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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu Yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua Jing-Yu He Jun Li Bai Du Ting-hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan Wang hai-Rong Wang Qin Yu Jing He Yi-Lin Mao xiao-Fang Bin Yue Deng Yu-Dan Tian Qing-Hua Han Da-Jin Liu Li-Qin Duan Ming-Jun Zhao Cui-Ying Zhang hai-Ying Dai Ze-Hua Li Ying xiao You-Zhi Hu xiao-Yu Huang Kun Xing Xin Jiang Chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying Yang Yao-Rong Dong Lei Zhang Guang Fu Ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li Yun xia Jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan Yang Lin Ya-Bin Zhou Jian-Fei Yang Guo-Qing Ma Hui-Jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu xiao-Jia Luo xiao-Hong Bin Ya-Nan Yu hai-xia dang Bing Li Fei Teng Wang-Min Qiao xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan Wang Yun-Dai Chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

The future of carbon-neutrality science and technology from an industrial transformation perspective:an interview with Hou-Liang Dai

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National Science Review 2023年第9期10卷 113-115页

作者： hai-xia Huang the Science and Technology Department of the China National Petroleum Corporation

Since China announced that it will strive to achieve its carbon peak by 2030 and carbon neutrality by 2060, it has determined to take steps, which will establish low carbon development and a transition to carbon neutrality,as part of its long-term strategyfor sustainable development and *** will be both a huge challenge and an *** achieve the dual-carbon goals,the whole society must undergo a broad and profound systemic transformation, involving changes in energy,technology,economy, industry and lifestyle, ***-neutrality science and technology should be the foundation of the transformation.

关键词： Carbon

HMvisor: dynamic hybrid memory management for virtual machines

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Science China(Information Sciences) 2021年第9期64卷 74-89页

作者： dang YANG haikun LIU hai JIN Yu ZHANG National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing LabSchool of Computer Science and Technology Huazhong University of Science and Technology

Emerging non-volatile memory(NVM) technologies promise high density, low cost and dynamic random access memory(DRAM)-like performance, at the expense of limited write endurance and high write energy consumption. It is more practical to use NVM combining with the traditional DRAM. However, the hybrid memory management such as page migration becomes more challenging in a virtualization environment because virtual machines(VMs) are unaware of the memory heterogeneity. In this paper, we propose HMvisor, a hypervisor and VM coordinated hybrid memory management mechanism to better utilize DRAM and NVM resources. HMvisor exposes the memory heterogeneity to VMs by mapping virtual NUMA nodes to different physical NUMA nodes. We propose a lightweight and efficient page migration mechanism by decoupling page hotness tracking from page migration. HMvisor performs those operations in the hypervisor and VMs separately, without disrupting the execution of VMs. We also propose a memory resource trading policy to adjust the capacity of DRAM and NVM for each VM, with the monetary cost unchanged. We implement our prototype system based on QEMU/KVM and evaluate it with several benchmarks. Experimental results show that HMvisor can reduce 50% of write traffic to NVM with less than 5% performance overhead. Moreover, the hybrid memory adjustment scheme in HMvisor can significantly improve application performance by up to 30×.

关键词： hypervisor virtual machine non-volatile memory hybrid memory management

CDCC Approaches and Roles of Closed Channels in d-Nucleus Reactions

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Communications in Theoretical Physics 2008年第9期50卷 719-724页

作者： AN hai-xia CAI Chong-hai Department of Physics Nankai University Tianjin 300071 China

The effect of deuteron breakup in d-nucleus reaction is treated with the continuum discretized coupled channels （CDCC） approach, and the effects on the total reaction cross sections and elastic scattering angular distributions are studied by comparing the calculations of CDCC and spherical optical model with our global deuteron optical potential [Phys. Rev. C 73 （2006） 054605] below 200 MeV, for target nuclei ranging from ^12C to ^208Pb. The contributions from the closed channels to the total reaction and breakup cross sections, and angular distributions of elastic scattering are also seriously discussed.

关键词： CDCC approach closed channel spherical optical model global deuteron optical potential

Charge transfer on porous silicon membranes studied by current-sensing atomic force microscopy

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Chinese Chemical Letters 2008年第2期19卷 199-202页

作者： Bing xia Qiang Miao Jie Chao Shou Jun xiao hai Tao Wang Zhong dang xiao State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China State Key Laboratory of Molecular and Biomolecular Electronics Southeast University Nanjing 210096 China

A visible rectification effect on the current-voltage curves of metal/porous silicon/p-silicon has been observed by current-sensing atomic force microscopy. The current-voltage curves of porous silicon membranes with different porosities, prepared through variation of etching current density for a constant time, indicate that a higher porosity results in a higher resistance and thus a lower rectification, until the current reaches a threshold at a porosity 〉55%. We propose that the conductance mode in the porous silicon membrane with porosities 〉55% is mainly a hopping mechanism between nano-crystallites and an inverse static electric field between the porous silicon and p-Si interface blocks the electron injection from porous silicon to p-Si, but with porosities ≤55%, electron flows through a direct continuous channel between nano-crystallites.

关键词： Porous silicon Current sensing AFM Electron transfer Porosity

Molecular Dynamics Investigation of Differences in Melting Behaviors of Cu57 and Cu58 Clusters

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Chinese Journal of Chemical Physics 2009年第1期22卷 69-74页

作者： Lin Zhang hai-xia Sun Institute of Materials Physics and Chemistry College of Science Northeastern University Shenyang 110004 China

Within the framework of the embedded-atom method, we performed molecular-dynamics calculations to investigate the structural transformation during melting of two copper clus- ters containing 57 and 58 atoms. The simulation results reveal how their different structural changes can strongly influence internal energy and radial distribution functions. The local structural patterns of different regions during the temperature increase, determined by atom density profiles, are identified for the melting of each cluster. The simulations show sensi- tivities of the structural changes for these two small size clusters with different structures.

关键词： Molecular dynamics Cluster Surface Melting

Thermal decomposition effect of MgCo_(2)O_(4)nanosheets on ammonium perchlorate-based energetic molecular perovskites

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Defence Technology（防务技术） 2023年第2期20卷 111-119页

作者： Er-hai An xiao-xia Li hai-xia Zhao Ying-xin Tan Xiong Cao Peng Deng School of Environment and Safety Engineering North University of ChinaTaiyuan030051ShanxiPeople's Republic of China School of Engineering for Safety and Emergency Management Taiyuan University of Science and TechnologyTaiyuan030024China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081People's Republic of China

Energetic molecular perovskites have attracted widespread attention in the fields of energy materials due to their high detonation *** this work,we reported the effect of MgCo_(2)O_(4) nanosheets on the thermal decomposition of ammonium perchlorate(NH_(4)ClO_(4),AP)-based energetic molecular perovskites(AP-based energetic molecular perovskites).The morphology and structure of the MgCo_(2)O_(4) nanosheets were *** their catalytic effect on the thermal decomposition of AP-based energetic molecular perovskites(H_2pz)[NH_(4)(ClO_(4))_(3)](PAP-4),(H_2dabco)[NH_(4)(ClO_(4))_(3)](DAP-4),(H_2mpz)[NH_(4)(ClO_(4))_(3)](PAP-M_(4)),and (H_2hpz)[NH_(4)(ClO_(4))_(3)](PAP-H_(4)) was *** results showed that MgCo_(2)O_(4) nanosheets had excellent intrinsically catalytic performance towards enhancing the thermal decomposition of AP-based energetic molecular *** adding MgCo_(2)O_(4) nanosheets,the thermal decomposition peak temperatures of PAP-4,DAP-4,PAP-M_(4),and PAP-H_(4) had been reduced by35.7℃,48.4℃,37.9℃,and 43.6℃,*** the activation energy(Ea)of the thermal decomposition of AP-based energetic molecular perovskites had been reduced,the Eaof PAP-H_(4) decreased by 46.4 kJ/mol at most among *** catalytic mechanism of MgCo_(2)O_(4) nanosheets for AP-based energetic molecular perovskites is *** work provides a reference for the future application of AP-based energetic molecular perovskites.

关键词： AP-based energetic molecular perovskites MgCo_(2)O_(4)nanosheets Thermal decomposition Catalytic performance

Optimal Placement of Active Members in Truss Adaptive Structures

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Chinese Journal of Mechanical Engineering 2010年第2期23卷 233-241页

作者： ZHANG Lianwen xia Renwei HUANG hai School of Mechanical Engineering Tianjin University of Commerce Tianjin 300134 China School of Astronautics Beijing University of Aeronautics ＆ Astronautics Beijing 100083 China

The mathematical model of optimal placement of active members in truss adaptive structures is essentially a nonlinear multi-objective optimization problem with mixed variables. It is usually much difficult and costly to be solved. In this paper, the optimal location of active members is treated in terms of （0, 1） discrete variables. Structural member sizes, control gains, and （0, 1） placement variables are treated simultaneously as design variables. Then, a succinct and reasonable compromise scalar model, which is transformed from original multi-objective optimization, is established, in which the （0, 1） discrete variables are converted into an equality constraint. Secondly, by penalty function approach, the subsequent scalar mixed variable compromise model can be formulated equivalently as a sequence of continuous variable problems. Thirdly, for each continuous problem in the sequence, by choosing intermediate design variables and temporary critical constraints, the approximation concept is carried out to generate a sequence of explicit approximate problems which enhance the quality of the approximate design problems. Considering the proposed method, a FORTRAN program OPAMTAS2.0 for optimal placement of active members in truss adaptive structures is developed, which is used by the constrained variable metric method with the watchdog technique （CVMW method）. Finally, a typical 18 bar truss adaptive structure as test numerical examples is presented to illustrate that the design methodology set forth is simple, feasible, efficient and stable. The established scalar mixed variable compromise model that can avoid the ill-conditioned possibility caused by the different orders of magnitude of various objective functions in optimization process, therefore, it enables the optimization algorithm to have a good stability. On the other hand, the proposed novel optimization technique can make both discrete and continuous variables be optimized simultaneously.

关键词： truss adaptive structure optimal placement active member multi-objective optimization mixed variables penalty function approach