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Admission white blood cell count predicts short-term clinical outcomes in patients with uncomplicated Stanford type B acute aortic dissection

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Journal of Geriatric Cardiology 2017年第1期14卷 49-56页

作者： Zhao-Ran CHEN Bi HUANG hai-song lu Zhen-Hua ZHAO Ru-Tai HUI Yan-Min YANG Xiao-Han FAN State Key Laboratory of Cardiovascular Disease Department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Stale Key Laboratory of Cardiovascular Disease Department of Cardiovascular Anesthesiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China State Key Laboratory of Cardiovascular Disease Department of Cardiovascular Surgery Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Objectives Inflammation has been shown to be related with acute aortic dissection （AAD）. The present study aimed to evaluate the association of white blood cell counts （WI3Cc） on admission with both in-hospital and long-term all-cause mortality in patients with uncom- plicated Stanford type B AAD. Methods From 2008 to 2010, a total of 377 consecutive patients with uncomplicated type B AAD were enrolled and then followed up. Clinical data and WBCc on admission were collected. The primary end points were in-hospital death and long-term all-cause death. Results The in-hospital death rate was 4.2%, and the long-term all-cause mortality rate was 6.9% during a median follow-up of 18.9 months. WBCc on admission was identified as a risk factor for in-hospital death by univariate Cox regression analysis as both a continuous variable and a categorical variable using a cut off of 11.0 × 109 cell/L （all P 〈 0.05）. After adjusting for age, sex and other risk factors, elevated admission WBCc was still a significant predictor for in-hospital death as both a continuous variable [hazard ratio （HR）： 1.052, 95% CI： 1.024-1.336, P = 0.002] and a categorical variable using a cut off of 11.0 × 109 cell/L （HR： 2.056, 95% CI： 1.673-5.253, P = 0.034）. No relationship was observed between WBCc on admission and long-term all-cause death. Conclusions Our results indicate that elevated WBCc upon admission might be used as a predictor for increased risk of in-hospital death in uncomplicated type B AAD. There might be no predictive value of WBCc for the long-term survival of type B AAD.

关键词： Acute aortic dissection In-hospital mortality Stanford type B Survival White blood cell

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CO2-mediated bicarbonate conversion to concentrated formate in a CEM-based electrolyzer

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Journal of Energy Chemistry 2025年第1期100卷 605-611页

作者： Haocheng Xiong Donghuan Wu Haonan Li Andrew Li Qikun Hu Siyao song Bingjun Xu Qi lu State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University College of Chemistry and Molecular Engineering Peking University Ordos Laboratory

Renewable energy-driven bicarbonate conversion to valuable chemicals presents an attractive strategy for mitigating CO2emissions,as bicarbonate can be efficiently generated from the capture of atmospheric CO2using alkaline solutions with reactive *** this work,we present a CO2-mediated bicarbonate conversion to pure formate using a cation exchange membrane-based electrolyzer with a 25 cm2electrode *** electrolysis achieved selectivities exceeding 75%for formate at a total current of 2.5 A,achieving formate concentrations up to 1.2 M and yields as high as 95%over extended *** techno-economic assessment confirmed the economic viability of the process,highlighting the potential for bicarbonate electrolysis as a sustainable method for producing valuable chemicals.

关键词： Electrocatalysis Techno-economic assessments Electrochemistry Flow electrolyzer

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Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua Gao Yunfeng Zhang Menglei Wang Ruoxuan Yang Shuai Feng Xuan Cao Yaping Zhang Zhongyuan lu Yingze song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Redox reactions

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka lu Ju-song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

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DJ-1 is required for ischemic preconditioning to attenuate ischemia/reperfusion-induced oxidant stress and to elicit delayed cardiopro tection

DJ-1 is required for ischemic preconditioning to attenuate i...

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第八届海峡两岸心血管科学研讨会

作者： He-ping Chen,hai-shan lu,song Wang,Qi-ren Huang,Ming He~* (Department of Pharmacology & Molecular Therapeutics,Nanchang University School of Pharmaceutical Science,Nanchang,330006,China)

＜正＞Ischemic preconditioning（IPC） is a powerful phenomenon that can attenuate ischemia/reperfusion （I/R） - induced oxidant stress and elicit delayed *** mechanisms involve upregulation of the protective antioxidant *** - 1 protein,as a multifunctional intracellular protein,plays an important role in regulating cell survival and anti - oxidant ***,it remains to be clarified whether DJ - 1 is involved in delayed cardioprotection of IPC and plays a pivotal role in anti - oxidant stress of *** study this,rat heart - derived H9c2 cells were exposed to ischemic（ischemic medium for 20 min） preconditioning. Twenty -four hours later cells were subjected to a simulated ischemia/reperfusion（sI/R）—culturing for 3 h in ischemic medium,followed by 2 - h reperfusion in normal medium—and then cell viability,lactate dehydrogenase （LDH）,antioxidant enzymes（superoxide dismutase,catalase and glutathione peroxidase）,malondialdehyde （MDA）,intracellular reactive oxygen species（ROS）,and DJ - 1 protein were measured appropriately. The results showed that IPC efficiently attenuated sI/R - induced viability loss and LDH leakage. Additionally,IPC up - regulated DJ - 1 protein expression,inhibited sI/R - induced the elevation of ROS and MDA contents followed by the increase of antioxidant enzymes（superoxide dismutase,catalase and glutathione peroxidase） ***,when DJ - 1 expression was specifically knocked down by siRNA,the delayed cardioprotection induced by IPC was abolished,and the inhibitory effect of IPC on sI/R - induced oxidant stress was also *** data indicate that DJ - 1 mediates the delayed cardioprotective effect of IPC against sI/R ***,IPC is required for IPC to inhibit sI/R - induced oxidant stress.

关键词： DJ-1 protein Ischemic preconditioning Delayed cardioprotection Oxidant stress

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige song Chao Xu Kai Zhao Guoqiang Liu Youming lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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Wetland and habitat dynamics in the evolving landscape of the Middle Yangtze River Basin

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Journal of Geographical Sciences 2025年第1期35卷 88-111页

作者： YANG Peng SUN Kaiya ZHU Yanchao XIA Jun HUANG Heqing song Jingxia SHI Xiaorui lu Xixi Hubei Key Laboratory of Regional Ecology and Environmental Change School of Geography and Information Engineering China University of Geosciences Department of Geography National University of Singapore State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University

Wetlands play a critical role in the global environment. The Middle Yangtze River Basin(MYRB), known for its abundant wetland resources, has experienced notable changes resulting from the complex interplay of environmental factors. Therefore, we investigated the spatiotemporal characteristics of wetland ecological quality in the MYRB from 2001 to *** the random forest(RF) regression algorithm and patch-generated land-use simulation(PluS) model, we forecasted variations in wetland habitat quality and their determinants under the Shared Socioeconomic Pathway-Representative Concentration Pathway(SSPRCP) framework from 2035 to 2095. The main findings are as follows:(1) The RF algorithm was optimal for land-use and land-cover(luLC) classification in the MYRB from 2001 to 2020,when notable changes were observed in water bodies and buildings. However, the forested area exhibited an increase and decrease of 3.9% and 1.2% under the SSP1-2.6 and SSP5-8.5 scenarios, respectively, whereas farmland exhibited a diminishing trend.(2) Wetlands were primarily concentrated in the central and eastern MYRB, with counties in the southwest exhibiting superior ecological-environmental quality from 2001 to 2020. Notably,wetland coverage revealed significantly high level, significant changes, frequent but relatively minor changes under the SSP1-2.6, SSP2-4.5, and SSP 5-8.5 scenarios, respectively.(3)Regions with lower habitat quality were primarily concentrated in urbanized areas characterized by frequent human activities, indicating a clear degradation in habitat quality across different scenarios. In conclusion, we established a foundational framework for future investigations into the eco-hydrological processes and ecosystem quality of watersheds.

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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儿童葡萄球菌性烫伤样皮肤综合征156例临床分析

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中国现代医学杂志 2017年第2期27卷 136-139页

作者：李冬芹宋青蔓张海璐王艳郑州大学第一附属医院皮肤科河南郑州450052 河南平顶山市第二人民医院皮肤科河南平顶山467000

目的探讨葡萄球菌性烫伤样皮肤综合征(SSSS)的临床特征、实验室检查及疗效,指导临床诊治,降低误诊率。方法回顾性分析郑州大学第一附属医院156例葡萄球菌性烫伤样皮肤综合征患儿的临床资料,将92例轻症患儿和64例重症患儿随机各分为两组... 详细信息

目的探讨葡萄球菌性烫伤样皮肤综合征(SSSS)的临床特征、实验室检查及疗效,指导临床诊治,降低误诊率。方法回顾性分析郑州大学第一附属医院156例葡萄球菌性烫伤样皮肤综合征患儿的临床资料,将92例轻症患儿和64例重症患儿随机各分为两组:对照组和治疗组,分别比较两组患儿临床症状改善情况及病程。结果 156例患者发病年龄平均(3.51±0.24)岁,男∶女为1.29∶1,9~11月份发病率明显增高,发病前有明显诱因者40例(25.6%),在当地医院误诊56例(35.9%)。64例重症患儿,治疗组较对照组在临床症状改善方面有明显优势,两组比较差异有统计学意义(P<0.05)。结论葡萄球菌性烫伤样皮肤综合征好发于3~5岁儿童,男多于女,秋季常见;发病前多有明显诱因,基层医院误诊率较高;重症SSSS患者可短期联合应用小量糖皮质激素。

关键词：葡萄球菌性烫伤样皮肤综合征糖皮质激素抗生素临床分析

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Carbon dots self-assembly enables near-infrared emission

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Science China Chemistry 2025年

作者： Shurong Ding Shasha Liu Yuzhuo Yang Linlin Shi Yongqiang Zhang Jingkun Yu Haoqiang song Yingge Shi Siyu lu College of Chemistry Pingyuan Laboratory Zhengzhou University Henan Institute of Advanced Technology Zhengzhou University

In the fields of biomedicine, detection, and anti-counterfeiting, there is a widespread demand for cost-effective, easily synthesized, and environmentally friendly near-infrared(NIR) materials. Carbon dots(CDs), a cheap and non-toxic zero-dimensional carbon nanomaterial exhibiting exceptional photoluminescence(PL) properties and facile structural modification, have emerged as a promising candidate for the development of novel NIR materials. This study presents the synthesis of CDs capable of emitting a wide range of wavelengths from blue to NIR(456–836 nm) as their concentrations increase. The incorporation of oxygen and nitrogen co-doped atoms facilitates the optimization of non-coplanar angles, thereby promoting favorable π-πstacking interactions. This leads to the formation of metal-free rigid clusters through interconnecting adjacent nanoparticles in a gear-like meshing pattern through self-assembly. Consequently, intramolecular motion is constrained, vibration coupling is mitigated, non-radiative transition losses are minimized, and efficient NIR emission from CD clusters in high concentrations is ensured. Furthermore, NIR light-emitting diode(NIR LED) based on the CD clusters was successfully fabricated and employed for various applications including information encryption, anti-counterfeiting, and penetration detection in the field of NIR imaging.

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