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Perinatal prevalence of birth defects in the Mainland of China,2000–2021:a systematic review and meta-analysis

World Journal of Pediatrics 2024年第7期20卷 669-681页

作者： Liang-Yu Kang Zi-Rui Guo Wei-Jing Shang Gui-Ying Cao Yi-ping Zhang Qiao-Mei Wang hai-ping shen Wan-Nian Liang Min Liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing100191China Vanke School of Public Health Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Department of Maternal and Child Health National Health Commission of the People’s Republic of ChinaNo.1Xizhimenwai South RoadXicheng DistrictBeijingChina Institute of Healthy China Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of Education BeijingNo.38Xueyuan RoadHaidian DistrictBeijing100191China

Background Although birth defects are of great concern globally,the latest national prevalence has not yet been quantified in *** conducted a systematic review and meta-analysis to estimate the perinatal prevalence of birth defects in the Mainland of China between 2000 and *** We performed a systematic literature search of six databases for relevant articles published between January 1,2000,and March 1,*** included published studies that reported data on the perinatal prevalence of birth defects in the Mainland of *** DerSimonian and Laird random-effects models were used to estimate the pooled prevalence and its 95%confidence interval(CI).We also conducted subgroup analyses and univariable meta-regressions to explore differences in prevalence by time period,geographic region,and other *** We included 254 studies reporting the perinatal prevalence of birth defects and 86 studies reporting only the prevalence of specific types of birth *** on 254 studies covering 74,307,037 perinatal births and 985,115 cases with birth defects,the pooled perinatal prevalence of birth defects was 122.54(95%CI 116.20–128.89)per 10,000 perinatal births in the Mainland of China during 2000–***,the perinatal prevalence of birth defects increased from 95.60(86.51–104.69)per 10,000 in 2000–2004 to 208.94(175.67–242.22)per 10,000 in 2020–*** were also significant disparities among different geographical *** heart defects(33.35 per 10,000),clefts of the lip and/or palate(13.52 per 10,000),polydactyly(12.82 per 10,000),neural tube defects(12.82 per 10,000),and inborn errors of metabolism(11.41 per 10,000)were the five most common types of birth *** perinatal prevalence among males was significantly higher than that among females(β=2.44×10^(−3),P=0.003);a higher perinatal prevalence of birth defects was observed among perinatal births whose mothers were≥35 years(β=4.34×10^(−3),P<0.001).Conclusion Compreh

关键词： Birth defects China Perinatal Prevalence

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Poly(meta-phenylene) Derivative with Rigid Twisted Biphenyl Units in Backbone:Synthesis,Structural Characterization,Photophysical Properties and Electroluminescence

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Chemical Research in Chinese Universities 2007年第6期23卷 720-725页

作者： ZHENG Yan YANG Bing ZHANG hai-quan LU ping shen Fang-zhong LIU Lin-lin XU hai YANG Guang-di MA Yu-guang Key Lab for Supramolecular Structure and Materials of Ministry of Education Jilin University Changchun 130012 P. R. China

A soluble poly（meta-phenylene） derivative with rigid twisted biphenyl unit was synthesized by the Yamamoto coupling reaction. The polymer is soluble in common organic solvents, and the number-average molecular weight is about 6500. The UV-Vis and quantum chemical calculation indicate that the different conformation segments named ＂conformers＂ exist in the polymer backbones; it was also further confirmed by the single crystal X-ray diffraction study of the dimeric model compound. The π-π^＊ transition of biphenyl segments of twisted and planar conformations made the polymer exhibit a strong absorption around 256 nm and a weak absorption at about 300 nm. Furthermore, the polymer exhibits a strong UV photoluminescence at 372 nm when the excitation wavelengths are longer than 300 run. The ultraviolet-emitting electroluminescence（EL） device with the single layer structure shows EL λmax of the derivative at 370 nm.

关键词： Poly(phenylene) Conformation UV light-emitting

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Seroepidemiology of Syphilis Infection among 2 Million Reproductive-age Women in Rural China：A Population-based, Cross-sectional Study

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Chinese Medical Journal 2017年第18期130卷 2198-2204页

作者： Kai-Ju Liao Shi-Kun Zhang Min Liu Qiao-Mei Wang Jue Liu hai-ping shen Yi-ping Zhang Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China Department of Maternal and Child Health National Health and Family Planning Commission of the People's Republic of China Beijing 100044 China

Background：Quantifying syphilis prevalence is important for planning interventions and advocating for resources on ***,data on large sample studies regarding the prevalence of syphilis among reproductive-age women in rural China were not available for *** aim of the study was to determine the prevalence,epidemiological characteristics,and related factors of syphilis infection among reproductive-age women in rural ***：Data were obtained from a nationwide,population-based,cross-sectional study under the National Free Preconception Health Examination Project which covered all the 31 provinces in China's *** intending to get pregnant within the next 6 months were enrolled between January 1,2010,and December 31,***,gynecological and obstetric characteristics,and other relevant information were obtained through face-to-face *** pallidum particle agglutination assay test was used to detect positive samples of *** and multivariate logistic regressions were performed to assess the associations between syphilis seropositivity and related ***：The overall seroprevalence of syphilis （SPS） among the 2,044,126 women who received syphilis screening test during 2010-2012 was 0.37% （95% confidence interval [CI]：0.36-0.37%）.The SPS appeared 0.24% （95% CI：0.23-0.26%） and 0.66% （95% CI：0.59-0.72%） in women at 21-24 and 40-44 years of age,respectively,showing an increase of SPS,parallel with age,and the difference was *** was significantly higher in ethnic minorities than that in Han nationality （0.58% vs.0.35%,respectively,odds ratio [OR] =1.41,95% CI：1.30-1.53） and higher in workers than that in farmers （0.45% vs.0.36%,respectively,OR =1.27,95% CI：1.14-1.41）.Women with primary school or below level had a higher SPS as compared to those with college or above educational level （0.61% vs.0.32%,respectively,OR =2.49,95% CI：2.14-2.89）,and the increase reversely correlated wi

关键词： Preconception Care Reproductive-age Women Seroprevalence:, Syphilis

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Aggregation-regulated bioreduction process of graphene oxide by Shewanella bacteria

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Chinese Journal of Chemical Engineering 2024年第5期69卷 56-62页

作者： Kaixin Han Yibo Zeng Yinghua Lu ping Zeng Liang shen Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Chinese Research Academy of Environmental Sciences Beijing 100012China

The bioreduction of graphene oxide(GO)using environmentally functional bacteria such as Shewanella represents a green approach to produce reduced graphene oxide(rGO).This process differs from the chemical reduction that involves instantaneous molecular *** bioreduction,the contact of bacterial cells and GO is considered the rate-limiting *** reveal how the bacteria-GO integration regulates rGO production,the comparative experiments of GO and three Shewanella strains were carried ***-transform infrared spectroscopy,X-ray photoelectron spectroscopy,Raman spectroscopy,and atomic force microscopy were used to characterize the reduction degree and the aggregation *** results showed that a spontaneous aggregation of GO and Shewanella into the condensed entity occurred within 36 h.A positive linear correlation was established,linking three indexes of the aggregation potential,the bacterial reduction ability,and the reduction degree(ID/IG)comprehensively.

关键词： Graphene oxide Reduced graphene oxide Bioreduction Aggregation Shewanella

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Influence of dexamethasone on inflammatory mediators and NF-κB expression in multiple organs of rats with severe acute pancreatitis

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World Journal of Gastroenterology 2007年第4期13卷 548-556页

作者： Xi-ping Zhang Ling Zhang Lin-Jie Chen Qi-Hui Cheng Jian-Mei Wang Wei Cai hai-ping shen Jun Cai Department of General Surgery Hangzhou First People's Hospital Hangzhou 310006 Zhejiang Province China Class s0201 of Seven Year's Clinical Medicine Shanxi Medical University Taiyuan 310001 Shanxi Province China Zhejiang University of Traditional Chinese Medical Hangzhou 310053 Zhejiang Province China Department of Gynaccology and Obstetrics Hangzhou First People's Hospital Hangzhou 310006 Zhejiang Province China Supply Room Hangzhou First People's Hospital Hangzhou 310006 Zhejiang Province China Operating Room Hangzhou First People's Hospital Hangzhou 310006 Zhejiang Province China

AIM: To observe the therapeutic effects of dexamethasone on rats with severe acute pancreatitis (SAP) and investigate the influences of dexamethasone on the inflammatory mediators and NF-κB expression in multiple organs of SAP rats as well as the mechanisms involved. METHODS: Ninety Sprague-Dawley (SD) rats with SAP were randomly divided into the model group (n = 45) and dexamethasone treatment group (n = 45), and another 45 rats were selected for the sham operation group. All groups were randomly subdivided into the 3 h, 6 h and 12 h groups, each group containing 15 rats. The survival of all groups and pathological changes of multiple organs (liver, kidney and lung) were observed at different time points after the operation. The pathologicalscore of multiple organs was carried out, followed by the determination of amylase, endotoxin and TNF-α contents in blood. The tissue microarray was used to detect the expression levels of NF-κB p65 protein in multiple organs. RESULTS: There was no marked difference between the model group and treatment group in the survival rate. The amylase content of the treatment group was significantly lower compared to the model group at 12 h (P < 0.01, 7791.00 vs 9195.00). Moreover, the endotoxin and TNF-α levels of the treatment group were significantly lower than that of the model group at 6 h and 12 h (P < 0.01, 0.040 vs 0.055, 0.042 vs 0.059 and P < 0.05, 58.30 vs 77.54, 38.70 vs 67.30, respectively). Regarding the changes in liver NF-κB expression, the model group significantly exceeded the sham operation group at 3 h (P < 0.01, 1.00 vs 0.00), and the treatment group significantly exceeded the sham operation group at 12 h (P < 0.01, 1.00 vs 0.00), whereas no marked difference was observed between the model group and treatment group at all time points. The kidney NF-κB expression level in the treatment group significantly exceeded the model group (P < 0.05, 2.00 vs 0.00) and the sham operation group (P < 0.01, 2.00 vs 0.00) at 12 h. N

关键词： Severe acute pancreatitis Dexamethasone NF-κB Tissue microarrays Mutiple organs

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Theoretical study on the effect of H_(2)O on the formation mechanism of NO_(x) precursors during indole pyrolysis

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 99-112页

作者： Ziqi Wang Jun shen Xuesong Liu Sha Wang shengxiang Deng hai Zhang Yun Guo School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The incineration technology of kitchen waste is one of the effective technologies to achieve the resource utilization of municipal solid *** is an important stage of *** is a rich initial product in the pyrolysis process of kitchen waste,and the presence of H_(2)O has a significant impact on the decomposition of indole to form NO_(x) ***,this study uses density functional theory method to study the effect of H_(2)O on the thermal decomposition of indole to produce NH_(3),HNCO,and *** H_(2)O participates in the reaction,it can provide oxidative groups to generate a new product HNCO,which is different from the previous findings by indole pyrolysis without the presence of H_(2)***,this study theoretically proves that NH_(3) is easier to form than *** is consistent with the phenomenon that NH_(3) release is higher than HCN release in pyrolysis *** addition,compared with the individual pyrolysis of indole,the participation of H_(2)O reduces the energy barriers for the formation of NH_(3) and HCN during indole pyrolysis,thereby promoting the formation of NH_(3) and HCN.

关键词： indole pyrolysis H_(2)O NO_(x)precursors DFT

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Therapeutic effect of Wendan Decoction combined with mosapride on gastroesophageal reflux disease after esophageal cancer surgery

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World Journal of Clinical Cases 2024年第13期12卷 2194-2200页

作者： Yu-Jing Zhang shen-ping Wu Department of Oncology Beijing Integrated Traditional Chinese and Western Medicine HospitalBeijing 100039China

BACKGROUND Gastroesophageal reflux disease(GERD)is a common complication of esophageal cancer surgery that can affect quality of life and increase the risk of esophageal stricture and anastomotic *** Decoction(WDD)is a traditional Chinese herbal formula used to treat various gastrointestinal disorders,such as gastritis,functional dyspepsia,and irritable bowel ***,a prokinetic agent,functions as a selective 5-hydroxytryptamine 4 agonist,enhancing gastrointestinal *** To evaluate the therapeutic effects of WDD combined with mosapride on GERD after esophageal cancer *** Eighty patients with GERD were randomly divided into treatment(receiving WDD combined with mosapride)and control(receiving mosapride alone)*** treatment was conducted from January 2021 to January *** primary outcome was improved GERD symptoms as measured using the reflux disease questionnaire(RDQ).The secondary outcomes were improved esophageal motility(measured using esophageal manometry),gastric emptying(measured using gastric scintigraphy),and quality of life[measured via the Short Form-36(SF-36)Health Survey].RESULTS The treatment group showed a notably reduced RDQ score and improved esophageal motility parameters,such as lower esophageal sphincter pressure,peristaltic amplitude,and peristaltic velocity compared to the control *** treatment group showed significantly higher gastric emptying rates and SF-36 scores(in both physical and mental domains)compared to the control *** serious adverse effects were observed in either *** WDD combined with mosapride is an effective and safe therapy for GERD after esophageal cancer *** can improve GERD symptoms,esophageal motility,gastric emptying,and the quality of life of *** studies with larger sample sizes and longer follow-up periods are required to confirm these findings.

关键词： Gastroesophageal reflux disease Esophageal cancer surgery Wendan Decoction Mosapride Treatment effects Gastroesophageal reflux disease symptoms

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In vivo 3-photon fluorescence microscopy of white matter in mouse brain excited at the 1700 nm window

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 81-87页

作者： Jie Huang Jincheng Zhong shen Tong Yingxian Zhang ping Qiu Ke Wang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060P.R.China School of Medical Information and Engineering Xuzhou Medical UniversityXuzhou 221004P.R.China

White matter,a densely packed collection of myelinated axons,plays an essential part in neural *** high spatial resolution and deep penetration,multi-photon microscopy(MPM)is promising for white matter imaging in animal models in *** third harmonic generation(THG)signal can be generated from white matter,but the bottom part of the white matter layer generates weak THG due to its high ***,we demonstrate an in vivo labeling and imaging technology,capable of visualizing the white matter layer in the mouse brain,combining°uorescence labeling with MitoTracker Red and three-photon°uorescence(3PF)microscopy excited at the 1700 nm window.3PF signals are several times higher than THG signals,resulting in deeper imaging of the white matter layer with the *** results indicate that 3PF microscopy is a promising technology for white matter imaging in the deep brain in vivo.

关键词： Three-photon microscopy white matter myelin MitoTracker Red

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Architecture Design of Protocol Controller Based on Traffic-Driven Software Defined Interconnection

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Chinese Journal of Electronics 2024年第2期33卷 362-370页

作者： Peijie LI Jianliang shen ping LYU Chunlei DONG Ting CHEN Information Engineering University

To solve the problems of redundant logic resources and poor scalability in protocol controller circuits among communication networks, we propose a traffic-driven software defined interconnection(TSDI) *** unified software defined interconnection interface standards and the normalized interconnection topology are designed to implement the architecture of TSDI-based protocol controller. The key indicators of power, performance and area(PPA) can be realized while resolving the flexible interconnection of the controller. We designed a TSDI-based Rapid IO controller as an example. Compared to traditional designs, the design could achieve more protocol scalability,and Rapid IO protocol standards of Gen4 could be supported directly. The key PPA indicators, such as a lower delay of 56.1 ns and more than twice throughput of 98.1 Gbps, were achieved at the cost of a 23.4% area increase.

关键词： Protocols Software design Scalability Integrated circuit interconnections Process control Computer architecture Throughput

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How variable progenitor clones construct a largely invariant neocortex

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National Science Review 2024年第1期11卷 129-144页

作者： Zhongfu shen Jiajun Yang Qiangqiang Zhang Kuiyu Wang Xiaohui Lv Xiaolin Hu Jian Ma Song-hai Shi New Cornerstone Science Laboratory IDG/McG overn Institute for Brain Research Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University Department of Computer Sciences Tsinghua University College of Life Sciences Nankai University Chinese Institute for Brain Research

The neocortex contains a vast collection of diverse neurons organized into distinct layers. While nearly all neocortical neurons are generated by radial glial progenitors(RGPs), it remains largely unclear how a complex yet organized neocortex is constructed reliably and robustly. Here, we show that the division behavior and neuronal output of RGPs are highly constrained with patterned variabilities to support the reliable and robust construction of the mouse neocortex. The neurogenic process of RGPs can be well-approximated by a consistent Poisson-like process unfolding over time, producing deep to superficial layer neurons progressively. The exact neuronal outputs regarding layer occupation are variable; yet, this variability is constrained systematically to support all layer formation, largely reflecting the variable intermediate progenitor generation and RGP neurogenic entry and exit timing differences. Together, these results define the fundamental features of neocortical neurogenesis with a balanced reliability and variability for the construction of the complex neocortex.

关键词： neocortex radial glial progenitor intermediate progenitor neurogenesis clonal variability layer formation

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