检索结果-南通市图书馆

A new approach for flow simulation in complex hydraulic fracture morphology and its application:Fracture connection element method

引用

Petroleum Science 2023年第5期20卷 3002-3012页

作者： Guang-Long Sheng Hui Zhao Jia-Ling Ma Hao Huang hai-yang deng Wen-Tao Zhan Yu-yang Liu College of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina Hubei Key Laboratory of Oil and Gas Drilling and Production Engineering(yangtze University) Wuhan430100HubeiChina China National Offshore Oil Corporation-hainan Haikou570100HainanChina CNOOC Research Institute Ltd. Beijing100020China

Efficient flow simulation and optimization methods of hydraulic fracture morphology in unconventional reservoirs are effective ways to enhance oil/gas *** on the connection element method(CEM)and distribution of stimulated reservoir volume,the complex hydraulic fracture morphology was accurately described using heterogeneous node connection *** a new fracture connection element method(FCEM)for fluid flow in stimulated unconventional reservoirs with complex hydraulic fracture morphology was *** the proposed FCEM,the arrangement of dense nodes in the stimulated area and sparse nodes in the unstimulated area ensures the calculation accuracy and *** key parameter,transmissibility,was also modified according to the strong heterogeneity of stimulated *** finite difference and semi-analytical tracking were used to accurately solve the pressure and saturation distribution between *** FCEM is validated by comparing with traditional numerical simulation method,and the results show that the bottom hole pressure simulated by the FCEM is consistent with the results from traditional numerical simulation method,and the matching rate is larger than 95%.The proposed FCEM was also used in the optimization of fracturing parameters by coupling the hydraulic fracture propagation method and intelligent optimization *** integrated intelligent optimization approach for multi-parameters,such as perforation number,perforation location,and displacement in hydraulic fracturing is *** proposed approach was applied in a shale gas reservoir,and the result shows that the optimized perforation location and morphology distribution are related to the distribution of porosity/*** the perforation location and displacement are optimized with the same fracture number,NPV increases by 70.58%,which greatly improves the economic benefits of unconventional *** work provides a new way for flow simulation and op

关键词： Unconventional reservoirs Multi-fractured horizontal wells Complex fracture morphology Fracture connection element method Integrated optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy

引用

Acta Pharmaceutica Sinica B 2024年第4期14卷 1742-1758页

作者： Renming Fan Ruizhuo Lin Shuo Zhang Aohua deng Yongrui hai Junyan Zhuang yang Liu Maosheng Cheng Gaofei Wei Institute of Medical Research Northwestern Polytechnical UniversityXi'an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationSchool of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China

Mitochondrial membrane remodeling can trigger the release of mitochondrial DNA (mtDNA), leading to the activation of cellular oxidative stress and immune responses. While the role of mitochondrial membrane remodeling in promoting inflammation in hepatocytes is well-established, its effects on tumors have remained unclear. In this study, we designed a novel Pt(IV) complex, OAP2, which is composed of oxaliplatin (Oxa) and acetaminophen (APAP), to enhance its anti-tumor effects and amplify the immune response. Our findings demonstrate that OAP2 induces nuclear DNA damage, resulting in the production of nuclear DNA. Additionally, OAP2 downregulates the expression of mitochondrial Sam50, to promote mitochondrial membrane remodeling and trigger mtDNA secretion, leading to double-stranded DNA accumulation and ultimately synergistically activating the intracellular cGAS-STING pathway. The mitochondrial membrane remodeling induced by OAP2 overcomes the limitations of Oxa in activating the STING pathway and simultaneously promotes gasdermin-D-mediated cell pyroptosis. OAP2 also promotes dendritic cell maturation and enhances the quantity and efficacy of cytotoxic T cells, thereby inhibiting cancer cell proliferation and metastasis. Briefly, our study introduces the first novel small-molecule inhibitor that regulates mitochondrial membrane remodeling for active immunotherapy in anti-tumor research, which may provide a creative idea for targeting organelle in anti-tumor therapy.

关键词： Anti-tumor drug Prodrug Platinum Chemo-immunotherapy Mitochondrial membrane modeling STING Pyroptosis mtDNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study of 26 Galactic Open Clusters with Extended Main-sequence Turnoffs

引用

Research in Astronomy and Astrophysics 2024年第6期24卷 28-37页

作者： yang-yang deng Zhong-Mu Li Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Institute of Astronomy and Information Dali UniversityDali 671003China

Recent studies indicate that some Galactic open clusters(OCs)exhibit extended main-sequence turnoff(eMSTO)in their color–magnitude diagrams(CMDs).However,the number of Galactic OCs with eMSTO structures detected so far is limited,and the reasons for their formation are still *** work identifies 26 Galactic OCs with undiscovered eMSTOs and investigates the causes of these *** population types and fundamental parameters of cluster samples are acquired using CMD fitting *** them,the results of 11 OCs are reliable as the observed CMDs are *** propose the crucial role of stellar binarity and confirm the importance of stellar rotation in reproducing eMSTO *** results also show that the impact of age spread is important,as it can adequately explain the structure of young OCs and fit the observed CMDs of intermediate-age OCs better.

关键词： (stars:)binaries:general Galaxy:fundamental parameters (Galaxy:)open clusters and associations:general (stars:)Hertzsprung Russell and C-M-diagrams

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microbes in mass extinction: an accomplice or a savior?

引用

National Science Review 2024年第1期11卷 12-15页

作者： Genming Luo deng Liu Hao yang State Key Laboratory of Geobiology and Environmental Geology China University of Geosciences (Wuhan)

Microbes include various types of organisms that are invisible to the naked eye,e.g. bacteria, archaea and microeukaryotes. Although the precise number remains largely unknown, microbes are recognized as the unseen majority of our biosphere [1]. As a group of organisms classified by body size, microbes cover a considerable spectrum of metabolisms,

关键词： AFTERMATH

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Scattering of Water Waves by Dual Symmetric Inclined Floating Porous Barriers Using the DBEM

引用

China Ocean Engineering 2024年第1期38卷 156-168页

作者： WANG Li-xian deng Yan-wen YE yang-sha deng Zheng-zhi Key Laboratory of High Performance Ship Technology(Wuhan University of Technology) Ministry of EducationWuhan 430063China School of Naval Architecture Ocean and Energy Power EngineeringWuhan University of TechnologyWuhan 430063China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China Institute of Port Coastal and Offshore EngineeringZhejiang UniversityZhoushan 316021China

The scattering of normally incident water waves by two surface-piercing inclined perforated barriers in water with a uniform finite depth is investigated within the framework of linear water wave *** that thin barriers are zero-thickness,a novel numerical method involving the the coupling of the dual boundary element method(DBEM)with damping layers is *** order to effectively damp out the reflected waves,two damping layers,instead of pseudoboundaries are implemented near the two side boundaries of the computational ***,the modified linearized free surface boundary conditions are formulated and used for solving both the ordinary boundary integral equation as well as the hypersingular boundary integral equation for degenerate *** newly developed numerical method is validated against analytical methods using the matched eigenfunction expansion method for the special case of two vertical barriers or the inclined angle to the vertical being *** influence of the length of the two damping layers has been ***,these findings are also validated against previous results for several *** validation,the numerical results for the reflection coefficient,transmission coefficient and dissipation coefficient are obtained by varying the inclination angle and porosity-effect *** effects of both the inclination angle and the porosity on the amplitudes of wave forces acting on both the front and rear barriers are also *** is found that the effect of the inclination angle mainly shifts the location of the extremal values of the reflection and the transmission ***,a moderate value of the porosity-parameter is quite effective at dissipating wave energy and mitigating the wave loads on dual barriers.

关键词： dual boundary element method inclined perforated floating breakwater reflection coefficient transmission coefficient damping layer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Large-aperture Telescope Tracking Control Based on Time-synchronization Strategy

引用

Research in Astronomy and Astrophysics 2024年第3期24卷 34-46页

作者： Yun Li Yu Ye Shi-hai yang Ling-Zhe Xu Jin Xu hai Wang Zhuang-Zhuang deng Rui-Qiang Liu Xiao-Jie Gu Bo-Zhong Gu Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China University of Chinese Academy of Sciences Beijing 100049China

A time-synchronization strategy for packetized transmission of target position about a large-aperture telescope observation control system has been proposed in this *** with the existing telescope tracking strategy,the target position packing and sending strategy based on the time synchronization method proposed in this paper has the advantages of high stability and ***,the telescope tracking observation control method was elaborated in this paper,including the motion pattern during telescope ***,the strategy for packetizes transmission of target positions based on time-synchronization is established and lists the detailed ***,the performance of the tracking strategy is verified using the 2.5 m telescope for the simulated uniform speed star and the blind-tracking fixed star HIP 31216,*** test results show that the accuracy root mean square of the tracking strategy proposed in this paper is less than 0".02 at 30 minutes,and the performance is much better than the design requirement of 0".*** most important advantage of this tracking strategy is that the telescope can guarantee normal tracking for a certain period of time even if the hardware or software of the host computer is abnormal.

关键词： miscellaneous-telescopes-methods observational-methods analytical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonlinear robust adaptive control for bidirectional stabilization system of all-electric tank with unknown actuator backlash compensation and disturbance estimation

引用

Defence Technology（防务技术） 2024年第2期32卷 144-158页

作者： Shusen Yuan Wenxiang deng Jianyong Yao Guolai yang School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China

Since backlash nonlinearity is inevitably existing in actuators for bidirectional stabilization system of allelectric tank,it behaves more drastically in high maneuvering *** this work,the accurate tracking control for bidirectional stabilization system of moving all-electric tank with actuator backlash and unmodeled disturbance is *** utilizing the smooth adaptive backlash inverse model,a nonlinear robust adaptive feedback control scheme is *** unknown parameters and unmodelled disturbance are addressed separately through the derived parametric adaptive function and the continuous nonlinear robust *** the unknown backlash parameters are updated via adaptive function and the backlash effect can be suppressed successfully by inverse operation,which ensures the system ***,the system disturbance in the high maneuverable environment can be estimated with the constructed adaptive law online improving the engineering ***,Lyapunov-based analysis proves that the developed controller can ensure the tracking error asymptotically converges to zero even with unmodeled disturbance and unknown actuator *** co-simulations and experiments illustrate the advantages of the proposed approach.

关键词： Bidirectional stabilization system Robust control Adaptive control Backlash inverse Disturbance estimation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Precision motion control for electro-hydraulic axis systems under unknown time-variant parameters and disturbances

引用

Chinese Journal of Aeronautics 2024年第1期37卷 463-471页

作者： Xiaowei yang Yaowen GE Wenxiang deng Jianyong YAO School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China

This article focuses on asymptotic precision motion control for electro-hydraulic axis systems under unknown time-variant parameters,mismatched and matched *** from the traditional adaptive results that are applied to dispose of unknown constant parameters only,the unique feature is that an adaptive-gain nonlinear term is introduced into the control design to handle unknown time-variant *** both mismatched and matched disturbances existing in electro-hydraulic axis systems can also be addressed in this *** skillful integration of the backstepping technique and the adaptive control,a synthesized controller framework is successfully developed for electro-hydraulic axis systems,in which the coupled interaction between parameter estimation and disturbance estimation is ***,this designed controller has the capacity of low-computation costs and simpler parameter tuning when compared to the other ones that integrate the adaptive control and observer/estimator-based technique to dividually handle parameter uncertainties and ***,a nonlinear filter is designed to eliminate the“explosion of complexity”issue existing in the classical back-stepping *** stability analysis uncovers that all the closed-loop signals are bounded and the asymptotic tracking performance is also ***,contrastive experiment results validate the superiority of the developed method as well.

关键词： Adaptive control Asymptotic convergence Electro-hydraulic axis system Precision motion control Unknown time-variant parameters and disturbances

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spontaneous anchoring Cl into α-Co（OH）2 as efficient and stable oxygen reduction electrocatalysts for seawater battery

引用

Rare Metals 2024年第7期43卷 3074-3083页

作者： Wang Zheng Xue-Rong Zheng Qi Lu Yan-Hui Cao yang Wang hai-Peng Fu Jin-Feng Zhang Yi-Da deng Wen-Bin Hu School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin University State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan University Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern University

Seawater battery is an advanced energy storage system that enables conversion of chemical energy to electricity by consuming metals,dissolved oxygen and seawater in anode,cathode and electrolyte,***,the oxygen reduction reaction（ORR） activity and stability of electrocatalysts can be easily deactivated due to the severe Cl-permeation and corrosion in seawater ***,we developed a structural buffer engineering strategy by spontaneously anchoring Cl-into α-Co（OH）2as efficient and stable ORR electrocatalysts,in which the ultrathin α-Co（OH）2nanosheets were synthesized using an ultrafast solution high-temperature shock（SHTS） *** large lattice space（～ 0.8 nm） of layered α-Co（OH）2ensured the spontaneously penetration of Cl-into the lattice structure and replaced part of OH-to form α-Co（OH）*** continuous leaching and compensating of saturated Cl in α-Co（OH）2-xClxcould enhance the Cl-corrosion resistance and modulate electronic structure of Co metallic sites,thus improving the ORR electrocatalytic activity and stability in seawater *** α-Co（OH）2-xClxseawater batteries display superior onset and half-wave potentials of 0.71 and 0.66 V,respectively,which are much better than the counterparts of α-Co（OH）2and of β-Co（OH）2with no Cl-penetrating and no buffer *** α-Co（OH）2-xClx-based seawater batteries display stable open-circuit potential of 1.69 V and outstanding specific capacity of 1345 mAh·g-1.

关键词： Seawater battery Oxygen reduction electrocatalyst Solution high-temperature shock Structural buffer engineering

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural network study of the nuclear ground-state spin distribution within a random interaction ensemble

引用

Nuclear Science and Techniques 2024年第3期35卷 216-227页

作者： deng Liu Alam Noor A Zhen-Zhen Qin yang Lei School of Mathematics and Physics Southwest University of Science and TechnologyMianyang 621010China School of Nuclear Science and Technology Southwest University of Science and TechnologyMianyang 621010China

The distribution of the nuclear ground-state spin in a two-body random ensemble(TBRE)was studied using a general classification neural network(NN)model with two-body interaction matrix elements as input features and the corresponding ground-state spins as labels or output *** quantum many-body system problem exceeds the capability of our optimized NNs in terms of accurately predicting the ground-state spin of each sample within the ***,our NN model effectively captured the statistical properties of the ground-state spin because it learned the empirical regularity of the ground-state spin distribution in TBRE,as discovered by physicists.

关键词： Neural network Two-body random ensemble Spin distribution of nuclear ground state

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：