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Expressions of Maspin,P53 and Skp2 in Colorectal Tumors and Their Clinicopathological Significance

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Chinese Journal of Cancer Research 2009年第2期21卷 147-153页

作者： Jiang-tao Ni Yong-fen Yi hai-peng shi Department of Pathology Molecular Medicine and Cancer Research Center Chongqing Medical UniversityChongqing 400016 China

Objective： To investigate the role of maspin, p53 and Skp2 expressions in the progression of colorectal tumors, and their clinicopathological significance. Methods： The expressions of maspin, p53 and Skp2 in colorectal adenocarcinoma （n=50）, adenoma （n=20） and normal tissue （n=20） were detected by immunohistochemistry and compared with the clinicopathological tumor parameters. The relationship among maspin, p53 and Skp2 expression was also analyzed in colorectal tumors. The reverse transcriptase PCR was carried out to detect the level of maspin mRNA from 31 colorectal adenocarcinoma and 10 normal control tissues. Results： Of 50 cases of colorectal adenocarcinoma, the positive expression rates for maspin, p53 and Skp2 in colorectal adenocarcinoma were 62% （31 of 50 cases）, 50% （25 of 50 cases）, 48%（ 24 of 50 cases）, respectively; The positive expression rates for maspin, p53 and Skp2 in adenoma were 90%, 5%, 5%, respectively; The positive expression rates for maspin, p53 and Skp2 in normal control were 95%, 5%, 5%, respectively. Maspin expression was much lower in colorectal adenocarcinoma than in adenoma and normal tissues （both P〈0.05）. Maspin expression showed a negative association with lymphatic metastasis and higher Dukes＇ stage （both P〈0.05）. Expression of maspin protein was negatively correlated with p53 expression （r =-0.536, P〈0.01, in adenocarcinoma; r=-0.668, P〈0.01, in adenoma）. However, there was no significant correlation between expression of p53 and Skp2 （r=0.000, P〉0.05, in adenocarcinoma; r=-0.053, P〉0.05, in adenoma）. Conclusion： Maspin might play an important role in tumorigenesis and progression （especially in lymph node metastasis） of colorectal adenocarcinoma. Maspin expression was inversely correlated with mutant p53 expression in colorectal tumors, which suggested that maspin expression was regulated by the p53 pathway. Skp2 might serve as an independent factor which participated in multistage process of colorectal carcinogenesis.

关键词： Maspin P53 Skp2 Colorectal Cancer Immunohistochemistry

TOWARDS AN ONTOLOGY-BASED MULTI-AGENT MEDICAL INFORMATION SYSTEM BASED ON THE WEB

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Journal of Shanghai Jiaotong university(Science) 2002年第2期7卷 194-197页

作者： ZHANG Quan-hai(张全海) shi peng-fei(施鹏飞) Inst. of Image Processing & Pattern Recognition Shanghai Jiaotong Univ. Shanghai 200030 China Inst. of Image Processing & Pattern Recognition Shanghai Jiaotong Univ. Shanghai 200030 China

This paper described an ontology based multi agent knowledge process made (MAKM) which is one of multi agents systems (MAS) and uses semantic network to describe agents to help to locate relative agents distributed in the workgroup. In MAKM, an agent is the entity to implement the distributed task processing and to access the information or knowledge. Knowledge query manipulation language (KQML) is adapted to realize the communication among agents. So using the MAKM mode, different knowledge and information on the medical domain could be organized and utilized efficiently when a collaborative task is implemented on the web.

关键词： multi-agents system (MAS) medical information semantic network ontology

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分布式协作模型及应用研究

计算机科学 2003年第6期30卷 13-18页

作者：张全海施鹏飞上海交通大学图像处理与模式识别研究所上海200030

With the development of the Web technology, the application environment has acquired many new characters such as dynamic, openness, distribution and information uncertainty. The processing mode of application systems Is more complicated than ever. For example, It requires application systems to have more commumty processing ability, interactive ability, distributed processing ability and collaborative ability. Accordingly the research and development of the computer application system transited from client/server information processing system into distributed collaborative processing system based on Web. Especially in the environment where the information and resources are highly distributed, the accomplishment of complicated tasks is dependent more on the resources coordination, information sharing and coordinator collaboration. The collaboration is one aspect of the group behavior and its goal is to provide a optimal method to utilize the resource through the information interaction and to solve the task which couldn't be accomplished by each coordinator alone and get the more total benefits than the sum of each benefit. The collaboration problem is the important one for distributed tasks processing. This paper surveys. the research and application status of distributed collaborative models and several representative architectures of distributed collaborative processing are proposed. However, the existing problems and the future researching direction are presented.

关键词：分布式协作模型计算机网络客户服务器信息处理系统

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基于本体的多智能体知识共享和协作

上海交通大学学报 2003年第9期37卷 1426-1429页

作者：张全海施鹏飞上海交通大学图像处理与模式识别研究所上海200030

研究了基于本体的知识建模过程及其应用模式,分析了采用本体模式的知识集成和共享,设计了本体知识库的集成和融合方法,提出了基于本体的多智能体知识共享和协作处理模型,并给出了该模型在医学中的应用.研究结果表明,利用本体方式来获取... 详细信息

研究了基于本体的知识建模过程及其应用模式,分析了采用本体模式的知识集成和共享,设计了本体知识库的集成和融合方法,提出了基于本体的多智能体知识共享和协作处理模型,并给出了该模型在医学中的应用.研究结果表明,利用本体方式来获取、重用、共享和组织知识,可以简化多智能体协作中知识交互的复杂性,加强异构知识源的融合.

关键词：本体协作知识共享多智能体分布式人工智能

Polymer-based smart fibers and textiles for wearable electronics

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Science China Technological Sciences 2025年第1期 85-120页

作者： Sanming HU Li WANG Zaixian YUAN Kun CHEN Wei peng hai YIN Zhijun shi Guang YANG School of Biomedical Engineering and Imaging Xianning Medical CollegeHubei University of Science and Technology College of Life Science and Technology Huazhong University of Science and Technology Wuhan Branch of the National Science Library Chinese Academy of Sciences

Smart fibers and textiles have attracted considerable interest for application in wearable devices because of their advantages of being human-friendly, lightweight, flexible, and comfortable. In addition, they are considered to have potential applications in health monitoring, energy management, and human-machine interaction systems. Polymers and polymer fibers,with excellent mechanical strength, wrinkle resistance, and heat resistance, are widely used to fabricate smart fibers and textiles. Herein, a comprehensive overview of polymer-based fibers and textiles is provided. First, we review the design principles of various polymer-based smart textiles, including textile-based sensors, energy capture and storage textiles, and computation and display textiles. Next, materials used for preparing polymer-based smart fibers, such as metals, carbon-based materials, and natural and synthetic polymers, particularly conductive polymers, are summarized. In addition, this review summarizes key technologies used for preparing smart fibers and the conventional structures of smart textiles. Furthermore, the applications of smart textiles in personal health monitoring, thermal management, energy capture and storage, and computation and displays are discussed. Finally, the current challenges, limitations, and future trends of smart fibers and textiles are discussed.

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基于离散元方法的煤层覆岩导水裂缝带影响因素研究

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山东煤炭科技 2018年第6期36卷 149-151,154页

作者：王诗海时鹏程冯宜语枣矿矿业集团高庄煤业有限公司山东微山277600 枣庄科技职业学院山东滕州277500

以山东济宁高庄矿地质情况建立基本地质模型,采用UDEC离散元方法对不同因素关于煤层导水裂缝带发育高度的影响进行模拟计算分析,得出不同采深、采厚、覆岩岩性组合、地质构造(主要指断层)等因素下的导水裂缝带高度发育规律,研究结果可... 详细信息

以山东济宁高庄矿地质情况建立基本地质模型,采用UDEC离散元方法对不同因素关于煤层导水裂缝带发育高度的影响进行模拟计算分析,得出不同采深、采厚、覆岩岩性组合、地质构造(主要指断层)等因素下的导水裂缝带高度发育规律,研究结果可对高庄矿湖下安全开采提供理论支撑,为微山湖周边类似地层条件矿井提供借鉴和参考依据。

关键词：导水裂缝带 UDEC 数值模拟覆岩破坏

渤南油田中部古近系沙河街组低渗透储层岩石学和成岩作用

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沉积与特提斯地质 2004年第1期24卷 84-90页

作者：李海燕彭仕宓黄述旺石油大学北京102200

该区储层岩石类型主要为岩屑质长石砂岩 ,溶解作用是主要的建设性成岩作用 ,压实、自生矿物充填和胶结作用是主要的破坏性成岩作用 ,成岩阶段处于晚成岩A亚期。该区储层较高的孔隙度是晚成岩期强烈的溶解作用形成次生溶孔的结果 ,而储... 详细信息

该区储层岩石类型主要为岩屑质长石砂岩 ,溶解作用是主要的建设性成岩作用 ,压实、自生矿物充填和胶结作用是主要的破坏性成岩作用 ,成岩阶段处于晚成岩A亚期。该区储层较高的孔隙度是晚成岩期强烈的溶解作用形成次生溶孔的结果 ,而储层砂岩较低渗透率的主要成因机理是成岩期各种自生矿物的充填和胶结作用 ;此外 ,溶蚀作用形成的孤立、互不连通的粒间孔也是形成低渗微细喉道储层的主要原因。有利孔隙组合为粒间溶蚀孔原生粒间孔粒内破碎缝 ,有利储层的分布受砂体分布。

关键词：古近系沙河街组低渗透成岩储层渤南油田

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao Kang Xiao-Li Zhao Lin Xu Linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng hai-Bo Yang Huakang Yu Xueliang shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding hai-Yan shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors