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Adaptive control of track tension estimation using radial basis function neural network

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Defence Technology（防务技术） 2021年第4期17卷 1423-1433页

作者： Ping-xin Wang Xiao-ting Rui hai-long yu Guo-ping Wang Dong-yang Chen Institute of Launch Dynamics Nanjing University of Science and TechnologyNanjing210094China College of Electrical Energy and Power EngineeringYangzhou UniversityYangzhou225000China

Track tension is a major factor influencing the reliability of a *** order to reduce the risk of track peel-off,it is necessary to keep track tension ***,it is difficult to measure the dynamic tension during off-road *** on the analysis of the relation and external forces depending on free body diagrams of the idler,idler arm,road wheel and road arm,a theoretical estimation model of track tension is *** estimation results with multibody dynamics simulation results,the rationality of track tension monitor is *** the aid of this monitor,a track tension control system is designed,which includes a self-tuning proportional-integral-derivative(PID)controller based on radial basis function neural network,an electro-hydraulic servo system and an idler *** tightness of track can be adjusted by turning the idler *** results of the vehicle starting process indicate that the controller can reach different expected tensions quickly and *** with a traditional PID controller,the proposed controller has a stronger anti-disturbance ability by amending control parameters online.

关键词： Track tension Monitor Multibody dynamics Neural network Anti-disturbance ability

Water Supply Changes N and P Conservation in a Perennial Grass Leymus chinensis

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Journal of Integrative Plant Biology 2009年第11期51卷 1050-1056页

作者： Ju-Ying Huang hai-long yu Ling-Hao Li Zhi-You yuan Samuel Barrels Center of New Technology Appfication and Research Ningxia University Yinchuan 750021 China State Key Laboratory of Vegetation and Environmental Change Institute of Botany the Chinese Academy of Sciences Beijing 100093 China College of Recourses and Environment Ningxia University Yinchuan 750021 China Faculty of Forestry and the Forest Environment Lakehead University Thunder Bay Ontario P7B 5E1 Canada

Changes in precipitation can influence soil water and nutrient availability, and thus affect plant nutrient conservation strategies. Better understanding of how nutrient conservation changes with variations in water availability is crucial for predicting the potential influence of global climate change on plant nutrient-use strategy. Here, green-leaf nitrogen （N） and phosphorus （P） concentrations, N- and P-resorption proficiency （the terminal N and P concentration in senescent leaves, NRP and PRP, respectively）, and N- and P-resorption efficiency （the proportional N and P withdrawn from senescent leaves prior to abscission, NRE and PRE, respectively） of Leymus chinensis （Trin.） Tzveh, a typical perennial grass species in northern China, were examined along a water supply gradient to explore how plant nutrient conservation responds to water change. Increasing water supply at low levels （〈 9000 mL/year） increased NRP, PRP and PRE, but decreased green-leaf N concentration. It did not significantly affect green-leaf P concentration or NRE. By contrast, all N and P conservation indicators were not significantly influenced at high water supply levels （〉 9000 mL/year）. These results indicated that changes in water availability at low levels could affect leaf-level nutrient characteristics, especially for the species in semiarid ecosystems. Therefore, global changes in precipitation may pose effects on plant nutrient economy, and thus on nutrient cycling in the plant-soil systems.

关键词： green-leaf nutrient concentration Leymus chinensis nutrient resorption nutrient conservation water supply gradient.

ESE1 expression correlates with neuronal apoptosis in the hippocampus after cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2019年第5期14卷 841-849页

作者： hai-long yu Liang-Zhu Wang Ling-Ling Zhang Bei-Lei Chen Hui-Juan Zhang yu-Ping Li Guo-Dong Xiao Ying-Zhu Chen Clinical Medical College of Yangzhou University Department of Neurology Northern Jiangsu People's Hospital Institute of Neuroscience Northern Jiangsu People's Hospital Drum Tower Hospital Medical School of Nanjing University Dalian Medical University Department of Neurology Second Affiliated Hospital of Soochow University

Epithelial-specific ETS-1(ESE1), a member of the ETS transcription factor family, is widely expressed in multiple tissues and performs various functions in inflammation. During neuroinflammation, ESE1 promotes neuronal apoptosis; however, the expression and biological functions of ESE1 remain unclear after cerebral ischemia/reperfusion. We performed in vivo and in vitro experiments to explore the role of ESE1 in cerebral ischemic injury. A modified four vessel occlusion method was used in adult Sprague-Dawley rats. At 6, 12, 24, 48, and 72 hours after model induction, the hippocampus was collected for analysis. Western blot assays and immunohistochemistry showed that the expression of ESE1, phosphorylated p65 and active caspase-3 was significantly up-regulated after ischemia. Double immunofluorescence staining indicated that ESE1 and NeuN were mostly co-located in the hippocampus after ischemia. Furthermore, ESE1 was also co-expressed with active caspase-3. PC12 cells were stimulated with cobalt chloride(CoCl_2) to establish a chemical hypoxia model. After ESE1 knockdown by siRNA for 6 hours, cell viability was detected by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assays. The levels of ESE1, phosphorylated p65 and active caspase-3 were also remarkably increased in PC12 cells after CoCl_2 stimulation. After ESE1 knockdown, PC12 cell viability was increased after hypoxia. siRNA knockdown of ESE1 decreased the level of p-p65 and active caspase-3 after CoCl_2 stimulation. These data reveal that ESE1 levels are elevated in the hippocampus after cerebral ischemia/reperfusion injury. This may play a role in neuronal apoptosis via activation of the nuclear factor-κB pathway.

关键词： stroke epithelial specific ETS-1 cerebral ischemia/reperfusion nuclear factor-κB inflammation caspase-3 neuroprotective effects neural regeneration cobalt chloride(CoCl2) siRNA transfection

Research on stress-induced apoptosis of natural killer cells and the alteration of their killing activity in mouse liver

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World Journal of Gastroenterology 2013年第37期19卷 6258-6264页

作者： Zhen Ma Yang Liu Xin Zhou hai-long yu Ming-Qi Li Chikako Tomiyama-Miyaji Toru Abo Xue-Feng Bai Department of Colorectal Surgery Harbin Medical University Cancer Hospital Department of General Surgery the Second Affiliated Hospital of Harbin Medical University Department of Immunology Niigata University School of Medicine

AIM:To investigate the stress-induced apoptosis of natural killer(NK)cells and the changes in their killing activity in mouse ***:A restraint stress model was established in *** cytometry was employed to measure the percentage of NK cells and the changes in their absolute number in mouse *** cytotoxicity of hepatic and splenic NK cells was assessed against YAC-1 target cells via a 4 h 51Cr-release ***:The restraint stress stimulation induced the apoptosis of NK cells in the liver and the spleen,which decreased the cell *** number and percentage of NK cells in the spleen ***,the number of NK cells in the liver decreased,whereas the percentage of NK cells was significantly *** apoptosis of NK cells increased gradually with prolonged stress time,and the macrophage-1(Mac-1)+NK cells were more susceptible to apoptosis than Mac-1-NK *** numbers of Mac-1-NK cells in the liver,which are more resistant to stress-induced apoptosis,were observed than the Mac-1-NK cells in the *** stress stimulation diminished the killing activity of NK cells in the spleen was significantly decreased,but the retention of numerous Mac-1-NK cells in the liver maintained the killing ***:Significant stress-induced apoptosis was observed among Mac-1+NK cells,but not Mac-1-NK cells in the mouse *** stimulation markedly decreased the killing activity of NK cells in the spleen but remained unchanged in the liver.

关键词： Restraint stress Natural killer cells Cell apoptosis Killing activity

Study on the influence of projectile on muzzle disturbance

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Defence Technology（防务技术） 2018年第5期14卷 570-577页

作者： Fei-fei Liu Yan-ming Song hai-long yu Wen-ding Lin Jie Zhang Zhi-hui Si Ming-kang Ding Xiao-ting Rui China Weapon Industry Corporation NHIC Nanjing Research Institute Nanjing210000China China Weapon Industry Corporation NHIC Baotou014000China Institute of Launch Dynamics Nanjing University of Science&TechnologyNanjing210094China

In order to make an efficient analysis of muzzle disturbance influenced by projectile mass, mass eccentricity, dynamic unbalance, load deviation, and clearance between projectile and bore, the orthogonal test method is extended to analyze the launch dynamics. Taking a tank as the research object, the launch dynamics equations of a tank system are established. Based on the stochastic simulation principle, the tank launch dynamic simulation system is constructed and through the development of the orthogonal test method, the influence of projectile on muzzle disturbance is studied. The study results provided both theoretical foundation and simulation approaches for improving the firing dispersion of the tank.

关键词： Muzzle disturbance Orthogonal test Projectile-barrel coupling Firing dispersion

Agrobacterium tumefaciens-mediated transformation of rice with the spider insecticidal gene conferring resistance to leaffolder and striped stem borer

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Cell Research 2001年第2期11卷 149-155页

作者： HUANG JIAN QIU, ZHI MING WEI, hai long AN, yu XIAN ZHU National Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China National La National Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai. jqhuang@***

Immature embryos of rice varieties 'Xiushui11' and 'Chunjiang 11' precultured for 4d were infected and transformed by Agrobacterium tumefaciens strain EHA101/pExT7 (containing the spider insecticidal gene). The resistant cant were transferred onto the differentiation medium and plants were regenerated. The transformation frequency reached 56%-72% measured as numbers of Geneticin (G418)-resistant calli produced and 36%-60% measured as numbers of transgenic plants regenerated, respectively. PCR and Southern blot analysis of transgenic plants confirmed that the T-DNA had been integrated into the rice genome. Insect bioassays using T1 transgenic plants indicated that the mortality of the leaffolder (Cnaphalocrasis medinalis) after 7d of leaf feeding reached 38%-61% and the corrected mortality of the striped stem borer (Chilo suppressalis) after 7d of leaf feeding reached 16%-75%. The insect bioassay results demonstrated that the transgenic plants expressing the spider insecticidal protein conferred enhanced resistance to these pests.

关键词： Rice Agrobacterium tumefaciens spider insecticidal gene transgenic plant Leaffolder striped stem borer insect bioassay.

EXPERIMENTS OF SEA ICE SIMULATION

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Journal of Hydrodynamics 2005年第6期17卷 686-692页

作者： LIU Xi-ying State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics （LASG） Institute of Atmospheric Physics （IAP） Chinese Academy of Sciences Beijing 100029 China

As a substitute for the original displaced pole grids, a simple rotated spherical coordinate system was intro duced into the Community Sea Ice Model version 4（CSIM4）, which is a component of the Community Climate System Model（CCSM） of the American National Center of Atmospheric Researeh（NCAR）, to deal with the ＂pole problems＂. In the new coordinates, both the geographical North Pole and South Pole lie in the model equator and grid sizes near the polar region are more uniform. With reanalysis dataset of American National Centers for Environment Prediction （NCEP） and Levitus dataset without considering sub-mixed layer heat flux, the model was integrated for 100 years with thermodynamics *** involved only in the former 49 years and both dynamic and thermodynamic processes involved in the left time. Inner consistency of model results was checked with no contradiction found. The results of last 10 years＇ model output were analyzed and it is shown that the simulated sea ice seasonal variation is rational whereas sea ice extent in the Barcnts Sea in winter is larger than that of observation, Numerical experiment on influence of sub-mixed layer heat flux was also carried out and it is shown that the sub-mixed layer heat flux can modulate seasonal variation of sea ice greatly. As a model component, the sea ice model with rotated spherical coordinates was coupled with other models （the oceanic general cir culation model is the LASG/IAP Climate System Ocean Model （LICOM） with reduced grid, other models are components of NCAR CCSM2） forming a climate system model and its preliminary results were also given briefly.

关键词： sea ice numerical simulation climate system model

Short-segment decompression/fusion versus long-segment decompression/fusion and osteotomy for Lenke-Silva type Ⅵ adult degenerative scoliosis

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Chinese Medical Journal 2019年第21期132卷 2543-2549页

作者： Hao-Cong Zhang hai-long yu Hui-Feng Yang Peng-Fei Sun Hao-Tian Wu Yang Zhan Zheng Wang Liang-Bi Xiang Department of Orthopaedics The General Hospital of Northern Theater CommandShenyangLiaoning 110016China Department of Orthopaedics Chinese PLA General HospitalBeijing 100853China.

Background:The effect of short-segment decompression/fusion versus long-segment decompression/fusion and osteotomy for Lenke-Silva type Ⅵ adult degenerative scoliosis(ADS)has not been *** study aimed to compare the clinical and radiographic results of short-segment fusion ***-segment fusion and osteotomy for patients with Lenke-Silva type Ⅵ ***:Data of 28 patients who underwent spinal surgery for ADS from January 2012 to January 2014 in the General Hospital of Northern Theater Command were *** the 28 patients,12 received long-segment fusion and osteotomy and 16 received short-segment *** imaging parameters and clinical outcomes,including the sagittal vertical axis(SVA),lumbar lordosis(LL)angle,pelvic tilt(PT),sacral slope(SS),the visual analog scale(VAS),Japanese Orthopedic Association(JOA),Oswestry disability index(ODI),and lumbar stiffness disability index(LSDI)scores,were *** difference between groups was compared using the dependent t test or Chi-squared ***:The Cobb and LL angles and SVA improved in both groups;however,PT and SS angles did not improve following short *** were significant differences in the post-operative SVA(26.8±5.4mm vs.47.5±7.6 mm,t=–8.066,Plong and short fusion *** patients had improved ODI,JOA,and VAS scores post-operatively(all P0.05).The post-operative LSDI score was 3.5±0.5 in the long fusion group,which was significantly higher than that of the short fusion group(1.4±0.7;Plong-segment decompression/fusion and osteotomy despite poor correction of sagittal ***,short-segment decompression/fusion

关键词： Degenerative scoliosis Short fusion long fusion Spine surgery Lenke-Silva type Ⅵ

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： yunfan long Jiajia Liu yu Wang haidong Guo Guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory