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Chinese Chemical Letters 2021年第9期32卷 2851-2855页

作者： Hong-Kai Li hai-lin ye Xiao-Xue Zhao Xiao-Long Sun Qian-Qian Zhu Zhang-ye Han Rongrong Yuan Hongming He Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China Department of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China

More and more attentions have been focused on design and synthesis of novel metal-organic framework/graphene oxide(MOF/GO)composites with unique ***-porphyrin MOF(PCN-222)is in-situ synthesis with the existence of GO with-COOH group to artfully fabricate a PCN-222/GO *** composite can be employed as functional material to modify the working *** to excellent electrical conductivity of GO,abundant mesoporous channels and numerous Zr(Ⅳ)metal sites of PCN-222,this composite can immobilize a large amount of aptamer through strongπ-πstacking interaction and high affinity between phosphate group of aptamer and Zr(Ⅳ)site of PCN-222 ***,an ultra-sensitive electrochemical aptasensor based on PCN-222/GO composite can quantificationally detect trace chloramphenicol with limit of detection of 7.04 pg/m L(21.79 pmol/L)from 0.01 ng/m L to 50 ng/m L by electrochemical impedance spectroscopy even in real ***,this fabricated aptasensor reveals good repeatability,outstanding selectivity and preferable long-term *** research provides a useful approach to construct MOF/GO composites for fabricating electrochemical aptasensors in the electrochemical detection field.

关键词： PCN-222/GO composite Aptamer Electrochemical aptasensor Chloramphenicol Electrochemical impedance spectroscopy

基于修订的心室肌细胞模型的短QT综合征病理仿真

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东北大学学报（自然科学版） 2015年第8期36卷 1097-1101页

作者：刘纪红林杨林海叶东北大学信息科学与工程学院辽宁沈阳110819 东北大学中荷生物医学与信息工程学院辽宁沈阳110819

基于已公布的人体心室肌细胞模型数据建立了一维心室肌细胞模型,仿真了伪心电图及心内膜细胞、心中间膜细胞和心外膜细胞这三种细胞的动作电位.基于构建的模型进行周期实验,针对实验中出现的问题修订模型中的参数.将修订后模型的仿真结... 详细信息

基于已公布的人体心室肌细胞模型数据建立了一维心室肌细胞模型,仿真了伪心电图及心内膜细胞、心中间膜细胞和心外膜细胞这三种细胞的动作电位.基于构建的模型进行周期实验,针对实验中出现的问题修订模型中的参数.将修订后模型的仿真结果与已经公布的实验数据进行对比,从而验证模型修订的合理性和可靠性.最后基于修订的心室肌细胞模型对与KCNJ2有关的短QT综合征的病理情况进行仿真,分析仿真结果,验证了修订模型的实用性.

关键词：病理仿真离子通道动作电位时程膜电导短QT综合征

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基于离子通道的心力衰竭病理分析仿真研究

东北大学学报（自然科学版） 2013年第11期34卷 1533-1536页

作者：刘纪红林海叶崔悦东北大学中荷生物医学与信息工程学院辽宁沈阳110819 东北大学信息科学与工程学院辽宁沈阳110819

通过计算机模拟人的心脏电生理活动,可以为经济、安全地研发心脏病治疗药物提供保障.针对这一需求,基于已建立的心肌细胞离子通道数学模型设计并实现了一种心肌细胞离子通道级仿真平台,仿真了Purkinje纤维细胞、心内膜细胞、心中间膜细... 详细信息

通过计算机模拟人的心脏电生理活动,可以为经济、安全地研发心脏病治疗药物提供保障.针对这一需求,基于已建立的心肌细胞离子通道数学模型设计并实现了一种心肌细胞离子通道级仿真平台,仿真了Purkinje纤维细胞、心内膜细胞、心中间膜细胞和心外膜细胞这四种细胞的动作电位.最后根据已发表的实验数据,应用这四种细胞的数学模型对心力衰竭疾病下离子通道开放程度发生变化的病理进行了仿真实验,并且对比分析了仿真得到的心力衰竭和正常心脏情况下的结果,结果与公认实验数据相符,从而验证了该仿真平台的可靠性.

关键词：心肌细胞离子通道心力衰竭数学模型心脏机能仿真

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En Zhou Yilin Li Xiaoming lin Jiaye ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

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自噬、自噬性细胞死亡与肿瘤的研究进展

生命科学 2017年第8期29卷 763-768页

作者：伍思霖黄玉莹丁海林顾晔张晓彪复旦大学附属中山医院神经外科上海200032

自噬是绝大部分真核细胞中一种依赖于溶酶体的极度保守的生理过程,是细胞内物质再循环的有效机制。适度的自噬是细胞抵御不良环境的生存方式,但当发生过度的自噬时,将引起细胞的死亡,这种死亡方式称为自噬性细胞死亡。自噬性细胞死亡不... 详细信息

自噬是绝大部分真核细胞中一种依赖于溶酶体的极度保守的生理过程,是细胞内物质再循环的有效机制。适度的自噬是细胞抵御不良环境的生存方式,但当发生过度的自噬时,将引起细胞的死亡,这种死亡方式称为自噬性细胞死亡。自噬性细胞死亡不同于凋亡,表现为细胞中出现大量包裹着细胞质和细胞器的自噬体。越来越多的研究提示,自噬与自噬性细胞死亡与某些恶性肿瘤的发生、发展关系密切。在各种不利环境下,自噬可作为一种应急机制维持肿瘤细胞的生存,而自噬性细胞死亡诱发后又可清除肿瘤细胞。现就自噬与肿瘤的研究进展作一综述。

关键词：自噬自噬性细胞死亡肿瘤 Beclin1 p53 PTEN

AML1-ETO阳性急性髓系白血病CD19的表达及其预后的意义

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中国免疫学杂志 2016年第12期32卷 1809-1814页

作者：边程何平王畅刘晓亮刘杉珊林海谭业辉高素君吉林大学白求恩第一医院肿瘤中心血液科长春130021 长春医学高等专科学校临床医学部内科教研室长春130000

目的:探讨CD19在AML1-ETO阳性急性髓系白血病(Acute myelogenous leukemia with AML1-ETO positive,AML with AML1-ETO positive)患者中的表达及对预后的影响。方法:收集我中心2010年1月至2015年12月共66例初治AML1-ETO阳性AML患者资料,回顾性分析CD19表达与一般临床特征的关系及对生存期的影响。结果:AML1-ETO阳性AML患者初诊时CD19的表达率为50.0%。CD19阳性与阴性患者在年龄、性别、初诊时血红蛋白、血小板、骨髓原始细胞比例、染色体核型、基因突变无统计学差异(P>0.05)。CD19阳性患者初诊时白细胞计数低于阴性患者,有统计学差异(P=0.027)。CD19阳性患者总体生存率明显优于CD19阴性患者(P=0.030),CD19阳性患者无复发生存率较阴性患者高,但差异无统计学意义(P=0.105)。多因素分析结果提示CD19阳性是AML1-ETO阳性AML患者OS的独立预后良好因素。结论:CD19阳性可能是AML1-ETO阳性AML患者预后良好的标志。

关键词：急性髓系白血病 AML1-ETO阳性 CD19 预后

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基于小波分析的海上声信号去噪试验研究

电脑知识与技术 2017年第5X期13卷 153-155页

作者：刘亚雷林海烨孟春宁公安海警学院机电管理系

对于海上声信号的分析中,为消除海上复杂环境中对声信号有用成分干扰的噪声,提出基于小波变换的声信号去噪法。利用matlab软件对给定的声信号进行传统滤波去噪与小波变换去噪两种形式的试验去噪,并将结果进行多方面对比。经过试验结果对... 详细信息

对于海上声信号的分析中,为消除海上复杂环境中对声信号有用成分干扰的噪声,提出基于小波变换的声信号去噪法。利用matlab软件对给定的声信号进行传统滤波去噪与小波变换去噪两种形式的试验去噪,并将结果进行多方面对比。经过试验结果对比,验证了小波变换在海上声信号去噪中的有效性。

关键词：海上声信号小波变换去噪

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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白扁豆的DNA条形码技术鉴别研究

食品与药品 2017年第4期19卷 244-246页

作者：罗晖明饶健肖炳燚聂平林海丁野湖南省药品检验研究院湖南长沙410001

目的鉴定白扁豆及其混伪品ITS2条形码,为白扁豆药材鉴定提供新方法。方法采用PCR法扩增ITS2序列,并双向测序,经Codon Code Aligner拼接后,利用MEGA软件进行数据处理,构建系统聚类树(NJ树)。结果白扁豆ITS2序列长度为218 bp,由所构建的... 详细信息

目的鉴定白扁豆及其混伪品ITS2条形码,为白扁豆药材鉴定提供新方法。方法采用PCR法扩增ITS2序列,并双向测序,经Codon Code Aligner拼接后,利用MEGA软件进行数据处理,构建系统聚类树(NJ树)。结果白扁豆ITS2序列长度为218 bp,由所构建的系统聚类树图可见,各物种均表现单系性,同时又可与其它物种明显区分。结论 ITS2条形码适用于白扁豆及其混淆品的快速鉴别,进一步验证了DNA条形码技术应用于中药材鉴别的有效性。

关键词： DNA条形码 ITS2 白扁豆 PCR扩增鉴别

Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong Zhu Hualong Wang Keqiang ye Guiqin Chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C