词：进化机器人智能机器人人工智能人工生命进化算法神经网络

4H综合征的临床表现与分子诊断(附1例报告)

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临床神经病学杂志 2017年第5期30卷 377-379页

作者：梁超陆海英郭虎南京医科大学附属儿童医院神经内科 210008

目的探讨4H综合征的临床表现与分子诊断。方法回顾性分析1例基因诊断明确的4H综合征患者的临床资料,并结合文献资料分析其临床特点。结果患儿,男,6岁8个月,双手抖动1年,自幼精神、运动发育落后,行走不稳,出牙延迟。眼科检查示近视、视... 详细信息

目的探讨4H综合征的临床表现与分子诊断。方法回顾性分析1例基因诊断明确的4H综合征患者的临床资料,并结合文献资料分析其临床特点。结果患儿,男,6岁8个月,双手抖动1年,自幼精神、运动发育落后,行走不稳,出牙延迟。眼科检查示近视、视神经萎缩。头颅MRI示两侧大脑半球广泛对称性脑白质病变。基因检查示POLR3A复合杂合变异(c.1781T>G,c.2693del T)。诊断为4H综合征。结论 4H综合征早期临床表现为精神、运动发育迟缓、出牙延迟,主要临床特点为脑白质髓鞘化不良、近视、共济失调,基因学特点为POLR3A或POLR3B突变。

关键词： 4H综合征临床特点基因学特点

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环境友好型复合纳米材料在食品包装中的应用

包装工程 2017年第19期38卷 29-34页

作者：魏海英郭红革陈强齐鲁工业大学济南250353 北京印刷学院北京102600

目的综述环保纳米包装材料的最新进展,为食品包装行业提供理论指导。方法从活性包装、智能包装和生物基包装这3个方面进行阐述,再对其安全性进行分析。结果纳米材料因其独特的尺寸效应,优异的物理化学性能、生态性能和加工性能等,使之... 详细信息

目的综述环保纳米包装材料的最新进展,为食品包装行业提供理论指导。方法从活性包装、智能包装和生物基包装这3个方面进行阐述,再对其安全性进行分析。结果纳米材料因其独特的尺寸效应,优异的物理化学性能、生态性能和加工性能等,使之在包装领域,尤其是食品包装得到了广泛的关注与应用,但需重点关注其安全性问题。结论纳米材料能有效改善包装材料的性能,使包装材料智能化,虽然该研究尚处于起步阶段,但纳米技术在食品包装领域具有显著的发展前景。由于可参考的数据不够充分,纳米材料的毒性问题以及迁移到食品中的安全性等还需进一步研究。

关键词：活性包装智能包装生物基包装

Synbiotic yacon juice fermented by Lactiplantibacillus plantarum QS7T attenuates dextran sodium sulfate-induced ulcerative colitis in mice

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Synbiotic yacon juice fermented by Lactiplantibacillus plant...

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

第五届益生菌益生元科学大会

作者： Yuan-ting Zhu Rui-tong Li Jian-xia Yang Yong Zuo hai-ying guo Yi-xin Wang Lan-yue Chen Gui-zhen Gong College of Life Science Sichuan Normal University

Ulcerative colitis(UC) is a common inflammatory bowel disease(IBD),which is widely believed to occur as the result of abnormal immune response to commensal *** of yacon tubers rich in fructooligosaccharides(FOS) has been known to have a positive effect on intestinal *** plantarum QS7T capable of efficiently utilizing inulin and FOS,is a promising probiotic and could be applied to ferment synbiotic yacon *** aim of this study was to investigate the effects of synbiotic yacon juice fermented by *** QS7T on the amelioration of UC and the modulation of gut microbiota in a dextran sodium sulfate(DSS)-induced colitis mouse model.C57BL/6 mice were divided into four groups:the control group(CK),the DSS-induced UC group(DSS),the unfermented yacon juice group(NFYJ),and the fermented yacon juice group(FYJ).The mice were given water in CK and DSS groups,yacon juice in NFYJ group,and fermented yacon juice in FYJ group as an intragastric intervention respectively for twenty-three days;a UC model was then established by having mice freely drink a 3%(w/v) DSS solution for seven days except for CK group when the intragastric intervention was still carried *** results showed that DSS successfully induced UC in C57BL/6 mice,and FYJ supplementation markedly ameliorated the histological scores compared with NFYJ ***,at the m RNA level,FYJ significantly suppressed the expression of pro-inflammatory factors IL-6,IL-1β,and TNF-α,while expression of the anti-inflammatory factor IL-10 and tight junction proteins(ZO-1 and claudin-1) significantly increased in colon tissue of DSS-treated mice through FYJ *** also significantly suppressed the protein expression levels of MyD88,p-IkBα,p-NF-kB p65,and TLR4,resulting in an inhibited TLR4/MyD88/NF-κB signaling ***,16S rRNA sequencing analysis indicated that FYJ treatment reversed DSS-induced alternation of the gut community diversity and co

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li hai-Wei Pu Xin-Yian guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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基于UWB系统的巴伦滤波器组合器件

微波学报 2010年第S1期26卷 351-354页

作者：杜泽保朱旻张海英郭天义中国科学院微电子研究所射频集成电路研究室医疗电子实验室北京100029

UWB超宽带系统的快速发展对滤波器和巴伦的带宽、损耗提出了新的要求。平衡滤波器能够实现良好的匹配和滤波特性,插入损耗较小,但仅适用于窄带情况;表贴巴伦和滤波器同时使用时不仅占用较大面积,彼此间的干扰会降低系统性能。本文采用... 详细信息

UWB超宽带系统的快速发展对滤波器和巴伦的带宽、损耗提出了新的要求。平衡滤波器能够实现良好的匹配和滤波特性,插入损耗较小,但仅适用于窄带情况;表贴巴伦和滤波器同时使用时不仅占用较大面积,彼此间的干扰会降低系统性能。本文采用补偿法,将多层LC滤波器和宽带Marchand巴伦通过耦合电容连接制作在同一LTCC基板内,减小面积的同时,缺点互补,巴伦改善了滤波器的衰减特性,滤波器改善了巴伦的匹配特性,适用于UWB宽带应用。根据这一思路制作的巴伦-滤波器的中心频率为7.65GHz,带宽为1GHz,幅度失配≤0.2dB,相位失配≤4.5°,5GHz处带外衰减≥60dB,9GHz处带外衰减≥40dB,元件尺寸为7mm*3mm*0.6mm。

关键词：巴伦滤波器 LTCC UWB

Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： guo-Fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors