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Schistosomiasis transmission in Zimbabwe:Modelling based on machine learning

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Infectious Disease Modelling 2024年第4期9卷 1081-1094页

作者： Hong-Mei Li Jin-Xin Zheng Nicholas Midzi Masceline Jenipher Mutsaka-Makuvaza Shan Lv Shang Xia Ying-jun Qian Ning Xiao Robert Berguist Xiao-nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai200025China National Institute of Health Research Ministry of Health and Child CareHarareZimbabwe University of Rwanda College of Medicine and Health SciencesSchool of Medicine and PharmacyDepartment of Microbiology and ParasitologyRwanda Ingerod 407 SE-45494BrastadSweden

Zimbabwe,located in Southern Africa,faces a significant public health challenge due to *** investigated this issue with emphasis on risk prediction of schistosomiasis for the entire *** this end,we reviewed available data on schistosomiasis in Zimbabwe from a literature search covering the 1980-2022 period considering the potential impact of 26 environmental and socioeconomic variables obtained from public *** studied the population requiring praziquantel with regard to whether or not mass drug administration(MDA)had been regularly *** machinelearning algorithms were tested for their ability to predict the prevalence of schistosomiasis in Zimbabwe based on the mean absolute error(MAE),the root mean squared error(RMSE)and the coefficient of determination(R2).The findings revealed different roles of the 26 factors with respect to transmission and there were particular variations between Schistosoma haematobium and *** *** found that the top-five correlation factors,such as the past(rather than current)time,unsettled MDA implementation,constrained economy,high rainfall during the warmest season,and high annual precipitation were closely associated with higher *** prevalence,while lower elevation,high rainfall during the warmest season,steeper slope,past(rather than current)time,and higher minimum temperature in the coldest month were rather related to higher *** *** random forest(RF)algorithm was considered as the formal best model construction method,with MAE=0.108;RMSE=0.143;and R^(2)=0.517 for ***,and with the corresponding figures for *** being 0.053;0.082;and *** on this optimal model,the current total schistosomiasis prevalence in Zimbabwe under MDA implementation was 19.8%,with that of *** at 13.8% and that of *** at 7.1%,requiring annual MDA based on a population of 3,003,*** MDA,the current total schistosomiasis prevalence would

关键词： Machine-learning Transmission risk model Schistosomiasis Zimbabwe

第三方水质检测机构建设案例的SWOT分析与运维优化

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中国给水排水 2024年第14期40卷 36-41页

作者：农晋琦深圳市宝安排水有限公司广东深圳518000 深圳市宝排水质检测中心有限公司广东深圳518000

随着国家环境治理的深入发展,政府监管提出治污企业需提供经资质认定的公正检测数据的要求,并逐步走向法制化、常态化,中型排水国企综合考虑成本、业务量及盈亏等因素,面临自行出资建设第三方实验室还是外委检测的“两难”选择。基于SWO... 详细信息

随着国家环境治理的深入发展,政府监管提出治污企业需提供经资质认定的公正检测数据的要求,并逐步走向法制化、常态化,中型排水国企综合考虑成本、业务量及盈亏等因素,面临自行出资建设第三方实验室还是外委检测的“两难”选择。基于SWOT分析,以深圳市某中型排水国企改制的某排水公司水质检测中心为例,对其改制以及随后的经营运维等进行了研究探讨,提出了战略选择意见、建议和运维优化对策。分析结果表明,中型排水国企出资设立第三方水质检测机构,具有依托国企母公司、商业信誉良好、业务来源稳定可靠等优势,总体来说机遇大于威胁,优势大于劣势。本项目的过程分析与相关结论,可为同行开展相关项目提供一定的借鉴。

关键词：中型排水国企第三方水质检测机构 SWOT分析运维优化

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毛泽东的知行观

毛泽东邓小平理论研究 2024年第1期 51-58,108,F0003页

作者：蒋建农华南师范大学历史文化学院

作为毛泽东哲学思想的重要组成部分,毛泽东认识论思想以认识与实践的关系为核心内容,对应于中国古代哲学中的“知行观”。在运用马克思主义指导中国革命和建设的长期实践中,毛泽东总结和提炼中国革命经验,批判地继承中国传统“知行观”... 详细信息

作为毛泽东哲学思想的重要组成部分,毛泽东认识论思想以认识与实践的关系为核心内容,对应于中国古代哲学中的“知行观”。在运用马克思主义指导中国革命和建设的长期实践中,毛泽东总结和提炼中国革命经验,批判地继承中国传统“知行观”,全面阐述了其“知行统一观”,并从认识论基本问题、认识论与中国共产党群众路线、促进理论与实践结合的调查研究方法三个角度出发,系统地丰富发展了马克思主义认识论,极大推动了马克思主义中国化进程。

关键词：毛泽东马克思主义中国化认识论知行观《实践论》

Mitigation of polycyclic aromatic hydrocarbons(PAHs)in roasted beef patties by cold plasma treatment and products quality evaluation

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Food Science and Human Wellness 2024年第5期13卷 2993-3005页

作者： Yuke Hou yangjian Hu Min Li Jiahui nong Fengyuan Xie Yuhan Fan Jianhao Zhang Xianming Zeng Minyi Han Xinglian Xu Xia Wang Key Laboratory of Animal Products Processing Ministry of AgricultureKey Laboratory of Meat Processing and Quality ControlMinistry of EducationJiangsu Synergetic Innovation Center of Meat Production and ProcessingCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 2100095China Center for Food and Drug Safety Inspection of Maanshan Maanshan Administration for Market RegulationMaanshan 243000China Henan Key Laboratory of Cold Chain Food Quality and Safety Control Zhengzhou University of Light IndustryZhengzhou 450001China Collaborative Innovation Center for Modern Grain Circulation and Safety Key Laboratory of Grains and Oils Quality Control and ProcessingCollege of Food Science and EngineeringNanjing University of Finance and EconomicsNanjing 210023China

The cold plasma(CP)technique was applied to alleviate the contamination of polycyclic aromatic hydrocarbon(PAH)in this *** different CP treatments methods were implemented in the production of beef patties,to investigate their inhibition and degradation capacity on *** 5 different cooking oils and fats addition,the inhibition mechanism of in-package cold plasma(ICP)pretreatment was explored from the aspect of raw patties fatty acids composition *** results of principal component analysis showed that the first two principal components accounted for more than 80%of the total variation in the original data,indicating that the content of saturated fatty acids was significantly positively correlated with the formation of *** pretreatment inhibited the formation of PAHs by changing the composition of fatty acids,which showed that the total amount of polyunsaturated fatty acids decreased and the total amount of monounsaturated fatty acids *** discrimination tests demonstrated there were discernable differences between 2 CP treated samples and the controls,utilization of the ICP pretreatment in meat products processing was expected to achieve satisfying eating *** conclusion,CP treatment degraded PAHs through stepwise ring-opening oxidation in 2 reported pathways,the toxicity of PAHs contaminated products was alleviated after CP treatment.

关键词： Roasted beef Polycyclic aromatic hydrocarbons Cold plasma Mitigation mechanism Product quality evaluation

Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception

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National Science Review 2024年第7期11卷 106-125页

作者： Yan-nong Dou Yuan Liu Wen-Qun Ding Qing Li Hua Zhou Ling Li Meng-Ting Zhao Zheng-Yi-Qi Li Jing Yuan Xiao-Fei Wang Wang-Yuan Zou Anan Li Yan-Gang Sun Institute of Neuroscience Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology CAS Center for Excellence in Brain Science&Intelligence Technology Chinese Academy of Sciences Department of Biology School of Life Science and TechnologyShanghaiTech University Lingang Laboratory University of Chinese Academy of Sciences Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsMoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Department of Anesthesiology Xiangya HospitalCentral South University HUST-Suzhou Institute for Brainsmatics JITRI

Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-opioid receptors（MORs） in GABAergic neurons of the central amygdala nucleus（CEA） in a persistent-hyperalgesia mouse model. Pharmacogenetic suppression of these CEAMORneurons, which mimics the effect of MOR activation, alleviated the persistent ***, single-neuron projection analysis revealed multiple projectome-based subtypes of CEAMORneurons, each innervating distinct target brain regions. We found that the suppression of axon branches projecting to the parabrachial nucleus（PB） of one subtype of CEAMORneurons alleviated persistent hyperalgesia, indicating a subtype-and axonal-branch-specific mechanism of action. Further electrophysiological analysis revealed that suppression of a distinct CEA-PB disinhibitory circuit controlled endogenous opioid antinociception. Thus, this study identified the central neural circuit that underlies endogenous opioid antinociception, providing new insight into the endogenous pain modulatory mechanisms.

关键词： endogenous opioid antinociception mu-opioid receptors central amygdala nucleus parabrachial nucleus single-neuron projectome

Spatially resolved transcriptomic profiling of placental development in dairy cow

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Zoological Research 2024年第3期45卷 586-600页

作者： Guang-Hui Tan Shi-Jie Liu Ming-Le Dou De-Feng Zhao Ao Zhang Heng-Kuan Li Fu-nong Luo Tao Shi Hao-Ping Wang Jing-Yuan Lei Yong Zhang Yu Jiang Yi Zheng Fei Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Northwest A&F UniversityYanglingShaanxi 712100China College of Information Engineering Northwest A&F UniversityYanglingShaanxi 712100China

The placenta plays a crucial role in successful mammalian *** animals possess a semi-invasive placenta characterized by a highly vascularized structure formed by maternal endometrial caruncles and fetal placental cotyledons,essential for full-term fetal *** cow placenta harbors at least two trophoblast cell populations:uninucleate(UNC)and binucleate(BNC)***,the limited capacity to elucidate the transcriptomic dynamics of the placental natural environment has resulted in a poor understanding of both the molecular and cellular interactions between trophoblast cells and niches,and the molecular mechanisms governing trophoblast differentiation and *** fill this knowledge gap,we employed Stereo-seq to map spatial gene expression patterns at near single-cell resolution in the cow placenta at 90 and 130 days of gestation,attaining high-resolution,spatially resolved gene expression *** on clustering and cell marker gene expression analyses,key transcription factors,including YBX1 and NPAS2,were shown to regulate the heterogeneity of trophoblast cell *** communication and trajectory analysis provided a framework for understanding cell-cell interactions and the differentiation of trophoblasts into BNCs in the placental *** analysis of cell trajectories identified a set of genes involved in regulation of trophoblast ***,spatial modules and co-variant genes that help shape specific tissue structures were ***,these findings provide foundational insights into important biological pathways critical to the placental development and function in cows.

关键词： Spatial transcriptomics Dairy cow Placenta Gestation

清代孙温绘全本《红楼梦》的“情本体”家具陈设研究

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家具与室内装饰 2024年第6期31卷 82-87页

作者：农先文广西艺术学院设计学院广西南宁530007

清代孙温绘全本《红楼梦》的家具空间是“生情”“传情”“共情”的情感化的美好生活情境,反映曹雪芹的“情本体”思想。本文结合绘本图像和历史文献,阐释孙温绘本的“情本体”内涵,探索空间营造方法,分析当代家具作品对于“情”的表现... 详细信息

清代孙温绘全本《红楼梦》的家具空间是“生情”“传情”“共情”的情感化的美好生活情境,反映曹雪芹的“情本体”思想。本文结合绘本图像和历史文献,阐释孙温绘本的“情本体”内涵,探索空间营造方法,分析当代家具作品对于“情”的表现,目的是构建“情本体”室内空间陈设的理论框架。该研究除了体现孙温绘本蕴含的家具文化价值外,还有利于在传统家具文化的传承和创新中,应对AI图像生成技术与文化价值的择取和生成、中外家具文化融合导致的文化的“断根性”问题等因素的冲击。

关键词：清代孙温绘全本《红楼梦》情本体家具陈设

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中心城区城市综合管廊与地铁合建型式研究

城市轨道交通研究 2024年第1期27卷 55-60页

作者：农兴中曾毅广州地铁设计研究院股份有限公司广州510010 广州环城地下管廊建设投资有限公司广州510010

[目的]中心城区地下综合管廊受地面实施条件与地下空间限制,可实施性差。对此,提出将综合管廊与地铁合建,实现同步规划、同步设计和同步实施,并探究综合管廊与地铁合建的不同型式。[方法]对管廊与地铁结合建设的必要性与建设原则进行研... 详细信息

[目的]中心城区地下综合管廊受地面实施条件与地下空间限制,可实施性差。对此,提出将综合管廊与地铁合建,实现同步规划、同步设计和同步实施,并探究综合管廊与地铁合建的不同型式。[方法]对管廊与地铁结合建设的必要性与建设原则进行研究。针对城市综合管廊与地铁合建型式进行分析。以广州中心城区地下综合管廊工程与广州地铁11号线合建项目为例,从用地节约、施工难度、协调要求等方面,分析不同结合型式的特点及适用情况。在结合各典型案例的具体情况讨论合建型式的适用性。[结果及结论]管廊与地铁相结合,同步规划、同步设计和同步实施,可以减少土地资源的占用,合理利用地下空间资源。共建共构是管廊与地铁结合建设宜优先采用的结合型式,可以大幅节省造价,最大程度地发挥合建的优点。管廊(井)与地铁主体和附属结构的结合方案的最终确定需因地制宜,结合现场实际情况综合确定。

关键词：地铁地下综合管廊盾构法共同建设中心城区

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Clinical Application of Sex Hormone in Different Physiological Periods in the Diagnosis of Infertility Patients

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Natural Science 2024年第6期16卷 102-110页

作者： Jianhong nong Daxian Tan Arshad Mehmood Tingchao Wang Xin Liu Li Deng Bowen Wei Department of Clinical Laboratory Reproductive Hospital of Guangxi Zhuang Autonomous Region Nanning China Department of Andrology Reproductive Hospital of Guangxi Zhuang Autonomous Region Nanning China Department of Neurology The Second Hospital of Hebei Medical University Shijiazhuang China

Background: Infertility is characterized by the inability to conceive after a year of regular unprotected intercourse. Aims: This study aimed to investigate the diagnostic value of sex hormone levels during different physiological periods in the diagnosis of infertility patients. Methods: From December 2019 to May 2021, a total of 93 infertility patients were admitted and selected as the observation group. Among them, 31 cases were in the follicular stage, 31 cases in the ovulation stage, and 31 cases in the luteal stage. Ninety-three healthy women for fertility evaluation due to male infertility were selected as the control group. The control group included 31 women in the follicular phase, 31 women in the ovulatory phase, and 31 women in the luteal phase. The levels of sex hormones (prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), testosterone (T), and progesterone (P)) during different physiological phases were compared between the observation and control groups. Results: The follicular phase showed no significant difference in LH levels between the observation group and the control group. The observation group showed higher levels of PRL and P compared to the control group, while the levels of FSH, E2, and T were lower in the observation group compared to the control group. The ovulation phase showed no significant difference in PRL levels between the two groups. The observation group showed lower levels of LH, FSH, E2, T, and P compared to the control group. The luteal phase showed no statistical difference in E2 levels between the two groups. The observation group showed higher levels of PRL, LH, and FSH compared to the control group, while the levels of T and P were lower in the observation group compared to the control group. Conclusion: Infertile women show variations in hormone levels compared to the normal levels during the follicular phase, ovulatory phase, and luteal phase.

关键词： Different Periods Sex Hormone Level Detection Infertility Auxiliary Diagnosis