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Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus:An observational study

World Journal of Gastroenterology 2021年第19期27卷 2394-2414页

作者： Xia Liu Yi-Wen Cheng Li Shao Shu-Hong Sun Jian Wu qing-hai song Hong-Sheng Zou Zong-Xin Ling Department of Intensive Care Unit Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Institute of Hepatology and Metabolic Diseases Hangzhou Normal UniversityHangzhou 310000Zhejiang ProvinceChina Institute of Translational Medicine The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310000Zhejiang ProvinceChina Department of Laboratory Medicine Linyi People’s HospitalLinyi 276000Shandong ProvinceChina Department of Geriatrics Lishui Second People's HospitalLishui 323000Zhejiang ProvinceChina Department of Intensive Care Unit People’s Hospital of RongchengRongcheng 264300Shandong ProvinceChina

BACKGROUND Gut microbiota dysbiosis is reportedly actively involved in autoimmune diseases such as type 1 diabetes mellitus(T1DM).However,the alterations in the gut microbiota and their correlation with fasting blood glucose(FBG)in Chinese children with T1DM remain *** To investigate alterations in the gut microbiota in Chinese children with T1DM and their associations with clinical *** Samples from 51 children with T1DM and 47 age-matched and gender-matched healthy controls were obtained,to explore the structural and functional alterations in the fecal *** V3-V4 regions of the 16S rRNA gene were sequenced on a MiSeq instrument,and the association with FBG were *** We found that the bacterial diversity was significantly increased in the T1DMassociated fecal microbiota,and changes in the microbial composition were observed at different taxonomic *** T1DM-reduced differential taxa,such as Bacteroides vulgatus ATCC8482,Bacteroides ovatus,Bacteroides xylanisolvens,and Flavonifractor plautii,were negatively correlated with FBG,while the T1DMenriched taxa,such as Blautia,Eubacterium hallii group,Anaerostipes hadrus,and Dorea longicatena,were positively correlated with *** vulgatus ATCC8482,Bacteroides ovatus,the Eubacterium hallii group,and Anaerostipes hadrus,either alone or in combination,could be used as noninvasive diagnostic biomarkers to discriminate children with T1DM from healthy *** addition,the functional changes in the T1DM-associated fecal microbiota also suggest that these fecal microbes were associated with altered functions and metabolic activities,such as glycan biosynthesis and metabolism and lipid metabolism,which might play vital roles in the pathogenesis and development of *** Our present comprehensive investigation of the T1DM-associated fecal microbiota provides novel insights into the pathogenesis of the disease and sheds light on the diagnosis and treatment of T1D

关键词： Dysbiosis Fasting blood glucose Sequencing Metabolism Type 1 diabetes mellitus

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Correction to“Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus:An observational study”

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World Journal of Gastroenterology 2022年第25期28卷 3006-3007页

作者： Xia Liu Yi-Wen Cheng Li Shao Shu-Hong Sun Jian Wu qing-hai song Hong-Sheng Zou Zong-Xin Ling Department of Intensive Care Unit The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Institute of Hepatology and Metabolic Diseases Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina Department of Laboratory Medicine Linyi People’s HospitalLinyi 276000Shandong ProvinceChina Department of Geriatrics Lishui Second People's HospitalLishui 323000Zhejiang ProvinceChina Department of Intensive Care Unit People’s Hospital of RongchengRongcheng 264300Shandong ProvinceChina

Liu X,Cheng YW,Shao L,Sun SH,Wu J,song QH,Zou HS,Ling *** microbiota dysbiosis in Chinese children with type 1 diabetes mellitus:An observational *** J Gastroenterol 2021;27(19):2394-2414[PMID:34040330 DOI:10.3748/wjg.v27.i19.2394].In this article,the affiliation of the first author was *** Liu,the first author,belonged to Department of Intensive Care Unit,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,310003,China.

关键词： Correction

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多级边坡施工效应的模型试验研究

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岩土力学 2017年第8期38卷 2261-2269页

作者：苏杭周海清武松后勤工程学院土木工程系 68612部队

根据边坡施工后坡体位移的相对变化趋势,给出了边坡开挖松弛区和预压区的明确定义,将开挖松弛区和预压区统称为坡体影响区,并通过大型模型试验模拟了多级边坡的施工过程,提出了影响区重叠效应的概念。若下级边坡的开挖松弛区(或预压区)... 详细信息

根据边坡施工后坡体位移的相对变化趋势,给出了边坡开挖松弛区和预压区的明确定义,将开挖松弛区和预压区统称为坡体影响区,并通过大型模型试验模拟了多级边坡的施工过程,提出了影响区重叠效应的概念。若下级边坡的开挖松弛区(或预压区)与上级边坡的预压区发生重叠,那么会对上级边坡重叠区域的岩土体产生松弛(或加固)作用,从而影响该重叠区域支挡结构的受力情况,重叠范围越大影响越大;对于重叠区范围之外的支挡结构,其受力不受影响,影响区重叠效应是支挡结构受力发生变化的根本原因。

关键词：多级边坡松弛区预压区影响区重叠效应模型试验

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中南半岛热带森林光合碳同化的季节动态

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Journal of Plant Ecology 2023年第3期16卷 131-153页

作者： Lian-Yan Yang Rui Yu Jin Wu Yongjiang Zhang Yoshiko Kosugi Natalia Restrepo-Coupe Afredo Huete Jie Zhang Yu-hai Liu Xiang Zhang Wen-Jie Liu Jun-Fu Zhao Jiye Zeng qing-hai song Ya-Jun Chen Liang song Zheng-Hong Tan Ecology Program Department of EcologySchool of Ecology and Environmental ScienceHainan UniversityHaikou 570228China School of Biological Sciences Faculty of ScienceThe University of Hong KongPokfulamHong KongChina School of Biology and Ecology The University of MaineOronoME 04469USA Forest Hydrology Lab Graduate School of AgricultureKyoto UniversityKyotoJapan School of Life Sciences University of Technology SydneyNew South WalesAustralia National Institute for Environmental Studies TsukubaJapan Xishuangbanna Tropical Botanical Garden Chinese Academy of SciencesMenglunYunan 666303China School of Ecology and Environmental Studies Yunnan UniversityKunming 650091China

热带森林因其生物量巨大、结构复杂和生物多样而著称。然而,关于这些森林光合作用的季节动态及其少水期间的生态适应仍知之甚少。本文利用中南半岛上跨20个纬度(2°-22°N)的自然梯度带,探讨了季节性水分条件变化对中南半岛热带森林光... 详细信息

热带森林因其生物量巨大、结构复杂和生物多样而著称。然而,关于这些森林光合作用的季节动态及其少水期间的生态适应仍知之甚少。本文利用中南半岛上跨20个纬度(2°-22°N)的自然梯度带,探讨了季节性水分条件变化对中南半岛热带森林光合作用季节动态的影响及其机理。研究结果表明,对于气候季节性明显的热带森林,不论其为常绿、落叶还是半落叶,其雨季的森林冠层光合作用(或称总初级生产总值,GPP)明显高于旱季。缺乏气候季节性的常湿热带雨林,GPP呈现“双峰”季节格局;而且,这种季节格局与太阳辐射之间有较好的对应关系。旱季或者是短干旱期内,冠层导度(Gs)有明显下降,显示出水分对气孔开度的抑制作用。然而,这种气孔开度的降低,并未导致近赤道的常湿低地雨林GPP的下降。也就是说,常湿低地雨林GPP在季节尺度上,表现为光限制而非水分限制。气候季节性明显的3个站点,不论Gs还是GPP在旱季明显低于雨季,则表现出明显的水分限制。

关键词：涡度相关法叶面积指数适应对策生态系统生理总初级生产力潜热通量水分利用效率

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Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease in China(RWE-PCSK study)

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Journal of Geriatric Cardiology 2021年第4期18卷 261-270页

作者： Yu-Qi LIU Dan-Dan LI Meng Chai Hong-Liang CONG Xiao-Qiang CONG Jun DAI Rong-Pin DU Ming GAO Jin-Cheng GUO Yan-qing GUO Xiao-Jian HONG Rong-Chong HUANG Feng-Shun JIA Jia-Yu LI qing LI Jia-Mei LIU Xin-Ping LIU Yu-Guo LIU Hong-Gang NIE Bing SHAO Xiao-Yu SHEN hai-qing song Yi-Jun song Li-Jun WANG Shuo WANG Dong-Mei WU Jing XIA Zhi-Yong YANG Hong-Ying YU Hui ZHANG Tie-Mei ZHANG Ji-Yi ZHAO Liang-Chen ZHAO Ming-Qi ZHENG Yun-Dai CHEN Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina Department of Cardiology Tianjin Chest HospitalTianjinChina Department of Cardiology the First Hospital of Jilin UniversityChangchunChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Hebei People’s HospitalShijiazhuangChina Department of Cardiology Kailuan General HospitalHebei Union UniversityTangshanChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology Shanxi Cardiovascular HospitalTaiyuanChina Department of Cardiology the Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Tangshan Worker’s HospitalTangshanChina Department of Cardiology China-Japan Friendship Hospital Affiliated Jilin UniversityChangchunChina Department of Cardiology Handan Central HospitalHebeiChina Heart Center Beijing Key Laboratory of HypertensionBeijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Department of Cardiology the First Affiliated Hospital of Dalian Medical UniversityLiaoningChina Department of Cardiology the Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology the Second Affiliated Hospital of Shenyang Medical CollegeShenyangChina Department of Cardiology the Second Hospital of Shanxi Medical UniversityTaiyuanChina Department of Neurology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Neurology Tianjin Medical University Gen

BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for *** In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real

关键词： LDL RWE-PCSK study Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high r

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Rationale and Study Design for a Single-Arm Phase Ila Study Investigating Feasibility of Preventing Ischemic Cerebrovascular Events in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events Using Remote Ischemic Conditioning

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Chinese Medical Journal 2018年第3期131卷 347-351页

作者： Shi-Meng Liu Wen-Le Zhao hai-qing song Ran Meng Si-Jie Li Chang-Hong Ren Bruce Ovbiagele Xun-Ming Ji Wu-Wei Feng Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China Department of PubLic HeaLth Sciences Medical University of South Carolina Charleston SC 29403 USA Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine Beijing 100053 China Department of Neurology Medical University of South Carolina Charleston SC 29403 USA

Background：Acute minor ischemic stroke （AMIS） or transient ischemic attack （TIA） is a common cerebrovascular event with a considerable high *** research demonstrated the effectiveness of regular long-term remote ischemic conditioning （RIC） in secondary stroke prevention in patients with intracranial *** hypothesized that RIC can serve as an effective adjunctive therapy to pharmacotherapy in preventing ischemic events in patients with AMIS/*** study aimed to investigate the feasibility,safety,and preliminary efficacy of daily RIC in inhibiting cerebrovascular/cardiovascular events after AMIS/***：This is a single-arm,open-label,multicenter Phase IIa futility study with a sample size of *** with AMIS/TIA receive RIC as an additional therapy to secondary stroke prevention *** consists of five cycles of 5-min inflation （200 mmHg） and 5-min deflation of cuffs on bilateral upper limbs twice a day for 90 *** antiplatelet strategy is based on individual physician＇s best practice：aspirin alone,clopidogrel alone,or combination of aspirin and *** will assess the recurrence rate of ischemic stroke/TIA within 3 months as the primary ***：The data gathered from the study will be used to determine whether a further large-scale,multicenter randomized controlled Phase Ⅱ trial is warranted in patients with AMIS/*** Registration：***,NCT03004820;https：//***/ct2/show/NCT03004820.

关键词： Ischemic Preconditioning Secondary Prevention Stroke Transient Ischemic Attack

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共沉淀条件对K/Co-MoS_2催化剂性能的影响及表征研究

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天然气化工—C1化学与化工 2018年第5期43卷 25-29,36页

作者：刘苏周海波宋庆英中国石化上海石油化工研究院上海201208

制备了一系列不同pH值下共沉淀的Co-MoS_2的前驱体,并与无水碳酸钾机械混合、高温分解后得到K/Co-MoS_2催化剂。对催化剂XRD、SEM、TPR和XPS表征表明,沉淀环境的pH值对Mo和Co的共沉淀效果有显著影响,中性条件下共沉淀的催化剂相比酸性... 详细信息

制备了一系列不同pH值下共沉淀的Co-MoS_2的前驱体,并与无水碳酸钾机械混合、高温分解后得到K/Co-MoS_2催化剂。对催化剂XRD、SEM、TPR和XPS表征表明,沉淀环境的pH值对Mo和Co的共沉淀效果有显著影响,中性条件下共沉淀的催化剂相比酸性和碱性条件下得到的催化剂晶粒较小,Co和Mo原子间的相互作用也较强,从而更倾向生成复合Co-MoS晶相,因此,在合成气制低碳醇反应中也显示出最高的活性和C_2^+醇选择性。

关键词：合成气低碳醇 Co-Mo-S催化剂共沉淀pH

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石灰固化海砂海泥混合料作为填料的室内试验研究

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科学技术与工程 2016年第31期16卷 261-264页

作者：陈庆张福海左庆松袁赛峰河海大学岩土力学与堤坝工程教育部重点实验室江苏省岩土工程技术工程研究中心(河海大学) 南京210098

为解决沿海地区缺乏填料的问题,将海砂海泥按质量比1.5∶1进行掺合,将混合料作为填筑材料,采用石灰作为固化剂,开展了一系列室内试验,包括无侧限抗压强度试验、直剪试验以及压缩试验。结果表明,固化混合料的无侧限抗压强度随着石灰掺量... 详细信息

为解决沿海地区缺乏填料的问题,将海砂海泥按质量比1.5∶1进行掺合,将混合料作为填筑材料,采用石灰作为固化剂,开展了一系列室内试验,包括无侧限抗压强度试验、直剪试验以及压缩试验。结果表明,固化混合料的无侧限抗压强度随着石灰掺量增加不断提高,掺量5%-7%之间时,强度变化最明显;7 d养护龄期的混合料的强度约为28 d养护龄期的50%左右,强度增长较为缓慢;石灰掺量大于7%之后,其强度增长速率明显减缓,甚至有减小的趋势;石灰掺量低于5%时固化效果不明显,在7%-9%之间时接近低压缩性土。

关键词：海砂-海泥混合料固化室内试验

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Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder:a randomized controlled trial

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Chinese Medical Journal 2020年第1期133卷 61-67页

作者： Hong-Xing Wang Kun Wang Wen-Rui Zhang Wen-Feng Zhao Xiao-Tong Yang Li Wang Mao Peng Zhi-Chao Sun qing Xue Yu Jia Ning Li Kai Dong Qian Zhang Shu-Qin Zhan Bao-Quan Min Chun-Qiu Fan Ai-Hong Zhou hai-qing song Lu Yin Tian-Mei Si Jing Huang Jie Lu hai-Xia Leng Wei-Jun Ding Yuan Liu Tian-Yi Yan Yu-Ping Wang Departm ent of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Key Laboratory of Neuromodulation Beijing 100053China Center of Epilepsy Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100053China Department of Neurology Beijing Puren HospitalBeijing 100062China Medical Research&Biometrics Centre National Centre for Cardiovascular DiseasesBeijing 102300China Peking University Sixth Hospital Beijing 100083China Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China School of Life Science Beijing Institute of TechnologyBeijing 100081China

Background:Transcranial alternating current stimulation(tACS)offers a new approach for adult patients with major depressive disorder(MDD).The study is to evaluate the efficacy and safety of tACS treating ***:This is an 8-week,double-blind,randomized,placebo-controlled ***-two drug-naive patients with MDD aged 18 to 65 years will receive 20 daily 40-min,77.5-Hz,15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks(week 4),following a 4-week observation period(week 8).The primary outcome is the remission rate defined as the 17-item Hamilton depression rating scale(HDRS-17)score≤7 at week *** outcomes are the rates of response at weeks 4 and 8 and rate of remission at week 4 based on HDRS-17,the proportion of participants having improvement in the clinical global impression-improvement,the change in HDRS-17 score(range,0-52,with higher scores indicating more depression)over the study,and variations of brain imaging and neurocognition from baseline to week *** will be assessed by vital signs at weeks 4 and 8,and adverse events will be collected during the entire ***:The tACS applied in this trial may have treatment effects on MDD with minimal side *** registration:Chinese Clinical Trial Registry,ChiCTR1800016479;http://***/***?proj=22048.

关键词： Major depressive disorder Transcranial alternating current stimulation Treatment Trial

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Nonlocal stress gradient formulation for damping vibration analysis of viscoelastic microbeam in thermal environment

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Applied Mathematics and Mechanics(English Edition) 2023年第5期44卷 773-786页

作者： hai qing Huidiao song State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

An integral nonlocal stress gradient viscoelastic model is proposed on the basis of the integral nonlocal stress gradient model and the standard viscoelastic model,and is utilized to investigate the free damping vibration analysis of the viscoelastic BernoulliEuler microbeams in thermal ***'s principle is used to derive the differential governing equations and corresponding boundary *** integral relations between the strain and the nonlocal stress are converted into a differential form with constitutive *** size-dependent axial thermal stress due to the variation of the environmental temperature is derived *** Laplace transformation is utilized to obtain the explicit expression for the bending deflection and *** the boundary conditions and constitutive constraints,one can get a nonlinear equation with complex coefficients,from which the complex characteristic frequency can be determined.A two-step numerical method is proposed to solve the elastic vibration frequency and the damping *** effects of length scale parameters,viscous coefficient,thermal stress,vibration order on the vibration frequencies,and critical viscous coefficient are investigated numerically for the viscoelastic Bernoulli-Euler microbeams under different boundary conditions.

关键词： damping vibration size effect integral nonlocal stress gradient model standard viscoelastic model Laplace transformation

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