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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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Experimental study of wind loads on gable roofs of low-rise buildings with overhangs

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Frontiers of Structural and Civil Engineering 2018年第3期12卷 300-317页

作者： Peng HUANG Ling tao Ming GU Yong quan i University Shanghai 200092China

Gable roofs with overhangs （eaves） are the common constructions of low-rise buildings on the southeastern coast of China, and they were vulnerable to typhoons from experience. The wind pressure distributions on gable roofs of low-rise buildings are investigated by a series of wind tunnel tests which consist of 99 test cases with various roof pitches, height-depth ratios and width-depth ratios. The block pressure coefficients and worst negative （block） pressure coefficients on different roof regions of low-rise buildings are proposed for the main structure and building envelope, respectively. The effects of roof pitch, height-depth ratio, and width-depth ratio on the pressure coefficients of each region are analyzed in detail. In addition, the pressure coefficients on the roofs for the main structure and building envelope are fitted according to roof pitch, height-depth ratio and width-depth ratio of the low-rise building. Meanwhile, the rationality of the fitting formulas is verified by comparing the fitting results with the codes of different countries. Lastly, the block pressure coefficients and worst negative pressure coefficients are recommended to guide the design of low-rise buildings in typhoon area and act as references for the future＇s modification of wind load codes.

关键词： low-rise building gable roof wind loads wind tunnel test block pressure coefficient load code

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A new scoring system to evaluate adjuvant chemotherapy for patients with T2N0M0 gastric cancer after D2 gastrectomy

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World Journal of Gastroenterology 2022年第38期28卷 5626-5635页

作者： quan Xu Wen-Zhe Kang Jian-Ping Xiong Xin-Xin Shao Wei-Kun Li hai-tao Hu Yan-tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND At present,there is insufficient medical evidence to determine whether adjuvant chemotherapy is necessary for T2N0M0 gastric *** To obtain a risk score to assess the need for adjuvant chemotherapy in patients with T2N0M0 gastric *** We identified 325 patients with pathological T2N0M0 stage primary gastric cancer at the National Cancer Center between 2011 and *** and multivariate Cox regression analyses were performed to predict factors affecting *** invasion,tumor site,and body mass index were assessed,and a scoring system was *** compared the survival outcomes and benefits of adjuvant chemotherapy between the different *** Five-year survival rates of the score 0,1,2,and 3 groups were 92%,95%,80%,and 50%,respectively(P<0.001).In the score 2-3 group,five-year survival rates for patients in the adjuvant chemotherapy group and postoperative observation group were 95%and 61%,respectively(P=0.021).CONCLUSION For patients with T2N0M0 stage gastric cancer and two or more risk factors,adjuvant chemotherapy after D2 gastrectomy may have a survival benefit.

关键词： Gastric cancer Risk score T2N0M0 Adjuvant chemotherapy D2

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Indirect Determination of CTMAB with Sodium Chloride and Ammonium Thiocyanate by Floatation and Separation of Zinc

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Chinese Chemical Letters 2003年第3期14卷 290-293页

作者： quan Min LI hai Xin BAI 等 CollegeofChemistryandEnvironmentalScience HenannormaluniversityKeyLaboratoryofEnvironmentalScienceandEngineeringEducationCommissionofHenanProvinceXinxiang453002 CollegeofChemis

A new method for indirect determination of cetyl-trimethyl ammonium bromide (CTMAB) with NaCl and NH4SCN by floatation and separation of zinc has been studied. The study shows that Zn(II) can associate with NH4SCN and CTMAB to form insoluble ternary ion-association complex, and the precipitate can float on the surface of the liquid phase. A good linear relationship is observed between the floatation yield (E%) of Zn(II) and the amount of CTMAB. On the ground, CTMAB can be indirectly determined by determining E% of Zn(II). The results were satisfactory.

关键词： Cetyl-trimethyl ammonium bromide ammonium thiocyanate floatation zinc.

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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Effect of Potassium Addition on Coprecipitated Iron Catalysts for Fischer-Tropsch Synthesis Using Bio-oil-syngas

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Chinese Journal of Chemical Physics 2008年第2期21卷 141-150页

作者： Zhao-xiang Wang Ting Dong tao Kan quan-xin Li Department of Chemical Physics Lab of Biomass Clean Energy University of Science and Technology of China Hefei 230026 China

The effects of potassium addition and the potassium content on the activity and selectivity of coprecipitated iron catalyst for Fischer-Tropsch synthesis （FTS） were studied in a fixed bed reactor at 1.5 MPa, 300 ℃, and contact time （W/F） of 12.5 gcath/mol using the model bio-oil-syngas of H2/CO/CO2/N2 （62/8/25/5, vol%）. It was found that potassium addition increases the catalyst activity for FTS and the reverse water gas shift reaction. Moreover, potassium increases the average molecular weight （chain length） of the hydrocarbon products. With the increase of potassium content, it was found that CH4 selectivity decreases and the selectivity of liquid phase products （C5＋） increases. The characteristics of FTS catalysts with different potassium content were also investigated by various characterization measurements including X-ray diffraction, X-ray photoelectron spectroscopy and Brunauer-Emmett-Teller surface area. Based on experimental results, 100Fe/6Cu/16Al/6K （weight ratio） was selected as the optimal catalyst for FTS from bio-oil-syngas. The results indicate that the 100Fe/6Cu/16Al/6K catalyst is one of the most promising candidates to directly synthesize liquid bio-fuel using bio-oil-syngas.

关键词： Bio-oil-syngas Fischer-Tropsch synthesis Potassium Coprecipitated iron

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Numerical Research on the Cold Start-up Strategy of a PEMFC Stack from-30℃

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Journal of Thermal Science 2023年第3期32卷 898-910页

作者： LEI Le HE Pu HE Peng tao Wen-quan Shaanxi Collaborative Innovation Center for PEMFC Performance Improvement Key Laboratory of Thermal Fluid Science and Engineering of MOESchool of Energy and Power EngineeringXi’an Jiaotong UniversityXi'an 710049China

The cold start-up of the PEMFC(proton exchange membrane fuel cell)stack from sub-zero temperature is considered one of the significant obstacles to its expansive commercial *** the cold start-up process,with the progress of hydrogen/oxygen chemical reaction,the produced water will freeze into ice,occupying the pores of the porous electrode,thus leading to a rapid deterioration of output performance and even making the cold start-up *** this work,a one-dimensional numerical model is adopted to study a cold start-up process of the PMEFC stack starting from-30℃.The stepwise-changed current loading mode is employed in the *** assisted preheating method is used to explore an optimal operating condition for a successful cold *** numerical results are validated by comparing the numerical result with the experimental data in reference,and they agree with the experimental data very *** results show that the optimal heating power in the studied range is 100 *** the initial current slope increased,the current peak value increased,but the cold start-up process ***,the start-up time and ice volume fraction are highly dependent on the initial current *** optimal initial current slope is 0.7 A/***,a higher initial current slope will cause a significant inner ohmic *** resistance of CLa(catalyst layer of the anode)is the key and primary part of the total ohmic *** details of the research and the analyzed results will help design the cold start-up strategy for the PEMFC stack start-up from-30℃.

关键词： cold start-up IPEMFCstack stepwise-changed current loading mode preheating

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Management of hepatocellular carcinoma patients with portal vein tumor thrombosis:A narrative review

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 134-144页

作者： Zi-Wen tao Bao-quan Cheng tao Zhou Yan-Jing Gao Department of Gastroenterology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012China

Background: Hepatocellular carcinoma(HCC) is one of the main reasons for malignancy-related death. Portal vein tumor thrombosis(PVTT) is the most common form of macrovascular invasion related to HCC occurring in 10%-60% of patients. HCC with PVTT is usually characterized by worsening liver function, vulnerability to blood metastasis, higher incidence of complications associated with portal hypertension, and intolerance to treatment when compared with that without PVTT. If only treated with supportive care, the median survival of HCC with PVTT is about 2.7 months. In the past, sorafenib was the only recommended therapy by guidelines with limited effectiveness. This narrative review aimed to describe the current management options for HCC with PVTT. Data sources: We have reviewed literature from Pub Med on the treatment of HCC with PVTT and compiled evidence-based facts on effective therapies available for different types of PVTT. Results: Sorafenib monotherapy is not much effective, but combining it with other methods can improve survival. Each type of PVTT can beneft from the combination of transarterial chemoembolization and sorafenib than sorafenib monotherapy. The tumor downstaging can be realized possibly after transarterial chemoembolization, but tumor invasion into the main trunk of the portal vein greatly impairs efficacy. Although surgery is a curative approach, it is often not recommended for Vp4 PVTT. Some new methods can broaden the indication, but further explorations are needed. Radiotherapy can decrease the possibility of Vp3 progression to Vp4, but building a forecast model of best radiation dose and response is necessary. Systemic chemotherapy, hepatic arterial infusion chemotherapy, radiofrequency ablation, portal stenting, and traditional Chinese medicine are also benefcial in Vp3-4 PVTT. The accurate diagnosis of PVTT can be made by radiomics, and prognostic classifcation models can be used to design personalized treatments. The application of new

关键词： Hepatocellular carcinoma Portal vein tumor thrombosis Transarterial chemoembolization Radiotherapy Surgery Sorafenib

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Coercivity enhancement of hot-deformed NdFeB permanent magnets with AlCuZn eutectic alloy grain boundary diffusion

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Rare Metals 2022年第1期41卷 226-231页

作者： Ye-Qi Yu Kuo-She Li hai-Jun Peng Xin-Yuan Bai Ning-tao quan Kai-Wen Wu Yang Luo Dun-Bo Yu National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous MetalsBeijing 100088China GRIREM Advanced Materials Co.Ltd.Beijing 100088China

It is approved that grain boundary diffusion is an effective method to increase the coercivity of hot-deformed NdFeB *** this paper,a new rare earth-free grain boundary diffusion source of hot-deformed magnet was *** powders blended with commercial NdFeB powders were hot-compacted to obtain fully dense magnets,hot-deformed into anisotropic magnets and finally annealed to gain better ***,the influences of annealing temperature and time on the magnetic properties of the specimens were studied and the optimal parameters of 600℃ and 60 min were ***,by changing the proportions of AlCuZn grain boundary diffusion,the coercivity,remanence and maximum energy product of the hot-deformed NdFeB magnets were *** result showed that with 1.0 wt%AlCuZn grain boundary diffusion and annealing at 600℃ for 60 min,the coercivity rose from 828 to 987 kA·m^(-1) without deteriorating the *** analysis confirmed that AlCuZn diffused into the intergranular boundaries and the magnet diffused with AlCuZn possessed finer grains than that of without AlCuZn grain boundary diffusion.

关键词： AlCuZn Grain boundary diffusion Hotdeformed Coercivity enhancement

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Molecular cytogenetic study on the plants of Elymus nutans with varying fertility on the Qinghai-Tibet Plateau

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Plant Diversity 2022年第6期44卷 617-624页

作者： Bo Liu Xiao-Yan tao quan-Wen Dou Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningChina Qinghai Province Key Laboratory of Crop Molecular Breeding XiningChina University of Chinese Academy of Sciences BeijingChina

A molecular cytogenetic investigation was conducted on plants of the allohexaploid species Elymus nutans with varying fertility on the Qinghai-Tibet *** karyotyping revealed that chromosome variants were distributed unevenly among genomes and among different homologue chromosomes in each *** plants with varying fertility exhibited significantly higher numbers of chromosome variants than did the normal fertility samples,although both kinds of plants showed the same pattern of high-to-low polymorphism from the Y to St and H *** and karyotype heterozygosity in the plants with varying fertility were 3-and 13-fold higher than those in normal samples,*** negative correlations were found not only between seed setting rates and total genome heterozygosity but also between seed setting rates and heterozygosity of each genome in the plants of varying *** pairing analysis was performed using genomic in situ hybridization in selected plants of different fertility *** pairing of chromosomes at meiotic metaphase I was mostly bivalent,although univalent,trivalent,quadrivalent,and other polyvalents also occurred;in addition,chromosome configuration forms and frequencies varied among the studied *** results showed that the average number of ring bivalents in the Y genome was significantly higher than those in the St and H *** positive correlations between pollen grain fertility and ring bivalent number were found in the St and H genomes but not in the Y ***,chromosome configuration parameters(total bivalents,numbers of ring and rod bivalents)were found to be significantly correlated with heterozygosity and seed setting rates in the St and H genomes,respectively,but not in the Y *** was inferred that the seed setting rate and pollen grain fertility in *** are strongly influenced by the heterozygosity of each genome,but the Y genome differs from the S

关键词： Chromosome pairing Elymus nutans Fertility FISH and GISH Karyotype variation

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