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Inhibition of expression of vascular endothelial growth factor and its receptors in pulmonary adenocarcinoma cell by TNP-470 in combination with gemcitabine

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第10期7卷 837-843页

作者： WANG Xue-fen tu ling-fang WANG Li-hong ZHOU Jian-ying Department of Respirology the First Affiliated HospitaL School of Medicine Zhejiang University Hangzhou 310003 China Department of Cardiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Angiogenesis is required for solid tumor growth and facilitates tumor progression and metastasis. The inhibition effects of O-（chloroacetyl-carbamoyl） fumagillol （TNP-470）, an angiogenesis inhibitor, and gemcitabine, a chemotherapeutic agent, on expression of growth factors were investigated using human pulmonary adenocarcinoma cell line, A549. The A549 cells were divided into four groups： control group, 10^-6 mg/ml gemcitabine treated group, 10^-4 mg/ml TNP-470 treated group and gemcitabine＋TNP-470 treated group. The mRNA and protein expression of vascular endothelial growth factor （VEGF） and its receptors, FMS-like tyrosine kinase-l （FLT-1） and kinase insert domain-containing receptor （KDR）, in different groups were measured. The growth of A549 cell cultured with gemcitabine or TNP-470 was inhibited in an almost dose-dependent manner. Although gemcitabine （10^-6 mg/ml） alone and TNP-470 （10^-4 mg/ml） alone had no effect on the mRNA and protein expression of VEGF and its receptors （FLT-1, KDR） in A549 cells compared to the control （P〉0.05）, 10^-6 mg/ml gemcitabine in combination with 10^-4 mg/ml TNP-470 had significant effect （P〈0.01）. Moreover, combination of the two drugs significantly inhibited the mRNA expression of VEGF, FLT-1 and KDR compared to either drug alone （P〈0.05）. This study suggests that combined treatment with TNP-470 plus gemcitabine may augment the antiangiogenic and antineoplastic effects in lung cancer cells in vitro.

关键词： TNP-470 Gemcitabine VEGF FLT-1 KDR

Predictive parameters on CT scan for dysthyroid optic neuropathy

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1266-1271页

作者： Bo Yu Can Gong Yuan-Fei Ji Yu Xia Yun-hai tu Wen-Can Wu Department of Orbital and Oculoplastic Surgery Eye Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Ophthalmology Loudi Central HospitalLoudi 417000Hunan ProvinceChina Eye Hospital of Wenzhou Medical University Wenzhou 325000ZhejiangProvinceChina

AIM:To evaluate the value of parameters on CT scan in predicting dysthyroid optic neuropathy(DON)and to provide guidance for early diagnosis of DON ***:A total of 67 eyes of 35 patients with thyroid-associated ophthalmopathy(TAO)were included in this *** were divided into 2 groups(DON group and non-DON group).Parameters were measured on high resolution CT,including muscle index(MI),superior ophthalmic vein(SOV)dilatation,extraocular muscle volume/orbit volume(MV/OV),and intracranial fat prolapsed,and be compared between these 2 *** relation between those parameters and visual function[visual acuity(VA)and visual field defect(VF defect)]were also ***:MI and MV/OV were significantly higher in DON group(P=0.00035 and P=0.00026).No significant difference was detected regarding intracranial fat prolapse existence and SOV dilatation(P=0.37 and P=0.15).MV/OV was found to have significant negative correlation with both VF defect(R=-0.332,P=0.0273)and VA(R=-0.635,P=0.00)while MI was found to have negative linear correlation with VA only(R=-0.456,P=0.00017).The area under receiver operating characteristic curves was 0.82 for MV/OV and 0.75 for *** best performance in detecting DON was achieved when MV/OV is set at 0.20 with 72%sensitivity and 87%specificity and MI is set at 0.52 with 64%sensitivity and 80%***:MI and MV/OV are predictive parameters for *** with clinical manifestations,MV/OV≥0.2 can be used as a good indicator for DON in TAO patients.

关键词： dysthyroid optic neuropathy muscle index superior ophthalmic vein dilatation intracranial fat prolapse muscle volume/orbital volume

Investigation of fluorescence resonance energy transfer ultrafast dynamics in electrostatically repulsed and attracted exciton-plasmon systems

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Chinese Physics B 2021年第2期30卷 529-534页

作者： Hong-Yu tu Ji-Chao Cheng Gen-Cai Pan Lu Han Bin Duan hai-Yu Wang Qi-Dai Chen Shu-Ping Xu Zhen-Wen Dai ling-Yun Pan State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China State Key Laboratory on Integrated Optoelectronics College of ElectronicsScience and EngineeringJilin UniversityChangchun 130012China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China

Following the gradual maturation of synthetic techniques for nanomaterials,exciton-plasmon composites have become a research hot-spot due to their controllable energy transfer through electromagnetic fields on the ***,most reports ignore fluorescence resonance energy transfer(FRET)under electrostatic repulsion *** this study,the FRET process is investigated in both electrostatic attraction and electrostatic repulsion *** changing the Au:quantum dot ratio,local-field induced FRET can be observed with a lifetime of ns and a fast component of hundreds of *** results indicate that the intrinsic transfer process can only elucidated by considering both steady and transient state information.

关键词： fluorescence resonance energy transfer(FRET) quantum dots excitons-plasmon composites

Mechanisms of support failure and prevention measures under double-layer room mining gobs——A case study: Shigetai coal mine

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International Journal of Mining Science and Technology 2019年第6期29卷 955-962页

作者： Defu Zhu Shihao tu Hongsheng tu Zhenqian Yang State Key Laboratory of Deep Coal Resource China University of Mining and Technology

In the practice of mining shallow buried ultra-close seams,support failure tends to occur during the process of longwall undermining beneath two layers of room mining goaf(TLRMG).In this paper,the factors causing support failure are summarized into geology and mining *** column lithology and composite beam theory,the key stratum of the rock strata is determined.A finite element numerical simulation is used to analyze the overlying load distribution rule of the main roof for different plane positions of the upper and lower room mining *** tributary area theory(TAT)is adopted to analyze the vertical load distribution of each pillar,and dynamic models of coal pillar instability and main roof fracture are *** key block instability analysis,two critical moments are established,of which critical moment A has the greater dynamic load *** economic losses and safety hazards are created by the dynamic load of the fracturing of the main *** reduce these negative effects,a method of pulling out supports is developed and two alternative measures for support failure prevention are proposed:reinforcing stope supports in conjunction with reducing mining height,or drilling ground holes to pre-split the main *** on a comprehensive consideration of economic factors and the two categories of support failure causes,the method of reinforcing stope supports while reducing mining height was selected for use on the mining site.

关键词： Multiple room mining goaf Mechanism of supports failure Numerical simulation Prevention measure

Absolute Structure Determination of Chiral Organic Nanocrystals Using Zone-Axis Electron Diffraction

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CCS Chemistry 2023年第11期5卷 2466-2472页

作者： Lijin Wang Junyan Li Yang ling tu Sun Yaqi Fan Yanhang Ma Shanghai Key Laboratory of High-Resolution Electron Microscopy School of Physical Science and TechnologyShanghaiTech UniversityShanghai 201210 State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012

Enantiomorphic identification of chiral molecules is essential in organic chemistry and the pharmaceutical industry,as two enantiomorphic structures can show distinctively different ***,we illustrate the absolute structural determination of organic nanocrystals using zone-axis electron diffraction by taking advantage of electron multiple *** enantiomorphs are distinguished by comparing the reflection intensities of Friedel pairs in the zone-axis electron diffraction pattern,after confirming the absolute indices of reflections by locating relative positions of diffraction spots from two patterns that deviate from a certain *** demonstrate the protocol with successful applications in two chiral drug nanocrystals.

关键词： chiral organic nanocrystal absolute structure electron diffraction multiple scattering absolute configuration

Creep behavior of plasma sprayed NiCr and NiCrAl coating-based systems

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 183-189页

作者： Shan-tung tu Key Laboratory of Safety Science of Pressurized System Ministry of EducationEast China University of Science and Technology

The creep behavior of the plasma sprayed NiCr and NiCrA1 coating/Nickel alloy 690 substrate systems at 1033 K was investigated. Results showed that there was almost no difference in the creep lives between the NiCr and NiCrA1 coated specimens at a given stress level, since the contents of Cr used in the NiCr and NiCrA1 powders are almost same. The relationship between the minimum creep rate and the applied stress followed the well-known Norton＇s power law, εmin=Aσ^n, with the values of A=2.66×10^-16 MPa^-n·h^-1 and n=6.48. The relation between the applied stress and time to rupture of the coated specimens can be estimated by using Larson-Miller equation. The θ projection method can be used to accurately characterize the creep behavior of the coated specimens.

关键词： Creep Coating θ projection method Minimum creep strainrate

Effectiveness and Safety of Moxibustion Robots on Primary Dysmenorrhea:A Randomized Controlled Pilot Trial

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Chinese Journal of Integrative Medicine 2021年第8期27卷 578-584页

作者： ZHANG Han-rui tu hai-yan WANG Yu XIA Shi-lin ZHAO Guo-you YANG Ting LI Ying-kun School of Acupuncture Moxibustion and tuina Chengdu University of Traditional Chinese MedicineChengdu610075China Department of Rehabilitation Chengdu Fifth People’s HospitalChengdu611130China College of Electrical Engineering Sichuan UniversityChengdu610065China Department of Acupuncture and Rehabilitation Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu610075China

Objective To conduct a pilot trial to explore the effectiveness and safety of moxibustion robots in treating primary dysmenorrhea(PD)and evaluate its feasibility in *** A total of 70 participants with PD were allocated to either moxibustion robot(MR)group(35 cases)or manual moxibustion(MM)group(35 cases)using computer-generated *** acupoint Guanyuan(CV 4)was selected to receive moxa heat *** groups of participants were given 3 menstrual cycles of MM and MR treatment respectively(once a day,5 days a session)and received another 3 menstrual cycles *** degree of pain was evaluated by short-form McGill pain questionnaire(SF-MPQ)and the symptoms of dysmenorrhea were evaluated by Cox Menstrual Symptom Scale(CMSS).The safety was measured by the occurrence rate of adverse events(AEs),including burns(blisters,red and swollen),itching,bowel changes,menstrual cycle disorder,menorrhagia and fatigue,*** A total of 62 patients completed the trial,32 in MR group and 30 in MM *** with baseline,scores of SF-MPQ and CMSS significantly decreased in both groups(P0.05).The total occurrence rate of AEs in MR group was 2.1%,which was significantly lower than MM group(7.2%,P<0.05).Conclusions MR has the same effect as MM at SF-MPQ and CMSS in patients with ***,MR is safer than MM(Trial registration ***1800018236).

关键词： primary dysmenorrhea moxibustion robot randomized controlled pilot trial

Creep crack growth in a Cr-Mo-V type steel: experimental observation and prediction

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Acta Metallurgica Sinica(English Letters) 2011年第2期24卷 81-91页

作者： Shan-tung tu Key Laboratory of Safety Science of Pressurized System Ministry of Education School of Mechanical and Power Engineering East China University of Science and Technology

In this study, the creep crack growth （CCG） properties and fracture mechanism of a Cr-Mo-V steel at 566 C in compact tension （CT） specimens were investigated, and the CCG rate was predicted by using the NSW model. The results show that the CCG rate measured by CT specimens is much lower than that predicted by the NSW model under plane-strain state. This means that the NSW model prediction for the CCG rate of the steel is over-conservative. In addition, the CCG rate da/dt versus C measured by the experiments shows the piecewise linear relation on log-log scale instead of a single linear relation predicted by the NSW model. The main reasons for these results are that the actual creep fracture mechanism of the steel and the actual creep crack tip stress field in the CT specimens have not been fully captured in the NSW model. The experimental observation shows that the creep crack propagates in a discontinuous way （step by step） at meso-scale, and the cracks at micro-scale are usually formed by the growth and coalescence of voids on grain boundaries. The NSW model based on the creep ductility exhaustion approach may not correctly describe this creep fracture process. In addition, the opening stress and triaxial stress ahead of crack tips calculated by three-dimensional finite element method is lower than those predicted by the HRR stress field which is used in the NSW model under plane-strain state. The use of the high HRR stress field will cause high CCG rates. The change in the creep fracture mechanism at micro-scale in different ranges of C may cause the piecewise linear relation between the da/dt and C . Therefore, it is necessary to study the actual CCG mechanism in a wide range of C and the actual creep crack tip stress field to establish accurate CCG prediction models.

关键词： Creep crack growth Prediction NSW model Fracture mechanism Finite element method

Effects of riser geometry on gas-solid flow characteristics in circulating fluidized beds

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Particuology 2020年第2期18卷 205-217页

作者： Qiuya tu haigang Wang Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 10090China University of Chinese Academy of Sciences Beijing 100049China

The performance of a circulating fluidized bed strongly depends on its parameter settings,including that of riser *** this study,a laboratory-scale circulating fluidized bed with three different riser geometries(circular,square,and rectangular)that had the same cross-sectional area and height was operated under two static bed heights(20,and 35 cm).Electrical capacitance tomography was combined with differential pressure transducers and an optical-fiber probe to measure the solids'volume fraction,differential pressure fluctuations,and radial particle concentration *** particle fluid dynamics simulations were also *** results showed that single bubbles appeared in the bottom region of the circular and square risers and double bubbles in the bottom region of the rectangular *** autocorrelation of capacitance signals was periodic for the circular and square risers and non-periodic for the rectangular *** radial particle concentration profiles showed a single-core annulus structure in the circular and square risers,but a double-core annulus structure along the long side and single-core annulus structure along the short side in the rectangular *** entropy analysis showed that fluidization was less disordered and most predictable for the rectangular riser.

关键词： Circulating fluidized bed Riser geometry Static bed height Bubble shape Electrical capacitance tomography Computational particle fluid dynamics