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Experimental study on motion and mechanical characteristics of the vertical wheel in the rock-breaking process

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Petroleum Science 2023年第1期20卷 495-506页

作者： Yan yang Ying-Xin yang hai-tao Ren Qing-Liang Qi Ze-Quan Huang Chun-Xiao Zhou International Faculty of Applied Technology Yibin UniversityYibinSichuan 644000China College of Mechanical and Electrical Engineering Southwest Petroleum UniversityChengduSichuan 610500China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengduSichuan 610500China Faculty of Intelligence Manufacturing Yibin UniversityYibinSichuan 644000China College of Engineering Southwest Petroleum UniversityNanchongSichuan 637001China

Polycrystalline diamond compact(PDC)drill bit often performs with low ROP,short service life and poor stability under complicated and difficult to drill ***,a vertical wheel PDC bit is proposed,which is a new drill bit technology applying an integrated unit combining the tooth wheel and the rotary shaft ***,the experiments on motion and mechanical characteristics of the vertical wheel under the conditions of tooth shape and number of teeth,normal deflection angle of the wheel,and different cutting depth were carried out using variable parameter experimental device,and the movement,force law,and crushing specific work of vertical wheel under different experimental conditions were *** comparative experiments of PDC cutting rock breaking under the conditions of parallel cutting of PDC unit and pre-damage of the wheel were also carried out,and the cutting load of PDC teeth under pre-damage conditions is between 38.72% and 70.95%lower than that of parallel cutting was ***,a comparative experiment of indoor drilling between vertical wheel PDC bit and conventional PDC bit was carried *** show than when drilling in gravel rock,under the same WOB,the torque response of vertical wheel PDC bit is equivalent to that of the PDC bit,while the ROP of vertical wheel PDC bit is 22.94%-53.33% higher than that of conventional PDC bit,and the threedimensional acceleration of the vertical wheel PDC bit is 19.17%-76.23% of that of the PDC *** experimental results contribute to a better understanding of vertical wheels and provide technical support for their use in PDC bits.

关键词： Difficult to drill formation Vertical wheel Vertical wheel PDC bit Rock-breaking mechanism Pre-damage

Photocatalytic in situ H_(2)O_(2) production and activation for enhanced ciprofloxacin degradation over CeO_(2)-Co_(3)O_(4)/g-C_(3)N_(4):key role of CeO_(2)

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Rare Metals 2024年第6期43卷 2695-2707页

作者： Hong-Jie Zhu Yi-Kai yang Ming-Hui Li Lu-Ning Zou hai-tao Zhao Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical Engin College of Ecology and Environment Anhui Normal UniversityWuhu241002China Liaocheng YiLu Advanced Materials Co. LtdLiaocheng 252000China

The abused ciprofloxacin antibiotics have caused significant environmental *** oxidative degradation of ciprofloxacin exhibits promising efficacy,it often entails excessive energy ***,it is necessary to explore an effective and ecologically sustainable degradation ***,we demonstrated that g-C_(3)N_(4) decorated with the coordinated CeO_(2)and Co_(3)O_(4)(CeO_(2)-Co_(3)O_(4)/CN)exhibited effective ciprofloxacin photodegradation via in situ H_(2)O_(2) production and activation *** indicate that the introduced CeO_(2) enhances the transference of photogenerated electrons to O_(2) by adjusting the oxygen vacancy of photocatalyst,thereby increasing the generation of superoxide radicals,which in turn generate H_(2)O_(2),resulting in a 22.4-fold increase in H_(2)O_(2) generation over g-C_(3)N_(4).Moreover,the in situ H_(2)O_(2)generation facilitated by CeO_(2) is confirmed to be essential for ciprofloxacin degradation via CeO_(2)-Co_(3)O_(4)/CN,as it provides enough oxidant for Co_(3)O_(4) to activate into hydroxyl radicals for the pollutants ***,CeO_(2)-Co_(3)O_(4)/CN achieves a ciprofloxacin degradation ratio of 97.7%within 80 *** study introduces a novel approach that combines H_(2)O_(2) generation and activation,offering an innovative perspective for achieving clean and efficient purification of antibiotic-contaminated water.

关键词： CeO_(2) In situ H_(2)O_(2)generation Ciprofloxacin degradation Photocatalyst

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang yang Liu Cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Trimethyl phosphate-enhanced polyvinyl carbonate polymer electrolyte with improved interfacial stability for solid-state lithium battery

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Rare Metals 2022年第6期41卷 1889-1898页

作者： Fei Zheng Hao-Tong Li Yan-Zhen Zheng Dan Wang Ning-Ning yang hai-yang Ding Xia tao Beijing Key Laboratory of Green Recovery and Extractionof Rare and Precious Metals University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China General Research Institute of Nonferrous Metals Beijing 100088China China Automotive Battery Research Institute Co. Ltd.Beijing 101407China

The polyvinyl carbonate(PVC)polymer solid electrolyte can be in-situ generated in the assembled lithium-ion battery(LIBs);however,its rigid characteristic leads to uneven interface contact between electrolyte and *** this work,trimethyl phosphate(TMP)is introduced into the precursor solution for in-situ generation of flexible PVC solid electrolyte to improve the interfacial contact of elec-trolyte and electrodes together with ionic *** PVC-TMP electrolyte exhibits good interface compatibility with the lithium metal anode,and the lithium symmetric battery based on PVC-TMP electrolyte shows no obvious polarization within 1000 h *** a consequence,the initial interfacial resistance of battery greatly decreases from 278Ω(LiFePO_(4)(LFP)/PVC/Li)to 93Ω(LFP/PVC-TMP/Li)at 50℃,leading to an improved cycling stability of the LFP/PVC-TMP/Li *** in-situ preparation of solid electrolyte within the battery is demonstrated to be very significant for commercial application.

关键词： Trimethyl phosphate Solid polymer electrolyte Interface stability Compatibility Lithium ion battery

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo Wan tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

Catalyst-free and Reprocessable Aromatic Polydithiourethanes

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Chinese Journal of Polymer Science 2024年第10期42卷 1435-1441,I0007页

作者： Bo yang hai-Jun Feng Tian-Tian Ni Xiao-Rui Zhou tao Xie Ning Zheng State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310058China Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and InterventionMinistry of EducationThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China

The incorporation of dynamic covalent bonds into thermosets facilitates the reprocessing of polymer networks,thereby meeting the sustainable requirements for polymer ***,the mechanical properties of many materials often decline significantly upon reprocessing due to side reactions caused by harsh processing *** this work,we find that the aromatic dithiocarbamate bond can undergo dissociation under mild conditions without the need for a catalyst,enabling the efficient reprocessing of the corresponding *** a consequence,the mechanical properties of the polydithiourethane can be largely preserved after *** discovery of this dynamic chemistry is anticipated to broaden the potential for material design in dynamic covalent polymer networks.

关键词： Reprocessing Polydithiourethane Dynamic covalent bond

Synthesis,Crystal Structure and Antitumor Activities of Ethyl 5-methyl-4-morpholino-2-(3-Methyl-phenylamino)-furo[2,3-d] pyrimidine-6-carboxylate

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Chinese Journal of Structural Chemistry 2013年第12期32卷 1868-1872页

作者： LI Yan TANG He-Xin GAO hai-tao HU yang-Gen School of Nuclear Technology & Chemistry and Biology Hubei University of Science and Technology Institute of Synthetic Organic and Medicinal Chemistry Hubei University of Medicine Taihe Hospital of Hubei University of Medicine

The title compound （C21H24N4O4, Mr = 396.44） has been synthesized by the func- tionalized ethyl 4-chloro-6-methyl-2-arylamino-furo[2,3-d]pyrimidine-5-carboxylates and mor- pholine. Its structure was confirmed by means of 1H NMR IR, MS and elemental analysis. The crystal structure of the title compound was determined by X-ray single-crystal diffraction. The compound crystallizes in triclinic system, space group P1, a = 7.9919（8）, b = 9.9312（1）, c = 12.9380（13） A, aα = 86.987（2）, β = 83.604（2）, γ = 89.641（2）°, V = 1019.08（18） A3, Z = 2, F（000） = 420, Dc = 1.292 g/cm3,μ = 0.091 mm-1, R = 0.0602 and wR = 0.1548 for 3943 independent （Rint = 0.0639） and 3414 observed （I 〉 2σ（I）） reflections, lntermolecular N-H…O and π-π stacking interactions contributed to the stability of the structure. The preliminary biological test indicated the title compound exhibited cytotoxicity against human lung cancer cell lines.

关键词： furo[2,3-d]pyrimidine synthesis crystal structure antitumor activity

Nondestructive determination of film thickness with laser-induced surface acoustic waves

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Chinese Physics B 2018年第9期27卷 457-461页

作者： Xia Xiao tao Kong hai yang Qi and Hui Quan Qing School of Microelectronic Tianjin Key Laboratory of Imaging and Sensing Microelectronic TechnologyTianjin UniversityTianjin 300072China

The application of surface acoustic waves（SAWs） for thickness measurement is presented. By studying the impact of film thickness h on the dispersion phenomenon of surface acoustic waves, a method for thickness determination based on theoretical dispersion curve v（ fh） and experimental dispersion curve v（ f） is developed. The method provides a series of thickness values at different frequencies f, and the mean value is considered as the final result of the measurement. The thicknesses of six interconnect films are determined by SAWs, and the results are compared with the manufacturer＇s *** relative differences are in the range from 0.4% to 2.18%, which indicates that the surface acoustic wave technique is reliable and accurate in the nondestructive thickness determination for films. This method can be generally used for fast and direct determination of film thickness.

关键词： thickness measurement dispersion curve surface acoustic waves layered structure

Genetic Algorithm-Based Optimization Used in Rolling Schedule

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Journal of Iron and Steel Research International 2008年第2期15卷 18-22页

作者： yang Jing-ming CHE hai-jun DOU Fu-ping ZHOU tao Institute of Electrical Engineering Yanshan University Qinhuangdao 006004 Hebei China

A genetic algorithm-based optimization was used for 1 370 mm tandem cold rolling schedule,in which the press rates were coded and *** superiority individual is reserved in every *** and comparison of optimized schedule with the existing schedule were *** is seen that the performance of the optimal rolling schedule is satisfactory and promising.

关键词： tandem cold rolling rolling schedule energy consumption genetic algorithm optimization