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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1555-1560页

作者： Qing-Lan Li Hong-yang Zhang Yong-Jie Qin Qian-Li Meng Xiao-Lei Yao hai-Ke Guo Department of Ophthalmology Ruikang Hospital affiliated to Guangxi University of Chinese Medicine Department of Ophthalmology Guangdong General Hospital and Guangdong Academy of Medical Sciences Zhengzhou Aier Eye Hospital Aier School of OphthalmologyCentral South University

AIM： To investigate the role of micro RNA-34a（mi R-34a） in the induction of apoptosis of human lens epithelial（HLE-B3） cells. METHODS： The apoptosis of HLE-B3 cells was detected by Annexin V-PE apoptosis detection kit after the treatment with 200 μmol/L H2O2 for 24h and lentiviral mi R-34 a vector transfection. The expression of mi R-34 a in the cells was quantified by quantitative real time polymerase chain reaction（q RT-PCR） in response to H2O2 exposure and the vector transfection. The effects of overexpression of mi R-34 a on the expression of B-cell lymphoma-2（Bcl-2） and silent information regulator 1（SIRT1） was determined by q RT-PCR and Western blot. RESULTS： The expression of mi R-34 a was up-regulated by the treatment of H2O2 in HLE-B3 cells. The increased expression of mi R-34 a is accompanied with the cell apoptosis. Consistence with the H2O2 exposure,ectopic overexpression of mi R-34 a in HLE-B3 cells promoted cells apoptosis. Importantly the anti-apoptosis factors Bcl-2 and SIRT1 were reduced significantly by up-regulation of mi R-34 a in HLE-B3 ***： Mi R-34 a promotes the apoptosis of HLE-B3 cells by down-regulating Bcl-2 and SIRT1,suggesting that mi R-34 a may involve in the pathogenesis of cataract formation and targeting mi R-34 a may be a potentially therapeutic approach for treatment of cataract.

关键词： human lens epithelial cells microRNA-34a apoptosis

Catalyst-controlled diastereoselective ring-opening formal [3+2]-cycloadditions of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines

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Science China Chemistry 2020年第6期63卷 785-791页

作者： Jun-An Xiao Xiu-Liang Cheng hai Peng Jin-Lian Li Zhen-Zhen Xie Wen-Qiang Chen Zhi-Ping Liu Qi Xiao Wei Su Hua yang Guangxi Key Laboratory of Natural Polymer Chemistry and Physics Nanning Normal UniversityNanning 530001China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

A diastereoselectivity-controllable formal[3+2]-cycloaddition of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines is developed,affording the corresponding tricyclic oxazolidine derivatives in moderate to excellent yields with excellent diastereoselectivities in the presence of palladium(0)or scandium(III)*** protocol allows selective synthesis of diastereomers of tricyclic oxazolidine derivatives under switchable and mild *** transformations of the obtained products were conducted by removing ester groups and arylvinyl moieties.

关键词： [3+2]-cycloaddition cyclic N-sulfonyl imine donor-acceptor oxirane ring-opening

Editorial of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1346-1347页

作者： Wei tao Center for Nanomedicine and Department of Anesthesiology Brigham and Women's HospitalHarvard Medical SchoolBostonMA02115USA

Ribonucleic acid(RNA)therapeutics are an emerging type of *** scientific research has been devoted to exploring the therapeutic potentials of diverse types of RNA therapeutics,such as small interfering RNA(siRNA),messenger RNA(mRNA)and RNA *** most recent successful example of RNA therapeutics is the COVID-19 vaccines enabled by m RNA nanotechnologies1.

关键词： medication Therapeutic Medical

Differentiation of Belamcandae Rhizoma and Iridis Tectori Rhizoma by Thin-Layer Chromatography and High-Performance Liquid Chromatography

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 63-70页

作者： Lu-Lu Xu yang Zhang Yue Chai Kuan Chen hai-Dong Wang Chun-Guo yang Min Ye Xue Qiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Shandong Medicinal Materials Co.LTD 28 Gongqingtuan RoadShizhong DistrictJinan CityShandong 250000China

Objective:Belamcandae Rhizoma and Iridis Tectori Rhizoma are easily confused with each *** main objective of this study is to distinguish them using chemical *** and Methods:Thin-layer chromatography(TLC)and high-performance liquid chromatography(HPLC)fingerprint methods were established to compare the chemical profile,while HPLC quantitation was used to determine the contents of three isoflavones in thirty batches of Belamcandae Rhizoma and Iridis Tectori Rhizoma ***:The two herbs could be distinguished by TLC using acetic acid-n hexane-ethyl acetate(1:90:80 v/v/v)as the mobile phase,according to the fluorescent band under 366 nm at R_(f) *** total,12 compounds were identified in the 24-min HPLC *** similarity coefficient between the two herbs was 0.54±***(1),tectoridin(2),iridin(3),irigenin(5),irisflorentin(6),and iristectorin A(9)were the main peaks in Belamcandae Rhizoma,while tectoridin(2)and tectorigenin(4)were the major peaks in Iridis Tectori *** contents of 2 in Iridis Tectori Rhizoma(2.50±0.20%)were 8.93 times higher than that of Belamcandae Rhizoma(0.28±0.08%),while the ones of 5 and 6 were slightly lower in Iridis Tectori ***:The study established fast and effective methods to distinguish Belamcandae Rhizoma from Iridis Tectori Rhizoma.

关键词： Belamcandae Rhizoma high-performance liquid chromatography fingerprint high-performance liquid chromatography quantitative analysis Iridis Tectori Rhizoma thin-layer chromatography

Machine-learning-assisted discovery of empirical rule for inherent brittleness of full Heusler alloys

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Journal of Materials Science & Technology 2022年第36期131卷 1-13页

作者： Hao-Xuan Liu hai-Le Yan Nan Jia Shuai Tang Daoyong Cong Bo yang Zongbin Li Yudong Zhang Claude Esling Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang 110819China State Key Lab of Rolling and Automation Northeastern UniversityShenyang 110819China Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China Laboratoire d’Étude des Microstructures et de Mécanique des Matériaux(LEM3) CNRS UMR 7239Universitéde LorraineMetz 57045France

Brittleness is a critical issue hindering the potential application of the X_2YZ-type full Heusler alloys in several fields of state-of-the-art *** realize optimization of brittleness or design a ductile Heuser alloy,it is greatly urgent to identify the key materials factors deciding brittleness and establish an empirical rule to effectively evaluate *** this purpose,by using a machine learning and human analysis cooperation approach,the brittleness of the X_2YZ-type Heusler alloys was systematically *** showed that the ductility is majorly decided by 6 key materials factors in the studied *** these 6 factors,a machine learning model to predict the Pugh's ratio k was *** analyses showed that the crystal structure of the X component could be the most critical factor deciding the *** X component has the face-centered cubic(FCC)structure for most of the alloys with superior *** effectively estimate ductility and guide materials design,an empirical formula of k=mEWF_(m+n)G_(m)+k_(0)was established based on the known information of electron work function(EWF)and shear modulus(G)of the X,Y,and Z elements where the subscript m represents the weight-average *** coefficients of m(negative)and n(positive)were confirmed to have opposite signs,which can be explained based on the relations between the ductility and the deformation/fracture *** work is expected to deepen the understanding in ductility and promote the design of advanced ductile Heusler alloys.

关键词： Heusler alloy Machine learning Ductility Empirical formula Pugh's ratio k

Synthesis of Isotactic Polystyrene-block-Polyethylene by the Combination of Sequential Monomer Addition and Hydrogenation of 1,4-Trans-polybutadiene Block

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Chinese Journal of Polymer Science 2017年第7期35卷 866-873页

作者： Hua-qing Liang Qi-hua Zhou Yong-jiang Long Wan-chu Wei Guo-dong Liang Qing Wu hai-yang Gao 祝方明 Guangdong Provincial Key Laboratory for High Performance Polymeric Composites School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 China Key Laboratory for Polymer Composite and Functional Materials of Ministry of Education School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 China

Herein, we demonstrate the synthesis of a well-defined diblock copolymer consisting of isotactic polystyrene （iPS） and linear polyethylene, isotactic polystyrene-block-polyethylene （iPS-b-PE）, by the combination of sequential monomer addition and hydrogenation. Isospecific living polymerization of styrene and living trans-1,4-polymerization of 1,3-butadiene were catalyzed by 1,4-dithiabutandiyl-2,2＇-bis（6-cumenyl-4-methylphenoxy） titanium dichloride （complex 1） activated by triisobutyl aluminum modified methylaluminoxane （MMAO） at room tempera^xre to provide highly isotactic polystyrene （iPS） and 1,4-trans-polybutadiene （1,4-trans-PBD） with narrow molecular weight distribution. Furthermore, the iPS-b-I,4- trans-PBD was synthesized via sequential monomer addition in the presence of complex 1 and MMAO. The hydrogenation of the 1,4-trans-PBD block was promoted by RuC12（PPh3）3 used as a catalyst to produce iPS-b-PE.

关键词： lsotactic polystyrene 1,4-Trans-polybutadiene Linear polyethylene Diblock copolymer Sequential monomeraddition Hydrogenation

Waste activated sludge treatment based on temperature staged and biologically phased anaerobic digestion system

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Journal of Environmental Sciences 2013年第10期25卷 2056-2064页

作者： Jingwen Yu1 Mingxia Zheng tao tao Jiane Zuo Kaijun Wang School of Environmental Science and Engineering Huazhong University of Science and Technology State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua University

The concept of temperature staged and biological phased （TSBP） was proposed to enhance the performance of waste-activated sludge anaerobic digestion. Semi-continuous experiments were used to investigate the effect of temperature （35 to 70℃） as well as the hydraulic retention time （HRT）（2, 4 and 6 days） on the acidogenic phase. The results showed that the solubilization degree of waste- activated sludge increased from 14.7% to 30.1% with temperature increasing from 35 to 70℃, while the acidification degree was highest at 45℃ （17.6%）, and this was quite different from the temperature impact on hydrolysis. Compared with HRT of 2 and 6 days, 4 days was chosen as the appropriate HRT because of its relatively high solubilization degree （24.6%） and acidification degree （20.1%） at 45℃. The TSBP system combined the acidogenic reactor （45℃, 4 days） with the methanogenic reactor （35℃, 16 days） and the results showed 84.8% and 11.4% higher methane yield and volatile solid reduction, respectively, compared with that of the single-stage anaerobic digestion system with HRT of 20 days at 35℃. Moreover, different microbial morphologies were observed in the acidogenic- and methanogenic-phase reactors, which resulted from the temperature control and HRT adjustment. All the above results indicated that 45℃ was the optimum temperature to inhibit the activity of methanogenic bacteria in the acidogenic phase, and temperature staging and phase separation was thus accomplished. The advantages of the TSBP process were also confirmed by a full-scale waste-activated sludge anaerobic digestion project which was an energy self-sufficient system.

关键词： temperature-staged and biologically-phased acidogenic and methanogenic phases temperature hydraulic retention time

Bone Microthrombus Promotes Bone Loss in Iron Accumulation Rats

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Current Medical Science 2020年第5期40卷 943-950页

作者： hai-feng HANG Long-jia DONG Xin-bing TANG Ai-fei WANG Fan yang Hui ZHANG You-jia XU Department of Orthopedics Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Department of Orthopedics The Affiliated Baiyun Hospital of Guizhou Medical UniversityGuizhou 550014China Osteoporosis Institute Soochow UniversitySuzhou 215004China Department of Orhopedics Jiangdu People's Hospital of YangzhouYangzhou 225200China

In the present study,we investigated the changes of the coagulation state,bone microthrombus,microvascular bed and bone density levels in iron accumulation ***,the effect of anticoagulation therapy on bone mineral density was further *** established two groups:a control(Ctrl)group and an iron intervention(FAC)*** in coagulation function,peripheral blood cell counts,bone microthrombus,bone vessels and bone mineral density were compared between the two *** designed the non-treatment group and treatment group to study the changes of bone mineral density by preventing microthrombus formation with the anticoagulant *** found that the fbrinogen and D-dimer contents were significantly higher,whereas the thrombin time(TT)and prothrombin time(PT)were significantly shorter in the FAC *** ink staining,the microvascular bed in the FAC group was significantly reduced compared with that in the Ctrl *** and Martius Scarlet Blue(MSB)staining showed microthrombus in the bone marrow of the iron accumulation *** anticoagulation therapy,the bone microcirculation vascular bed areas in the treatment group rats were significantly ***,the bone mineral density was increased in the treatment group compared with that in the non-treatment *** experiments,we found that the blood in iron accumulation rat was relatively hypercoagulable;moreover,there was microthrombus in the bone marrow,and the bone vascular bed was ***,anticoagulation was helpful for improving bone microcirculation,reducing microthrombus and decreasing bone loss.

关键词： iron accumulation osteoporosis coagulation state microvascular bed bone microthrombus anticoagulant

A Stochastic Collocation Method for Delay Differential Equations with Random Input

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Advances in Applied Mathematics and Mechanics 2014年第4期6卷 403-418页

作者： tao Zhou Institute of Computational Mathematics Academy of Mathematics and Systems SciencesThe Chinese Academy of SciencesBeijing 100190China

In this work,we concern with the numerical approach for delay differential equations with random *** first show that the exact solution of the problem considered admits good regularity in the random space,provided that the given data satisfy some reasonable assumptions.A stochastic collocation method is proposed to approximate the solution in the random space,and we use the Legendre spectral collocation method to solve the resulting deterministic delay differential *** property of the proposed method is *** is shown that the numerical method yields the familiar exponential order of convergence in both the random space and the time *** examples are given to illustrate the theoretical results.

关键词： Delay differential equations stochastic collocation sparse grid legendre spectral method

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超构材料中的光学量子自旋霍尔效应

物理学报 2017年第22期66卷 84-94页

作者：龙洋任捷江海涛孙勇陈鸿同济大学物理科学与工程学院声子学与热能科学中心先进微结构材料教育部重点实验室上海200092

电子的量子自旋霍尔效应的发现推进了当今凝聚态物理学的发展,它是一种电子自旋依赖的具有量子行为的输运效应.近年来,大量的理论和实验研究表明,描述电磁波场运动规律的麦克斯韦方程组内禀了光的量子自旋霍尔效应,存在于界面的倏逝波... 详细信息

电子的量子自旋霍尔效应的发现推进了当今凝聚态物理学的发展,它是一种电子自旋依赖的具有量子行为的输运效应.近年来,大量的理论和实验研究表明,描述电磁波场运动规律的麦克斯韦方程组内禀了光的量子自旋霍尔效应,存在于界面的倏逝波表现出强烈的自旋与动量关联性.得益于新兴的光学材料:超构材料(metamaterials)的发展,不仅能够任意设定光学参数,同时也能引入很多复杂的自旋-轨道耦合机理,让我们能够更加清晰地了解和验证其中的物理机理.本文对超构材料中量子自旋霍尔效应做了简要的介绍,内容主要包括真空中光的量子自旋霍尔效应的物理本质、电单负和磁单负超构材料能带反转导致的不同拓扑相的界面态、拓扑电路系统中光量子自旋霍尔效应等.

关键词：量子自旋霍尔效应超构材料拓扑相变