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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-Yun zhao Shao-Lin Xiong xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An ke Gong Jin-Yuan Liao Yan-Qiu Zhang Yue Huang Lu Li Xing Wen Fei Zhang jing Duan chen-Wei wang Dong-Li Shi Peng Zhang Qi-Bin yi Chao-Yang Li Yan-bing Xu xiao-Hua liang Ya-qing Liu Da-Li Zhang Xi-Lei sun Fan Zhang Gang chen Huan-Yu wang Sheng Yang xiao-jing Liu Min Gao mao-Shun Li Jin-Zhou wang Xing Zhou yi zhao wang-chen Xue Chao Zheng Jia-cong Liu Xing-Bo Han Jin-Ling Qi Jia Huang ke-ke Zhang Can chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa wang Rui Qiao xiang ma xiao-Bo Li Ping wang Xin-ying Song Li-Ming Song Shi-Jie Zheng bing Li Hong-Mei Zhang Yue Zhu Wei chen jian-jian He Zhen Zhang Jin Hou Hong-Jun wang Yan-Chao Hao xiang-Yu wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi hui wang hui-Zhen wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang cheng-Mo Zhang Zhi-cheng Tang cheng cheng key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： bing-Tao Zhang Jun-Zheng wang Li-Tao Yang Qian Yue ke-Jun Kang Yuan-jing Li hai-Peng An C.Greeshma jian-Ping Chang Yun-Huan chen jian-Ping cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-chen Huang hai-Tao Jia Xi jiang S.Karmakar Hao-Bin Li jian-Min Li Jin Li Qian-Yun Li Ren-Ming-Jie Li Xue-Qian Li Yu-Lan Li yi-Fan liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan Liu Shu-Kui Liu Yan-Dong Liu Yu Liu Yuan-Yuan Liu Zhong-Zhi Liu Hao ma Yu-Cai mao Qi-Yuan Nie Jin-Hua Ning hui pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She manoj Kumar Singh Tian-Xi sun Chang-jian Tang Wei-You Tang Yang Tian Guang-Fu wang Li wang qing wang Yu-Feng wang Yun-xiang wang Henry-Tsz-King Wong Shi-Yong Wu Yu-cheng Wu Hao-Yang Xing Rui Xu yin Xu Tao Xue Yu-Lu Yan Nan yi Chun-Xu Yu hai-Jun Yu jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang zhao Ming-Gang zhao Ji-Fang Zhou Zu-ying Zhou jing-Jun Zhou key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients

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World Journal of Gastroenterology 2010年第36期16卷 4611-4615页

作者： jian-cong sun,xiao-ting liang,ke pan,hui wang,jing-jing zhao,jian-Jun Li,hai-qing ma,yi-bing chen,jian-chuan xia,State key Laboratory of Oncology in South China,Cancer Center,sun Yat-Sen University,Guangzhou 510060,Guangdong Province,China State key Laboratory of Oncology in Southern China Cancer Center Sun Yat-Sen University 651 Dongfeng East Road Guangzhou 510060 Guangdong Province China. xiajch@***

AIM:To determine the role of epidermal growth factor-like repeats and discoidin I-like domains 3(EDIL3)in pathogenesis of hepatocellular carcinoma(HCC)by investigating the EDIL3 expression in HCC and its prognostic value for ***:EDIL3 expression was detected in 101 HCC surgical tissue samples with immunohistochemistry method,and its relation with clinicopathologic features and prognosis of HCC patients was ***:EDIL3 was highly expressed in 48.5%of the HCC *** the EDIL3 expression level did not correlate with any clinicopathological parameters,KaplanMeier survival analysis showed that high expression level of EDIL3 resulted in a significantly poor prognosis of HCC patients(log-rank test,P=0.010).Multivariate Cox's analysis showed that the EDIL3 expression level was a significant and independent prognostic parameter for the overall survival rate of HCC patients(hazard ratio=1.978,95%confidence interval =1.139-3.435,P=0.015).CONCLUSION:High expression level of EDIL3 pre-dicts poor prognosis of HCC ***3 may be a potential target of antiangiogenic therapy for HCC.

关键词： Epidermal growth factor-like repeats and discoidin I-like domains 3 Hepatocellular carcinoma Prognosis Angiogenesis

自体CIK、DC-CIK与半合子DC-CIK抗肿瘤免疫反应的比较研究(英文)

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Chinese Journal of Cancer 2010年第7期29卷 641-648页

作者：王其京王慧潘科 State key Laboratory of Oncology in Southern China Department of Experimental Research Sun Yat-sen University Cancer Center

Background and Objective:Cytokine-induced killer(CIK) cells and autologous dendritic cells-CIK(DCCIK) cells co-cultured with autologous dendritic cells(DCs) and CIK cells are commonly used for immunotherapy *** compared the anti-tumor immune response of CIK cells,autologous DC-CIK cells,and semi-allogeneic DC-CIK cells to explore a more effective anti-tumor adoptive immunotherapy *** hods:Peripheral monocytes were isolated from patients with renal carcinoma,lung cancer,or maxillary squamous cell carcinoma and their healthy adult *** cells were cultured and induced as DCs and CIK cells in *** cells from patients were co-cultured with autologous DCs and DCs from their children respectively,generating DC-CIK cells and semi-allogeneic DC-CIK *** anti-tumor activities of autologous CIK cells,autologous DC-CIK cells,and semi-allogeneic DC-CIK cells were measured by LDH *** staining was used to test the secretion of *** cytometry was applied for detecting the phonotype changes of these three types of *** proliferation and cell apoptosis were detected by 5,6carboxyfluorescein diacetate succinimidyl ester(CFSE) and Annexin V/PI *** s:Compared with autologous CIK cells and DC-CIK cells,semi-allogeneic DC-CIK cells significantly enhanced the anti-tumor activity and IFN-γ secretion,reduced IL-4 secretion,increased the ratio of CD3+CD56+ cells and CD3+CD8+ cells,decreased the number of CD4+CD25+ cells,promoted cell proliferation,and lessened cell ***:Semi-allogeneic DC-CIK cells had a stronger anti-tumor effect than did autologous CIK cells and DC-CIK *** results provided experimental evidence for clinical application of DC-CIK cells.

关键词：抗肿瘤活性细胞免疫反应细胞因子树突状细胞体外诱导 CIK DC 自体

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai yijian Cai yizhou Cai Yuchen Cai haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-Xing chen huirun chen Jinhui chen Ji-Yuan chen Kai chen mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen xiang chen xiaoyu chen Xin chen Xun chen Xurong chen Ye chen ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu Yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua jing-Yu He Jun Li Bai Du ting-hai Du Lin-Lin Niu Xue-Jun jiang Bo Cui jiang-Bin chen Yang-Gan wang hai-Rong wang Qin Yu jing He yi-Lin mao xiao-Fang Bin Yue Deng Yu-Dan Tian qing-Hua Han Da-Jin Liu Li-Qin Duan Ming-Jun zhao Cui-ying Zhang hai-ying Dai Ze-Hua Li ying xiao You-Zhi Hu xiao-Yu Huang Kun Xing Xin jiang Chao-Feng Liu jing An Feng-Chun Li Tao Tao Jin-Fa jiang ying Yang Yao-Rong Dong Lei Zhang Guang Fu ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun sun ying-Qiang zhao Jie Li Yun xia Jun Liu Fan Liu Wen-Jin He ying Li jian-cong Tan Yang Lin Ya-Bin Zhou jian-Fei Yang Guo-qing ma hui-Jun chen He-Ping Liu Zong-Wu Liu jian-Xiong Liu xiao-Jia Luo xiao-Hong Bin Ya-Nan Yu hai-xia Dang bing Li Fei Teng wang-Min Qiao xiao-Long Zhu bing-Wei chen Qi-Guang chen Chun-Ti Shen Yong-Yan wang Yun-Dai chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1845-1855页

作者： huijie Bian zhao-hui Zheng Ding Wei Aidong Wen Zheng Zhang jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao jing wang Rong-Hua Xie ke Dong Jie-Lai xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang zhao-Wei Gao Hong Du Na Yao qing wang ke wang Jie-Jie Geng Bin wang ting Guo Ruo chen Yu-Meng Zhu Li-Juan wang Qian He Rui-Rui Yao ying Shi xiang-Min Yang jian-Sheng Zhou yi-Nan ma Ya-Tao wang Xue liang Fei Huo Zhe wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling wang xiao-Chun chen Hao Tang Shuang-Shuang Liu qing-yi wang Zhi-Nan chen Ping Zhu National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'anChina Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi'anChina Center for Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Nuclear Medicine Xijing HospitalFourth Military Medical UniversityXi'anChina department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXKanChina College of Military Preventive Medicine Fourth Military Medical UniversityXi'anChina Department of Pharmaceutics Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Pathology Fourth Military Medical UniversityXi'anChina jiangsu Pacific Meinuoke Biopharmaceutical Co.Ltd ChangzhouChina Department of Foreign Languages Fourth Military Medical UniversityXi'anChina

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 *** is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)***,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 *** phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was *** serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic *** obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each *** biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to *** the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent *** meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control *** results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.

关键词： patients dosage phase

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Biomarkers of aging

Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium hainan Bao jiani Cao Mengting chen Min chen Wei chen xiao chen Yanhao chen Yu chen Yutian chen Zhiyang chen Jagadish K Chhetri yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia haiping jiang ying jing Dingfeng Li Jiaming Li jingyi Li Qinhao liang Rui liang Feng Liu xiaoqian Liu Zuojun Liu Oscar Junhong Luo jianwei Lv jingyi ma kehang mao Jiawei Nie Xinhua Qiao Xinpei sun xiaoqiang Tang jianfang wang Qiaoran wang Siyuan wang Xuan wang Yaning wang Yuhan wang Rimo Wu Kai xia Fu-hui xiao Lingyan Xu yingying Xu Haoteng Yan liang Yang Ruici Yang Yuanxin Yang yilin ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang chen Guobing chen Hou-Zao chen Jun chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao jing-Dong JHan Kai Huang Zhenyu Ju qing-Peng Kong Ji Li jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu xianghang Luo Shuai ma Xinran ma Zhiyong mao jing Nie Yaojin Peng jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang yi Eve sun Yu sun Mei Tian Shusen wang Si wang xia wang xiaoning wang Yan-jiang wang Yunfang wang Catherine CL Wong Andy Peng xiang yichuan xiao Zhengwei Xie Daichao Xu jing Ye Rui Yue Cuntai Zhang Hongbo Zhang liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao zhao Yuzheng zhao Dahai Zhu Weiguo Zou Gang Pei Guang-hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai key Laboratory of maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu Yue Huang Guang-cheng xiao qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei Jia Fang-Jun Lu xiang ma Lian Tao Wei Zhang Li chen Li-Ming Song Ti-Pei Li Yu-Peng Xu Xue-Lei Cao Yong chen cong-Zhan Liu Ce Cai Zhi Chang Gang chen Tian-xiang chen yi-Bao chen Yu-Peng chen Wei Cui Wei-Wei Cui jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan cheng-cheng Guo Da-Wei Han Jia Huo Lu-Hua jiang Wei-Chun jiang jing Jin Yong-Jie Jin Ling-Da Kong bing Li cheng-Kui Li Gang Li mao-Shun Li Wei Li xian Li xiao-Bo Li Xu-Fang Li Yang-Guo Li Zheng-Wei Li xiao-Hua liang jing-Yuan Liao Bai-Sheng Liu Guo-qing Liu Hong-Wei Liu xiao-jing Liu yi-Nong Liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng yi Nang jian-yin Nie Ge Ou Na Sai Ren-cheng Shang Xin-ying Song liang sun ying Tan You-Li Tuo chen wang Guo-Feng wang Juan wang Ling-Jun wang Weng-Shuai wang Yu-Sa wang xiang-Yang Wen Bai-Yang Wu Bo-bing Wu Mei Wu Shuo xiao Shao-Lin Xiong He Xu Jia-Wei Yang Sheng Yang Yan-Ji Yang yi-Jung Yang Qi-Bin yi Qian-qing yin Yuan You Ai-Mei Zhang cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-zhao Zhang yi Zhang yi-Fei Zhang Yong-Jie Zhang Yuan-Hang Zhang Yue Zhang zhao Zhang Zhi Zhang Zi-liang Zhang hai-Sheng zhao xiao-Fan zhao Shi-Jie Zheng Yao-Guang Zheng Deng-ke Zhou jian-Feng Zhou Yu-Xuan Zhu Ren-Lin Zhuang Yue Zhu key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031