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Electrochemically promoted N-heterocyclic carbene polymercatalyzed cycloaddition of aldehyde with isocyanide acetate

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Science China Chemistry 2022年第10期65卷 1873-1878页

作者： Chu-Hong Ou Ying-Ming Pan hai-tao tang State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China

N-heterocyclic carbene(NHC) is a potent organic small-molecule catalyst.However,its high synthetic price and frequent use in combination with excess oxidants have limited its utilization in industrial production.We designed and synthesized a porous organic polymer with NHC as the core structure to solve the above problems.The catalytic performance of the polymer was tested in this work.The polymer can successfully catalyze the cycloaddition reaction of aldehyde and ethyl isocyanoacetate under electro-oxidation.The results showed that the polymer catalyst can be recycled and had higher catalytic activity than homogeneous NHC.The developed catalytic system(organic electrochemistry and NHC polymer) solves the existing problems of NHC catalysis and provides a reference for the development of new green catalytic systems.

关键词： NHC catalysis electrochemistry heterogeneous catalysis cycloaddition

Trace amount of single-atom palladium-catalyzed selective hydrosilylation of allenes

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Nano Research 2022年第8期15卷 7091-7098页

作者： Li-Ping Pang Xin-Yu Li Shi-Cheng Ren Hong-Min Lin Ying-Chun Wang Ying-Ming Pan hai-tao tang State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China College of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China

Using fewer catalysts to promote the chemical conversion of more substrates is the dream synthesis pursued by synthetic chemists.Achieving highly selective reactions using trace amounts(100:1).The catalyst could be recycled numerous times in a continuous flow system without reductions in activity and selectivity.This work demonstrated the application prospect of the SAC in the synthesis of complex organic compounds and trace amount catalysis,which can lay the foundation for its large-scale and industrialized application in drug synthesis and other fields.

关键词： trace catalysis single-atom catalysts hydrosilylation allenes

Photocatalyst-controlled and visible light-enabled selective oxidation of pyridinium salts

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Science China Chemistry 2021年第5期64卷 753-760页

作者： Xiang-Jun Peng hai-Ping He Qian Liu Kun She Bao-Qi Zhang Heng-Shan Wang hai-tao tang Ying-Ming Pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education Gannan Medical UniversityGanzhou 341000China

This study proposes two different methods of photocatalytic-controlled and visible light-induced selective oxidation of pyridiniums with air as the terminal oxidant.The key to these transformations is to choose the appropriate light source and photocatalyst.Pyridiniums are successfully converted into pyrroles through oxygen-mediated cycloaddition,proton-coupled electron transfer(PCET),pyridine ring opening,and recyclization.The other route is that pyridiniums selectively form 4-carbonyl pyridines through free radical rearrangement/aerobic oxidation under the catalysis of cobalt(Ⅱ).

关键词： photocatalytic-controlled reaction proton-coupled electron transfer ring opening/recyclization process rearrangement/aerobic oxidation the Ladenburg rearrangement pyridinium

Prefrontocortical Astrocytes Regulate Dominance Hierarchy in Male Mice

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Neuroscience Bulletin 2024年第3期40卷 415-417页

作者： Yong tang hai-Yan Yin Peter Illes School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China International Joint Research Center on Purinergic Signaling Chengdu University of Traditional Chinese MedicineChengdu 610075China Rudolf Boehm Institute for Pharmacology and Toxicology University of Leipzig04107 LeipzigGermany

Social hierarchy is a general self-organizational scheme in animal societies in which each member achieves a certain status of domination or subordination when getting access to resources,with profound consequences for survival,health,reproductive success,and multiple behaviors[1,2].The prefrontal cortex(PFC)was recognized as a central regulator of neuronal circuits determining the formation of social hierarchy;brain areas upstream of the PFC convey information about social status,and downstream brain regions execute dominance behavior[3].Social deficits have been suggested to be due to an elevation of excitatory/inhibitory(E/l)balance within the mouse dorsomedial(dm)PFC[4].A compensatory increase of inhibitory cell excitability partially rescued social deficits caused by such a disturbance of E/l balance.

关键词： consequences hierarchy determining

Two-color emissive AIEgens with anti-Kasha property for dual-organelle imaging and phototherapy

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Science China Chemistry 2024年第5期67卷 1740-1752页

作者： Pu Chen Guogang Shan Qingli Nie Yuting Yan Pengfei Zhang Zujin Zhao hai-tao Feng Ben Zhong tang AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Institute of Functional Material Chemistry and National&Local United Engineering Lab for Power Battery Faculty of ChemistryNortheast Normal UniversityChangchun 130024China College of Chemistry&Materials Science Northwest UniversityXi’an 710127China Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-induced emission luminogens(AIEgens)with donor-π-acceptor structures were designed and synthesized, namely QT-1 and QF-2. Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha's rule, and could stain lipid droplets(LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species(ROS) generation efficiency of QT-1, it was chosen as a photodynamic therapy agent to selectively kill cancer cells from normal cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential(MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo. This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dualorganelle targeting-based phototheranostics.

关键词： aggregation-induced emission anti-Kasha luminescence fluorescent probe bioimaging photodynamic therapy

Positive definiteness of real quadratic forms resulting from the variable-step L1-type approximations of convolution operators

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Science China Mathematics 2024年第2期67卷 237-252页

作者： Hong-Lin Liao tao tang tao Zhou School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China Division of Science and Technology BNU-HKBU United International CollegeZhuhai 519087China SUSTech International Center for Mathematics Shenzhen 518055China NCMIS&LSEC Institute of Computational Mathematics and Scientific/Engineering ComputingAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

The positive definiteness of real quadratic forms with convolution structures plays an important rolein stability analysis for time-stepping schemes for nonlocal operators. In this work, we present a novel analysistool to handle discrete convolution kernels resulting from variable-step approximations for convolution operators.More precisely, for a class of discrete convolution kernels relevant to variable-step L1-type time discretizations, weshow that the associated quadratic form is positive definite under some easy-to-check algebraic conditions. Ourproof is based on an elementary constructing strategy by using the properties of discrete orthogonal convolutionkernels and discrete complementary convolution kernels. To our knowledge, this is the first general result onsimple algebraic conditions for the positive definiteness of variable-step discrete convolution kernels. Using theunified theory, we obtain the stability for some simple nonuniform time-stepping schemes straightforwardly.

关键词： discrete convolution kernels positive definiteness variable time-stepping orthogonal convolution kernels complementary convolution kernels

The Investigation of Data Voting Algorithm for Train Air-Braking System Based on Multi-Classification SVM and ANFIS

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Chinese Journal of Electronics 2024年第1期33卷 274-281页

作者： Juhan WANG Ying GAO Yuan CAO tao tang School of Electronics and Information Engineering Beijing Jiaotong University Graduate Department China Academy of Railway Science National Engineering Research Center of Rail Transportation Operation and Control System Beijing Jiaotong University

The pressure data of the train air braking system is of great significance to accurately evaluate its operation state. In order to overcome the influence of sensor fault on the pressure data of train air braking system, it is necessary to design a set of sensor fault-tolerant voting mechanism to ensure that in the case of a pressure sensor fault, the system can accurately identify and locate the position of the faulty sensor, and estimate the fault data according to other normal data. A fault-tolerant mechanism based on multi-classification support vector machine(SVM) and adaptive network-based fuzzy inference system(ANFIS) is introduced. Multi-classification SVM is used to identify and locate the system fault state, and ANFIS is used to estimate the real data of the fault sensor. After estimation, the system will compare the real data of the fault sensor with the ANFIS estimated data. If it is similar,the system will recognize that there is a false alarm and record it. Then the paper tests the whole mechanism based on the real data. The test shows that the system can identify the fault samples and reduce the occurrence of false alarms.

关键词： Multi-classification support vector machine Adaptive network-based fuzzy inference system Train air braking system Fault-tolerant voting Multi-sensors

Enhancing single-cell encapsulation in droplet microfluidics with fine-tunable on-chip sample enrichment

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Microsystems & Nanoengineering 2024年第1期10卷 149-160页

作者： tao tang Hao Zhao Shaofei Shen Like Yang Chwee Teck Lim Department of Biomedical Engineering National University of Singapore117583 SingaporeSingapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of Singapore119077 SingaporeSingapore Shanxi Key Lab for Modernization of TCVM College of Life ScienceShanxi Agricultural UniversityTaiguShanxi 030801China Institute for Health Innovation&Technology National University of Singapore117599 SingaporeSingapore Mechanobiology Institute National University of Singapore117411 SingaporeSingapore Institute for Digital Molecular Analytics and Science Nanyang Technological University636921 SingaporeSingapore

Single-cell encapsulation in droplet microfluidics is commonly hindered by the tradeoff between cell suspension density and on-chip focusing performance.In this study,we introduce a novel droplet microfluidic chip to overcome this challenge.The chip comprises a double spiral focusing unit,a flow resistance-based sample enrichment module with fine-tunable outlets,and a crossflow droplet generation unit.Utilizing a low-density cell/bead suspension(2×10^(6) objects/mL),cells/beads are focused into a near-equidistant linear arrangement within the double spiral microchannel.The excess water phase is diverted while cells/beads remain focused and sequentially encapsulated in individual droplets.Focusing performance was assessed through numerical simulations and experiments at three flow rates(40,60,80μL/min),demonstrating successful focusing at 40 and 80μL/min for beads and cells,respectively.In addition,both simulation and experimental results revealed that the flow resistance at the sample enrichment module is adjustable by punching different outlets,allowing over 50%of the aqueous phase to be removed.YOLOv8n-based droplet detection algorithms realized the counting of cells/beads in droplets,statistically demonstrating single-cell and bead encapsulation rates of 72.2%and 79.2%,respectively.All the results indicate that this on-chip sample enrichment approach can be further developed and employed as a critical component in single-cell encapsulation in water-in-oil droplets.

关键词： beads outlet sample

Correction:Electrochemically-mediated C-H functionalization of allenes and 1,3-dicarbonyl compounds to construct tetrasubstituted furans

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Organic Chemistry Frontiers 2022年第3期9卷 890-890页

作者： Mu-Xue He Yan Yao Chun-Zhi Ai Zu-Yu Mo Yu-Zheng Wu Qi Zhou Ying-Ming Pan hai-tao tang State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Public Health Guilin Medical UniversityGuilin 541004China Pharmacy School Guilin Medical UniversityGuilin 541004China Adesis Inc.A Universal Display Company New CastleDelaware 19720USA

Correction for‘Electrochemically-mediated C-H functionalization of allenes and 1,3-dicarbonyl compounds to construct tetrasubstituted furans’by Mu-Xue He et al.,Org.Chem.Front.,2022,DOI:10.1039/d1qo01458g.One of the author names(hai-tao tang)was spelled incorrectly in the published article;the corrected version is shown here.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

关键词： substituted Electrochemical furan