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Journal of Advanced Ceramics 2024年第7期13卷 1002-1010页

作者： Xiaocui Rao Xueling Yang Renbing sun peng Du hai Jiang Yao Huang Laihui Luo Department of Microelectronics Science and Engineering School of Physical Science and TechnologyNingbo UniversityNingbo 315211China College of Materials Science and Engineering Ningbo University of TechnologyNingbo 315016China

0-3 type ferroelectric-phosphor composite ceramics cannot be prepared by the traditional solid-state sintering(SSS)method due to the strong chemical reaction between ferroelectrics and phosphors during high-temperature *** cold sintering process(CSP)may solve this issue by densifying ceramics at ultralow sintering *** this work,dense 0-3 type 0.8BaTiO_(3)-0.2CaTiO_(3):Pr^(3+)(0.8BT-0.2CT:Pr^(3+))binary composite ceramics were fabricated at an ultralow temperature of 225℃via CSP with the Ba(OH)2·8H2O hydrated *** effects of the Ba(OH)_(2)·8H2O content,sintering temperature,and sintering time on the microstructure and densification of the ceramics were *** density of the composite ceramics prepared by the optimized sintering parameters reaches 89%.Both energy-dispersive X-ray(EDX)spectroscopy and X-ray diffraction(XRD)confirm the existence of BT and CT:Pr^(3+)phases in the prepared ceramics.A strong ferroelectric performance is obtained,and the luminescent properties of CT:Pr^(3+)are preserved for the ***,the 0.8BT-0.2CT:Pr^(3+)composite ceramics prepared by CSP have stronger photoluminescence and photo-stimulated luminescence than their counterparts prepared by cold sintering assistance(CSA)and SSS ***,CSP is a promising method for combining luminescent and ferroelectric properties into 0-3 type composite ceramics.

关键词： single-step densification cold sintering composite ceramics ferroelectric luminescence

Virus-like supramolecular assemblies formed by cooperation of base pairing interaction and peptidic association

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Science China Chemistry 2016年第3期59卷 310-315页

作者： Meiwen Cao Ningning Wang peng Zhou Yawei sun Jiqian Wang Shengjie Wang hai Xu Centre for Bioengineering and Biotechnology State Key Laboratory of Heavy Oil ProcessingCollege of Chemical EngineeringChina University of Petroleum(East China)Qingdao266555China

A peptide nucleic acid （PNA）-peptide conjugated molecule, T＇3（AKAE）2, was designed to have both a PNA segment for oligo- nucleotide binding and an ionic self-complementary peptide sequence for self-association. T＇3（AKAE）2 could co-assemble with oligoadenines （d（A）x） to form virus-like supramolecular structures whose morphology showed dependence on the chain length and rigidity of the d（A）x molecules. Smaller nanospheres with diameters of 13.0±2.0 nm were produced in the case of d（A）6. Wormlike aggregates with lengths of 20-50 nm and diameters of 15.0±2.5 nm were found in the cases of d（A）12, d（A）ls, d（A）24 and d（A）30. And larger spherical aggregates with diameters of 18±5 nm came into presence in the cases of d（A）36 and d（A）42＋. These nanostructures were suggested to be formed under a cooperative effect of base pair recognition and peptidic association. The study provides insights into the programmed assembly of a multi-components system as well as control of the size and shade of the co-assembled structures, which is of great significance in develouing gene/drug deliverv systems.

关键词： peptide nucleic acid oligonucleotide artificial virus co-assembly supramolecular complex

Ulinastatin suppresses endoplasmic reticulum stress and apoptosis in the hippocampus of rats with acute paraquat poisoning

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Neural Regeneration Research 2015年第3期10卷 467-472页

作者： hai-feng Li Shi-xing Zhao Bao-peng Xing Ming-li sun Department of Emergency Medicine the First Hospital of Jilin University-the Eastern Division

Lung injury is the main manifestation of paraquat poisoning. Few studies have addressed brain damage after paraquat poisoning. Ulinastatin is a protease inhibitor that can effectively stabilize lysosomal membranes, prevent cell damage, and reduce the production of free radicals. This study assumed that ulinastatin would exert these effects on brain tissues that had been poisoned with paraquat. Rat models of paraquat poisoning were intraperitoneally injected with ulinastatin. Simultaneously, rats in the control group were administered normal saline. Hematoxylin-eosin staining showed that most hippocampal cells were contracted and nucleoli had disappeared in the paraquat group. Fewer cells in the hippocampus were concentrated and nucleoli had dis- appeared in the ulinastatin group. Western blot assay showed that expressions of GRP78 and cleaved-caspase-3 were significantly lower in the ulinastatin group than in the paraquat group. Immunohistochemical findings showed that CHOP immunoreactivity was significantly lower in the ulinastatin group than in the paraquat group. Terminal deoxynucleotidyl transferase-medi- ated dUTP nick end labeling staining showed that the number of apoptotic cells was reduced in the paraquat and ulinastatin groups. These data confirmed that endoplasmic reticular stress can be induced by acute paraqnat poisoning. Ulinastatin can effectively inhibit this stress as well as cell apoptosis, thereby exerting a neuroprotective effect.

关键词： nerve regeneration paraquat poisoning rats endoplasmic reticulum stress apoptosis ulinastatin CHOP GRP78 caspase-3 hippocampus reactive oxygen species neural regeneration

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie Runxue Zhou Jin Deng Weihong Nie Shuwei sun haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang Chenyang Zhang Linlin Wu Wei sun Hongliang Zhang Jianhua Chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

关节镜下松解联合韧带重建术治疗复发性髌骨脱位的效果分析

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中国骨与关节损伤杂志 2017年第10期32卷 1029-1032页

作者：陈冬黄炎李海鹏伍罕孙维姚建华解放军陆军总医院骨三科北京100000

目的通过探讨远端重排术和松解联合韧带重建术治疗复发性髌骨脱位的效果,为关节镜下松解联合韧带重建术治疗复发性髌骨脱位的广泛应用提供一定的科学依据。方法笔者自2014-01—2016-01分别采用远端重排术(远端重排组)及松解联合韧带重建... 详细信息

目的通过探讨远端重排术和松解联合韧带重建术治疗复发性髌骨脱位的效果,为关节镜下松解联合韧带重建术治疗复发性髌骨脱位的广泛应用提供一定的科学依据。方法笔者自2014-01—2016-01分别采用远端重排术(远端重排组)及松解联合韧带重建术(松解联合韧带重建组)治疗50例复发性髌骨脱位。采用Lysholm和HSS评分评价2组手术前后膝关节功能。2组在术后1、3、6、12个月进行髌骨倾斜试验、髌骨恐惧试验、脱位次数等专项检查,并统计阳性例数。结果 2组获得随访12个月。2组术前Lysholm和HSS评分、髌骨倾斜试验阳性率、髌骨恐惧试验阳性率、脱位次数比较差异均无统计学意义(P>0.05)。松解联合韧带重建组术后1、3、6、12个月Lysholm评分高于远端重排组,差异有统计学意义(P<0.05);松解联合韧带重建组术后1、3、6、12个月HSS评分高于远端重排组,差异有统计学意义(P<0.05);术后1、3个月松解联合韧带重建组髌骨恐惧试验阳性率明显低于远端重排组,差异有统计学意义(P<0.05)。结论关节镜下松解联合韧带重建术治疗复发性髌骨脱位较远端重排术疗效更佳,值得临床推广。

关键词：复发性髌骨脱位关节镜松解联合韧带重建术远端重排术

Unique Ergodicity for Zero-entropy Dynamical Systems with the Approximate Product Property

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Acta Mathematica Sinica,English Series 2021年第2期37卷 362-376页

作者： peng sun China Economics and Management Academy Central University of Finance and EconomicsBeijing 100081P.R.China

We show that for every topological dynamical system with the approximate product property, zero topological entropy is equivalent to unique ergodicity. Equivalence of minimality is also proved under a slightly stronger condition. Moreover, we show that unique ergodicity implies the approximate product property if the system has periodic points.

关键词： Approximate product property unique ergodicity topological entropy ergodic measure minimality specification gluing orbit interval map periodic points

可罗卡林对血管平滑肌细胞增殖及c-myc基因表达的影响

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心血管康复医学杂志 2003年第3期12卷 226-228,225页

作者：李玮彭海孙圣刚童萼塘华中科技大学同济医学院附属协和医院神经内科湖北武汉市430022

目的:观察对大鼠主动脉平滑肌细胞起负调节作用的可罗卡林(cromakalim对同型半胱氨酸(hcy)刺激的血管平滑肌细胞(vascular smooth muscle cells,VSMC)增殖及c-myc基因表达的影响。方法:在建立hcy诱导的平滑肌细胞增殖模型后,应用流式细... 详细信息

目的:观察对大鼠主动脉平滑肌细胞起负调节作用的可罗卡林(cromakalim对同型半胱氨酸(hcy)刺激的血管平滑肌细胞(vascular smooth muscle cells,VSMC)增殖及c-myc基因表达的影响。方法:在建立hcy诱导的平滑肌细胞增殖模型后,应用流式细胞术观察VSMC增殖周期的变化;并用免疫细胞化学方法观察可罗卡林对VSMC增殖及c-myz基因蛋白表达的影响。结果:可罗卡林使VSMC处于G_0/C_1期的细胞数显著增多(P<0.01),S期G_2+M期的细胞数显著减少(P<0.01),能够抑制hcy诱导的VSMC增殖和c-myc基因蛋白表达的增加。结论:可罗卡林对hey诱导的VSMC增殖有显著的抑制作用,其作用机制与抑制c-myc基因表达有关。

关键词：可罗卡林血管平滑肌细胞增殖 c-myc 基因表达动脉粥样硬化同型半胱氨酸大鼠

Innovative dual-mode device integrating capacitive desalination and solar vapor generation for high-efficiency seawater desalination

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Journal of Energy Chemistry 2025年第1期100卷 171-179页

作者： Jiacheng Wang Zhaoyu Chen Ruduan Yuan Jiaxin Luo Ben Zhang Keju Ji Meng Li Juanxiu Xiao Kuan sun National Innovation Center for Industry-Education Integration of Energy Storage Technology MOE Key Laboratory of Low-grade Energy Utilization Technologies and SystemsCollege of Energy & Power Engineering Chongqing University Xuefeng Mountain Energy Equipment Safety National Observation and Research Station CQU-NUS Renewable Energy Materials & Devices Joint Laboratory Chongqing University Southwest Technology and Engineering Research Institute Jiangsu Provincial Key Laboratory of Bionic Functional Materials College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University

Solar-driven interface evaporation with high solar-to-steam conversion efficiency has shown great potential in seawater ***,due to the influence of latent heat and condensation efficiency,the water yield from solar-driven interface evaporation remains insufficient,posing a significant challenge that requires *** this work,we designed a dual-mode high-flux seawater desalination device that combines solar-driven interface evaporation and capacitive *** utilizing coupled desalination materials exhibiting both photothermal conversion and capacitance activity,the device demonstrated photothermal evaporation rates of 1.41 and 0.97 kg m-2h-1for condensate water yield under one-sun ***,the device exhibited a salt adsorption capacity of up to48 mg g-1and a salt adsorption rate of 2.1 mg *** addition,the salt adsorption capacity increased by approximately 32% under one-sun ***,photo-enhanced capacitive desalination performance was explored through numerical simulations and theoretical *** calculations and characterizations confirmed that the defect energy levels formed by the introduction of sulfur vacancies can effectively widen the light absorption range,improve photothermal conversion performance,and stimulate more photoelectrons to participate in capacitive ***,the electron distribution state of molybdenum disulfide with sulfur vacancies and surface defect sites contributes to ion/electron transport at the solid-liquid *** work provides a novel pathway for integrating solar vapor generation with other low-energy desalination technologies.

关键词： Desalination

Deep learning-based software engineering: progress,challenges, and opportunities

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Science China(Information Sciences) 2025年第1期68卷 57-144页

作者： Xiangping CHEN Xing HU Yuan HUANG He JIANG Weixing JI Yanjie JIANG Yanyan JIANG Bo LIU Hui LIU Xiaochen LI Xiaoli LIAN Guozhu MENG Xin peng hailong sun Lin SHI Bo WANG Chong WANG Jiayi WANG Tiantian WANG Jifeng XUAN Xin XIA Yibiao YANG Yixin YANG Li ZHANG Yuming ZHOU Lu ZHANG School of Journalism and Communication Sun Yat-sen University School of Software Technology Zhejiang University School of Software Engineering Sun Yat-sen University School of Software Dalian University of Technology School of Computer Science and Technology Beijing Institute of Technology Key Laboratory of High Confidence Software Technologies (Peking University) Ministry of EducationSchool of Computer Science Peking University State Key Laboratory for Novel Software Technology Nanjing University School of Computer Science and Engineering Beihang University Institute of Information Engineering Chinese Academy of Sciences School of Computer Science Fudan University State Key Laboratory of Complex & Critical Software Environment (CCSE) School of Software Beihang University School of Computer and Information Technology Beijing Jiaotong University School of Computer Science and Technology Harbin Institute of Technology School of Computer Science Wuhan University Huawei Technologies

Researchers have recently achieved significant advances in deep learning techniques, which in turn has substantially advanced other research disciplines, such as natural language processing, image processing, speech recognition, and software engineering. Various deep learning techniques have been successfully employed to facilitate software engineering tasks, including code generation, software refactoring, and fault localization. Many studies have also been presented in top conferences and journals, demonstrating the applications of deep learning techniques in resolving various software engineering tasks. However,although several surveys have provided overall pictures of the application of deep learning techniques in software engineering,they focus more on learning techniques, that is, what kind of deep learning techniques are employed and how deep models are trained or fine-tuned for software engineering tasks. We still lack surveys explaining the advances of subareas in software engineering driven by deep learning techniques, as well as challenges and opportunities in each subarea. To this end, in this study, we present the first task-oriented survey on deep learning-based software engineering. It covers twelve major software engineering subareas significantly impacted by deep learning techniques. Such subareas spread out through the whole lifecycle of software development and maintenance, including requirements engineering, software development, testing, maintenance, and developer collaboration. As we believe that deep learning may provide an opportunity to revolutionize the whole discipline of software engineering, providing one survey covering as many subareas as possible in software engineering can help future research push forward the frontier of deep learning-based software engineering more systematically. For each of the selected subareas,we highlight the major advances achieved by applying deep learning techniques with pointers to the available datasets i

关键词： deep learning software engineering software benchmark software artifact representation survey