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Science Bulletin 2018年第4期63卷 209-212页

作者： Jian-Qing Lin Qi Zhou hai-qiong yang Li-Ming Fang Ke-Yi Tang Li Sun Qiu-Hong Wan Sheng-Guo Fang The Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education and State Conservation Center for Gene Resources of Endangered WildlifeCollege of Life SciencesZhejiang UniversityHa ngzhou 310058China Life Sciences Institute Zhejiang UniversityHangzhou 310058China Changxing Yinjiahian Chinese Alligator Nature Reserve Changxing 313100China

Sex determination(SD)is a critical embryonic development process that has profound impacts on the morphology of individuals and the survival of populations[1].In vertebrates,sex can be determined by either genetic or environmental factors[2],with the underlying molecular mechanism unknown for most species except for a few model organisms[3,4].Unlike mammals and birds,

关键词：温度依赖短吻鳄性别中国机制分子性染色体脊椎动物

The sex ratio of wild Chinese alligators Alligator sinensis

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Current Zoology 2013年第6期59卷 725-731页

作者： Lan ZHAO hai-qiong yang Li-Ming FANG Guo-Liang PAN Wei-Qiang ZOU Da-Bin REN Qiu-Hong WAN Sheng-Guo FANG The Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education State Conservation Center for Gene Resources of Endangered Wildlife College of Life Sciences Zhejiang University Hangzhou 310058 China Changxing Yinjiabian Chinese Alligator Nature Reserve Changxing 313100 Zhejiang China

The Chinese alligator Alligator sinensis is one of the most endangered crocodilian species, and typically exhibits temperature-dependent sex determination. It is extremely important to clarify the sex structure of Chinese alligators to implement recovery projects successfully. However, the sex ratio of wild Chinese alligators remains unknown. In this study, we collected 28 years of sex ratio data from Chinese alligators residing in the natural and artificial habitats of Changxing Nature Reserve, China, and examined the differences in the sex ratio dynamics between these two populations. We observed that the sex ratio of wild Chinese alligators is 1 male to 4.507 females, which was significantly lower compared to that of the captive population （1 to 2.040; P 〈 0.001）, and is significantly different to previously documented sex ratios for this species （all P 〈 0.01）. Furthermore, we documented an annually stable （P = 1.000） female-biased sex ratio for wild alligators at hatching [1 male to 4.747 females; 0.174 （0.167~）.182）], in contrast to a dramatically fluctuating sex ratio （P 〈 0.001） in captivity [1 male to 1.674 females; 0.374 （0.246-0.593）], showing a potential mechanism for adjusting the sex structure. Finally, we found that the hatchling sex ratios were similar to that of the population sex ratio （P = 0.748）, with little correlation to air temperature values in the 60-70 day incubation period during the breeding season （July and August; both P 〉 0.05）. Overall, this study indicates that the stabilized female-biased sex ratio of Changxing Chinese alligators might result from selection pressure caused by local mate competition and major inbreeding .

关键词： Reptile Female-biased Temperature-dependent sex determination Conservation

免疫肠内营养对重症急性胰腺炎病人肠黏膜屏障和细胞因子的影响

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肠外与肠内营养 2016年第5期23卷 275-278页

作者：王庆华管清海商琼琼杨斌李玲陈强谱滨州医学院护理学人文教研室山东滨州256603 滨州医学院附属医院临床营养中心山东滨州256603

目的:探讨免疫肠内营养(IEN)治疗对重症急性胰腺炎(SAP)病人肠黏膜屏障和细胞因子的影响。方法:将46例病人随机分为IEN组和对照组,每组23例。对照组病人采用传统保守治疗,IEN组在保守治疗基础上给予IEN治疗。观察两组病人住院期间血、... 详细信息

目的:探讨免疫肠内营养(IEN)治疗对重症急性胰腺炎(SAP)病人肠黏膜屏障和细胞因子的影响。方法:将46例病人随机分为IEN组和对照组,每组23例。对照组病人采用传统保守治疗,IEN组在保守治疗基础上给予IEN治疗。观察两组病人住院期间血、尿淀粉酶恢复时间,腹痛缓解时间和两组间的并发症、治愈等情况以及细胞因子和肠黏膜屏障功能的变化。结果:两组病人腹痛缓解时间、血和尿淀粉酶变化、并发症的发生率和治愈率等比较均有显著性差异(P<0.05)。治疗前、治疗后第7和第14天分别检测T淋巴细胞亚群(CD3^+、CD4^+、CD8^+和CD4^+/CD8^+)、炎性细胞因子(TNF-α、IL-6、IL-8)、血D-乳酸和内毒素水平变化均有显著性差异(P<0.05)。结论:IEN可改善SAP病人的肠黏膜屏障功能和细胞因子功能。

关键词：免疫肠内营养重症急性胰腺炎免疫功能肠黏膜屏障细胞因子

A Quasi-periodic Oscillation of ~4.6 yr in the Radio Light Curves of Blazar PKS 0607-157

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Research in Astronomy and Astrophysics 2023年第9期23卷 105-113页

作者： Xiao-Pan Li hai-Yan yang Yan Cai Xie-Fei Song hai-Tao yang Yu-qiong Shan College of Physics and Information Engineering Zhaotong UniversityZhaotong 657000China

We present periodicity search analyses on long-term radio light curves at 4.8,8,and 14.5 GHz of blazar PKS 0607–157 observed by the University of Michigan Radio Astronomical Observatory *** highly variable radio emissions are approximately distributed as a log-normal probability distribution *** Power Spectral Density for the radio light curves can be well characterized by a power-law *** the Weighted Wavelet Z-transform and Lomb-Scargle periodogram methods,significant Quasi-periodic Oscillation(QPO)of∼4.6 yr in the radio light curve has been observed above the 3σconfidence level,which presents an interesting case among blazar QPO *** explore three plausible physical models to explain the observed QPOs:a supermassive binary black hole system,Lense-Thirring precession of the disk,and helical motion of plasma blobs within the jet.

关键词： galaxies active-(galaxies )BL Lacertae objects general-(galaxies )BL Lacertae objects individual(PKS 0607-157)

Tomographic PIV investigation on coherent vortex structures over shark-skin-inspired drag-reducing riblets

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Acta Mechanica Sinica 2016年第2期32卷 284-294页

作者： Shao-qiong yang Shan Li hai-Ping Tian Qing-Yi Wang Nan Jiang Department of Mechanics Tianjin UniversityTianjin 300072 China Tianjin Key Laboratory of Modern Engineering Mechanics Tianjin 300072 China School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore 639805 Singapore

Nature has shown us that the microstructure of the skin of fast-swimming sharks in the ocean can reduce the skin friction drag due to the well-known shark-skin *** the present study,the effect of shark-skin-inspired riblets on coherent vortex structures in a turbulent boundary layer（TBL） is *** is done by means of tomographic particle image velocimetry（TPIV） measurements in channel fl ws over an acrylic plate of drag-reducing riblets at a friction Reynolds number of *** turbulent fl ws over drag-reducing riblets are verifie by a planar time-resolved particle image velocimetry（TRPIV） system initially,and then the TPIV measurements are ***-dimensional（2D） experimental results with a dragreduction rate of around 4.81% are clearly visible over triangle riblets with a peak-to-peak spacing s＋of 14,indicating from the drag-reducing performance that the buffer layer within the TBL has thickened;the logarithmic law region has shifted upward and the Reynolds shear stress decreased.A comparison of the spatial topological distributions of the spanwise vorticity of coherent vortex structures extracted at different wall-normal heights through the improved quadrant splitting method shows that riblets weaken the amplitudesof the spanwise vorticity when ejection（Q2） and sweep（Q4） events occur at the near wall,having the greatest effect on Q4 events in *** so-called quadrupole statistical model for coherent structures in the whole TBL is verified Meanwhile,their spatial conditional-averaged topological shapes and the spatial scales of quadrupole coherent vortex structures as a whole in the overlying turbulent fl w over riblets are changed,suggesting that the riblets dampen the momentum and energy exchange between the regions of near-wall and outer portion of the TBL by depressing the bursting events（Q2 and Q4）,thereby reducing the skin friction drag.

关键词： Turbulent boundary layer(TBL) Coherent vortex structure Flow control Drag reduction Shark-skininspired riblet Tomographic particle image velocimetry(TPIV)

An appropriate level of autophagy reduces emulsified isoflurane-induced apoptosis in fetal neural stem cells

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Neural Regeneration Research 2020年第12期15卷 2278-2285页

作者： Ze-Yong yang Lei Zhou qiong Meng Hong Shi Yuan-hai Li Department of Anesthesiology International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Embryo Original DiseaseShanghai Municipal Key Clinical SpecialtyShanghaiChina Department of Anesthesiology First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Department of Anesthesiology Shanghai Pulmonary HospitalTongji UniversityShanghaiChina

Autophagy plays essential roles in cell ***,the functions and regulation of the autophagy-related proteins Atg5,LC3B,and Beclin 1 during anesthetic-induced developmental neurotoxicity remain *** study aimed to understand the autophagy pathways and mechanisms that affect neurotoxicity,induced by the anesthetic emulsified isoflurane,in rat fetal neural stem *** neural stem cells were cultured,in vitro,and neurotoxicity was induced by emulsified isoflurane *** effects of pretreatment with the autophagy inhibitors 3-methyladenine and bafilomycin and the effects of transfection with small interfering RNA against ATG5(siRNA-Atg5)were *** viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,and apoptosis was assessed using flow *** changes were analyzed through transmission electron *** levels of the autophagy-related proteins LC3B,Beclin 1,Atg5,and P62 and the pro-apoptosis-related protein caspase-3 were analyzed using western blot *** inhibition of cell proliferation and that of apoptosis rate increased after treatment with emulsified ***,monolayer membrane formation due to lysosomal degradation,were *** autophagy-related proteins LC3B,Beclin 1,Atg5,and P62 and caspase-3 were *** results confirm that emulsified isoflurane can induce toxicity and autophagy in fetal neural stem ***-treatment with 3-methyladenine and bafilomycin increased the apoptosis rate in emulsified isoflurane-treated fetal neural stem cells,which indicated that the complete inhibition of autophagy does not alleviate emulsified isoflurane-induced fetal neural stem cell ***5 expression was decreased significantly by siRNA-Atg5 transfection,and cell proliferation was *** results verify that the Atg5 autophagy pathway can be regulated to maintain appropriate levels of autophagy,which can inhibit

关键词： apoptosis Atg5 autophagy emulsified isoflurane fetal neural stem cells LC3B MTT neurodegenerative neurotoxicity

Transparently manipulating spin-orbit qubit via exact degenerate ground states

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Chinese Physics B 2020年第8期29卷 217-227页

作者： Kuo hai Wenhua Zhu qiong Chen Wenhua hai Department of Physics and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China

By investigating a harmonically confined and periodically driven particle system with spin-orbit coupling(SOC)and a specific controlled parameter,we demonstrate an exactly solvable two-level model with a complete set of spin-motion entangled Schrödinger kitten(or cat)*** the undriven case,application of a modulation resonance results in the exact stationary *** show a decoherence-averse effect of SOC and implement a transparent coherent control by exchanging positions of the probability-density wavepackets to create transitions between the different degenerate ground *** expected energy consisting of quantum and continuous parts is derived,and the energy deviations caused by the exchange operations are much less than the quantum *** results could be directly extended to a weakly coupled single-particle chain for transparently encoding spin-orbit qubits via the robust spin-motion entangled degenerate ground states.

关键词： transparent coherent control spin-orbit qubit exact degenerate ground state spin-orbit coupling spin-motion entanglement

Image De-occlusion via Event-enhanced Multi-modal Fusion Hybrid Network

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Machine Intelligence Research 2022年第4期19卷 307-318页

作者： Si-Qi Li Yue Gao qiong-hai Dai Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Institute for Brain and Cognitive Sciences Tsinghua UniversityBeijing 100084China Beijing Laboratory of Brain and Cognitive Intelligence Beijing Municipal Education CommissionTsinghua UniversityBeijing 100084China Key Laboratory for Information System Security School of SoftwareTsinghua UniversityBeijing 100084China Department of Automation Tsinghua UniversityBeijing 100084China

Seeing through dense occlusions and reconstructing scene images is an important but challenging *** framebased image de-occlusion methods may lead to fatal errors when facing extremely dense occlusions due to the lack of valid information available from the limited input occluded *** cameras are bio-inspired vision sensors that record the brightness changes at each pixel asynchronously with high temporal ***,synthesizing images solely from event streams is ill-posed since only the brightness changes are recorded in the event stream,and the initial brightness is *** this paper,we propose an event-enhanced multi-modal fusion hybrid network for image de-occlusion,which uses event streams to provide complete scene information and frames to provide color and texture *** event stream encoder based on the spiking neural network(SNN)is proposed to encode and denoise the event stream efficiently.A comparison loss is proposed to generate clearer *** results on a largescale event-based and frame-based image de-occlusion dataset demonstrate that our proposed method achieves state-of-the-art performance.

关键词： Event camera multi-modal fusion image de-occlusion spiking neural network(SNN) image reconstruction

Entangled chimeras in nonlocally coupled bicomponent phase oscillators:From synchronous to asynchronous chimeras

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Frontiers of physics 2020年第6期15卷 115-123页

作者： qiong-Lin Dai Xiao-Xuan Liu Kai yang Hong-Yan Cheng hai-Hong Li Fagen Xie Jun-Zhong yang School of Science Beiing University of Posts and TelecommunicationsBeijing 100876China Department of Research and Eoaluation Kaiser Permanente Southern CaliforniaPasadenaCA 91101USA

Chimera states,a symmetry-breaking spatiotemporal pattern in nonlocally coupled identical dynamical units,have been identified in various systems and generalized to coupled nonidentical *** has been shown that strong heterogeneity in the frequencies of nonidentical oscillators might be harmful to chimera *** this work,we consider a ring of nonlocally coupled bicomponent phase oscillators in which two types of oscillators are randomly distributed along the ring:some oscillators with *** w1 and others with *** this model,the heterogeneity in frequency is measured by frequency mismatch|w1-w2|between the oscillators in these two *** report that the nonlocally coupled bicomponent phase oscillators allow for chimera states no matter how large the frequency mismatch *** bicomponent oscillators are composed of two chimera states,one supported by oscillators with natural frequency wI and the other by oscillators with natural frequency *** two chimera states in two subpopulations are synchronized at weak frequency mismatch,in which the coberent oscillators in thern share similar mean phase velocity,and are desynchronized at large frequency mismatch,in which the coherent oscillators in different subpopulations have distinct mean phase *** synchronization-desynchronization transition between chimera states in these two subpopulations is observed with the increase in the frequency *** observed phenomena are theoretically analyzed by passing to the continuum limit and using the Ott-Antonsen approach.

关键词： chimera states bicomponent phase oscillators nonlocal coupling desynchronization transition

Chimera dynamics in nonlocally coupled moving phase oscillators

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Frontiers of physics 2019年第4期14卷 109-116页

作者： Wen-Hao Wang qiong-Lin Dai Hong-Yan Cheng hai-Hong Li Jun-Zhong yang School of Science Beijing University of Posts and Telecommunications Beijing 100876 China

Chimera states,a symmetry-breaking spatiotemporal pattern in nonlocally coupled dynamical units,prevail in a variety of ***,the interaction structures among oscillators are static in most of studies on chimera *** this work,we consider a population of *** agent carries a phase *** assume that agents perform Brownian motions on a ring and interact with each other with a kernel function dependent on the distance between *** agents are motionless,the model allows for several dynamical states including two different chimera states (the type-Ⅰ and the type-Ⅱ chimeras).The movement of agents changes the relative positions among them and produces perpetual noise to impact on the model *** find that the response of the coupled phase oscillators to the movement of agents depends on both the phase lag α,determining the stabilities of chimera states,and the agent mobility *** low mobility,the synchronous state transits to the type-Ⅰ chimera state for α close to π/2 and attracts other initial states *** intermediate mobility,the coupled oscillators randomly jump among different dynamical states and the jump dynamics depends on α.We investigate the statistical properties in these different dynamical regimes and present the scaling laws between the transient time and the mobility for low mobility and relations between the mean lifetimes of different dynamical states and the mobility for intermediate mobility.

关键词： chimera states Brownian motion nonlocal coupling phase oscillators