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Development and validation of a predictive score for perioperative transfusion in patients with hepatocellular carcinoma undergoing liver resection

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 394-400页

作者： hai-Qing Wang Jian yang Jia-Yin yang Wen-tao Wang Lu-Nan Yan Department of Liver Surgery West China Hospital Sichuan University

Liver resection is a major surgery requiring perioperative blood transfusion. Predicting the need for blood transfusion for patients undergoing liver resection is of great importance. The present study aimed to develop and validate a model for predicting transfusion requirement in HBV-related hepatocellular carcinoma patients undergoing liver resection. METHODS： A total of 1543 consecutive liver resections were included in the study. Randomly selected sample set of 1080 cases （70% of the study cohort） were used to develop a predic- tive score for transfusion requirement and the remaining 30% （n=463） was used to validate the score. Based on the preopera- tive and predictable intraoperative parameters, logistic regres- sion was used to identify risk factors and to create an integer score for the prediction of transfusion requirement. RESULTS： Extrahepatic procedure, major liver resection, hemoglobin level and platelets count were identified as inde- pendent predictors for transfusion requirement by logistic regression analysis. A score system integrating these 4 factors was stratified into three groups which could predict the risk of transfusion, with a rate of 11.4%, 24.7% and 57.4% for low, moderate and high risk, respectively. The prediction model appeared accurate with good discriminatory abilities, generat- ing an area under the receiver operating characteristic curve of 0.736 in the development set and 0.709 in the validation set. CONCLUSIONS： We have developed and validated an integer- based risk score to predict perioperative transfusion for pa- tients undergoing liver resection in a high-volume surgicalcenter. This score allows identifying patients at a high risk and may alter transfusion practices.

关键词： liver resection transfusion hepatocellular carcinoma

Combination of low-energy shock-wave therapy and bone marrow mesenchymal stem cell transplantation to improve the erectile function of diabetic rats

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Asian Journal of Andrology 2017年第1期19卷 26-33页

作者： hai-tao Shan hai-Bo Zhang Wen-tao Chen Feng-Zhi Chen tao Wang Jin-Tai Luo Min Yue Ji-Hong Lin An-yang Wei Department of Urology Medical Center for Overseas Patients Nanfang Hospital Southern Medical University Guangzhou China Department of Urology Shawan People's Hospital Panyu District Guangzhou China Shenzhen Hyde Medical Equipment Co. Ltd. Shenzhen China Department of Urology Longjiang HospitalShunde District Foshan China Laboratory Animals Center Southern Medical University Guangzhou China.

Stem cell transplantation and low-energy shock-wave therapy （LESWT） have emerged as potential and effective treatment protocols for diabetic erectile dysfunction. During the tracking of transplanted stem cells in diabetic erectile dysfunction models, the number of visible stem cells was rather low and decreased quickly. LESWT could recruit endogenous stem cells to the cavernous body and improve the microenvironment in diabetic cavernous tissue. Thus, we deduced that LESWT might benefit transplanted stem cell survival and improve the effects of stem cell transplantation. In this research, 42 streptozotocin-induced diabetic rats were randomized into four groups： the diabetic group （n = 6）, the LESWT group （n = 6）, the bone marrow-derived mesenchymal stem cell （BMSC） transplantation group （n = 15）, and the combination of LESWT and BMSC transplantation group （n = 15）. One and three days after BMSC transplantation, three rats were randomly chosen to observe the survival numbers of BMSCs in the cavernous body. Four weeks after BMSC transplantation, the following parameters were assessed： the surviving number of transplanted BMSCs in the cavernous tissue, erectile function, real-time polymerase chain reaction, and penile immunohistochemical assessment. Our research found that LESWT favored the survival of transplanted BMSCs in the cavernous body, which might be related to increased stromal cell-derived factor-1 expression and the enhancement of angiogenesis in the diabetic cavernous tissue. The combination of LESWT and BMSC transplantation could improve the erectile function of diabetic erectile function rats more effectively than LESWT or BMSC transplantation performed alone.

关键词： bone marrow mesenchymal stem cell diabetes mellitus erectile function low-energy shock-wave therapy

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie yang Ganggang Zhang Chen Wang Yanlian yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

Quantum corrections to the entropy in a driven quantum Brownian motion model

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Communications in Theoretical Physics 2021年第9期73卷 136-144页

作者： Tian Qiu hai-tao Quan School of Physics Peking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing100871China

The quantum Brownian motion model is a typical model in the study of nonequilibrium quantum *** is one of the most fundamental physical concepts in *** this work,by solving the quantum Langevin equation,we study the von Neumann entropy of a particle undergoing quantum Brownian *** obtain the analytical expression of the time evolution of the Wigner function in terms of the initial Wigner *** result is applied to the thermodynamic equilibrium initial state,which reproduces its classical counterpart in the high temperature *** on these results,for those initial states having well-defined classical counterparts,we obtain the explicit expression of the quantum corrections to the entropy in the weak coupling ***,we find that for the thermodynamic equilibrium initial state,all terms odd inÿ are exactly *** results bring important insights to the understanding of entropy in open quantum systems.

关键词： quantum Brownian motion time-dependent evolution quantum entropy

Photocatalytic in situ H_(2)O_(2) production and activation for enhanced ciprofloxacin degradation over CeO_(2)-Co_(3)O_(4)/g-C_(3)N_(4):key role of CeO_(2)

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Rare Metals 2024年第6期43卷 2695-2707页

作者： Hong-Jie Zhu Yi-Kai yang Ming-Hui Li Lu-Ning Zou hai-tao Zhao Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical Engin College of Ecology and Environment Anhui Normal UniversityWuhu241002China Liaocheng YiLu Advanced Materials Co. LtdLiaocheng 252000China

The abused ciprofloxacin antibiotics have caused significant environmental *** oxidative degradation of ciprofloxacin exhibits promising efficacy,it often entails excessive energy ***,it is necessary to explore an effective and ecologically sustainable degradation ***,we demonstrated that g-C_(3)N_(4) decorated with the coordinated CeO_(2)and Co_(3)O_(4)(CeO_(2)-Co_(3)O_(4)/CN)exhibited effective ciprofloxacin photodegradation via in situ H_(2)O_(2) production and activation *** indicate that the introduced CeO_(2) enhances the transference of photogenerated electrons to O_(2) by adjusting the oxygen vacancy of photocatalyst,thereby increasing the generation of superoxide radicals,which in turn generate H_(2)O_(2),resulting in a 22.4-fold increase in H_(2)O_(2) generation over g-C_(3)N_(4).Moreover,the in situ H_(2)O_(2)generation facilitated by CeO_(2) is confirmed to be essential for ciprofloxacin degradation via CeO_(2)-Co_(3)O_(4)/CN,as it provides enough oxidant for Co_(3)O_(4) to activate into hydroxyl radicals for the pollutants ***,CeO_(2)-Co_(3)O_(4)/CN achieves a ciprofloxacin degradation ratio of 97.7%within 80 *** study introduces a novel approach that combines H_(2)O_(2) generation and activation,offering an innovative perspective for achieving clean and efficient purification of antibiotic-contaminated water.

关键词： CeO_(2) In situ H_(2)O_(2)generation Ciprofloxacin degradation Photocatalyst

Experimental study on motion and mechanical characteristics of the vertical wheel in the rock-breaking process

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Petroleum Science 2023年第1期20卷 495-506页

作者： Yan yang Ying-Xin yang hai-tao Ren Qing-Liang Qi Ze-Quan Huang Chun-Xiao Zhou International Faculty of Applied Technology Yibin UniversityYibinSichuan 644000China College of Mechanical and Electrical Engineering Southwest Petroleum UniversityChengduSichuan 610500China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengduSichuan 610500China Faculty of Intelligence Manufacturing Yibin UniversityYibinSichuan 644000China College of Engineering Southwest Petroleum UniversityNanchongSichuan 637001China

Polycrystalline diamond compact(PDC)drill bit often performs with low ROP,short service life and poor stability under complicated and difficult to drill ***,a vertical wheel PDC bit is proposed,which is a new drill bit technology applying an integrated unit combining the tooth wheel and the rotary shaft ***,the experiments on motion and mechanical characteristics of the vertical wheel under the conditions of tooth shape and number of teeth,normal deflection angle of the wheel,and different cutting depth were carried out using variable parameter experimental device,and the movement,force law,and crushing specific work of vertical wheel under different experimental conditions were *** comparative experiments of PDC cutting rock breaking under the conditions of parallel cutting of PDC unit and pre-damage of the wheel were also carried out,and the cutting load of PDC teeth under pre-damage conditions is between 38.72% and 70.95%lower than that of parallel cutting was ***,a comparative experiment of indoor drilling between vertical wheel PDC bit and conventional PDC bit was carried *** show than when drilling in gravel rock,under the same WOB,the torque response of vertical wheel PDC bit is equivalent to that of the PDC bit,while the ROP of vertical wheel PDC bit is 22.94%-53.33% higher than that of conventional PDC bit,and the threedimensional acceleration of the vertical wheel PDC bit is 19.17%-76.23% of that of the PDC *** experimental results contribute to a better understanding of vertical wheels and provide technical support for their use in PDC bits.

关键词： Difficult to drill formation Vertical wheel Vertical wheel PDC bit Rock-breaking mechanism Pre-damage

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang yang Liu Cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Trimethyl phosphate-enhanced polyvinyl carbonate polymer electrolyte with improved interfacial stability for solid-state lithium battery

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Rare Metals 2022年第6期41卷 1889-1898页

作者： Fei Zheng Hao-Tong Li Yan-Zhen Zheng Dan Wang Ning-Ning yang hai-yang Ding Xia tao Beijing Key Laboratory of Green Recovery and Extractionof Rare and Precious Metals University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China General Research Institute of Nonferrous Metals Beijing 100088China China Automotive Battery Research Institute Co. Ltd.Beijing 101407China

The polyvinyl carbonate(PVC)polymer solid electrolyte can be in-situ generated in the assembled lithium-ion battery(LIBs);however,its rigid characteristic leads to uneven interface contact between electrolyte and *** this work,trimethyl phosphate(TMP)is introduced into the precursor solution for in-situ generation of flexible PVC solid electrolyte to improve the interfacial contact of elec-trolyte and electrodes together with ionic *** PVC-TMP electrolyte exhibits good interface compatibility with the lithium metal anode,and the lithium symmetric battery based on PVC-TMP electrolyte shows no obvious polarization within 1000 h *** a consequence,the initial interfacial resistance of battery greatly decreases from 278Ω(LiFePO_(4)(LFP)/PVC/Li)to 93Ω(LFP/PVC-TMP/Li)at 50℃,leading to an improved cycling stability of the LFP/PVC-TMP/Li *** in-situ preparation of solid electrolyte within the battery is demonstrated to be very significant for commercial application.

关键词： Trimethyl phosphate Solid polymer electrolyte Interface stability Compatibility Lithium ion battery

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo Wan tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target